piperacillin sodium/tazobactam sodium / Generic mfg. - LARVOL DELTA

Impact of broad-spectrum antibiotic exposure on outcomes following autologous stem cell transplantation for patients with relapsed diffuse large B-cell lymphoma or Hodgkin lymphoma (ASH 2025) - "Antibiotic exposure in the peri-transplant period was recorded, defined as receipt of greater than one day of: broad-spectrum intravenous antibiotics (cefepime, piperacillin-tazobactam, cephalosporins, or monobactams) or vancomycin. The BSA group was separately analyzed according to specific anaerobic coverage (metronidazole, carbapenems, piperacillin-tazobactam, or clindamycin) or not... In this retrospective cohort study of ASCT recipients, early exposure to BSA and AA were associated with decreased OS in univariate analysis, however in multivariate analysis only age remained significant. These findings suggest that while antibiotic exposure may correlate with outcomes, its effect is likely mediated by other clinical factors such as age, or may reflect underlying illness severity, rather than a direct causal relationship. Prospective studies are needed to clarify whether modification of antibiotic exposure can meaningfully improve long-term transplant outcomes without..."

Clinical • B Cell Lymphoma • Bone Marrow Transplantation • Diffuse Large B Cell Lymphoma • Hematological Malignancies • Hodgkin Lymphoma • Lymphoma • Non-Hodgkin’s Lymphoma • Transplantation

Less is more: Improving outcomes in haemato-oncology with optimal antibiotic use for febrile neutropenia (ASH 2025) - "Management of FN: Rapid administration of piperacillin-tazobactam and amikacin (Piptaz/Ami) for fever (≥38°C) with neutropenia (≤0.5x10 9 /L or expected neutropenia) after taking BCs...Two patients had relapsed AML, 2 newly diagnosed AML (on Venetoclax/Azacytidine and one on palliative Hydroxycarbamide), and 1 post-haploidentical HSCT for lymphoma... Patient population: 49% had AML/MDS; 66% had active disease (presentation or relapse). Treatment modalities: intensive chemotherapy (37%) autologous (37%) or allogeneic HSCT (13%). Median age was 57 years (23-85)."

Acute Lymphocytic Leukemia • Acute Myelogenous Leukemia • Bone Marrow Transplantation • Cerebral Hemorrhage • Febrile Neutropenia • Hematological Disorders • Hematological Malignancies • Immunology • Infectious Disease • Leukemia • Lymphoma • Myelodysplastic Syndrome • Neutropenia • Pneumonia • Renal Disease

Impact of antibiotic use in early fever after haploidentical hematopoietic stem cell transplantation with post-transplant cyclophosphamide (ASH 2025) - "All patients received PTCY 50 mg/kg on days +3 and +4, followed by tacrolimus and mycophenolate mofetil as graft-versus-host disease (GVHD) prophylaxis...Eleven patients received tocilizumab for CRS grade ≥2. Levofloxacin prophylaxis was used in 72.8% of cases. Most (85/103, 82.5%) received empirical BSA, mainly piperacillin/tazobactam (67%)... The median patient age was 53 years, and 60.3% were male. The most frequent diagnosis was AML (38.8%). Most patients had intermediate disease risk (65.3%) and a high age-adjusted HCT-CI (76%)."

Post-transplantation • Acute Graft versus Host Disease • Bone Marrow Transplantation • Chronic Graft versus Host Disease • Graft versus Host Disease • Immunology • Infectious Disease • Inflammation • Pneumonia • Transplantation • CRP

