Q-Force (quercetin) / Quercis Pharma, Temple University - LARVOL DELTA

Dasatinib and Quercetin in Patients with Relapsed, Refractory Multiple Myeloma Receiving CAR-T Therapy: First Report from the Safety Run-in of the Phase II DART Trial (IMS 2026) - P2 | "In the safety run-in of the DART trial, D+Q with cilta-cel was feasible and showed a safety profile consistent with cilta-cel alone, and no new signals associated with D+Q. Updated clinical and correlative results including additional TIS analysis in bone marrow biopsy will be reported."

CAR T-Cell Therapy • Clinical • P2 data • Cardiovascular • Hematological Malignancies • Hypertension • Infectious Disease • Multiple Myeloma • Neutropenia • Pneumonia • Respiratory Diseases • B3GAT1 • CD14 • KLRG1

AT2 Cell Senescence Increases Susceptibility to ARDS-Like Injury in a Sin3a-Deficient Mouse Model (ERS 2026) - "Sftpc-CreER Sin3a-flx/flx (Sin3a-LOF) mice received tamoxifen (TMX) to delete Sin3a in AT2 cells...Senolytic dasatinib plus quercetin (DQ) was given on days 35–48...In Sin3a-LOF mice with senescence-associated pulmonary fibrosis, profibrotic AT2 cells impaired type I IFN-mediated inflammatory responses and induced profibrotic macrophages, leading to sustained neutrophil activation during LPS challenge. These findings provide insight into mechanisms of acute exacerbation in interstitial lung disease."

Preclinical • Acute Respiratory Distress Syndrome • Fibrosis • Immunology • Inflammation • Interstitial Lung Disease • Pulmonary Disease • Respiratory Diseases

Combination of ferulic acid, quercetin and glycyrrhizic acid in bleomycin-induced pulmonary fibrosis (ERS 2026) - "Synergy analysis showed that FA, QU, and GA at a 2:1:1 ratio exerted synergistic inhibitory effects on lung fibroblast viability. Conclusion The combination of ferulic acid, quercetin, and glycyrrhizic acid attenuates bleomycin-induced pulmonary fibrosis, potentially through synergistic suppression of ECM accumulation and EMT."

Fibrosis • Idiopathic Pulmonary Fibrosis • Immunology • Pulmonary Disease • Respiratory Diseases • TGFB1

Multi-Ethnic Epigenome-Wide Meta-Analysis Identifies Novel Blood Methylation Associations with Asthma and Exacerbations Mostly Driven by T Cells (ERS 2026) - "Genome-wide CpGs were enriched in air pollution, smoking, autoimmune diseases, Th1/2/17 cell differentiation, IGF pathway, and genes targeted by tamatinib, ilorasertib, quercetin, and resveratrol. The first meta-EWAS of asthma with exacerbations in diverse populations identifies novel DNAm biomarkers driven by T cells and potential therapies for severe asthma. Funding: NIH (R01HL155024,R01ES031259); MCIN/AEI/10.13039/501100011033,FEDER,EU (PID2024-160302OB-I00); Catalina Ruiz, ACIISI"

IO biomarker • Retrospective data • Asthma • Immunology • Inflammation • Respiratory Diseases • ADRB2 • CCL18

Senolytic treatment during normothermic machine perfusion dampens ischemia reperfusion injury in old livers (TTS 2026) - " Isolated livers from old male Sprague Dawley rats (12 months) were treated with a perfusate solution supplemented with a combination of Dasatinib (2 μM) and Quercetin (20 μM) (D&Q) during 6 hours of NMP... Together, these data demonstrate for the first time that senolytic treatment during NMP is feasible and effective in dampening age-specific IRI which may be applicable not only for livers but older organ transplantation in general."

Cardiovascular • Hepatology • Liver Failure • Reperfusion Injury • Solid Organ Transplantation • CDKN1A • IL17A • IL6 • MMP3 • TNFA

Cellular Senescence Drives Age-Related Resistance to Costimulatory Blockade in Transplantation (TTS 2026) - " Aged C57Bl/6 mice (18-month) were pre-treated with senolytics—Dasatinib+Quercetin, "D/Q"—or vehicle (control) for 2 months, before undergoing fully-mismatched heterotopic heart transplantation from young (3-month) Balb/c donors... Senescent cell depletion with senolytics dramatically improves CTLA4-Ig efficacy in aged recipients, with graft survival nearing that of young mice. These findings identify senescence as a major driver of age-related resistance to costimulatory blockade. The upregulation of PD-1 checkpoint may play a critical mechanistic role, serving as a potential target for augmenting co-stimulatory blockade in aged recipients."

IO biomarker • Transplantation • CD8 • PD-L2

Pseudomonas aeruginosa virulence factors pyocyanin and 1- hydroxyphenazine show strong synergism and iron-dependent toxicity in reporter airway cells (NACFC 2026) - "Moreover, addition of low- ?M non-chelatable heme iron increased the cytotoxicity of PYO tenfold, and the effect could be mitigated only by a large excess of N-acetylcysteine. This work reveals previously unknown ability of PA phenazines to synergistically interact against airway cells and macrophages. Such synergy can dramatically enhance the cytotoxicity of PYO, which could be further reinforced by heme iron."

