GIFT 15 / Jewish General Hospital - LARVOL DELTA

Regulatory B cell CCL3 competency promotes disease resolution and oligodendrogenesis in experimental autoimmune encephalomyelitis. (PubMed, Commun Biol) - "Collectively, these findings identify CCL3 as a non-redundant effector of Breg-mediated protection, acting primarily through peripheral T-cell and myeloid remodeling, with secondary CNS impacts. These results highlight the translational potential of CCL3-competent, spleen-derived GIFT15 Bregs for therapeutic modulation of autoimmune demyelination."

Journal • CNS Disorders • Immunology • Multiple Sclerosis • Solid Tumor • CCL3 • CSF2 • FOXP3 • GZMB • IL10 • IL15 • MRC1