piperacillin sodium/tazobactam sodium / Generic mfg. - LARVOL DELTA

Rothia mucilaginosa Sepsis in a Kidney Transplant Recipient Following Dental Procedure Despite Clindamycine Prophylaxis: A Case Report. (PubMed, Transplant Proc) - "A 64-year-old female kidney transplant recipient receiving maintenance immunosuppression with tacrolimus, mycophenolate mofetil, and prednisone underwent dental treatment because of profound dental caries with gingival inflammation. The patient was successfully treated with intravenous piperacillin/tazobactam. Our case demonstrates the importance of recognizing uncommon oral pathogens in transplant recipients presenting with sepsis after dental procedures, as well as the limited antimicrobial activity of clindamycin against Rothia species."

Journal • Dental Disorders • Infectious Disease • Inflammation • Septic Shock • Transplantation

Virulence arsenal and antibiotic resistance backgrounds in Pseudomonas aeruginosa isolates from hospital wastewater samples from Iraq. (PubMed, Mol Biol Rep) - "The most P. aeruginosa isolates possessed toxA and lasB genes. The results indicated that hospital effluents are critical sources of MDR and virulent P. aeruginosa, and there is an urgent demand to improve the management of wastewater."

Journal

Duodenal Neuroendocrine Tumor Revealed by Escherichia coli Bacteremia: Possible Implication of Tirzepatide (ACG 2026) - "Case Description/ A 62-year-old female with known history of hypertension, hyperlipidemia and obesity, for which she was initially on liraglutide then switched to tirzepatide two months prior to admission...The Patient was diagnosed with sepsis and started immediately on piperacillin tazobactam...The patient received pantoprazole 40 mg twice daily and sucralfate, resulting in improvement of abdominal pain...In our patient, the ulcer likely contributed actively to the translocation, especially in the neoplastic conditions. Figure: Duodenal Bulbar Ulcer With Pigmented Material"

Cardiovascular • Dyslipidemia • Endocrine Cancer • Gastroenterology • Gastrointestinal Disorder • Genetic Disorders • Hepatology • Hypertension • Immunology • Infectious Disease • Neuroendocrine Tumor • Obesity • Oncology • Peptic Ulcer • Septic Shock • Solid Tumor

A Case of Ischemic Colitis in a 39-Year-Old Man on GLP-1 Therapy (ACG 2026) - "Case Description/ A 39-year-old male with obesity on tirzepatide presented with sudden-onset severe abdominal pain and multiple episodes of hematochezia...He was admitted for intravenous fluids and started on empiric piperacillinâtazobactam...Close outpatient follow-up is crucial to detect early warning signs, prevent progression, and reduce hospitalization rates related to medication side effects. Figure: Colonoscopy images Figure: Colonoscopy images"

Clinical • Atherosclerosis • Cardiovascular • Constipation • Gastroenterology • Gastrointestinal Disorder • Genetic Disorders • Hepatology • Immunology • Inflammation • Inflammatory Bowel Disease • Obesity • Pancreatitis • Vasculitis

From Acute to Necrotizing: A Case of Tirzepatide-Induced Pancreatic Injury (ACG 2026) - "Introduction: With rising rates of obesity, use of weight loss medication is bound to increase...Antibiotics were given and he was discharged on IV piperacillin/tazobactam for infected NP treatment and plans for an endoscopic ultrasound (EUS) six weeks later...Figure: Figure 1: enlarged pancreas with surrounding peripancreatic inflammatory changes, consistent with acute pancreatitis Figure: Figure 2: Extensive necrotizing pancreatitis and peripancreatic phlegmonous/necrotizing fluid collection versus evolving abscess. It extends and involves the greater curvature of the stomach which shows wall thickening however, no definite fistulous connection identified on current study, however not excluded."

