Q-Force (quercetin) / Quercis Pharma, Temple University - LARVOL DELTA

CD177+ neutrophils promote endothelial senescence through extracellular traps in Behçet's Disease (EULAR 2025) - "Differentially expressed proteins in NETs produced by BD and HC CD177 + PMNs were determined by Mass spectrometry, and were used to induce senescence and SASP of VECs, which were treated with dasatinib and quercetin (DQ)... Increased CD177 + PMN in BD patients promoted senescence and senescence-associated secretory phenotype in vascular endothelial cells through secreting NETs enriched with H3.1, which potentially contributed to vascular damage in BD."

Rare Diseases • Vasculitis • CD177 • CDKN1A • CXCL8 • ICAM1 • IL6

PolyPal: A Python Package for Molecular Dynamics Simulation of Amorphous Polymers. (PubMed, J Chem Theory Comput) - "In conjunction with the programs ORCA, Q-Force, Assemble!, and GROMACS, a highly accessible methodology is established for force field (FF) parametrization, creation of initial configurations, and simulation of various nonporous and porous polymers...FF accuracy was also validated through solid-state NMR studies. These simulations will not only open new avenues for the rational design of high-performance POPs through the contribution of improved insight but also provide a streamlined pathway for simulating previously unexplored porous polymeric materials."

Journal

Quercetin decreased steatosis by the inhibition of CYP450 on high-fat high-fructose diet-induced model (ECO 2025) - "Our results suggest that polyphenols like Quercetin can reduces hepatic steatosis by inhibiting CYP450 in MASLD and its related comorbidities such as obesity."

Genetic Disorders • Hepatology • Metabolic Disorders • Metabolic Dysfunction-Associated Steatohepatitis • Metabolic Dysfunction-Associated Steatotic Liver Disease • Obesity • CYP2E1

Network pharmacology analysis of phytochemicals in targeting cancer: A systems biology approach. (ASCO 2025) - "Our findings suggest that the multi-target and pleiotropic actions of these compounds are instrumental in mitigating cancer's complex pathophysiology. By integrating in silico predictions with experimental validations, we provide a blueprint for developing phytochemical-based combinatory therapies tailored to specific cancer types. This study not only advances our understanding of plant-derived compounds in oncology but also emphasizes the potential of network pharmacology as a transformative approach in drug discovery."

Oncology

Advanced glycation end products induced M1-like macrophages exacerbate photoaging via PTX3 (SID 2025) - "Our study reveals that AGEs-induced M1-like macrophages exacerbate skin photoaging through PTX3 secretion, and that inhibition of macrophage M1 polarization may offer a potential therapeutic strategy for photoaging."

Late-breaking abstract • Metastases • Inflammation • PTX3

Screening for novel senolytic compounds for skin care treatments using machine learning approach. (SID 2025) - "For the ex vivo model we used Navitoclax and quercetin as reference compounds. *identity of the compounds to be disclosed at poster presentation after IP filing"

IO biomarker • Machine learning

Reactive Oxygen Species Promote Sarcoidosis Granuloma Formation Through Heme Oxygenase-1 and STAT3 (ATS 2025) - "The magnitude of the granulomatous responses was quantified based on computational MIPAR image analysis following pretreatment with a flavonoid antioxidant (quercetin), cell permeable superoxide dismutase mimetic (TEMPOL), HO-1 inhibitor (OB 24) or STAT3 inhibitor (Stattic), compared to prednisone...These findings are consistent with prior clinical studies indicating that quercetin treatment is associated with reduced systemic markers of oxidative stress and inflammation (PMID: 21324570) and elevation of HO-1 levels in the lungs of pulmonary sarcoidosis patients (PMID: 19453654). The mechanisms promoting oxidant stress and the clinical implications of antioxidants remain to be determined but mitochondrial oxidative stress is implicated by gene expression analysis."

Immunology • Inflammation • Sarcoidosis • HMOX1 • IFNG • STAT3

Senescence Is Elevated in Airway and Liver Cells in Alpha-1 Antitrypsin Deficiency and Is Tractable to Targeted Therapy (ATS 2025) - "Further, HepG2 hepatocytes expressing Z-AAT were treated with senolytic drug combination, dasatinib and quercetin (DQ)... Accumulation of Z-AAT polymers within cells induces senescence that then likely promotes persistent inflammation. This study prompts further investigation into the utility of targeted therapies against senescence to mitigate inflammation and, hence, lung function decline and disease progression in AATD."

