cetirizine oral / Generic mfg. - LARVOL DELTA

Multimodal Evaluation of Surface Topography and Color Stability in Pediatric Restorative Materials Exposed to Antihistamine Syrups. (PubMed, J Funct Biomater) - "Standardized repeated exposure to ketotifen and cetirizine syrups was associated with material-dependent changes in surface topography and color stability, with GH showing the greatest change and NHC/PMC comparatively greater stability; clinical extrapolation requires further study."

Journal • Pediatrics

Anti-Allergic Potentials of Actinodaphne angustifolia: Integrated In Vivo Evaluation and In Silico Analysis of Bioactive Compounds. (PubMed, Chem Biodivers) - "A marked reduction in serum IgE levels further indicated suppression of hypersensitivity responses, with effects comparable to cetirizine...Molecular docking demonstrated strong binding affinities of these compounds toward key allergic targets, namely histamine H1 receptor, interleukin-4, and phospholipase A2, supporting their mechanistic roles in anti-allergic activity. The findings validate the ethnomedicinal relevance of A. angustifolia and highlight its potential as a source of plant-derived anti-allergic agents."

Journal • Preclinical • Allergy • Immunology • IL4

Outpatient Desensitisation for Imid-Induced Delayed Hypersensitivity: Pharmacist- and Nurse-Led Retrospective Case Series (IMS 2026) - "The protocol included graded dose escalation, premedication with prednisolone and cetirizine, patient education and close monitoring via a pharmacist- and nurse practitioner-led outpatient service with haematologist oversight...Reactions ranged from grade 1 rash to extensive eruptions involving >80% body surface area, including one case of DRESS syndrome attributed to co-trimoxazole in the setting of concurrent lenalidomide therapy... A pharmacist- and nurse practitioner-led outpatient desensitisation pathway was feasible and enabled most patients with iMiD-associated delayed hypersensitivity reactions to safely continue treatment without recurrent hypersensitivity reactions. Preliminary findings suggest this approach preserved access to iMiD therapy in most patients, with breakthrough reactions remaining manageable and treatment discontinuation occurring primarily due to intercurrent clinical factors rather than refractory hypersensitivity. By preventing premature..."

Retrospective data • Hematological Malignancies • Immunology • Infectious Disease • Multiple Myeloma

Effect of Switching the Histamine-1 Receptor Antagonist Clemastine to Cetirizine in Paclitaxel Premedication Regimens: The H1-Switch Study. (PubMed, JCO Oncol Pract) - "Premedication containing oral cetirizine is as safe as premedication containing intravenous clemastine in preventing paclitaxel-induced HSR grade ≥3. These findings could contribute to optimization of care for patients and improve efficiency and sustainability."

Journal • Immunology

Improved transcutaneous delivery of cetirizine hydrochloride for the treatment of post-chemotherapy alopecia: Poke and emulgel approach. (PubMed, Pak J Pharm Sci) - "The prepared cetirizine HCl-loaded emulgel and microneedle combination may be a promising approach to treating chemotherapy-induced alopecia."

Journal • Alopecia • Cardiovascular • Contact Dermatitis • Dermatitis • Dermatology • Immunology • Oncology

Can a single dose of cetirizine and meclizine be quantified in hair up to one year after intake? (PubMed, Forensic Sci Int) - "The findings demonstrate that a single dose of cetirizine or meclizine may be detectable and quantifiable in hair for several months. Moreover, temporal patterns following a single dose may resemble those observed after repeated intake, highlighting the need for drug-specific single-dose studies."

Journal

HPLC-characterized phenolics from Acer oblongifolium attenuate inflammation, pain, and CNS-related disturbances: docking, edema, nociception, and behavioural studies. (PubMed, Inflammopharmacology) - "Acer oblongifolium and its phenolic constituents, principally Gentisic acid and vanillic acid, showed analgesic, anti-inflammatory, and anxiolytic-like activity in this preclinical model, potentially mediated via modulation of pro-inflammatory cytokines."

