Q-Force (quercetin) / Quercis Pharma, Temple University - LARVOL DELTA

RAPID COLORIMETRIC SENSOR FOR EARLY DETECTION OF PERITONITIS IN PD PATIENTS: TOWARD REAL-TIME INFECTION MONITORING (ISN-WCN 2026) - "L-cysteine functionalization enhanced affinity and sensitivity toward bacterial compounds, allowing early discrimination between infected and non-infected samples.Conclusion We developed a rapid, selective, and low-cost colorimetric sensor with strong potential for early detection of peritoneal dialysis-associated peritonitis. This platform could represent a clinically useful innovation for infection surveillance and prompt management in PD patients.Download: Download high-res image (324KB)Download: Download full-size image"

Clinical • Chronic Kidney Disease • Infectious Disease • Nephrology • Renal Disease

EFFECTS OF SENOLYTIC DRUGS ON KIDNEY TISSUE IN AGED MICE (ISN-WCN 2026) - "This study aimed to examine how the senolytic drugs dasatinib and quercetin (DQ), known for their rejuvenating properties, influence the expression of inflammation- and fibrosis-related genes in the kidneys of aged mice.Methods Mice were divided into five groups based on age and treatment with or without DQ administration: Young mice (4–6 months old); Aged mice (23–24 months old, n=10); DQ-treated Aged mice (Aged+DQ, 23–24 months old); Old mice (26–30 months old); and DQ-treated Old mice (Old+DQ, 26–30 months old)...Comprehensive analysis suggests that suppression of inflammation is a principal mechanism underlying the renoprotective action of senolytic drugs. The reduction of inflammatory cytokine secretion appears to be a key process contributing to the kidney-protective effects of DQ."

Preclinical • Fibrosis • Immunology • Inflammation • Renal Disease • CCL7 • MMP7

QUERCETIN-LOADED IR783 NANOPARTICLES ATTENUATE ACUTE KIDNEY INJURY IN DIABETIC KIDNEY DISEASE BY SUPPRESSING PDK4-MEDIATED OXIDATIVE STRESS (ISN-WCN 2026) - "In vitro, treatment with quercetin-loaded IR783 attenuated ROS accumulation, preserved mitochondrial membrane potential. Mechanistically, nanoparticle treatment suppressed PDK4 expression and downstream oxidative stress signaling, as demonstrated that overexpression of PDK4 abolished the protective effects, whereas PDK4 knockdown mimicked the benefits of nanoparticle treatment.Conclusion Higher dietary quercetin intake is associated with reduced mortality in DKD patients, and quercetin encapsulated in IR783 nanoparticles protects against AKI in DKD by attenuating PDK4/oxidative stress signaling.I have potential conflict of interest to disclose.This study was supported by grants from the Hong Kong Research Grants Council (17125323, 17125524, and 17125925), and the HKU Seed Funds (2402101703).I did not use generative AI and AI-assisted technologies in the writing process."

Oxidative stress • Acute Kidney Injury • Cardiovascular • Chronic Kidney Disease • Diabetes • Diabetic Nephropathy • Nephrology • Renal Disease • Reperfusion Injury • PDK4

DYRK1A AS A TARGET FOR NEUROINFLAMMATION: EXPERIMENTAL AND COMPUTATIONAL ANALYSIS OF QUERCETIN AND VANILLIN BINDING MECHANISMS (ADPD 2026) - "These findings propose that targeting DYRK1A with natural compounds like quercetin and vanillin can be a good way to deal with AD. Furthermore, research is still needed for clinical trials to validate these findings and explore the potential therapeutics of these compounds for the treatment of AD."

Alzheimer's Disease • CNS Disorders • Inflammation

QUERCETIN RESTORES MITOCHONDRIAL FUNCTION AND LIMITS MTDNA RELEASE UNDER OXIDATIVE STRESS IN PRKN KO CELLS (ADPD 2026) - "Our findings highlight a mechanistic link between impaired mitophagy, mitochondrial fragmentation, and mtDNA release in PRKN-deficient cells. Quercetin mitigates oxidative stress, rescues mitochondrial function, and reduces mtDNA release, supporting its potential as a therapeutic strategy for mitochondrial dysfunction in PRKN-related PD."

