cetirizine oral / Generic mfg. - LARVOL DELTA

A rare case of KIT-negative indolent systemic mastocytosis without anaphylaxis (ASH 2025) - "That same month, he began cetirizine 10mg daily for diffuse pruritus, later increased to cetirizine 10mg twice a day and 10mg famotidine daily for abdominal pain. Conclusion Clinicians should maintain a high index of suspicion for indolent systemic mastocytosis even when only a single hallmark symptom is present. Recognizing atypical presentations such as this one is essential to avoid delays in diagnosis and ensure timely care that can prevent worsening symptoms and complications."

Clinical • CNS Disorders • Dermatology • Gastrointestinal Disorder • Hematological Disorders • Hepatology • Immunology • Infectious Disease • Orthopedics • Pruritus • Respiratory Diseases • CD2 • IL2RA

Tumor flare pain reaction during teclistamab step-up dosing with tocilizumab prophylaxis: An underrecognized toxicity in the outpatient setting (ASH 2025) - "Otherpremedications consisted of dexamethasone (16 mg), acetaminophen (975 mg) and cetirizine (10 mg) forthe first three doses. Our results support that outpatient administration with tocilizumab prophylaxis is a safe and feasibleoption for teclistamab step-up dosing. Prophylactic use of tocilizumab reduces both CRS incidence andseverity with a very low rate of admission. Tumor flare pain reaction seems to be an under-recognizedyet clinically significant adverse event occurring during teclistamab step-up dosing, often presenting asacute and severe bone pain with or without pseudo-progression."

Clinical • Hematological Malignancies • Multiple Myeloma • Musculoskeletal Pain • Oncology • Pain • IL10 • IL2 • IL6

New Onset Pruritus Following Discontinuation of Cetirizine or Levocetirizine. (PubMed, J Allergy Clin Immunol Pract) - No abstract available

Journal • Dermatology • Pruritus

Postmortem distribution of isotonitazene and its three metabolites in the first lethal case observed in France. (PubMed, Forensic Sci Int) - "To the best of our knowledge, this is the first reported fatal IZN intoxication with comprehensive postmortem analysis, including quantification of active metabolites in solid organs. The case is marked by low peripheral blood levels, extensive redistribution, and selective tissue accumulation. Active metabolites: N-desethyl IZN, 4'-hydroxy-nitazene, and 5-amino IZN showed distinct distribution and elimination profiles. These findings highlight the high potency, rapid metabolism, and complex toxicokinetic of IZN."

Journal

Targeted LC-MS/MS method for quantifying respiratory pharmaceuticals in wastewater. (PubMed, Environ Sci (Camb)) - "Application to 12 neighborhood-level wastewater samples detected 9 of the 10 target compounds, with 6 (albuterol, amoxicillin, azithromycin, cetirizine, diphenhydramine, and fexofenadine), detected above their quantification limits. Fexofenadine was the most abundant, reaching 3309 ng L-1. This robust, low-volume, high-throughput LC-MS/MS method enables the reliable detection of respiratory pharmaceuticals in wastewater, supporting WBE applications for pharmaceutical use surveillance."

Journal • Respiratory Diseases

Cetirizine ameliorates cyclophosphamide-induced placental toxicity via modulation of TGF-β/NOX4 signaling pathway in rats. (PubMed, Naunyn Schmiedebergs Arch Pharmacol) - "Histological changes, transforming growth factor-β (TGF-β) immuno-expression were also evaluated. CZ caused a significant reduction in placental oxidative stress, inflammation and apoptosis induced by CP. Current study revealed that CZ protective role against CP-induced placental damage involves modulation of TGF-β/NOX4 signaling pathway (Fig. 1). Fig. 1 Graphical abstract of our manuscript."

Journal • Preclinical • Immunology • Oncology • CASP3 • NOX4 • TGFB1

Adverse Event Grade IV of Tyrosine Kinase Inhibitors (TKIs) on the Skin of Stage IV Lung Adenocarcinoma Patients with Positive Epidermal Growth Factor Receptor (EGFR) Mutations (APSR 2025) - "Tyrosine kinase inhibitors (TKIs) such as erlotinib and gefitinib treat lung cancer with positive EGFR mutations, improving patient survival...In addition to discontinuing erlotinib therapy, the patient also received dexamethasone injection 2×2.5mg, cetirizine 1×10 mg gentamicin cream and vaseline cream...Mild rashes may be treated with gentamicin cream and vaseline cream, while severe cases could require oral antihistamines or postponing treatment. The report highlights the importance of early diagnosis and treatment of rashes to improve quality of life and treatment adherence."

