RQ-00000010 / RaQualia - LARVOL DELTA

A method to synthesize analytical rhodoquinone standards for quantitative analysis in tissue specimen. (PubMed, J Lipid Res) - "LC-MS/MS analysis of murine kidney tissue with RQ-9 analytical standard spike-in corroborate the identity of the endogenous murine RQ-9 and enable absolute quantification of its levels. Thus, we synthesized and purified RQ-9 and RQ-10 analytical standards that will enable absolute quantification in mammalian tissues and in vitro reconstitution studies on RQ-9 and RQ-10 in the mammalian ETC."

Journal

A method to synthesize analytical rhodoquinone standards for quantitative analysis in tissue specimen. (PubMed, bioRxiv) - "LC-MS/MS analysis of murine kidney tissue with RQ-9 analytical standard spike-in corroborate the identity of the endogenous murine RQ-9 and enable absolute quantification of its levels. Thus, we synthesized and purified RQ-9 and RQ-10 analytical standards that will enable absolute quantification in mammalian tissues and in vitro reconstitution studies on RQ-9 and RQ-10 in the mammalian ETC."

Journal

Protocol to extract and measure ubiquinone and rhodoquinone in murine tissues. (PubMed, STAR Protoc) - "We then detail procedures for analyzing UQ and RQ by integrating peak areas for UQ-9 and RQ-9 (abundant in mice) or UQ-10 and RQ-10 (abundant in human). Thus, through enrichment of mitochondria, we establish a method to measure UQ and RQ in tissues. For complete details on the use and execution of this protocol, please refer to Valeros et al.1."

Journal • Preclinical

Fumarate respiration of Fasciola flukes as a potential drug target. (PubMed, Front Cell Infect Microbiol) - "Furthermore, rhodoquinone-10 (RQ10 Em'= -63 mV), a low-potential electron mediator used in fumarate respiration was found to be predominant in adults...These findings demonstrate that NEJs have active hybrid respiration, in which they can properly use both oxygen and fumarate respiration, depending on oxygen availability. Thus, fumarate respiration is a promising drug target for Fasciola flukes, because it plays an essential role in both adults and NEJs."

Journal

RQ-10: RQ-00000010 for Gastroparesis and Constipation in Parkinson's Disease (clinicaltrials.gov) - P1; N=75; Recruiting; Sponsor: Leslie J. Cloud

New P1 trial • Biosimilar • Gene Therapies • Parkinson's Disease

RQ-10: RQ-00000010 for Gastroparesis and Constipation in Parkinson's Disease (clinicaltrials.gov) - P1; N=51; Completed; Sponsor: Virginia Commonwealth University; Recruiting ➔ Completed; N=75 ➔ 51

Enrollment change • Trial completion