Oxidative stress • CNS Disorders • Inflammation • Metabolic Disorders • Movement Disorders • Parkinson's Disease

BOOSTING THE THERAPEUTIC POTENTIAL OF MESENCHYMAL STEM CELLS (MSCS) SECRETOMES IN PARKINSON'S DISEASE VIA CALORIC RESTRICTION MIMETICS (CRMS) (ADPD 2026) - "Caloric restriction mimetics (CRMs), quercetin, resveratrol, metformin, and spermidine, may enhance MSCs function by activating protective pathways... CRM priming reprograms MSCs to produce secretomes with enhanced neuroprotective and neuroregenerative properties. Among the compounds tested, resveratrol and spermidine consistently produced the strongest benefits, improving both neuronal survival and dopaminergic lineage commitment. These findings support CRM priming as a scalable and clinically translatable strategy to optimize MSCs-derived secretomes, offering a promising acellular therapeutic avenue to slow or modify PD progression."

CNS Disorders • Movement Disorders • Parkinson's Disease

Beyond the cutoff: Hybrid ML/MM electrostatics for neural network potentials. (PubMed, J Chem Phys) - "The resulting ANI/MM NNP outperforms the accurate, ab initio-fitted classical force field Q-Force and exhibits good transferability to new solutes, provided that the training set includes relevant structural fragments of the target molecule. Together, these findings demonstrate that hybrid ML/MM neural architectures offer a promising route toward chemically accurate, scalable modeling of complex molecular systems."

Journal

Integrative Network and Molecular Docking Analysis Reveal STAT3 and uPAR as Promising Targets for Innovative Therapies in Hereditary Angioedema (AAAAI 2026) - "Peptide-based docking further solidified uPAR as a viable target for intervention. Conclusions This integrative network and molecular modeling approach identifies STAT3 and uPAR as novel therapeutic targets in HAE, highlighting miRNAs, flavonoids, and peptides as cost-effective preventive strategies that warrant validation through in vitro and in vivo studies."

Cardiovascular • Complement-mediated Rare Disorders • Hereditary Angioedema • MIR124-3 • miR-125b • MIR143 • STAT3

Targeting BRD4 to reshape the inflammatory microenvironment of senescent bone marrow mesenchymal stem cells for improved hematopoietic stem cell transplantation reconstitution (ASH 2025) - "Crucially,dual-pathway intervention combining senolytic agents (dasatinib + quercetin, D+Q) with JQ1 exhibitedsynergistic efficacy, reducing SASP secretion more substantially than either monotherapy...We further demonstrate that a novel dual-pathway strategy combiningsenescent cell clearance (via dasatinib + quercetin) with BRD4 inhibition synergistically restores theinflammatory hematopoietic microenvironment. This approach offers a promising therapeutic solutionfor improving post-transplantation HSC reconstitution, with BRD4-targeted interventions demonstratingsignificant potential for clinical translation."

Bone Marrow Transplantation • Transplantation • BRD4

Oxidative stress and hemoglobin-c denaturation drive hemoglobin SC pathophysiology and can be ameliorated by antioxidants and hydroxyurea (ASH 2025) - "Overall, these results support a causal role for HbC-mediated oxidative membrane damagein impairing RBC rheology. Notably, hydroxyurea treatment, even with modest HbF induction, canmitigate oxidative injury and restore critical aspects of RBC membrane health, an effect similarly achievedthrough antioxidant supplementation in HbSC mice. Our findings highlight the central role of oxidativedamage, particularly Heinz body accumulation, in the pathophysiology of HbSC disease."

Oxidative stress • Genetic Disorders • Hematological Disorders • Retinal Disorders • Sickle Cell Disease

Quercetin-Induced Membrane-TRAIL Release Promotes Apoptosis in Glioblastoma (SNO 2025) - "Thus, we found that quercetin, in vitro, can induce apoptosis in GBM cells by promoting trafficking of endogenous mTRAIL to the cancer cell surface, which can then interact with DR5 on cancer cells in a paracrine or autocrine manner, destroying the tumor cells. This novel mechanism of GBM self-destruction in the presence of quercetin, combined with quercetin's reported ability to cross the blood-brain barrier, highlights its potential as a promising therapeutic for GBM."

Brain Cancer • Glioblastoma • Solid Tumor • TNFRSF10B

Exploring GBM vulnerabilities by a combinational approach of inhibiting ARHGAP activity and inducing synergetic effects with plant-derived therapeutics (SNO 2025) - "Temozolomide (TMZ) remains the sole cytotoxic chemotherapeutic option in the management of Glioblastoma (GBM), with tumours eventually developing resistance...Its inhibition potentiates TMZ efficacy and may synergize with selective plant-derived therapeutics. These findings support the rationale for novel combination strategies integrating selective targeting of the cytoskeleton with RhoGTPase modulators and selective inhibitors to overcome GBM therapy resistance."