Journal • Inflammation • Pain • IL1B • IL6 • TNFA

Association of Common Anti-Inflammatory Medications with Reduced Risk of Vision-Threatening Diabetic Retinopathy in Type 2 Diabetes. (PubMed, Ophthalmology) - "Cetirizine, ibuprofen, and prednisone were associated with reduced incidence of DME and PDR in adults with T2DM, with effect sizes comparable to those of the fenofibrate positive control. These findings support prospective evaluation of anti-inflammatory medications for the prevention of vision-threatening diabetic retinopathy."

Journal • Diabetes • Diabetic Macular Edema • Diabetic Retinopathy • Metabolic Disorders • Ophthalmology • Retinal Disorders • Type 2 Diabetes Mellitus

Antihistamines in the Treatment of Irritable Bowel Syndrome With Diarrhea (clinicaltrials.gov) - P3 | N=0 | Withdrawn | Sponsor: University of Cincinnati | Phase classification: P ➔ P3 | N=100 ➔ 0 | Trial completion date: Aug 2021 ➔ Aug 2026 | Not yet recruiting ➔ Withdrawn | Trial primary completion date: Aug 2021 ➔ Aug 2026

Enrollment change • Phase classification • Trial completion date • Trial primary completion date • Trial withdrawal • Gastrointestinal Disorder

Mast Cell Derived Histamine Negatively Regulates Hematopoiesis. (PubMed, Exp Hematol) - "Teaser Abstract: Mast cell-derived histamine restrains hematopoietic stem cell activity by shaping the bone marrow niche. Blocking histamine signaling with the FDA-approved antihistamine cetirizine expands the stem and progenitor pool and accelerates hematopoietic recovery after transplant, pointing to a repurposable strategy for boosting blood regeneration in patients."

Journal • Hematological Disorders • Transplantation

Levocetirizine-induced paradoxical fixed drug eruption: A case report with causality assessment. (PubMed, Indian J Pharmacol) - "FDE due to levocetirizine, as well as with cetirizine, is less common in the literature. This case shows that antihistamines such as levocetirizine can trigger FDE in susceptible individuals. Improving clinical awareness through robust Pharmacovigilance activities, educating patients about triggers, and discouraging self-medication are crucial for preventing recurrence."

Journal • Immunology • CD8

Second-generation H1 antihistamines for the treatment of chronic urticaria: a network meta-analysis. (PubMed, Front Med (Lausanne)) - "To evaluate the efficacy and safety of 10 commonly used second-generation H1 antihistamines (cetirizine, levocetirizine, loratadine, desloratadine, ebastine, bilastine, olopatadine, rupatadine, fexofenadine, and mizolastine) at licensed doses in treating chronic urticaria using network meta-analysis. In addition, fexofenadine had the lowest incidence of adverse reactions. However, the conclusions of this study still need to be validated by further high-quality randomized controlled trials."

Journal • Retrospective data • Review • Chronic Spontaneous Urticaria • Dermatology • Immunology • Urticaria

Paracetamol-induced hepatic injury following intentional self-poisoning: a case report and therapeutic considerations. (PubMed, Naunyn Schmiedebergs Arch Pharmacol) - "N-acetylcysteine (NAC) remains the established antidote for preventing the progression of hepatic injury when administered promptly. We describe the case of an 18-year-old female who intentionally ingested eight tablets of paracetamol (650 mg each; total dose 5.2 g) and four tablets of cetirizine (10 mg each) following psychosocial distress...Psychiatric assessment identified underlying psychosocial factors contributing to the intentional overdose, and appropriate pharmacological treatment and follow-up were initiated before discharge. This case demonstrates that favorable outcomes can be achieved through early risk assessment, guideline-directed NAC therapy, serial biochemical monitoring, and multidisciplinary management addressing both the toxicological and psychosocial aspects of intentional paracetamol overdose."