Alpha-1 Antitrypsin Deficiency • Chronic Obstructive Pulmonary Disease • Genetic Disorders • Hepatology • Immunology • Inflammation • Pulmonary Disease • Respiratory Diseases • Tobacco Cessation

Flavonoid Quercetin Enhances Nuclear Factor Erythroid 2-related Factor 2 (Nrf2) Pathway Activation and Reduces Inflammatory Cytokines in Asthmatic Airway Epithelial Cells (ATS 2025) - "This study provides evidence that quercetin, through the activation of the Nrf2 pathway and subsequent reduction in pro-inflammatory cytokines, holds therapeutic potential in asthma. Future clinical studies are warranted to validate these findings and to determine quercetin's efficacy in improving asthma outcomes."

Asthma • Immunology • Oncology • Respiratory Diseases • IL13 • NQO1 • TNFA

Senescence: a translational perspective for uremic cardiomyopathy (ERA 2025) - "Mice were treated with a senolytic cocktail of dasatinib and quercetin (D&Q) twice weekly for 8 weeks... Senescent cardiomyocytes contribute to heart fibrosis and dysfunction in CKD through IS-induced AhR activation. Senolytics treatment suppressed AhR activation, reducing oxidative stress and inflammation, which provided therapeutic potential for uremic cardiomyopathy."

Cardiomyopathy • Cardiovascular • Chronic Kidney Disease • Fibrosis • Immunology • Inflammation • CDK1 • CDK4 • CDKN1A • CDKN2A • CTGF • IL1B • IL6 • TGFB1 • TNFA • VIM

Synergistic Chemotherapy and Immunomodulatory Effects of Quercetin in Cancer: A ReviewProvisionally accepted (Frontiers) - "Quercetin (QUE) is a natural flavonoid that is widely found in fruits and vegetables. It not only has anticancer effects but also has anti-inflammatory, antioxidant, and neuroprotective properties. More and more studies have found that the combination of QUE and chemotherapy drugs has a better anti-tumor effect than traditional chemotherapy drugs alone. To a certain extent, it can inhibit the side effects of chemotherapy drugs such as nephrotoxicity, cardiotoxicity, reproductive toxicity, and neurotoxicity, which has attracted great attention. The immune system plays a significant role in the development of tumors.Notably, several studies have revealed that QUE may have immunomodulatory functions in the tumor microenvironment."

Review • Oncology

Immunomodulatory Mechanisms of Radix Hedysari in Colorectal Cancer via Multi-Omics Analysis (IMMUNOLOGY 2025) - "Pathway enrichment analyses showed significant involvement in PI3K-Akt, Hippo, HIF-1, and cholesterol metabolism signaling pathways critical to cancer immunity and immune cell activity, including tumor-associated macrophages, T regulatory cells, and cytotoxic T lymphocytes. These findings indicate that RH and formononetin modulate tumor growth and the tumor-immune microenvironment by targeting key immune signaling pathways, offering insights into RH's mechanisms and its potential as a foundation for CRC immunotherapy.Keywords: Animals Human; Cells T Cells; Molecules Protein Kinases/Phosphatases; Processes Cell Proliferation; Techniques/Approaches Molecular Biology"

Immunomodulating • Late-breaking abstract • Colon Cancer • Colorectal Cancer • Oncology • Solid Tumor • CA9 • HIF1A • MME

TRADITIONAL MEDICINE PIEN TZE HUANG IMPROVES CHOLESTASIS LIVER DISEASE THROUGH ABSORBING ACTIVE INGREDIENTS AND RESHAPING INTESTINAL MICROBIOTA (DDW 2025) - "PZH improves cholestatic liver injury by absorbing active ingredients and reshaping intestinal microbiota. PZH has a potential utility as a therapeutic agent for CLD."

Cholestasis • Colorectal Cancer • Fibrosis • Hepatology • Immunology • Liver Cirrhosis • Liver Failure • Oncology • Solid Tumor • ABCB4

Niosome-Encapsulated Quercetin for Enhanced Thyroid Cancer Therapy and Potential Minimization of Thyroid Surgery (ESPE-ESE 2025) - "Further in vitro and in vivo studies are warranted to evaluate efficacy and safety in preclinical thyroid cancer models, specifically investigating the potential to minimize surgical intervention. This research contributes to improved, less invasive thyroid cancer treatments."

