GIFT 15
/ Jewish General Hospital
- LARVOL DELTA
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January 01, 2026
Regulatory B cell CCL3 competency promotes disease resolution and oligodendrogenesis in experimental autoimmune encephalomyelitis.
(PubMed, Commun Biol)
- "Collectively, these findings identify CCL3 as a non-redundant effector of Breg-mediated protection, acting primarily through peripheral T-cell and myeloid remodeling, with secondary CNS impacts. These results highlight the translational potential of CCL3-competent, spleen-derived GIFT15 Bregs for therapeutic modulation of autoimmune demyelination."
Journal • CNS Disorders • Immunology • Multiple Sclerosis • Solid Tumor • CCL3 • CSF2 • FOXP3 • GZMB • IL10 • IL15 • MRC1
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