BB-401 / Benitec BioPharma - LARVOL DELTA

Dissection of amino acid acquisition pathways in Borrelia burgdorferi uncovers unique physiological responses. (PubMed, bioRxiv) - "Using conditional mutants for both peptide transport and BB0401, we characterize these systems throughout the enzootic cycle, both confirming their essential role during murine infection and revealing that they are, surprisingly, dispensable during prolonged colonization of the tick midgut. We broadly define the metabolic perturbations resulting from these amino acid starvation models and show that, even under the most severe amino acid stress, B. burgdorferi is unable to modulate its physiological response via the canonical (p)ppGpp-driven stringent response."

Journal • Infectious Disease • Inflammatory Arthritis • Lyme Disease • GLTP

Comparative Studies on a Putative Glutamate Symporter Bb0401 and Oligopeptide Transport Sys. for Dissecting the Amino Acid Transport Mechanisms of Borrelia Burgdorferi (ASM Microbe 2023) - "These studies will include morphological analysis of starved mutants by electron microscopy, peptidoglycan synthesis tracking using fluorescent analogs, along with transcriptional and proteomic comparisons. Additionally, radioactive transport assays will be used to confirm bb0401function, and bb0401cond will be evaluated during the enzootic cycle."

Infectious Disease • Inflammatory Arthritis • Lyme Disease

A Study of BB-401 in Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma (clinicaltrials.gov) - P2; N=16; Completed; Sponsor: Benitec BioPharma Ltd; Active, not recruiting ➔ Completed; Trial completion date: Oct 2020 ➔ Apr 2020

Clinical • Trial completion • Trial completion date • Head and Neck Cancer • Oncology • Solid Tumor • Squamous Cell Carcinoma • Squamous Cell Carcinoma of Head and Neck

A Study of BB-401 in Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma (clinicaltrials.gov) - P2; N=16; Active, not recruiting; Sponsor: Benitec BioPharma Ltd; Trial completion date: Oct 2019 ➔ Oct 2020; Trial primary completion date: Apr 2019 ➔ Jun 2020

Clinical • Trial completion date • Trial primary completion date