Impact of antibiotic timing on survival outcomes in CD19 and BCMA CAR-T cell therapy (ASH 2025) - "In particular, the PIM(piperacillin-tazobactam, imipenem, and meropenem) have been implicated with poor outcomes.This ispossibly related to dysregulation of the gut microbiome and/or impairment of hematopoietic recovery.Here, we aimed to investigate the effect of pre and post CAR-T antibiotics in patients receiving both CD19and BCMA CAR-T cell therapy. This is a single-center retrospective study of adult patients with multiple myeloma, B-celllymphoma, and acute lymphoblastic leukemia treated with autologous CD19 and BCMA targeting CAR-Tcell therapy at our center between April 2017 and August 2024. CD19 CAR-T cell products includedlisocabtagene maraleucel, tisagenlecleucel, brexucabtagene autoleucel, and axicabtagene ciloleucel.BCMA CAR-T cell products included idecabtagene vicleucel and ciltacabtagene autoleucel...Post CAR-T antibiotics were largely fourthgeneration cephalosporins such as cefepime in combination with vancomycin... Exposure to antibiotics in the 30 days..."

CAR T-Cell Therapy • Acute Lymphocytic Leukemia • B Cell Lymphoma • Hematological Malignancies • Infectious Disease • Leukemia • Lymphoma • Multiple Myeloma • Non-Hodgkin’s Lymphoma

Pulmonary complications in acute myelogenous leukemia in post allogenic hematopoietic stem cell transplant period and yield of bronchoalveolar lavage and biopsy- single center experience (ASH 2025) - "Piperacillin-tazobactam was the most used empiric antibiotictherapy (36%) and then meropenem (22%). Despite low diagnostic yield, BAL did impact changes in antimicrobial modification in 1/3 ofthe cases, supporting an early role prior to extensive antimicrobial exposure. The positive predictivevalue of BAL Aspergillus galactomannan was 18% so the results should be analyzed with caution and highclinical suspicion."

Biopsy • Clinical • Acute Myelogenous Leukemia • Bone Marrow Transplantation • Graft versus Host Disease • Hematological Disorders • Hematological Malignancies • Immunology • Infectious Disease • Leukemia • Novel Coronavirus Disease • Pneumonia • Respiratory Diseases • Respiratory Syncytial Virus Infections • Septic Shock • Transplantation

Unwelcome guests: Risk factors for multidrug-resistant bacterial infections in adults with acute lymphoblastic leukemia (ASH 2025) - "For carbapenem-resistantorganisms (CRO), a probability of 35% was observed when two risk factors were present.Among the 367 infectious episodes, first-line empirical therapy consisted of a carbapenem in 52.1%(n=197), piperacillin/tazobactam in 36.2% (n=137), and other antibiotics in 8.8%...The prevalence of multidrug-resistant (MDR) infections in adults with acute lymphoblastic leukemia (ALL)is high (36%). The main risk factors are previous hospitalization, recent antibiotic use, hypoalbuminemia,and ICU admission. MDR infections are associated with increased mortality."

Clinical • Acute Lymphocytic Leukemia • Hematological Malignancies • Infectious Disease • Leukemia

Reduced post-transplant alpha-diversity and domination by enterococcus faecium are associated with increased mortality in pediatric recipients of allogeneic hematopoietic cell transplantation. (ASH 2025) - "Prophylactic antibiotics variedby site: Rome utilized piperacillin/tazobactam (pip/tazo); MSK initially used ceftriaxone but transitionedto levofloxacin in 2020; and BCH used none.During the peri-transplant period (day -30 to day +30), microbiome α-diversity, as measured bySimpson reciprocal index, declined significantly post-HCT (median 4.0 pre- vs. 2.1 post-HCT; p<0.001)indicating substantial microbiome injury. This large, multicenter study highlights significant age- and center-specific variability in gut microbiomediversity and composition during pediatric allo-HCT. We found that reduced post-HCT a-diversity anddomination by Enterococcus faecium were associated with increased mortality."

Clinical • Post-transplantation • Acute Graft versus Host Disease • Graft versus Host Disease • Immunology • Pediatrics • Transplantation

Applying the Lasso Model to Identify Risk Factors for Piperacillin-Tazobactam-Induced Leukopenia. (PubMed, Drug Des Devel Ther) - "Clinicians should recognize the potential association between TZP administration and leukopenia. Routine hematologic monitoring should emphasize leukocyte trends to assess both therapeutic response and drug safety."

