Q-Force (quercetin) / Quercis Pharma, Temple University - LARVOL DELTA

Targeting BRD4 to reshape the inflammatory microenvironment of senescent bone marrow mesenchymal stem cells for improved hematopoietic stem cell transplantation reconstitution (ASH 2025) - "Crucially,dual-pathway intervention combining senolytic agents (dasatinib + quercetin, D+Q) with JQ1 exhibitedsynergistic efficacy, reducing SASP secretion more substantially than either monotherapy...We further demonstrate that a novel dual-pathway strategy combiningsenescent cell clearance (via dasatinib + quercetin) with BRD4 inhibition synergistically restores theinflammatory hematopoietic microenvironment. This approach offers a promising therapeutic solutionfor improving post-transplantation HSC reconstitution, with BRD4-targeted interventions demonstratingsignificant potential for clinical translation."

Bone Marrow Transplantation • Transplantation • BRD4

Oxidative stress and hemoglobin-c denaturation drive hemoglobin SC pathophysiology and can be ameliorated by antioxidants and hydroxyurea (ASH 2025) - "Overall, these results support a causal role for HbC-mediated oxidative membrane damagein impairing RBC rheology. Notably, hydroxyurea treatment, even with modest HbF induction, canmitigate oxidative injury and restore critical aspects of RBC membrane health, an effect similarly achievedthrough antioxidant supplementation in HbSC mice. Our findings highlight the central role of oxidativedamage, particularly Heinz body accumulation, in the pathophysiology of HbSC disease."

Oxidative stress • Genetic Disorders • Hematological Disorders • Retinal Disorders • Sickle Cell Disease

Quercetin-Induced Membrane-TRAIL Release Promotes Apoptosis in Glioblastoma (SNO 2025) - "Thus, we found that quercetin, in vitro, can induce apoptosis in GBM cells by promoting trafficking of endogenous mTRAIL to the cancer cell surface, which can then interact with DR5 on cancer cells in a paracrine or autocrine manner, destroying the tumor cells. This novel mechanism of GBM self-destruction in the presence of quercetin, combined with quercetin's reported ability to cross the blood-brain barrier, highlights its potential as a promising therapeutic for GBM."

Brain Cancer • Glioblastoma • Solid Tumor • TNFRSF10B

Exploring GBM vulnerabilities by a combinational approach of inhibiting ARHGAP activity and inducing synergetic effects with plant-derived therapeutics (SNO 2025) - "Temozolomide (TMZ) remains the sole cytotoxic chemotherapeutic option in the management of Glioblastoma (GBM), with tumours eventually developing resistance...Its inhibition potentiates TMZ efficacy and may synergize with selective plant-derived therapeutics. These findings support the rationale for novel combination strategies integrating selective targeting of the cytoskeleton with RhoGTPase modulators and selective inhibitors to overcome GBM therapy resistance."

Brain Cancer • Glioblastoma • Solid Tumor • ARHGAP

Quercetin-Induced Membrane-TRAIL Release Promotes Apoptosis in Glioblastoma (WFNOS 2025) - "Thus, we found that quercetin, in vitro, can induce apoptosis in GBM cells by promoting trafficking of endogenous mTRAIL to the cancer cell surface, which can then interact with DR5 on cancer cells in a paracrine or autocrine manner, destroying the tumor cells. This novel mechanism of GBM self-destruction in the presence of quercetin, combined with quercetin’s reported ability to cross the blood-brain barrier, highlights its potential as a promising therapeutic for GBM."

Brain Cancer • Glioblastoma • Glioma • Solid Tumor • TNFRSF10B

Exploring GBM vulnerabilities by a combinational approach of inhibiting ARHGAP activity and inducing synergetic effects with plant-derived therapeutics (WFNOS 2025) - "Temozolomide (TMZ) remains the sole cytotoxic chemotherapeutic option in the management of Glioblastoma (GBM), with tumours eventually developing resistance...Its inhibition potentiates TMZ efficacy and may synergize with selective plant-derived therapeutics. These findings support the rationale for novel combination strategies integrating selective targeting of the cytoskeleton with RhoGTPase modulators and selective inhibitors to overcome GBM therapy resistance."

