Cresp (darbepoetin alfa biosimilar) / Dr. Reddy’s - LARVOL DELTA

A Diffusion Tensor Imaging Study: Relation of Wisconsin Card Sorting Covariates to White Matter Abnormalities in Traumatic Brain Injury. (PubMed, Life (Basel)) - "Results show that WCST covariates (such as percentile perseverative responses (Ep), non-perseverative responses (Enp), and conceptual response (CResp)) significantly deviate beyond standard percentile scores and correlate with lower FA in white matter regions in the frontal cortex, demonstrating executive function deficits. These frontal regions include the inferior frontal, superior frontal, and corpus callosum (CC), correlated with greater errors in WCST percentile scores. This study investigates the correlation between WCST covariates and DTI parameters as valuable tools in the diagnosis and prognosis of persistent cognitive impairment for patients with a history of chronic traumatic brain injury."

Journal • Alzheimer's Disease • CNS Disorders • Cognitive Disorders • Vascular Neurology

Potential metabolic records in isotope signals of chondrichthyan hard tissues. (PubMed, J Fish Biol) - "Highly active thunniform species had significantly more negative δ13Cvert (and higher Cresp) values than species with less active swimming types, conforming to expectations...Many knowledge gaps related to the relationships between structural tissue isotope compositions and carbon respiratory physiology of elasmobranch remain. However, our results provide evidence that carbon isotopes of structural carbonate in cartilaginous tissues of chondrichthyan fishes offer potential as a proxy for metabolic level."

Journal

Cresp®: transforming the landscape of chemotherapy-induced anemia - a comprehensive retrospective real-world analysis in 523 Indian patients. (PubMed, Front Oncol) - "DA demonstrates impressive efficacy and safety in managing CIA, leading to substantial improvements in mean hemoglobin levels in palliative setting. This has the potential to reduce the need for blood transfusions and enhance the quality of life for patients."

Journal • Real-world evidence • Retrospective data • Anemia • Cardiovascular • Chemotherapy-Induced Anemia • Fatigue • Hematological Disorders • Hypertension • Oncology • Pulmonary Disease • Solid Tumor • Thrombosis

Developing isotopic proxies to reconstruct the metabolic rates and thermal histories of octopus. (PubMed, Mar Environ Res) - "The proportion of metabolically derived carbon, or respired carbon (Cresp), increased as the octopus grew (slope = 0.076, R2 = 0.72), suggesting an influence of somatic growth rate and body mass on δ13C values...Our experiment aids in interpreting stable isotopic values in statoliths and their application as temperature and metabolic proxies in wild-caught octopus. Such proxies will increase our monitoring capabilities of these ecologically and commercially significant cephalopods and contribute to their conservation and effective management."

Journal • Infectious Disease

Relationship Between Hospitalization, Surgery and Achievement of Clinical Remission or Clinical Response in Moderate to Severe Crohn’s Disease Patients: Results From the UNITI/IM-UNITI Trials (ACG 2022) - "The analysis included a total of 773 patients in CRem, 723 in CResp and 1,255 in active CD. BC results showed significantly fewer hospitalizations per 100 patient-years (PY) in CRem (6.50), and numerically fewer per 100 PY in CResp (14.37) compared to active CD (20.82). Similarly, patients in CRem had significantly fewer surgeries per 100 PY vs active CD (4.18 vs 15.57), and the difference was not statistically significant vs patients in CResp, who incurred 11.35 surgeries/100 PY."

Clinical • Crohn's disease • Gastroenterology • Immunology • Inflammatory Bowel Disease

Decision-making and improvements in health-related quality of life in patients with kidney stones: comparing surgery versus observation using a mixed methods analysis. (PubMed, Urolithiasis) - "Patients who underwent surgery for kidney stones reported improvements in quality of life after treatment via WISQOL and CReSP. A conceptual framework was developed for the patient experience of kidney stones which provides a common language for patients and clinicians."

HEOR • Journal • Nephrology • Renal Calculi • Urolithiasis

[VIRTUAL] Surgery versus observation for nephrolithiasis: experiences and health-related quality of life metrics from decision-making (AUA 2021) - "Patients who chose surgery for kidney stones reported improvements in quality of life after treatment via WISQOL and CReSP. An understanding of patient experiences provides insight into the shared decision-making process."

Clinical • HEOR • Nephrology • Renal Calculi • Urolithiasis • Urology

Differences in metabolic rate between two Atlantic cod (Gadus morhua) populations estimated with carbon isotopic composition in otoliths. (PubMed, PLoS One) - "Cresp was on average 0.275 and 0.295 in Icelandic and NEA stock, respectively. Our results provide an insight into the physiological basis for differences in growth characteristics between these two cod stocks, and how that may vary over time."

