LidoColl (lidocaine HCl) / Innocoll - LARVOL DELTA

Comparing Bupivacaine, Lidocaine, and a Combination of Bupivacaine and Lidocaine for Labor Epidural Activation (clinicaltrials.gov) - P3; N=75; Completed; Sponsor: University of Alabama at Birmingham; N=4575 ➔ 75

Clinical • Enrollment change • Pain

Management of Postdural Puncture Headache in a Patient on Anticoagulation (ASRA-PM 2017) - "...Two long cotton-tipped applicators with 5% lidocaine jelly were applied to each nostril and advanced posteriorly until resistance was met...The last Lovenox dose had been given 24 hours prior so an EBP was performed at L4-L5 with 20mL of autologous blood...While this patient reported only mild and temporary relief from the block, it was an appropriate and temporizing option for her at the time due to recent anticoagulation. Hence, topical sphenopalatine ganglion block may a less invasive option for cases in which EBP is contraindicated to relieve PDPH."

Clinical • Biosimilar • Demo Pain • Immunology • Pain

Lid splinting eyelid retraction technique: a minimised sterile approach for intravitreal injections. (PubMed, Br J Ophthalmol) - "The technique of eyelid retraction for intravitreal injection has a low rate of endophthalmitis, similar to the reported rates using a metal lid speculum. This is beneficial for both the physician and the patient as it minimises patient discomfort as well as the duration of the procedure. To our knowledge, this is one of the largest studies performed to date evaluating intravitreal injection-related endophthalmitis."

Journal • Biosimilar • Immunology • Ocular Infections • Ocular Inflammation • Ophthalmology

The Pharmacokinetics of Atomized Lidocaine Administered via the Trachea: A Randomized Trial. (PubMed) - Anesth Analg - "Our results suggest that when using atomized delivery of lidocaine, less drug is required to achieve a near equivalent plasma lidocaine concentration. Atomized drug administration may be a more efficient method for endotracheal drug administration."

Journal • Biosimilar

Profile of the capsaicin 8% patch for the management of neuropathic pain associated with postherpetic neuralgia: safety, efficacy, and patient acceptability. (PubMed) - Patient Prefer Adherence - "The nature of administration and relatively high cost of capsaicin patches can significantly limit their use to a small number of patients with severe refractory symptoms. This review highlights recent evidence related to the use and effectiveness of the 8% capsaicin patch for Postherpetic Neuralgia and discusses its safety and side-effect profiles."

Journal • Review • Biosimilar • Cardiovascular • Demo Pain • Pain

Intracameral mydriatics and analgesics in cataract surgery (SOE 2017) - "Purpose: The objective of the study was to evaluate if intracameral injection of Mydrane (tropicamide 0,02%, phenylephrine 0,31% and lidocaine 1%) is as safe and effective as conventional topical mydriatics and analgesics for cataract surgery?... This study demonstrates that Mydrane can be safe and effective alternative to a standard topical mydriatics and analgesics and helps to maintain adequate mydriasis during cataract surgery without intra-operative pupil constriction even in patients with glaucoma and pseudoexfoliation syndrome."

Clinical • Biosimilar • Diabetes • Glaucoma • Ophthalmology • Pain

A case of erythromelalgia with a previously unclassified missense mutation of the SCN9A gene (BAD 2017) - "Neuromolecular Med 2013; 15: 265–78). We present this case as a novel missense mutation and for discussion of treatment options."

Biomarker • Clinical • HEOR • Biosimilar • Ophthalmology • Pain

Efficacy of Benzocaine 20% Topical Anesthetic Compared to Placebo Prior to Administration of Local Anesthesia in the Oral Cavity: A Randomized Controlled Trial. (PubMed) - "Regarding gender, male patients had higher values on the VAS compared with female patients, but these differences were not meaningful. The topical anesthetic and the placebo had similar effects on pain perception for injection of local anesthesia for the PSA and GPN."