Cystic Fibrosis • Genetic Disorders • Immunology • Infectious Disease • Inflammation • Respiratory Diseases • ATF4 • ATF6 • STAT1

Plant-Derived Compounds as Antibiotic Adjuvants Against Drug-Resistant ESKAPE Pathogens: Mechanisms of Action, Synergistic Strategies, and Translational Challenges. (PubMed, Antibiotics (Basel)) - "For instance, the flavonoid quercetin inhibits the NorA efflux pump in Staphylococcus aureus, restoring ciprofloxacin susceptibility, while the sulfur-containing compound ajoene from garlic disrupts quorum sensing in Pseudomonas aeruginosa, sensitizing biofilms to tobramycin... Plant-derived antibiotic adjuvants represent a promising strategy to combat multidrug-resistant ESKAPE pathogens. However, greater emphasis on translational research, standardized methodologies, and clinically relevant experimental models is required to facilitate their development toward therapeutic applications."

Journal • Review • Infectious Disease • Pneumonia

Effect of assembly sequence on the digestibility of potato starch-based binary and ternary complexes under heat moisture treatment: a dual steric hindrance-enzymatic inhibition perspective (ACS-Fall 2026) - "Specifically, QC acts as a predominantly competitive mixed-type inhibitor (Kic < Kiu) against both α-amylase and α-glucosidase, whereas RP specifically function as an uncompetitive-leaning mixed inhibitor (Kiu < Kic) targeting the α-glucosidase–substrate complex. These findings provide a novel hierarchical assembly strategy for developing functional, low-glycemic starch-based ingredients."

Kalanchoe Pinnata nanoparticles for enhancing antioxidant- antimicrobial activity of edible films | Poster Board #1196 (ACS-Fall 2026) - "The solution is then incubated at 37°C ± 1°C for 24 hours. The results,UV-Vis FF:pink(anthocyanins),545 nm band(aromatic ring),70mg/mL eq quercetin.FTIR:N-H 1516 cm-1.Halo confirms antimicrobial of BP."

Comparative metabolomic profiling of leaf and stem tissues in red and green lettuce(Lactuca sativa L.) cultivars | Poster Board #1054 (ACS-Fall 2026) - "These findings suggest that secondary metabolism associated with antioxidant activity is more active in leaves, whereas primary metabolism related to growth and basic physiological processes is more prominent in stems. Overall, this study provides fundamental insights into tissue-specific metabolite distribution in lettuce and offers valuable information for the exploration of functional compounds and the evaluation of the nutritional value of lettuce."

Metabolic Disorders

Turning winery wastewater into a resource: Valorizing a sustainable source of phenolic compounds (ACS-Fall 2026) - "Adsorption behavior was influenced by contact time, flow conditions, and system design. This approach presents a sustainable solution by repurposing almond shells for wastewater treatment while enabling the recovery of valuable phenolic compounds."

Transition metal-based bio-derived molecular complexes for photocatalytic CO2 reduction | Poster Board #1279 (ACS-Fall 2026) - "This catalytic platform, characterized by its environmental friendliness and cost-effectiveness, exhibits a CO2 conversion rate of 37 µmol h-1 g-1 which is about two orders of magnitude larger than pristine bio-derived organic chromophore. This indicates that straightforward, sustainable, and nature-inspired catalytic devices may effectively transform CO2 utilizing solar energy."

Engineered artificial metalloproteins: Insights into cambialistic dioxygenases | Poster Board #1621 (ACS-Fall 2026) - "Here, we present developments in a series of artificial metalloproteins (ArMs) designed to mimic structural aspects of the active sites found in QDs and to stabilize mechanistically relevant intermediates generated during turnover. Crystallographic, spectroscopic and thermodynamic results will be discussed and compared to what is known of the naturally occurring variants."

Comparative evaluation of cerium oxide nanoparticles synthesized via diverse methods (ACS-Fall 2026) - "This comparative study highlights the critical role of synthesis strategy in regulating CeO surface chemistry. In addition, it provides insights into tailoring nanoparticle adsorbents for pollutant removal."

Quercetin-Eudragit® non-covalent polymers complexes with enhanced loading, solubility, stability, and charge-based targeting of the inflamed colon mucosa | Poster Board #1731 (ACS-Fall 2026) - "Non-covalent quercetin-Eudragit® polymer complexes improved loading, solubility, stability, and site-specific delivery. The enhanced aqueous solubility and in vitro anti-cancer activity highlight their potential as therapeutics for colon cancer and inflammatory bowel diseases."