Adverse events • Clinical • Metastases • Dermatitis • Dermatology • Immunology • Lung Adenocarcinoma • Lung Cancer • Non Small Cell Lung Cancer • Oncology • Pruritus • Solid Tumor • EGFR

Chronic Spontaneous Urticaria as a Mimicker of Non-Accidental Injury in Childhood (ISDS 2025) - "Her symptoms improved dramatically with oral cetirizine...Early recognition of dermatologic inflammatory mimickers is critical to avoid unnecessary legal and psychosocial consequences, such as disruption of the parent–child bond, stigmatization of caregivers, legal proceedings, and prolonged emotional distress for families. Prompt diagnosis and management can alleviate symptoms for the patient and provide reassurance for families and clinicians alike."

Clinical • Chronic Spontaneous Urticaria • Dermatology • Immunology • Inflammation • Pruritus • Urticaria

Development of Spray-Dried Mannitol-Pregelatinized Rice Starch Using SeDeM-Based Approach for Direct Compressible Cetirizine Dihydrochloride Tablets. (PubMed, Pharmaceutics) - "The tablets met all pharmacopeial physicochemical requirements, including uniform mass, adequate tensile strength, rapid disintegration, and dissolution profiles comparable to a reference product, with dissimilarity (f1 = 4.28) and similarity (f2 = 64.03) factors within regulatory acceptance limits. These findings represented the first application of SeDeM methodology to a co-processed mannitol-pregelatinized rice starch system, enabling predictive optimization of powder flow and compressibility in direct compression formulations."

Journal

A probiotic containing L. plantarum and P. acidilactici strains for treating upper respiratory infection in children aged 6 months to 5 years: a randomized, double-blind trial. (PubMed, Eur J Pediatr) - " Intervention with this probiotic formula was associated with a shorter duration of fever and pain/discomfort in pediatric URIs with pharyngitis."

Clinical • Journal • Infectious Disease • Novel Coronavirus Disease • Pain • Pediatrics • Respiratory Diseases • Respiratory Syncytial Virus Infections

The anti-allergic effect of Lactobacillus plantarum GUANKE on allergic rhinitis induced by either ragweed pollen or house dust mites in mice. (PubMed, Front Nutr) - "The treatment group mice were orally administered cetirizine (10 mg/kg) as positive control or three different doses of L. plantarum GUANKE (106, 108, or 101⁰ CFU/mouse) after daily intranasal challenges...Moreover, histopathological analysis showed that L. plantarum GUANKE significantly reduced nasal mucosal thickness, eosinophil infiltration, and goblet cell proliferation. This study demonstrated the L. plantarum GUANKE can alleviate AR symptoms induced by RAGW or HDM in mice by inhibiting the levels of IgE and Th2 cytokines as well as restoring the histopathological changes of nasal mucosa."

Journal • Preclinical • Allergic Rhinitis • Immunology • Inflammation • IL13 • IL4 • IL5

Dual Biologic Therapy In Eosinophilic Esophagitis: A Case Report (ACAAI 2025) - "Despite treatment with dexlansoprazole, ranitidine, montelukast, cetirizine, budesonide (swallowed), and multiple food elimination diets, she experienced persistent retrosternal chest pain, dysphagia, abdominal pain, nausea and recurrent oral sores...After unsuccessful trials of crisaborole and cyclosporine, dupilumab was started...Discussion The 2025 American College of Gastroenterology guidelines support dupilumab use in EoE, however no recommendation exists for or against benralizumab use. This case highlights the potential role of dual biologic use, particularly in patients with severe EoE and coexisting atopic disease, though further research is needed."

Case report • Clinical • Allergic Rhinitis • Asthma • Contact Dermatitis • Dermatitis • Dermatology • Eosinophilic Esophagitis • Gastrointestinal Disorder • Immunology • Inflammation • Respiratory Diseases • IL13 • IL4 • IL5

CURE-AU: Comparing Standard-Dose and High-Dose Cetirizine for Acute Urticaria (clinicaltrials.gov) - P=N/A | N=140 | Not yet recruiting | Sponsor: University of Phayao

New trial • Dermatology • Immunology • Urticaria

Safety and Efficacy of Ivosidenib Based Regimen in Patients with IDH1 Mutanted Acute Myeloid Leukemia: A Retrospective Case Series (ASH 2024) - "After adding gilteritinib for the FLT-3 mutation, one month later showed a reduction to 19% blasts, and then switched to a regimen of azacitidine, venetoclax, selinexor, and ivosidenib...The patient has remained on ivosidenib, with CR lasting over 65 months and overall survival since diagnosis exceeding 94 months.Pt 1 experienced grade 4 neutropenia and grade 3 rash during ivosidenib plus cytarabine consolidation therapy, leading to temporary discontinuation of ivosidenib. During maintenance, the patient was co-administered cetirizine, with no reported AEs...All patients achieved or maintained CR, with a favorable response and prolonged duration of remission. Further studies with larger cohorts are necessary to confirm these findings."