Journal • Biosimilar • Pain

Tolerability of 2.5% Lidocaine/Prilocaine Hydrogel in Children Undergoing Cryotherapy for Molluscum Contagiosum. (PubMed) - Pediatr Dermatol - "These adverse reactions were considered unlikely to be related to the test product, because a patch test was negative in one of the individuals and the other event occurred in only one of the two treated areas. Nanorap is an efficacious and well-tolerated option for topical anesthesia in children undergoing cryotherapy for MC."

Journal • Biosimilar • Dermatitis • Eczema • Immunology

Economic Evaluation of Lidocaine/Tetracaine Patch Versus Lidocaine/Prilocaine Cream for Topical Anaesthesia Before Vascular Access In Egypt. (PubMed) - Value Health - No abstract available.

Journal • Biosimilar

Topical ketamine-amitriptyline-lidocaine for chronic pruritus: A retrospective study assessing efficacy and tolerability. (PubMed) - No abstract available.

Journal • Biosimilar

SPONTANEUS PRENGNANCY AFTER VAGINISMUS TREATMENT (EBCOG 2017) - "...Pharmacological approach such as the use of local anaesthetics (lidocaine), muscle relaxants (nitroglycerin ointment and botulinum toxin) and anxiolytic medication has been touted for its efficacies...Dilatation alone appeared to result in favourable outcomes. Traditionally, progressive vaginal dilatation for desensitisation, sexual education, psycho-sexual therapy to reduce fear, negative conditioning and phobia, hypnotherapy, and biofeedback generally produced good outcome."

Clinical • Biosimilar • Endometriosis • Immunology • Pain • Vaginal Cancer

Event-level impact of Promescent on quality of sexual experience in men with subjective premature ejaculation. (PubMed) - Int J Impot Res - "The product was reported as easy to use and did not interrupt the sexual experience. Findings suggest that the use of this topical spray significantly improves QSE and perception of partner experience, and that these improve with longer duration of use.International Journal of Impotence Research advance online publication, 25 August 2016; doi:10.1038/ijir.2016.31."

Journal • Biosimilar

Preparation and characterization of textile-based carrier systems for anal fissure treatment. (PubMed, J Microencapsul) - "In vitro drug release from tampons were also examined. According to the results, textile-based carrier systems loaded microparticles containing nifedipine and lidocaine HCl will be an effective and promising alternative for current anal fissure treatment."

Journal • Biosimilar • CNS Disorders • Pain

An Investigation into Dental Local Anaesthesia Teaching in United Kingdom Dental Schools. - SAAD Dig - "2% Lidocaine with 1:80,000 Adrenaline remains the gold standard dental local anaesthetic with teaching about its safety and uses in all but a few situations. Most are taught the use of additional aids such as safety syringes and topical anaesthesia. There is variation with regards to the use of alternative anaesthetic agents."

Journal • Biosimilar

The effect of a lidocaine/prilocaine topical anesthetic on pain and discomfort associated with orthodontic elastomeric separator placement. (PubMed) - Prog Orthod - "The discomfort and pain resulting from the initial placement of orthodontic elastomeric separators can be significantly reduced with the lidocaine/prilocaine topical anesthetic."

Journal • Biosimilar • Pain

An Evidence-Based Approach to Minimizing Acute Procedural Pain in the Emergency Department and Beyond. (PubMed) - Pediatr Emerg Care - "In summary, there currently remains a knowledge-to-practice gap in the treatment of children's procedure-related pain. This article has identified multiple age-specific methods to improve the treatment of procedural pain. These simple interventions can improve the care provided to ill and injured children."

Journal • Biosimilar • Pain

A Sprayable Analgesic for Neuropathic Pain (AAPS 2016) - " Encouraged by preclinical study results, Andros has filed INDs with FDA and TFDA, respectively, and currently has an on-going Phase I PK and safety study in Taiwan. Phase II/III studies are currently in development."