Surgery • Endocrine Cancer • Oncology • Solid Tumor • Thyroid Gland Carcinoma

The Role of Senolytics in Reducing Senescence Induced by Cannabinoids and Nicotine in Prenatal Human Lung (ATS 2025) - "Subsequently, senolytics, Dasatinib (D, 250nM) and Quercetin (Q, 375nM), were added or not for an additional 24 hours... Taken together, our results showed that the combinatorial exposure to CBD, THC, and nicotine increases senescence, DNA damage, and the senescence-associated secretory phenotypes (SASP) secretion. The use of senolytics (D+Q) may prove to be a promising therapeutic option, alleviating several of the negative effects induced by the different substances."

Inflammation • CCL4 • CDKN1A • CDKN2A • CSF1 • CXCL8 • IL6 • TNFA • TSLP

Induction of liver injury in metabolic dysfunction-associated steatotic liver disease by microbial metabolite 3-4-Hydroxyphenyllactate through hepatic cellular senescence (EASL 2025) - "To explore causality, wild-type mice on a chow diet were administered the candidate metabolite daily, with or without senolytics (dasatinib and quercetin, D+Q)... Liver senescence is linked to more severe disease in individuals with obesity. The microbial metabolite HPLA correlates with senescence markers and is associated with liver disease severity and increased liver-related mortality risk. In mice, HPLA induces hepatic injury and steatosis, effects that are mitigated by senolytic treatment."

Diabetes • Genetic Disorders • Hepatology • Liver Failure • Metabolic Disorders • Metabolic Dysfunction-Associated Steatohepatitis • Metabolic Dysfunction-Associated Steatotic Liver Disease • Obesity • CDKN1A

TREATMENT OF LABILE BLOOD PRESSURE AND HYPERTENSION IN PERIMENOPAUSE WITH MAST CELL TARGETED THERAPIES: A CONNECTION BETWEEN HYPERTENSION AND MAST CELL ACTIVATION SYNDROME - Jillian Balser (ACC 2025) - "A trial of therapy with a histamine receptor antagonist (fexofenadine 180 mg twice daily) and Quercetin (mast cell stabilizer) were recommended, in addition to avoidance of triggers and continuation of her amlodipine and triamterene-hydrochlorothiazide... During perimenopause, mast cell dysfunction may develop or worsen due to fluctuations in estrogen levels, leading to increased mast cell mediator release. This may contribute to symptoms of fatigue, flushing, urticaria, and anxiety, as well as labile blood pressures and worsening hypertension. In this case, treatment (with high dose antihistamines & Quercetin) and trigger avoidance improved symptoms."

Cardiovascular • Dermatology • Dyslipidemia • Fatigue • Gynecology • Hypertension • Immunology • Mood Disorders • Pain • Psychiatry • Urticaria

POLYPHENOLIC PREPARATION FROM FRUITS USEFUL FOR NUTRITIONAL SUPPORT OF ALZHEIMER'S DISEASE TREATMENT (ADPD 2025) - "A new polyphenolic preparation possessing strong anticholinesterase, anti -inflammatory and antioxidant activities was created for the nutritional support of Alzheimer's disease treatment."

Alzheimer's Disease • CNS Disorders

PROTECTIVE ACTION OF PHYTOCHEMICALS IN PALMITATE -INDUCED BRAIN MITOCHONDRIAL DYSFUNCTION. (ADPD 2025) - "Our study shows how antioxidant phytochemicals could be useful enhancers of mitochondrial function and revert PA -linked MitD in the brain, thus protecting neurons from degeneration and slowing the progression of AD. Interestingly, target -analysis with Quercetin performed in our lab has revealed mitochondrial proteins as potential targets. Further studies will reveal whether the two mitochondria enhancing phytochemicals act via different intracellular pathways."