Retrospective data • Acute Myelogenous Leukemia • Hematological Disorders • Hematological Malignancies • Infectious Disease • Leukemia • Neutropenia • Oncology • Respiratory Diseases • DNMT3A • FLT3 • IDH1 • KRAS • NPM1 • PHF6 • TP53

Successful Management of D816V Mutated c-KIT Systemic Mastocytosis with Chronic Imatinib: A Case Report (ASH 2023) - "When reactions did occur, she treated them at one point with a cocktail of an histamine-2 blocker (ranitidine), histamine-1 blocker (diphenhydramine), and a mast cell stabilizer (cromolyn) and without requiring the use of epinephrine...After the most recent BMB the patient altered her daily regimen due to gastric upset and found she could take of her histamine-1 blocker (diphenhydramine) once daily along with a twice daily regimen of her imatinib (split into two smaller daily doses), histamine-1 antagonist (cetirizine), her histamine-2 antagonist (famotidine), and citalopram (selective serotonin reuptake inhibitor or SSRI) with improved symptomatic control to this day. This case serves to illustrate the diagnostic and therapeutic challenges associated with SM, as well as the potential therapeutic use of imatinib in patients with D816V outside of its original FDA indication. Further characterization of the effect of imatinib on D816V mutated SM may warrant the..."

Case report • Clinical • Atrial Fibrillation • Endocrine Disorders • Gastroenterology • Gastroesophageal Reflux Disease • Hematological Disorders • Metabolic Disorders • Myeloproliferative Neoplasm • Oncology • Rare Diseases • FLT3 • IDH1 • IDH2 • KIT • NPM1

Comparing Antihistamine Premedication Regimens for Preventing Rituximab-Associated Infusion Reactions in Hemato-Oncology Patients: A Retrospective Analysis (ASH 2024) - "Results : Three antihistamines were identified : diphenhydramine 50 mg, loratadine 10 mg, and cetirizine 10 mg. Using one dose of less sedating second-generation antihistamines may improve patient safety without compromising clinical efficacy. By recognizing second-generation antihistamines as a safer and equally efficacious option for rituximab premedication, standard antihistamine prescribing practices should be re-evaluated with the goal of optimizing patient safety and medication burden."

Retrospective data • Hematological Malignancies • Oncology

Kounis Syndrome: A Report of Two Cases and a Review of the Literature. (PubMed, Cureus) - "The second case involves a 73-year-old male with a history of prostate cancer and cerebral aneurysm, who had an allergic reaction after consuming dairy products, which was treated with cetirizine. Thereafter, it transitioned into a STEMI with atrial fibrillation with rapid ventricular response and was treated with thrombolytics and amiodarone. Finally, a medicated stent was implanted in the main vessel after a coronary arteriography.  These cases highlight the importance of considering allergic etiologies in the differential diagnosis of acute coronary syndromes to ensure accurate identification and tailored treatment."

Journal • Acute Coronary Syndrome • Allergy • Atrial Fibrillation • Cardiovascular • Coronary Artery Disease • Genito-urinary Cancer • Hematological Disorders • Immunology • Myocardial Infarction • Oncology • Pain • Prostate Cancer • Solid Tumor • Thrombosis • Vascular Neurology

A comparative study of efficacy and tolerability of cetirizine and bilastine in patients of allergic rhinitis: An open-label, randomized, parallel-group study. (PubMed, Perspect Clin Res) - "Adverse events were reported more in the cetirizine group. Bilastine is equally efficacious as cetirizine and a favorable tolerability profile may make it a more tolerable H1-antihistaminic than cetirizine."

Journal • Allergic Rhinitis • Allergy • Dermatology • Immunology • Inflammation • Otorhinolaryngology • Urticaria

Case Report: Setmelanotide and Urticaria Resolution in Bardet-Biedl Syndrome (OBESITY WEEK 2025) - "She also had a history of chronic idiopathic urticaria (CIU) resistant to dual antihistamine therapy, necessitating daily use of diphenhydramine and cetirizine. This case demonstrates the resolution of chronic idiopathic urticaria with the use of setmelanotide in a patient diagnosed with BBS. BBS is primarily caused by mutations in genes essential for ciliary function, leading to impaired cellular signaling pathways, particularly those involved in development and metabolism. This dysfunction results in a range of clinical manifestations due to disrupted intercellular communication, but is not typically associated with inflammatory or dermatologic conditions."