Addiction (Opioid and Alcohol) • Colon Cancer • Colorectal Cancer • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammatory Bowel Disease • Solid Tumor

Computational studies of quercetin derivatives using first principles electronic structure calculations | Poster Board #1351 (ACS-Fall 2026) - "The molecular structures were optimized using Density Functional Theory (DFT) at the B3LYP/6-31G (d,p) level using the Gaussian software to determine central electronic properties, including HOMO-LUMO energy gaps and molecular electrostatic potential (MEP) maps. These results offer a promising approach for more efficient nutrient delivery systems by providing a theoretical framework for the creation of oral quercetin-lipid conjugates intended to avoid first-pass metabolism via the lymphatic pathway."

Molecular Simulation guided adsorption mechanism of anthocyanin, capsanthin on macro reticular ion exchange resin (ACS-Fall 2026) - "This also affirmed that the competitive adsorption certainly took place. This study launched for the first time to give a valuable insight onto adsorption mechanism of anthocyanin on macroporous resins."

Quercetin in COPD: A Multi-Target Approach to Modulate Inflammation, Oxidative Stress, and Epithelial Dysfunction. (PubMed, Int J Mol Sci) - "This review compiles the current understanding of the biological properties of quercetin and its potential therapeutic role in COPD. We also summarize its potential benefits over the current therapeutic drugs used to treat COPD."

Journal • Review • Chronic Obstructive Pulmonary Disease • Immunology • Inflammation • Pneumonia • Pulmonary Disease • Respiratory Diseases • MMP9

Antiplatelet potential of extracts from Muehlenbeckia sagittifolia and Smilax campestris: phytochemical and functional study (ISTH 2026) - "The varying concentrations of these compounds across species might account for differences in their inhibitory behaviour. Table or Figure Upload (1) Page 2 DOI*10.1016/j.rpth.2026.105581"

Addiction (Opioid and Alcohol)

Lactoferrin-Quercetin-ORMOSIL Nanoparticles Confer Neuroprotection in Scopolamine-Induced Cognitive Deficits (EAN 2026) - "Conclusion LF-Q-ORMOSIL nanoparticles enhance quercetin's brain delivery, neuroprotective effects, and therapeutic efficacy against cognitive impairment, and shows promise as a nanotherapeutic for Scopolamine-induced amnesia."

Alzheimer's Disease • Cognitive Disorders

Multifunctional Smart Antibacterial Dressings for Infected Wounds in Metabolic Disorders (ENDO 2026) - "Conclusion These multifunctional smart dressings significantly improve healing of infected wounds under controlled experimental conditions and represent a promising translational strategy for managing infected wounds in metabolic and endocrine disorders. Keywords: Diabetic wound; Antibacterial hydrogel; Smart dressing; Metabolic complications; Regenerative biomaterials"

Diabetes • Endocrine Disorders • Inflammation • Metabolic Disorders

Quercetin Supplementation in Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Trials (ENDO 2026) - "Quercetin supplementation demonstrated changes in LH and SHBG; however, it does not exhibit reliable benefits in metabolic parameters in women with PCOS. Larger randomized trials with longer follow-up are required before routine clinical use can be recommended."

Late-breaking abstract • Retrospective data • Review • Metabolic Disorders • Polyendocrine Metabolic Ovarian Syndrome

Cellular Senescence Limits the Efficacy of Co-Stimulatory Blockade in Aged Recipients (ATC 2026) - "Here, we delineate how cellular senescence—a hallmark of aging—impacts alloimmune response and elucidate the link between senescence accumulation with age-dependent costimulatory blockade effect.* Aged C57Bl/6 mice (18-month) were pre-treated with senolytics—Dasatinib+Quercetin, "D/Q"—or vehicle (control) for 2 months, before undergoing fully-mismatched heterotopic heart transplantation from young (3-month) Balb/c donors... Senescent cell depletion with senolytics dramatically improves CTLA4-Ig efficacy in aged recipients, with graft survival nearing that of young mice. These findings identify senescence as a major driver of age-related resistance to costimulatory blockade. The upregulation of PD-1 checkpoint may play a critical mechanistic role, serving as a potential target for augmenting co-stimulatory blockade in aged recipients."

Clinical • IO biomarker • CD8

Targeting Cellular Senescence and TGF-β Signaling as a Novel Treatment for Chronic Rejection (ATC 2026) - "We hypothesize that chronic rejection reflects a process of accelerated aging mediated by senescence driven inflammation and TGF-β-mediated fibrosis, and introduce the combined treatment with senolytics and losartan as a novel therapy.* In a mouse chronic heart allograft rejection model based on CTLA4-Ig treatment, recipients received senolytics (Dasatinib + Quercetin) and/or the angiotensin receptor blocker losartan post-transplant... Cellular senescence drives CAV and fibrotic remodeling in cardiac allografts through TGF-β-driven inflammation and EndoMT. Dual targeting of senescence and TGF-β-mediated fibrosis demonstrated synergistic effects preserving graft integrity. These data introduce cellular senescence as a novel therapeutic axis mitigating chronic rejection."

IO biomarker • Cardiovascular • Fibrosis • Immunology • Inflammation • Transplant Rejection • CD8 • CDH5 • CDKN2A • ICAM1 • TGFB1