Journal • CNS Disorders • Hepatology • Liver Failure • Pain • Psychiatry

Paraneoplastic dermatomyositis-like syndrome preceding diagnosis of small cell lung cancer: a case report. (PubMed, Front Oncol) - "However, treatment with ketotifen, cetirizine, and the immunosuppressant cyclosporine led only to partial regression of the rash, with persistent pruritus. Chemotherapy for SCLC resulted in resolution of the skin lesions and disease control. This case underscores the critical role of PNS as an early indicator of occult malignancy and highlights the therapeutic challenges in managing paraneoplastic dermatomyositis-like syndrome."

Journal • Dermatology • Dermatomyositis • Dermatopathology • Gastrointestinal Disorder • Immunology • Lung Cancer • Myositis • Oncology • Pruritus • Rosacea • Small Cell Lung Cancer • Solid Tumor

Rabies post-exposure prophylaxis after previous immediate hypersensitivity: A case report. (PubMed, Am J Emerg Med) - "After the first two doses were tolerated during 16- and 8-h observation periods, the third and fourth doses were administered after oral cetirizine with 4-h monitoring in a standard monitored area. After individualized assessment, prophylaxis may be completed despite previous immediate hypersensitivity when full resuscitation preparedness and progressive de-escalation of monitoring are used. Premedication does not prevent anaphylaxis and must not replace prompt epinephrine treatment."

Journal • Allergy • Dermatology • Immunology • Urticaria

Microneedling-Assisted Delivery of Cetirizine Versus Latanoprost in Alopecia Areata (clinicaltrials.gov) - P=N/A | N=80 | Completed | Sponsor: Tanta University

New trial • Alopecia • Dermatology • Immunology

Ultra-Sensitive and Validated method for Trace Quantification of Carcinogenic Benzene in Cetirizine Dihydrochloride. (PubMed, Biomed Chromatogr) - "Linearity and accuracy studies yielded an outstanding percentage of samples spiked BEN in the drug substance and drug product of CTZ and LCTZ and found within acceptance limit, approving the method's validity in presence of the drug atmosphere. Conventional headspace GC-FID/GC-MS are established techniques for benzene analysis; the proposed HPLC method offers a simpler, cost-effective, and validated method, making it well suited for routine quality control laboratories where GC facilities may not be readily available."

Journal

Antihistamines for atopic dermatitis (eczema): systematic review and network meta-analysis of randomised trials. (PubMed, BMJ) - "Among patients with atopic dermatitis, adding H1 antihistamines probably results in a clinically unimportant reduction in atopic dermatitis severity and itch severity, and may not reduce sleep disturbance or atopic dermatitis exacerbations. First generation agents increase cognitive impairment and may increase treatment discontinuation because of adverse events. Cognitive impairment risk differs among second generation agents. These findings provide evidence against routine antihistamine use in atopic dermatitis management and will inform updated clinical guidelines."

Clinical • Journal • Retrospective data • Review • Alzheimer's Disease • Atopic Dermatitis • CNS Disorders • Cognitive Disorders • Dermatitis • Dermatology • Immunology • Sleep Disorder

The impact of antihistamine use on allergic reactions in pregnancy. (PubMed, Drug Metab Pers Ther) - "Physiological changes during pregnancy modify the pharmacokinetic parameters of drugs, reducing plasma protein concentrations by 20-40 %, However, cetirizine and loratadine demonstrate a favourable safety profile based on data from more than 186,000 exposures in Scandinavian registries, and the relative infant dose remains below the 5 % safety threshold. The findings support the use of second-generation antihistamines as first-line therapy for allergic diseases in pregnancy and provide an evidence base for selecting safe pharmacological agents at different gestational stages."

Journal • Allergy

Forecasting seasonal allergic rhinitis through integrated analysis of social media and online drug sales data. (PubMed, World Allergy Organ J) - "We analyzed daily data for urban Beijing from March 1, 2022 to October 15, 2024, including pollen concentration (grains per 1000 mm3), the Baidu search index for "allergic rhinitis," and online purchase rates of 4 oral second-generation H1-antihistamines (loratadine, desloratadine, cetirizine, levocetirizine) from the Meituan platform, standardized per 100,000 population. The ARIMAX (1,1,1) model integrating both pollen and Baidu Index achieved the best forecasting performance (1-day RMSE = 3.80, MAPE = 7.68%, PCC = 0.89) and consistently outperformed single-predictor models and the random-walk benchmark across all horizons. Pollen exposure influences antihistamine demand both directly and indirectly through public information-seeking behavior captured by the Baidu Index, and integrating environmental and digital data enables timely surveillance of seasonal allergic-rhinitis-related medication use."