Brain Cancer • Glioblastoma • Solid Tumor • ARHGAP

Galloylated Polyphenols Represent a New Class of Antithrombotic Antagonists of Thiol Isomerases (ASH 2023) - "Galloyltransferases are found in many plants and galloylated polyphenols are abundant in commonly consumed beverages such as teas. Members of this class of compounds may be useful in the setting of COVID19 as inhibitors of thrombosis and viral replication."

Cardiovascular • Hematological Disorders • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases • Thrombosis

Dasatinib and Quercetin Combination Increases Kidney Damage in Acute Folic Acid-Induced Experimental Nephropathy (KIDNEY WEEK 2025) - "Conclusion Contrary to expectations, senolytic treatment with D&Q did not protect against folic acid-induced AKI and instead exacerbated markers of kidney damage and senescence. These findings highlight the complexity of targeting senescence in acute settings and suggest caution when considering the use of D&Q in AKI patients."

Acute Kidney Injury • Chronic Kidney Disease • Nephrology • Renal Disease • CDKN1A • KIM1

Therapy Induced Senescence Is Associated with a Myeloid Gene Signature in Multiple Myeloma Plasma Cells (ASH 2024) - "Current standard of care includes autologous stem cell transplant (ASCT) with high-dose melphalan (HDM) administered as a conditioning agent...HDM-5TGM1 cells were more sensitive to senolysis by dasatinib+quercetin (viability : HDM 54.9%±0.09%, Veh 76.0%±0.05%, N=2)...Further, CD138+ PC burden post-ASCT positively correlated with time in remission in relapsed patients (R=0.697, p=0.03).Bortezomib reduced serum M-spike in Vk*MYC-engrafted mice (p=0.0003); M-spike was further reduced by HDM/SCT compared to Veh-treated mice (p=0.0007)...Greater MM burden post-ASCT appears to be associated with longer durable response, again suggesting that these cells may be in growth arrest consistent with TIS. Finally, senolytics may be a novel approach to eliminate surviving MM cells and prevent relapse."

Gene Signature • Hematological Malignancies • Multiple Myeloma • Oncology • AXL • BCL2L1 • CDKN1A • CDKN1C • FCER1G • ICAM1 • MMP13 • SDC1

Quercetin Ameliorates the Astrocyte Cytoxicity Induced By HIV-1 gp120 Via Promoting Insoluble Stress Granules Disassembly (ASH 2024) - "QC treatment is able to significantly reduce the number of SGs formation both in the brain tissue of Gp120 tgm and in primary astrocytes induced with HIV-1 gp120. In addition, QC is capable to significantly improve the neural cognitive impairment of Gp120 tgm in the gut-blood-brain way as a dietary supplement."

Alzheimer's Disease • CNS Disorders • Cognitive Disorders • Dementia • Developmental Disorders • Human Immunodeficiency Virus • Infectious Disease • Movement Disorders • Parkinson's Disease • G3BP1

Phytocompounds Act Synergistically to Stimulate Lipolysis and Thermogenesis in Human Adipocytes (OBESITY WEEK 2025) - "Treatment with NRBC+ArtC has the potential to stimulate greater weight loss than NR alone. ArtC has a 12-hour half-life and all three phytocompounds have high bioavailability. Lipolysis provides the fuel for thermogenesis, and NRBC+ArtC increases responsiveness to lipolysis-linked hormones that have the capacity for thermogenesis."

Genetic Disorders • Obesity • PPARA

Improved Treatment of 1-4 Interactions in Force Fields for Molecular Dynamics Simulations. (PubMed, J Chem Theory Comput) - "Furthermore, by leveraging the automated parametrization capabilities of the Q-Force toolkit, we efficiently determine the necessary coupling terms without the need for manual adjustment. Our approach is first validated on a range of small molecule systems, encompassing both flexible and rigid structures, and shows a significant improvement in force field accuracy, obtaining subkcal/mol mean absolute error for every molecule tested. We further extend the bonded-only model for 1-4 interactions to Amber ff14sb, CHARMM36, and OPLS-AA force fields to reproduce ab initio gas and implicit solvent ϕ,ψ surfaces of alanine dipeptide."