Clinical • Journal

Are digital interventions effective in reducing suicidal ideation and self-harm? A systematic review. (PubMed, J Ment Health) - "The possible mediating effects of depression are also discussed. The databases Pubmed, Medline, PsycInfo, Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, IEEEXplore, ACM and CRESP were searched...Although findings were more consistent for the effectiveness of online Cognitive Behavioural Therapy (CBT), Mindfulness-Based CBT and Dialectical Behavioural Therapy, there was insufficient research to consider any as evidence-based treatments for suicidal ideation and self-harm. Digital interventions for suicidal ideation and self-harm can be a safe and acceptable option for individuals unwilling or unable to access face-to-face interventions. However, further research is needed to understand the types of interventions that could support people and the risk-benefit ratio of digital interventions for these individuals."

Journal • Review • CNS Disorders • Depression • Suicidal Ideation

Internet-Based Cognitive Behavioral Therapy to Reduce Suicidal Ideation: A Systematic Review and Meta-analysis. (PubMed, JAMA Netw Open) - "A systematic search of PsycINFO, MEDLINE, Cochrane Central Register of Controlled Trials (CENTRAL), and the Centre for Research Excellence of Suicide Prevention (CRESP) databases for trials from inception to April 6, 2019, was performed, supplemented by reference searches...Considering their high scalability, iCBT interventions have the potential to reduce suicide mortality. Future research should assess the effect of these digital health interventions on suicidal behavior and identify moderators and mediators to advance understanding of the mechanisms of effectiveness of these interventions."

Journal • Retrospective data • Review • Suicidal Ideation

Current status and role of Patient reported outcome measures (PROMs) in Endourology. (PubMed, Urology) - "Key PROMs in Urology now include USSQ, WISQOL, CUSP, CReSP and USIQOL. This article serves to provide an overview of these tools and help delineate their role in current practice."

Clinical • Journal • Review • Renal Calculi • Urolithiasis • Urology

[VIRTUAL] Urgency consultations for respiratory diseases in children 5-14 years old and their association with environmental factors in the town of Calama, Chile (ERS 2020) - "= 1 n = 186. The study shows that the Tmin, Hmin, NOx, CO, and SO2 significantly correlate with the cRESP in the 5-14 year group."

Clinical • Respiratory Diseases

Qualitative exploration of the renal stone patients' experience and development of the renal stone-specific Patient-Reported Outcome Measure "Development of the Renal Stone PROM". (PubMed, BJU Int) - "Although pain was the most frequent symptom, other health-related and social well-being issues significantly impacted patients' lives. Our validated patient-derived CReSP is a new instrument, specifically tailored to measure renal stone disease health outcomes from the patient's point of view."

Clinical • Journal • Gastrointestinal Disorder • Mood Disorders • Nephrology • Pain • Renal Calculi

LONG-TERM SAFETY AND EFFICACY OF RISANKIZUMAB TREATMENT IN PATIENTS WITH CROHN’S DISEASE: FINAL RESULTS FROM THE PHASE 2 OPEN-LABEL EXTENSION STUDY (DDW 2020) - P2 | " Pts achieving clinical response (CResp) (decrease from baseline [BL] in CD Activity Index [CDAI] ≥100) without remission (CRem) (CDAI <150) after Period 2 (Wk 26) or CResp/CRem after Period 3 (Wk 52) of the preceding study1 received open-label 180 mg subcutaneous (SC) RZB every 8 wks (Q8W) for up to 206 wks. In this final analysis of pts with CD receiving long-term open-label RZB treatment, the safety profile of RZB remained consistent with previous data2 with no new safety signals. Clinical and endoscopic remissions were sustained."

Clinical • P2 data • Crohn's disease • Fatigue • Gastroenterology • Immunology • Infectious Disease • Inflammation • Inflammatory Bowel Disease • Tuberculosis

Role of Cresp in the management of chemotherapy-induced anemia in cancer patients: A real-world clinical practice audit. (PubMed, South Asian J Cancer) - "There were no new toxicities, and only two patients required discontinuation of darbepoetin due to toxicity. Darbepoetin is safe and effective in the prevention and management of anemia among patients receiving myelosuppressive chemotherapy."

Clinical • Journal • Real-World Evidence

Knockdown of CERB expression inhibits proliferation and migration of glioma cells line U251. (PubMed, Bratisl Lek Listy) - "In conclusion, our data suggest that over expression of CREB may contribute to progression of glioma and knockdown of CREB expression may serve as a novel target for therapy (Tab. 1, Fig. 6, Ref. 25)."

IO Biomarker • Journal

Development and validation of the Cambridge Renal stone Patient (CRESP) reported outcome measure (AUA 2019) - "Our validated patient-derived CRESP is a new instrument, specifically tailored to measure renal stone disease health outcomes from the patient's point of view."

Clinical