Clinical • Diabetes • Gastroenterology • Genetic Disorders • Metabolic Disorders • Obesity • Pancreatitis • Type 2 Diabetes Mellitus

Sintilimab‑related cystitis/ureteritis in high‑grade endometrial stromal sarcoma: A case report and structured literature review. (PubMed, Hum Vaccin Immunother) - "We present a 44‑year‑old female patient with high‑grade endometrial stromal sarcoma who developed severe urinary frequency, urgency, and dysuria after three cycles of sintilimab combined with nab‑paclitaxel and carboplatin...A subsequent urine culture grew Enterococcus faecalis, and the addition of piperacillin-tazobactam resulted in further symptom resolution...Subsequently, due to disease progression, treatment was switched to tislelizumab, and the urinary symptoms did not recur. The patient's urinary symptoms were sintilimab‑related cystitis/ureteritis with possible concomitant or partially suppressed bacterial infection. This case, together with a structured literature review of other immunotherapy‑related cystitis/ureteritis cases and subsequent ICI use, provides a practical reference for the diagnosis and management of ICI‑related urological irAEs and for subsequent anti‑tumor treatment."

Journal • Review • Infectious Disease • Oncology • Sarcoma • Solid Tumor • Uterine Cancer

Antibiotic prescription in critical care units in Sri Lanka: a prospective multi-centre survey. (PubMed, Ceylon Med J) - "HAP was the main indication for antibiotics in critical care. Compliance on antibiotic prescription and documentation is inadequate and the extensive use of meropenem remains a cause for concern. Therefore, strict antibiotic stewardship guidelines and regular review of antibiotics are indicated in critical care units."

Journal • Critical care • Infectious Disease • Pneumonia • Respiratory Diseases

Phenotypic antimicrobial resistance associated with different bla genotypes and their combinations in Enterobacterales. (PubMed, Ceylon Med J) - "In conclusion, this study showed that Enterobacterales with different bla gene combinations manifest variations in phenotypic resistance to both β-lactam and non-β-lactam antibiotics."

Journal

IMPACT OF BILE CULTURES ON ANTIBIOTIC MANAGEMENT IN ACUTE CHOLANGITIS (UEGW 2026) - "Anaerobic bacteria were identified in 3.9% of positive cultures, and Candida species accounted for 10.2% of isolates.Overall susceptibility analysis showed that amikacin was the most active antibiotic (93.3%), followed by imipenem (77.9%) and piperacillin–tazobactam (77.2%). Ceftriaxone demonstrated intermediate activity (66.7%), whereas amoxicillin–clavulanate showed low overall sensitivity (31.4%), particularly in grade II disease.Antibiotic therapy was modified in 46 patients (38.0%)... Bile cultures in acute cholangitis show a high microbiological yield, dominated by Gram-negative organisms with heterogeneous resistance profiles. More than one-third of patients required antibiotic modification, most often enabling de-escalation after effective drainage. These findings support the clinical value of bile sampling to optimise antibiotic management in routine practice."

Cholangiocarcinoma • Gallbladder Cancer • Hepatology • Infectious Disease • Pneumonia • Solid Tumor

REAL-WORLD MANAGEMENT PATTERNS IN ACUTE PANCREATITIS: A 10-YEAR NATIONWIDE ANALYSIS OF TREATMENT TRENDS AND HOSPITAL RESOURCE UTILISATION ACROSS US ADMISSIONS (UEGW 2026) - "Lactated Ringer's use more than doubled from 29.6% in 2016 to 61.6% in 2025, with incremental annual rates of 34.6%, 42.8%, 49.2%, 54.6%, 57.8%, 60.6%, 62.4%, and 60.0% from 2017 to 2024, while normal saline declined modestly from 88.7% to 82.6% but remained the predominant fluid throughout.Systemic antibiotics were administered in 46.78% of admissions, rising from 42.5% in 2016 to a peak of 49.5% in 2023 before a modest decline to 48.3% in 2025; piperacillin-tazobactam was the most frequently prescribed agent (20.2%), followed by ceftriaxone (15.3%), vancomycin (9.9%), metronidazole (9.6%), and cefepime (5.9%).Computed tomography (CT) of the abdomen was the most frequently utilised imaging modality (70.0%), followed by abdominal ultrasound (42.23%) and magnetic resonance imaging (MRI) of the abdomen (21.7%). This nationwide analysis of AP admissions documents a substantial and sustained real-world shift toward lactated Ringer's over the past decade, reflecting..."