Journal • Observational data • Retrospective data • Hematological Disorders • Infectious Disease • Leukopenia • Neutropenia

Bacteraemia with Hepatic Abscess Due to Actinomyces Odontolyticus Associated with Gastrointestinal Foreign Body. (PubMed, Eur J Case Rep Intern Med) - "Always consider gastrointestinal foreign bodies: In elderly patients with dementia presenting with liver abscesses that do not respond to conventional treatment, foreign body perforation should be suspected and actively investigated using a contrast-enhanced computed tomography scan.Actinomyces spp. should be considered: In cases of liver abscess of unknown aetiology, Actinomyces spp. should be considered - a slow-growing anaerobic bacterium requiring matrix-assisted laser desorption/ionization matrix-assisted laser desorption/Ionization time-of-flight mass spectrometry for accurate species identification and targeted antibiotic therapy guidance.Combined treatment is the key to success: Optimal management requires a combination of three elements - surgical removal of the foreign body, thorough abscess drainage, and prolonged beta-lactam antibiotics to prevent recurrence."

Journal • Alzheimer's Disease • CNS Disorders • Dementia • Hepatology • Infectious Disease • Pain

Nanocurcumin: An Innovative Strategy to Combat Virulence and Methicillin Resistance in Staphylococcus aureus Isolated from Burn Wounds. (PubMed, Iran J Med Sci) - "The 50 selected isolates were resistant to cefoxitin, amoxicillin, benzylpenicillin, ampicillin/sulbactam, piperacillin/tazobactam, cloxacillin, oxacillin, and azithromycin. No significant changes were seen in fnbA and ftsZ. Nanocurcumin inhibits S. aureus virulence and resistance genes, reducing biofilm formation and toxin production, but lacks effect on fnbA and ftsZ, requiring further research."

Journal • Infectious Disease

A rare cause of cellulitis and bacteremia by Achromobacter xylosoxidans in a patient with X-linked agammaglobulinemia: a case report. (PubMed, Ann Med Surg (Lond)) - "He was initially treated with piperacillin/tazobactamand received a dose of intravenous immunoglobulin. Trimethoprim/sulfamethoxazole was prescribed upon discharge...Initial empiric broad spectrum followed by de-escalation based on culture and susceptibility test is recommended. Clinicians must be aware of A. xylosoxidans as a potential pathogen in SSTIs, especially in immunocompromised patients."

Journal • Cystic Fibrosis • Dermatology • Genetic Disorders • Immunology • Infectious Disease • Pain • Primary Immunodeficiency • Pulmonary Disease • Respiratory Diseases • BTK

Pediatric Complicated Appendicitis: Results of a Standardized Antibiotic Protocol in a Tertiary Center. (PubMed, J Pediatr Surg) - "One in seven children with CA required an antibiotic switch. Elevated preoperative CRP levels and intra-abdominal abscess were significantly associated with the need for CM to PT switch. These patients may benefit from first-line PT treatment."

Journal • Gastroenterology • Gastrointestinal Disorder • Pediatrics • CRP

Bacterıal pathogens ın ventılator-assocıated pneumonıa; molecular assessment of resıstance profıles. (PubMed, Folia Microbiol (Praha)) - "baumannii strains exhibited 100% resistance to ciprofloxacin and carbapenems, and 70.83% to colistin...pneumoniae strains demonstrated 94.73% resistance to carbapenems and 100% to piperacillin-tazobactam and colistin...This study provides a comprehensive molecular characterisation of VAP pathogens based on an extensive dataset. The results underscore the need for stricter infection control, restrained use of broad-spectrum antibiotics, and ongoing surveillance of resistance mechanisms."

Journal • Critical care • Infectious Disease • Pneumonia • Respiratory Diseases

ICG clearance as an indicator of augmented hepatic clearance and subtherapeutic drug concentrations in septic patients. (PubMed, BMC Anesthesiol) - "AHC is a prevalent phenotype in sepsis and identifies a patient subgroup at high risk for subtherapeutic concentrations of hepatically or partially cleared antibiotics. ICG-derived parameters, particularly ICG-PDR, are robust predictors of inadequate drug exposure, supporting the use of dynamic liver function monitoring to optimize antibiotic dosing in septic patients."