Biosimilar • Demo Pain • Depression • Pain

Effective needle-free buccal anesthesia by mucoadhesive films containing prilocaine and lidocaine hydrochlorides: "The end of jabs"? (PubMed, J Control Release) - "The total amount of drug retained in the epithelium showed to modulate the extent of both shallow and deep anesthesia. Thus, the combination of LCL and PCL in mucoadhesive films may offer dentists and their patients a safe improvement for pain management during dental procedures."

Journal • Biosimilar • CNS Disorders • Pain

Ipsilateral and contralateral sensory changes in healthy subjects after experimentally induced concomitant sensitization and hypoesthesia. (PubMed) - BMC Neurol - P=N/A; "The present experimental model using combined application of capsaicin and LA imitates partly the complex sensory changes observed in patients with unilateral neuropathic pain and might be used as an additional surrogate model. Only the concomitant use both agents in the same area induces both positive and negative sensory signs ipsilaterally as well as parallel contralateral sensory changes (to a lesser extent)."

Journal • Biosimilar • Demo Pain • Pain

Metamizole: an effective solution for vasospasm. (PubMed) - J Plast Surg Hand Surg - "These findings show that topically applied metamizole is as effective as papaverine at alleviating vasospasm during the 30 minutes time interval. This administration may be considered as a good alternative to correct vasospasm during microsurgery."

Journal • Biosimilar

Effects of Experimental Pain and Lidocaine on Mechanical Somatosensory Profile and Face Perception. (PubMed) - "Short-lasting experimental muscle pain was capable of causing loss of tactile sensitivity as well as perceptual distortion of the face, regardless of preconditioning with a topical lidocaine patch. Short-term application of a lidocaine patch did not significantly affect the mechanical somatosensory profile."

Journal • Biosimilar • CNS Disorders • Pain

Lidocaine enhances the effects of chemotherapeutic drugs against bladder cancer. (PubMed, Sci Rep) - "However, the combination of 0.66 mg/mL MMC and 5 mg/mL lidocaine prolonged survival (from 34.62 ± 6.49 to 49.30 ± 6.72 days; n = 8, P < 0.05) and reduced bladder wet weight (from 68.94 ± 53.61 to 20.26 ± 6.07; n = 8, P < 0.05). Intravesical instillation of lidocaine combined with other chemotherapeutic agents potentially could be an effective therapy for bladder cancer."

Journal • Biosimilar • Bladder Cancer • Genito-urinary Cancer • Graft versus Host Disease • Immunology • Oncology • Solid Tumor • Urothelial Cancer

Anesthetic ointment only (lidocaine/prilocaine) instead of injectable local lidocaine in trans-radial catheterization: A viable no-needle alternative. (PubMed, J Interv Cardiol) - "The time to obtain radial access was also not affected by the use of anesthetic ointment (AO: 62.24 ± 25.7 s vs LA: 64.04 ± 18.78 sec, P = NS). The rate of clinical or angiographic radial artery spasm was similar (8-10%) between the groups (P = NS) Use of a local anesthetic ointment, versus injectable lidocaine, in trans-radial cardiac catheterization as means of local anesthesia, was found to be equally effective in terms of pain, artery spasm, or artery cannulation speed."

Journal • Biosimilar • CNS Disorders • Pain

PO293 - Intracameral vs. Topical Mydriasis for Routine Cataract Surgery: Comparison of Surgical, Functional, and Patient-Reported Outcomes (AAO 2017) - "...Methods Sixty eyes (Group 1) underwent cataract surgery with intraoperative mydriasis using intracameral tropicamide / phenylephrine / lidocaine...Conclusion Compared with topical mydriatics for cataract surgery, intracameral intraoperative mydriatics are associated with greater satisfaction and comparable VA. The higher rate of adverse intraoperative events warrants further study."

Clinical • Ophthalmology