Clinical • HEOR • Real-world • Real-world evidence • Pancreatitis

ENDOSCOPIC ULTRASOUND-GUIDED ASPIRATION OF A PROSTATIC ABSCESS AFTER INCOMPLETE TRANSURETHRAL RESECTION OF THE PROSTATE: A MINIMALLY INVASIVE APPROACH (UEGW 2026) - "Intravenous piperacillin-tazobactam was initiated.Interventional radiology was consulted, and planned for a transcutaneous approach, as transrectal approach was deemed more challenging under radiology...Follow-up magnetic resonance imaging at 6 weeks demonstrated complete resolution.This case highlights EUS-guided drainage as a minimally invasive option for complex prostatic abscesses when conventional drainage techniques are not feasible. The proximity of the prostate to the rectal wall allows precise real-time needle targeting, potentially reducing procedural risk in anatomically challenging cases."

Back Pain • Cardiovascular • Constipation • Gastroenterology • Gastrointestinal Disorder • Gout • Hypertension • Infectious Disease • Inflammatory Arthritis • Musculoskeletal Pain • CRP

HOLE IN THE WALL: A RARE CASE OF LENVATINIB-ASSOCIATED PEPTIC ULCER PERFORATION IN HEPATOCELLULAR CARCINOMA (UEGW 2026) - "Empiric antibiotic therapy with piperacillin-tazobactam was initiated for suspected peritonitis secondary to GI perforation. This case highlights the importance of clinician awareness regarding the potential for serious, albeit uncommon, gastrointestinal complications associated with lenvatinib therapy. Early recognition and timely surgical intervention are critical to improving patient outcomes and reducing the risk of morbidity and mortality."

Clinical • Cardiovascular • Gastric Cancer • Gastroenterology • Heart Failure • Hematological Disorders • Hepatocellular Cancer • Infectious Disease • Oncology • Peptic Ulcer • Solid Tumor

SPONTANEOUS FUNGAL PERITONITIS AS THE INITIAL PRESENTATION OF ALCOHOL-RELATED CIRRHOSIS COMPLICATED BY HEPATOCARDIORENAL SYNDROME: A FATAL CASE (UEGW 2026) - "Diagnostic paracentesis showed >250 polymorphonuclear cells/mm³ and empirical ceftriaxone was initiated for presumed spontaneous bacterial peritonitis.Concurrently, the patient developed acute heart failure...Depletive therapy was initiated; terlipressin was withheld considering the severe cardiac dysfunction and hemodynamic instability.Due to clinical deterioration, computed tomography excluded secondary peritonitis, and antimicrobial therapy was subsequently escalated to piperacillin–tazobactam. However, serial paracentesis demonstrated <25% decline in polymorphonuclear cell count, suggesting resistant or fungal infection, further supported by a positive serum β-D-glucan level (201 pg/mL).Repeated ascitic fluid cultures grew Candida albicans, confirming spontaneous fungal peritonitis (SFP) and prompting initiation of fluconazole...Early suspicion, lack of response to antibiotics and β-D-glucan testing may expedite diagnosis. Concomitant cirrhotic..."

Clinical • Acute Kidney Injury • Cardiomyopathy • Cardiovascular • Congestive Heart Failure • Fibrosis • Heart Failure • Hematological Disorders • Hepatology • Immunology • Infectious Disease • Liver Failure • Nephrology • Portal Hypertension • Thrombocytopenia • CRP

DON'T STOP AT ONE: CONCURRENT BARTONELLA HENSELAE AND HEV INFECTION PRESENTING AS GRANULOMATOUS HEPATITIS IN AN IMMUNOCOMPROMISED HOST (UEGW 2026) - "Empirical therapy with metronidazole, caspofungin, and piperacillin-tazobactam was commenced...Due to persistent HEV replication three months after, ribavirin therapy was administered for 12 weeks. Granulomatous hepatitis in transplant recipients requires a comprehensive differential diagnostic evaluation. This case demonstrates the coexistence of Bartonella henselae and HEV and underscores the importance of thorough infectious disease assessment in immunocompromised patients, in whom multiple coinfections requiring specific therapies may be present."

Hepatology • Infectious Disease • Inflammation • Solid Organ Transplantation • CRP

WHEN EOSINOPHILIC ESOPHAGITIS DISSECTS THE ESOPHAGUS – PNEUMOMEDIASTINUM AS AN INITIAL PRESENTATION (UEGW 2026) - "Management included bowel rest, parenteral nutrition, empirical antibiotics (piperacillin-tazobactam and fluconazole), double-dose pantoprazole, and swallowed fluticasone.Imaging at 72h showed resolution of pneumomediastinum but a persistent 13cm double lumen. This case underscores the importance of including EoE in the differential diagnosis of spontaneous pneumomediastinum. Early endoscopic recognition and a conservative approach are crucial for a favorable outcome, avoiding unnecessary surgical intervention in most cases."