Journal • Critical care • Infectious Disease • Septic Shock

Agrobacterium radiobacter Bacteremia in a Gastric Cancer Patient: A Case Report and Literature Review. (PubMed, Infect Drug Resist) - "Empirical piperacillin/tazobactam transiently improved symptoms, but recurrent fever prompted CVC removal on day 10 of hospitalization, leading to rapid resolution of fever, normalization of procalcitonin, and negative follow-up blood cultures. This case highlights the critical role of catheter removal and susceptibility-guided antibiotic therapy for A. radiobacter infections in immunocompromised patients, addressing biofilm challenges and informing antimicrobial stewardship. Collaborative research integrating microbiology, genomics, and clinical data is essential to refine treatment algorithms and improve outcomes in immunocompromised hosts."

Journal • Gastric Adenocarcinoma • Gastric Cancer • Infectious Disease • Oncology • Solid Tumor

Deciphering the emergence of mutations in Pseudomonas aeruginosa after ceftolozane/tazobactam treatment and evaluating therapeutic alternatives. (PubMed, BMC Microbiol) - "Ceftolozane/tazobactam resistance development was associated mainly with chromosomal mutations in the ampC gene but also with mutations in its regulatory genes. Knowledge about these mutations and gene polymorphisms is essential for interpreting resistance phenotypes from genomic data."

Journal

A Case of Legionella Pneumonia Suspected as Typical Pneumonia After Lung Cancer Surgery, Diagnosed by a Repeat Urinary Legionella Antigen Test. (PubMed, Cureus) - "Outpatient urinary antigen tests for pneumococcus and Legionella were negative, and oral garenoxacin was initiated...Broad-spectrum β-lactams (sulbactam/ampicillin, followed by piperacillin/tazobactam) were ineffective...Subsequent targeted therapy with azithromycin (days 6-8 and 13-15), alongside levofloxacin, resulted in clinical improvement...This case report highlights that a single negative urinary antigen test does not rule out Legionella infection. We accordingly recommend early repeat antigen testing, ideally within one week, for postoperative pneumonia unresponsive to β-lactams, together with prompt macrolide or fluoroquinolone therapy."

Journal • Acute Kidney Injury • Cardiovascular • Diabetes • Infectious Disease • Inflammation • Lung Cancer • Metabolic Disorders • Nephrology • Oncology • Pneumococcal Infections • Pneumonia • Renal Disease • Respiratory Diseases • Solid Tumor

Case Report: Omadacycline in the Treatment of Community-Acquired Pneumonia in a Child With Multiple Antimicrobial Allergies. (PubMed, Clin Case Rep) - "This case report presents a 4-year-old girl with a mixed infection of CAP who exhibited hypersensitivity to multiple antimicrobial agents (piperacillin-tazobactam, ceftazidime, fosfomycin, meropenem, and levofloxacin), was treated with omadacycline followed by doxycycline, and underwent bronchoscopy with bronchoalveolar lavage. Potential adverse effects of omadacycline were evaluated, along with its utilization and dosage in children. Omadacycline has the potential to be a viable alternative anti-infective agent for the treatment of pediatric CAP in the absence of other drug options and with adequate safety evaluation and monitoring."

Journal • Allergy • Immunology • Infectious Disease • Pediatrics • Pneumonia • Respiratory Diseases

Antibiotic prophylaxis in trauma and orthopedic surgery : Current practices across 36 German hospitals and comparison with recently published national guidelines. (PubMed, Unfallchirurgie (Heidelb)) - "While guideline adherence is high in routine indications, significant deviations remain in open fractures and distal phalanx fractures of the fingers. Extended prophylaxis beyond 72 h in GA type III fractures and the frequent use of antibiotics in distal phalanx injuries contrast with current recommendations. Stronger implementation of national standards is essential to reduce overtreatment and support antimicrobial stewardship."