Journal • Allergic Rhinitis • Immunology • Inflammation

Anticholinergic Burden, Falls, and the Concept of Appropriate Polypharmacy in Indonesian Geriatric Clinics: A Multicentre Observational Study. (PubMed, Acta Med Indones) - "The prevalence of a high ACB score and falls were 1.8% and 16.8%, respectively. Approximately one in two older adults had polypharmacy. We observed a non-significant inverse relationship between polypharmacy and falls. This may possibly suggest appropriate polypharmacy and closer monitoring applied in geriatric settings, which requires further investigation."

Journal • Observational data • Cardiovascular • CNS Disorders • Depression • Psychiatry

Successful oral desensitization to temozolomide in a patient with immediate hypersensitivity reaction. (PubMed, Cancer Chemother Pharmacol) - "The protocol included stepwise dose escalation using diluted oral solutions followed by capsule administration, with premedication using cetirizine and methylprednisolone. The successful repetition of desensitization further supports the safety of this approach. This protocol may assist clinicians in maintaining first-line TMZ therapy in patients with HSRs, thereby preventing unnecessary treatment interruptions and improving clinical outcomes."

Journal • Brain Cancer • Dermatology • Glioblastoma • Glioma • High Grade Glioma • Immunology • Oncology • Solid Tumor • Urticaria

Not so innocent after all: H1-antihistamine-induced Fixed Drug Eruption confirmed by lesional Patch Testing (BAD 2026) - "H1-antihistamines can be grouped by chemical structure into alkylamines (chlorphenamine), piperazines (hydroxyzine and cetirizine) and piperidines (loratadine and fexofenadine)...Symptoms persisted despite oral prednisolone but improved rapidly after stopping antihistamines...Repeat patch testing with fexofenadine and diphenhydramine is planned to assess cross-sensitivity. This case describes a rare antihistamine-associated fixed drug eruption with postulated class-related crossreactivity in a presumed safe drug class and highlights in situ patch testing as a safe diagnostic tool."

Immunology • Inflammation • Urticaria

Temozolomide induced urticarial reaction: Case series and approach to management of a unique drug side effect (ISPNO 2026) - "She required treatment with intravenous corticosteroids and epinephrine, resulting in complete resolution of her symptoms...Three days after completing cycle 5 of maintenance TMZ, she developed an urticarial eruption that resolved with cetirizine, hydroxyzine and diphenhydramine... All cases demonstrated onset of urticaria occurring approximately three days after TMZ exposure, with two of them having delayed presentation after tolerating drug for multiple cycles. While antihistamine premedication mitigated symptoms, hypersensitivity reactions recurred in patients who continued therapy, highlighting the importance of recognition and management of delayed TMZ hypersensitivity."

Adverse events • Clinical • Brain Cancer • Cardiovascular • CNS Tumor • Dermatology • Ependymoma • Glioma • High Grade Glioma • Immunology • Solid Tumor • Urticaria

Not so innocent after all: H1-antihistamine-induced Fixed Drug Eruption confirmed by lesional Patch Testing (BAD 2026) - "H1-antihistamines can be grouped by chemical structure into alkylamines (chlorphenamine), piperazines (hydroxyzine and cetirizine) and piperidines (loratadine and fexofenadine)...Symptoms persisted despite oral prednisolone but improved rapidly after stopping antihistamines...Repeat patch testing with fexofenadine and diphenhydramine is planned to assess cross-sensitivity. This case describes a rare antihistamine-associated fixed drug eruption with postulated class-related crossreactivity in a presumed safe drug class and highlights in situ patch testing as a safe diagnostic tool."

Immunology • Inflammation • Urticaria