Eosinophilic Esophagitis • Gastrointestinal Disorder • Immunology

Phenotypic Susceptibility, Resistance-Associated Genomic Determinants, and Mobile-Genetic-Element Context of Canine Otitis Externa-Associated Pseudomonas aeruginosa Collected in Hungary in 2010 and 2017. (PubMed, Vet Sci) - "European Committee on Antimicrobial Susceptibility Testing epidemiological cut-off values identified non-wild-type subsets for ciprofloxacin (7/67), tobramycin (4/67), imipenem (1/67), and piperacillin-tazobactam (51/67), whereas all isolates remained within the available wild-type distributions for ceftazidime, gentamicin, and amikacin. The discordance between conserved resistance-gene repertoires and heterogeneous MICs demonstrates that sequence-based detection alone is insufficient for therapeutic inference. Integrated phenotypic and genomic surveillance is therefore required to support evidence-based antimicrobial stewardship in canine pseudomonal otitis."

Journal • Otorhinolaryngology

Polymicrobial Catheter-Related Bloodstream Infection Involving Brevundimonas diminuta and Streptococcus anginosus: A Case Report and Literature Review. (PubMed, Microorganisms) - "The patient made a full clinical recovery after prompt PICC removal and intravenous piperacillin-tazobactam therapy. This case emphasizes the emerging clinical significance of B. diminuta and S. anginosus as potential causes of polymicrobial bloodstream infection in patients with indwelling central venous catheters and underlines the need to consider uncommon environmental Gram-negative organisms in catheter-related infection."

Journal • Cardiovascular • CNS Disorders • Hypertension • Infectious Disease • Oncology • Pituitary Gland Carcinoma

Necrotizing Fasciitis of the Extremities: Microbial Spectrum, Antimicrobial Resistance, and Clinical Outcomes in a 7-Year Retrospective Cohort Study. (PubMed, Medicina (Kaunas)) - "An increased resistance rate to antibiotics was recorded, with a 32.7% MDR rate; moderate to high resistance to piperacillin + tazobactam, most cephalosporins, most carbapenems (for Gram-negative strains), and quinolones was noted. Multidisciplinary management, comprising intensive medical support, prompt targeted antibiotic therapy, and immediate surgical intervention, was critical for achieving favorable patient outcomes. Increasing antibiotic resistance may alter the prognosis in patients with NF."

Clinical data • Journal • Retrospective data • Acute Kidney Injury • Infectious Disease • Nephrology • Renal Disease • Septic Shock

A Military Veteran with Pulmonary Fibrosis, Hepatic Cirrhosis, Bone Marrow Dysfunction and Shortened Telomeres Found to Have GAVE, a Potential Unsuspected Consequence of Telomere Spectrum Disorder. (PubMed, J Clin Med) - "Treated with AVAPS, IV Zosyn, IV Lasix, steroids, bronchodilators, and diuretics. Its occurrence in this patient suggests an unrecognized gastrointestinal manifestation of TSD as the patient does not have known history of portal hypertension. This represents an potentially underreported manifestation of acquired TSD presenting with combined hepatic, pulmonary, hematologic, and gastrointestinal (GAVE) involvement."

Journal • Aplastic Anemia • Atrial Fibrillation • Cardiovascular • Chronic Obstructive Pulmonary Disease • Diabetes • Fibrosis • Gastrointestinal Disorder • Hematological Disorders • Hepatology • Hypertension • Idiopathic Pulmonary Fibrosis • Immunology • Infectious Disease • Liver Cirrhosis • Metabolic Disorders • Oncology • Portal Hypertension • Pulmonary Disease • Respiratory Diseases • Septic Shock • Thrombocytopenia • DKC1 • TERT • TINF2

The addition of clotrimazole reduces but does not abrogate fungal dysbiosis during effective antibacterial therapy for canine otitis externa. (PubMed, J Small Anim Pract) - "Piperacillin-tazobactam-clotrimazole is highly efficacious in the treatment of refractory bacterial otitis; incorporation of clotrimazole markedly reduces but does not abrogate fungal dysbiosis."