Journal • Infectious Disease • Musculoskeletal Diseases • Orthopedics

Antimicrobial Resistance Patterns and Prevalence of Salmonella Species in Blood Samples: Insights From a Tertiary Care Center in Nepal. (PubMed, Interdiscip Perspect Infect Dis) - "No multidrug resistance was observed, and all isolates were susceptible to third- and fourth-generation cephalosporins (e.g., cefixime, ceftriaxone, and cefepime) and β-lactamase inhibitors (e.g., piperacillin-tazobactam).Salmonella Paratyphi showed 100% sensitivity to ampicillin, amoxicillin, and cotrimoxazole, while susceptibility to chloramphenicol was high for both S. Typhi (88.9%) and S. Paratyphi (92.9%)...High resistance to ciprofloxacin and gentamicin was observed, while susceptibility to ampicillin, chloramphenicol, and cotrimoxazole re-emerged, suggesting their potential for reintroduction in treatment. No multidrug resistance or resistance to third- and fourth-generation cephalosporins (e.g., cefixime, ceftriaxone, cefepime) and β-lactamase inhibitors (e.g., piperacillin-tazobactam) was noted, supporting their reliability for empirical therapy. These findings underscore the need for ongoing antimicrobial surveillance to guide effective treatment strategies."

Journal • Infectious Disease

Characteristics of Patients with Type 2 Diabetes Mellitus with Sodium-Glucose Cotransporter Protein-2 Inhibitor-Related Urinary Tract Infections: Pathogen Distribution and Drug Resistance. (PubMed, Arch Esp Urol) - "The distribution of pathogenic bacteria complicated by UTI in patients with T2DM treated with SGLT-2 inhibitors was dominated by Gram-negative bacteria such as E. coli, some Gram-positive bacteria, and a small number of fungi. Antibiotics should be used appropriately in this population because of the pharmacological mechanism of SGLT-2 inhibitors."

Journal • Retrospective data • Diabetes • Infectious Disease • Metabolic Disorders • Nephrology • Pneumonia • Type 2 Diabetes Mellitus

"Emergence and Clonal Transmission of Elizabethkingia meningoseptica in Adult and Paediatric Intensive Care Units: An Integrated Clinical, Microbiological, and Genomic Analysis". (PubMed, Indian J Med Microbiol) - "Universal resistance to piperacillin/tazobactam, aminoglycosides but susceptibility to minocycline was observed. Following targeted interventions including enhanced disinfection and thermal water flushing, no new cases occurred during three-month follow-up. This study highlights environmental surveillance and integrated infection control importance."

Journal • Critical care • Infectious Disease • Pediatrics

Delayed presentation of penile strangulation by a foreign object: Case report with review of literature. (PubMed, Int J Surg Case Rep) - "Early recognition, appropriate technique selection, and multidisciplinary care are key to preventing long-term sequelae. This case reinforces the effectiveness of conservative decompression methods in low-grade injuries despite delayed presentation."

Journal • Infectious Disease

Atypical Presentation of Lemierre Syndrome Without an Oropharyngeal Source in a Young Adult Male Patient. (PubMed, Cureus) - "Evaluation for oropharyngeal disease, a more common cause, was negative, making this an atypical presentation. The patient was initially treated with piperacillin-tazobactam, then tailored to metronidazole based on susceptibility for four weeks, and had a full recovery."

Journal • Acute Kidney Injury • Cardiovascular • Hematological Disorders • Otorhinolaryngology • Pulmonary Embolism • Renal Disease • Respiratory Diseases • Thrombosis

Morganella morganii Urinary Tract Infection in Jordanian Children: Case series from a Tertiary Hospital. (PubMed, Infect Chemother) - "M. morganii should be considered in pediatric UTIs, especially among children with urinary tract anomalies or catheter use. Awareness of its distinct resistance profile is critical for selecting appropriate empiric therapy."

Journal • Infectious Disease • Nephrology • Pediatrics