Journal

Rodent Models of Oropouche Virus Infection for Antiviral Screening (ASTMH 2025) - "Treatment with chloroquine or quercetin had a moderate effect on the median survival time of Oropouche infected mice...A subset of infected hamsters experienced transient weight loss indicative of a nonlethal infection. Results from this study show that the Ifnar1-/- mouse model with demonstrated susceptibility to contemporary OROV, offers a predictive model for testing antiviral efficacy and the evaluation of potential therapies for this emerging disease."

Late-breaking abstract • Preclinical • Infectious Disease • IFNAR1

A DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED, SINGLE-CENTER, PILOT STUDY EVALUATING THE EFFICACY OF A SYNBIOTIC FORMULATION IN MODULATING GUT MICROBIOTA BIODIVERSITY IN PATIENTS WITH MILD-TO-MODERATE UC IN CLINICAL AND ENDOSCOPIC REMISSION [WITHDRAWN] (UEGW 2025) - "Our proof-of-concept study shows that the treatment with this synbiotic formulation used in addition to 5-ASA is able to improve both psychological and gastrointestinal symptoms in patients with UC, while maintaining their clinical and endoscopic remission. No direct effects have been observed on gut microbiota modulation. Further investigations are underway to confirm these findings."

Clinical • Gut Microbiota • Gastroenterology • Gastrointestinal Disorder • Inflammatory Bowel Disease • Ulcerative Colitis

DIETARY QUERCETIN SUPPLEMENTATION ATTENUATES ALCOHOL INDUCED HEPATIC ER STRESS AND APOPTOSIS BY DECREASING KYNURENINE LEVELS (AASLD 2025) - "Alcohol induced liver injury in mice is associated with decreased hepatic quercetin levels and increased production of kynurenine. Dietary quercetin supplementation decreases the levels and pathogenic signaling of kynurenine caused by alcohol."

Hepatology • Liver Failure • Metabolic Disorders • ATF3 • CYP1A1 • GADD45B

Targeting senescent immune cells as a potential treatment for multiple sclerosis (ECTRIMS 2025) - "Senolytic compounds navitoclax, quercetin, and dasatinib showed preliminary potential beneficial effects in the context of progressive forms of MS."

Immune cell • CNS Disorders • Multiple Sclerosis • CD69 • IL2RA

Late Breaking Abstract - Targeting senescence to reduce inflammation in alpha-1 antitrypsin deficiency (AATD) (ERS 2025) - " PBMCs from ZZ-AATD patients were differentiated into monocyte-derived macrophages (MDMs) and treated with dasatinib & quercetin (D+Q)... This study demonstrates for the first time that immune cells from both the peripheral blood and lungs of individuals with ZZ-AATD exhibit a pronounced senescent phenotype. These findings reveal senescence as a driver of inflammation in AATD and highlight the therapeutic potential of targeting senescent cells to mitigate chronic lung inflammation."

Late-breaking abstract • Alpha-1 Antitrypsin Deficiency • Chronic Obstructive Pulmonary Disease • Genetic Disorders • Hepatology • Inflammation • Pneumonia • Pulmonary Disease • Respiratory Diseases • CDKN1A • IL13 • IL1B • LMNB1 • TNFA

Prophylactic quercetin attenuates pulmonary fibrosis via ferroptosis-resistant priming of alveolar epithelial cells (ERS 2025) - "Co-administration with NAC/z-VAD attenuated quercetin-induced ROS without significantly altering senescence/apoptosis in healthy alveolar epithelial cells, but abolished its protective effects against bleomycin damage, confirming that preconditioning via adaptive stress underlies prophylaxis. Our findings unveil quercetin's potential as a preventive agent against IPF, mediated through alveolar epithelial cell preconditioning to enhance ferroptosis resistance, and advocate for prophylactic strategies targeting early epithelial vulnerability."

Fibrosis • Idiopathic Pulmonary Fibrosis • Immunology • Pulmonary Disease • Respiratory Diseases • GPX4

Senolytic Potential of Fisetin and ABT Compounds in Dermal Fibroblasts (ESDR 2025) - "This study aimed to identify effective senolytics for dermal aging treatment by comparing the senolytic properties of several known compounds—including Dasatinib, Fisetin, Quercetin, Navitoclax (ABT263), ABT737, and Resveratrol—in senescent human dermal fibroblasts (HDFs)...The SASP-driven effects on normal cells were effectively mitigated. Overall, all tested compounds demonstrated senolytic activity, but Fisetin, ABT263, and ABT737 exhibited the highest efficacy in HDFs, highlighting their potential as promising candidates for future studies on dermal aging interventions."