Journal • Otorhinolaryngology

Beyond the Cumulative Antibiogram: A Weighted-Incidence Syndromic Combination Antibiogram to Guide Empirical Therapy of Bloodstream Infections in the Emergency Department. (PubMed, Infect Dis Ther) - "WISCA complements the cAST by providing regimen-level, syndrome- and subgroup-specific coverage estimates, capturing pathogen diversity missed by species-threshold cAST reporting. Integrating WISCA into local antimicrobial-stewardship programs may refine empirical treatment choices for ED bacteremia, especially according to the BSI source and patient-specific characteristics, while supporting judicious use of broad-spectrum agents."

Journal • Infectious Disease • Nephrology

Polymicrobial Spontaneous Fungal and Bacterial Peritonitis With Candida albicans in Decompensated Cirrhosis: A Case Report of a Rare and Life-Threatening Complication (ACG 2026) - "She was started on piperacillin-tazobactam and micafungin. Clinicians should obtain routine fungal cultures and initiate early echinocandin therapy in cirrhotic patients with peritonitis failing standard antibiotics. Figure: Table 1: Runyon Criteria Assessment Secondary vs. Spontaneous Peritonitis Figure: Table 2: Ascitic Fluid and Serum Biochemical Analysis"

Case report • Clinical • Addiction (Opioid and Alcohol) • CNS Disorders • Fibrosis • Gastroenterology • Gastrointestinal Disorder • Hematological Disorders • Hepatic Encephalopathy • Hepatology • Immunology • Infectious Disease • Liver Cirrhosis • Peptic Ulcer • Thrombocytopenia

Streptococcus pasteurianus Bacteremia in a Hemodialysis Patient: A Warning for Occult Colon Pathology (ACG 2026) - "The patient was started on vancomycin/piperacillin-tazobactam, then de-escalated to penicillin after sensitivity results showed pan-susceptibility. Clinicians must maintain a high index of suspicion for a GI source when S. bovis is isolated, regardless of an obvious line infection. A standard workup covering both CRBSI and S. bovis protocols (TEE and colonoscopy) is critical to prevent overlooked outcomes."

Clinical • Alzheimer's Disease • Chronic Kidney Disease • CNS Disorders • Colon Cancer • Colorectal Cancer • Dementia • Gastrointestinal Disorder • Infectious Disease • Inflammatory Arthritis • Lewy Body Disease • Pneumonia • Renal Disease • Respiratory Diseases • Solid Tumor

Fever and Elevated Liver Enzymes: Murine Typhus and Hepatic Involvement (ACG 2026) - "Patientâs temperature peaked at 103.1°F; intravenous piperacillin-tazobactam was initiated, but nightly fevers and elevated liver enzymes persisted...Values demonstrate hepatocellular injury, hyponatremia, and thrombocytopenia at presentation with normalization by discharge following doxycycline initiation. Figure: Figure 1. Liver biopsy demonstrating portal and lobular inflammation (H&E, 20x) Hematoxylin and eosin stain showing a portal tract with dense lymphohistiocytic infiltrate (arrow) surrounding a central vein, consistent with portal and lobular hepatitis."

Preclinical • Autoimmune Hepatitis • Cardiovascular • Fibrosis • Gastrointestinal Disorder • Genetic Disorders • Heart Failure • Hematological Disorders • Hepatology • Immunology • Infectious Disease • Inflammation • Liver Failure • Pancreatitis • Septic Shock • Thrombocytopenia

When Infection Masquerades as Cancer: Syphilitic Proctitis in an HIV-Positive Patient (ACG 2026) - "The patient was treated with intravenous piperacillin-tazobactam during hospitalization, followed by doxycycline daily and intramuscular penicillin G once weekly for three weeks. Panel B shows one of multiple soft tissue nodules/masses within the perirectal region/presacral fat. Panels C and D show prominent mesenteric and retroperitoneal lymph nodes in left pelvic side wall and left groin."

Clinical • Beta-Thalassemia • Colorectal Cancer • Cytomegalovirus Infection • Gastroenterology • Genetic Disorders • Herpes Simplex • Human Immunodeficiency Virus • Infectious Disease • Oncology • Rectal Cancer • Sickle Cell Disease • Solid Tumor • CD4