Case report • Clinical • Bardet–Biedl Syndrome • Chronic Spontaneous Urticaria • Dermatology • Genetic Disorders • Immunology • Inherited Retinal Dystrophy • Obesity • Ophthalmology • Urticaria • BBS9 • KIDINS220

Minocycline-Induced Delayed Dermographism With Tolerance to Doxycycline. (PubMed, J Dermatol) - "Minocycline, a semisynthetic tetracycline, is widely used to treat inflammatory skin diseases such as acne and rosacea...Symptoms resolved following drug discontinuation and a 2-day course of oral cetirizine...The underlying immunopathogenesis remains unclear, potentially involving mast cell activation or superantigen-like effects. This case underscores the importance of prolonged drug rechallenge in identifying rare delayed adverse reactions such as minocycline-induced late-onset symptomatic dermographism and supports the safe use of doxycycline as an alternative."

Journal • Acne Vulgaris • Cardiovascular • Dermatology • Immunology • Inflammation • Rosacea • Urticaria

Benefit of Up-Dosed Omalizumab in Treatment-Refractory Neutrophilic Urticaria (ACAAI 2025) - "Case Description 44 y/o Female BMI 33 presented with pruritic, painful urticaria starting on the lower extremities, becoming generalized with facial angioedema, despite cetirizine 20 mg, famotidine 40 mg BID, prednisone 60mg daily, then Kenalog 60 mg IM...Based on histology, dapsone 100 mg BID with colchicine was trialed for 1 month without improvement...The clinical significance of neutrophilia on skin biopsy remains unclear, is not well established within phenotype/endotype paradigms, and in treatment-refractory cases, broadens considerations to include other neutrophilic dermatoses. This patient demonstrated significant benefit from up-dosed omalizumab, supporting this as a therapeutic option."

Cardiovascular • Chronic Spontaneous Urticaria • Dermatology • Immunology • Urticaria • Vasculitis

Delayed Urticaria And Serum Sickness-Like Reaction In A 4-Year-Old Receiving Omalizumab (ACAAI 2025) - "After generalized urticaria emerged 3 days following dose 10, and persisted for 12 days despite high dose cetirizine, omalizumab was discontinued. Delayed onset urticaria and SSLR-like presentations are atypical. This case adds to the limited omalizumab-related adverse events in young children and could inform future patient discussions and therapy regimens."

Atopic Dermatitis • Dermatitis • Dermatology • Eosinophilic Esophagitis • Food Hypersensitivity • Gastrointestinal Disorder • Hematological Disorders • Immunology • Infectious Disease • Inflammation • Musculoskeletal Pain • Urticaria

Identifying and Managing Anaphylaxis During Hemodialysis (ACAAI 2025) - "Patient A experienced recurrent hypotension during dialysis refractory to albumin, midodrine, dialysis without ultrafiltration, and premedication with a corticosteroid, antihistamine and H2 blocker...Patient B tolerated HD with the cellulose membrane, cetirizine and famotidine premedication, and priming the tubing with 2L NS due to continued ethylene oxide exposure from the tubing. Discussion Rising numbers of patients on HD makes recognition and management of hypersensitivity reactions crucial, particularly in resource-limited situations. Though medications are the most common cause of severe reactions, providers should consider dialyzer membranes, which are associated with pseudoallergic reactions, and the sterilizing agent ethylene oxide, which is a known trigger of anaphylaxis."

Chronic Kidney Disease • Dermatology • Hematological Malignancies • Hypotension • Immunology • Multiple Myeloma • Renal Disease • Urticaria

KIT D816Y Mutation in An Infant With Diffuse Cutaneous Mastocytosis (ACAAI 2025) - "He was started on high-dose cetirizine, famotidine, and topical steroids. It is unclear if this mutation is somatic or germline and requires further investigation. Additionally, although the patient does not currently have evidence of extracutaneous involvement, ongoing surveillance is necessary."

Dyspepsia • Hematological Disorders • Hepatology • Rare Diseases • Thrombocytopenia • KIT

Comparing Antihistamines for Chronic Urticaria: Systematic Review Dose Response and Network Meta-Analysis of Randomized Trials (ACAAI 2025) - "Sedation likely increases with higher doses, with first-generation agents among the most sedating; cetirizine, ketotifen, levocetirizine, and rupatadine among the intermediate sedating; and bilastine, desloratadine, fexofenadine, and loratadine among the least sedating. Cetirizine and loratadine are among the most effective for all components of urticaria activity, but cetirizine is intermediately sedating and loratadine has lower certainty on improving quality of life and sleep. Higher doses may have diminishing benefits and increased risks."

Retrospective data • Review • Anesthesia • Cardiovascular • CNS Disorders • Dermatology • Immunology • Pruritus • Sleep Disorder • Urticaria