Brain Cancer • Glioblastoma • Solid Tumor • ARHGAP

Quercetin-Induced Membrane-TRAIL Release Promotes Apoptosis in Glioblastoma (WFNOS 2025) - "Thus, we found that quercetin, in vitro, can induce apoptosis in GBM cells by promoting trafficking of endogenous mTRAIL to the cancer cell surface, which can then interact with DR5 on cancer cells in a paracrine or autocrine manner, destroying the tumor cells. This novel mechanism of GBM self-destruction in the presence of quercetin, combined with quercetin’s reported ability to cross the blood-brain barrier, highlights its potential as a promising therapeutic for GBM."

Brain Cancer • Glioblastoma • Glioma • Solid Tumor • TNFRSF10B

Exploring GBM vulnerabilities by a combinational approach of inhibiting ARHGAP activity and inducing synergetic effects with plant-derived therapeutics (WFNOS 2025) - "Temozolomide (TMZ) remains the sole cytotoxic chemotherapeutic option in the management of Glioblastoma (GBM), with tumours eventually developing resistance...Its inhibition potentiates TMZ efficacy and may synergize with selective plant-derived therapeutics. These findings support the rationale for novel combination strategies integrating selective targeting of the cytoskeleton with RhoGTPase modulators and selective inhibitors to overcome GBM therapy resistance."

Brain Cancer • Glioblastoma • Solid Tumor • ARHGAP

Galloylated Polyphenols Represent a New Class of Antithrombotic Antagonists of Thiol Isomerases (ASH 2023) - "Galloyltransferases are found in many plants and galloylated polyphenols are abundant in commonly consumed beverages such as teas. Members of this class of compounds may be useful in the setting of COVID19 as inhibitors of thrombosis and viral replication."

Cardiovascular • Hematological Disorders • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases • Thrombosis

Dasatinib and Quercetin Combination Increases Kidney Damage in Acute Folic Acid-Induced Experimental Nephropathy (KIDNEY WEEK 2025) - "Conclusion Contrary to expectations, senolytic treatment with D&Q did not protect against folic acid-induced AKI and instead exacerbated markers of kidney damage and senescence. These findings highlight the complexity of targeting senescence in acute settings and suggest caution when considering the use of D&Q in AKI patients."

Acute Kidney Injury • Chronic Kidney Disease • Nephrology • Renal Disease • CDKN1A • KIM1

Therapy Induced Senescence Is Associated with a Myeloid Gene Signature in Multiple Myeloma Plasma Cells (ASH 2024) - "Current standard of care includes autologous stem cell transplant (ASCT) with high-dose melphalan (HDM) administered as a conditioning agent...HDM-5TGM1 cells were more sensitive to senolysis by dasatinib+quercetin (viability : HDM 54.9%±0.09%, Veh 76.0%±0.05%, N=2)...Further, CD138+ PC burden post-ASCT positively correlated with time in remission in relapsed patients (R=0.697, p=0.03).Bortezomib reduced serum M-spike in Vk*MYC-engrafted mice (p=0.0003); M-spike was further reduced by HDM/SCT compared to Veh-treated mice (p=0.0007)...Greater MM burden post-ASCT appears to be associated with longer durable response, again suggesting that these cells may be in growth arrest consistent with TIS. Finally, senolytics may be a novel approach to eliminate surviving MM cells and prevent relapse."

Gene Signature • Hematological Malignancies • Multiple Myeloma • Oncology • AXL • BCL2L1 • CDKN1A • CDKN1C • FCER1G • ICAM1 • MMP13 • SDC1

Quercetin Ameliorates the Astrocyte Cytoxicity Induced By HIV-1 gp120 Via Promoting Insoluble Stress Granules Disassembly (ASH 2024) - "QC treatment is able to significantly reduce the number of SGs formation both in the brain tissue of Gp120 tgm and in primary astrocytes induced with HIV-1 gp120. In addition, QC is capable to significantly improve the neural cognitive impairment of Gp120 tgm in the gut-blood-brain way as a dietary supplement."