Alzheimer's Disease • CNS Disorders • Diabetes • Inflammation • Metabolic Disorders • Type 2 Diabetes Mellitus

ALPHA-SYNUCLEINOPATHY INDUCES NEURONAL SENESCENCE IN VIVO AND SENOLYTIC TREATMENT ATTENUATES DISEASE IN MOUSE MODEL OF ALPHA-SYNUCLEINOPATHY (ADPD 2025) - "To determine the pathologic significance of senescence, aS PFF inoculated TgA53T mice were treated once a week with a senolytic cocktail [Dasatinib (12 mg/kg) and Quercetin (50 mg/kg) (D+Q)]...Conclusions α-synucleinopathy induces senescence first in neurons and secondarily in glial cells. Targeting senescent cells using senolytics may provide neuroprotection from α-synucleinopathy."

Preclinical • CNS Disorders • Cognitive Disorders • Inflammation • Movement Disorders • Parkinson's Disease • CDKN1A • CDKN2A • ERCC1 • HMGB1

Investigating the Molecular Mechanism of Yinchenhao decoction in Treating Autoimmune Hepatitis through Network Pharmacology and Molecular Docking Methods (APASL 2025) - "Through network pharmacology and molecular docking, this study delineated the potential mechanism of YCHD in the treatment of AIH, providing insights and directions for future research. However, since the study initiated with a network prediction approach and did not consider the concentration of each component or their changes during combined use, further validation of the results is necessary."

Autoimmune Hepatitis • Fibrosis • Hepatology • Immunology • Inflammation • Liver Cirrhosis • Liver Failure • AKT1 • CDC37 • CTNNB1 • HSP90AA1 • MAPK1 • MAPK3 • PIK3CA • PIK3R1 • RELA • TP53

Reconsider: Ferroptosis in NAFLD, molecular mechanisms of its regulation, and therapeutic implications (APASL 2025) - "Ferroptosis, a mode of regulatory cell death driven by accumulated lipid peroxidation in an ferrous iron manner, and is considered to be an important factor in the pathogenesis .For example, ferroptosis causes hepatic steatosis and abnormal accumulation of hepatic lipids at different stages of the disease, and accelerates the progression from simple steatosis to nonalcoholic fatty liver disease by inducing an inflammatory response in the liver that a. Destroying normal liver cells, thereby aggravating liver injury b. Activating liver cell death, ameliorating fibrosis, thereby improving the liver microenvironment .This creates a mutually antagonistic situation. Table and Figure:Figure 1.The molecular mechanisms of ferroptosis"

Fibrosis • Hepatology • Immunology • Inflammation • Liver Failure • Metabolic Dysfunction-Associated Steatotic Liver Disease • AIFM2 • GPX4 • TMSB4X

Suppression of IRS-2 aggravated hepatocyte senescence by regulating autophagy in high-fat diet state (APASL 2025) - "Decreased IRS-2 expression could accelerate hepatocyte senescence via AMPK/mTOR mediated autophagy in high-fat diet state. Dasatinib and quercetin may play the anti-senescence role by mediate IRS-2 expression. Table and Figure:Figure 1.IRS2 was the downregulated in senescence mouse liver tissue Figure 2.Electron microscope results show severe level of autophagy in HepG2 with different treatment"

Hepatology • Metabolic Disorders • IL6 • IRS2 • TNFA

The therapeutic effect of Scutellaria barbata on hepatocellular carcinoma: validation based on the effective compound luteolin (APASL 2025) - "Luteolin is the effective compound of anti-tumor of SBA, which promotes the apoptosis by up-regulating Caspase3 and inhibiting the proliferation by down-regualting CCNB1, CDK1 and BCL2. Table and Figure:Figure 1."

IO biomarker • Hepatocellular Cancer • Hepatology • Oncology • Solid Tumor • BCL2 • CASP3 • CCNA2 • CCNB1 • CDK1 • E2F1 • MMP1

Quercetin inhibits mitophagy-mediated apoptosis and inflammatory response by targeting the PPARy/PGC-1a/NF-KB axis to improve acute liver failure (APASL 2025) - "In short, our results provide the first evidence that QUE improves acute liver failure by promoting mitophagy through regulating the PPARγ/PGC-1α/NF-κB axis and inhibiting apoptosis and inflammatory responses mediated by mitochondrial dysfunction, which provides evidence for the potential of QUE in the treatment of ALF. Table and Figure:Figure 1.Graphical abstract"

Hepatology • Inflammation • Liver Failure • Metabolic Disorders • PPARG