IL6

Bioactive materials from cottonseed regulate glucose transport gene expression in mouse macrophages (ACS-Fall 2025) - "Similar effect was observed on Glut3 mRNA, but Glut4 mRNA levels were not affected by gossypol. This study demonstrate that cottonseed ethanol extracts have modest effect but gossypol has stronger effect on stimulating Glut gene expression and suggest that cottonseed bioactive materials may effect macrophage immunity."

Preclinical • Metabolic Disorders • SLC2A1 • SLC2A3 • SLC2A4

Reactive Oxygen Species Promote Sarcoidosis Granuloma Formation (WASOG-AASOG 2025) - "The magnitude of the granulomatous responses was quantified based on computational MIPAR image analysis following pretreatment with a flavonoid antioxidant (quercetin), cell permeable superoxide dismutase mimetic (TEMPOL), and inhibitors of NRF2/HO-1/STAT3 and inflammasome (caspase inhibitors), compared to prednisone...These findings are consistent with prior clinical studies indicating that quercetin treatment is associated with reduced systemic markers of oxidative stress and inflammation (PMID: 21324570) and elevation of HO-1 levels in the lungs of pulmonary sarcoidosis patients (PMID: 19453654). The mechanisms promoting oxidant stress and the clinical implications of antioxidants remain to be determined but mitochondrial oxidative stress is implicated by gene expression analysis."

Immunology • Infectious Disease • Inflammation • Respiratory Diseases • Sarcoidosis • Tuberculosis • HMOX1 • IFNG

Self-assembled shellac nanoparticles for potential delivery of lipophilic polyphenols (ACS-Fall 2025) - "Although gum arabic and Tween 20 keep shellac micelles dispersed at pH 4.5 and 3.0, the visually stable dispersions show particle growth during storage. These features of shellac micelles have potential for incorporating lipophilic polyphenols into functional foods and beverages to utilize their bioactivity."

Colon Cancer • Colorectal Cancer • Solid Tumor

Novel Sorghum bicolor variant producing a polyphenol-rich leaf tissue that exhibits bioactive properties in vitro and in clinical study (ACS-Fall 2025) - "The study included two different doses of the extract and found participants in the treatment groups had a significantly greater recovery in peak torque output during the 24-72 hours following EIMD than the placebo group and demonstrated faster recovery of peak torque. Treatment arm participants also had significant increases in pain pressure threshold, a quantitative measure of soreness, during recovery period while the placebo group was unchanged."

Preclinical • CAT • IL12A • IL1B • IL2 • IL2RA • IL6 • TNFA

Bioactivity of polyphenol-rich sorghum substrates in the production of Pleurotus ostreatus grain spawn (ACS-Fall 2025) - "While the control and white sorghum substrates showed minimal inhibition of advanced glycation end-products (AGEs), Sumac100 demonstrated substantial antiglycation activity—reducing AGE formation by 40–50% in early glycation (BSA-FRU) and 15–30% in intermediate stages (BSA-MGO).In conclusion, high-polyphenol sorghum, particularly Sumac100, supports robust mycelial growth and enhances the bioactivity of mushroom grain spawn, notably through increased phenolic content and antiglycation potential. Optimizing sterilization protocols to retain heat-sensitive phenolics could further enhance the nutraceutical value of sorghum-based spawn for functional food applications."

Phytochemical study and evaluation of the antioxidant activity of hydroalcoholic extract of Juniperus oxycedrus from Morocco (ACS-Fall 2025) - "Antioxidant activity was evaluated using DPPH and ABTS assays, with IC50 values of 45 ± 2 µg/mL and 30 ± 1.5 µg/mL, respectively, indicating a strong antioxidant capacity comparable to that of ascorbic acid (IC50 = 20 ± 1 µg/mL).These results highlight the potential of Juniperus oxycedrus as a natural source of powerful antioxidants, in agreement with previous studies. The combination of qualitative and quantitative phytochemical analyses particularly using HPLC-UV, offers promising perspectives for the valorization of this plant in pharmaceutical and food industries."