Alzheimer's Disease • CNS Disorders • Cognitive Disorders • Dementia • Developmental Disorders • Human Immunodeficiency Virus • Infectious Disease • Movement Disorders • Parkinson's Disease • G3BP1

Phytocompounds Act Synergistically to Stimulate Lipolysis and Thermogenesis in Human Adipocytes (OBESITY WEEK 2025) - "Treatment with NRBC+ArtC has the potential to stimulate greater weight loss than NR alone. ArtC has a 12-hour half-life and all three phytocompounds have high bioavailability. Lipolysis provides the fuel for thermogenesis, and NRBC+ArtC increases responsiveness to lipolysis-linked hormones that have the capacity for thermogenesis."

Genetic Disorders • Obesity • PPARA

Improved Treatment of 1-4 Interactions in Force Fields for Molecular Dynamics Simulations. (PubMed, J Chem Theory Comput) - "Furthermore, by leveraging the automated parametrization capabilities of the Q-Force toolkit, we efficiently determine the necessary coupling terms without the need for manual adjustment. Our approach is first validated on a range of small molecule systems, encompassing both flexible and rigid structures, and shows a significant improvement in force field accuracy, obtaining subkcal/mol mean absolute error for every molecule tested. We further extend the bonded-only model for 1-4 interactions to Amber ff14sb, CHARMM36, and OPLS-AA force fields to reproduce ab initio gas and implicit solvent ϕ,ψ surfaces of alanine dipeptide."

Journal

Rodent Models of Oropouche Virus Infection for Antiviral Screening (ASTMH 2025) - "Treatment with chloroquine or quercetin had a moderate effect on the median survival time of Oropouche infected mice...A subset of infected hamsters experienced transient weight loss indicative of a nonlethal infection. Results from this study show that the Ifnar1-/- mouse model with demonstrated susceptibility to contemporary OROV, offers a predictive model for testing antiviral efficacy and the evaluation of potential therapies for this emerging disease."

Late-breaking abstract • Preclinical • Infectious Disease • IFNAR1

A DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED, SINGLE-CENTER, PILOT STUDY EVALUATING THE EFFICACY OF A SYNBIOTIC FORMULATION IN MODULATING GUT MICROBIOTA BIODIVERSITY IN PATIENTS WITH MILD-TO-MODERATE UC IN CLINICAL AND ENDOSCOPIC REMISSION [WITHDRAWN] (UEGW 2025) - "Our proof-of-concept study shows that the treatment with this synbiotic formulation used in addition to 5-ASA is able to improve both psychological and gastrointestinal symptoms in patients with UC, while maintaining their clinical and endoscopic remission. No direct effects have been observed on gut microbiota modulation. Further investigations are underway to confirm these findings."

Clinical • Gut Microbiota • Gastroenterology • Gastrointestinal Disorder • Inflammatory Bowel Disease • Ulcerative Colitis

DIETARY QUERCETIN SUPPLEMENTATION ATTENUATES ALCOHOL INDUCED HEPATIC ER STRESS AND APOPTOSIS BY DECREASING KYNURENINE LEVELS (AASLD 2025) - "Alcohol induced liver injury in mice is associated with decreased hepatic quercetin levels and increased production of kynurenine. Dietary quercetin supplementation decreases the levels and pathogenic signaling of kynurenine caused by alcohol."

Hepatology • Liver Failure • Metabolic Disorders • ATF3 • CYP1A1 • GADD45B

Targeting senescent immune cells as a potential treatment for multiple sclerosis (ECTRIMS 2025) - "Senolytic compounds navitoclax, quercetin, and dasatinib showed preliminary potential beneficial effects in the context of progressive forms of MS."

Immune cell • CNS Disorders • Multiple Sclerosis • CD69 • IL2RA

Late Breaking Abstract - Targeting senescence to reduce inflammation in alpha-1 antitrypsin deficiency (AATD) (ERS 2025) - " PBMCs from ZZ-AATD patients were differentiated into monocyte-derived macrophages (MDMs) and treated with dasatinib & quercetin (D+Q)... This study demonstrates for the first time that immune cells from both the peripheral blood and lungs of individuals with ZZ-AATD exhibit a pronounced senescent phenotype. These findings reveal senescence as a driver of inflammation in AATD and highlight the therapeutic potential of targeting senescent cells to mitigate chronic lung inflammation."

Late-breaking abstract • Alpha-1 Antitrypsin Deficiency • Chronic Obstructive Pulmonary Disease • Genetic Disorders • Hepatology • Inflammation • Pneumonia • Pulmonary Disease • Respiratory Diseases • CDKN1A • IL13 • IL1B • LMNB1 • TNFA