diclofenac sodium oral / Generic mfg. - LARVOL DELTA

Cross-linked alginate/pozzolan (Alg@PZ) microcapsules for sodium diclofenac removal as emerging contaminant. (PubMed, J Microencapsul) - "Thermodynamic analysis showed that the reaction was spontaneous and exothermic. However, [email protected] represents a scalable, eco-friendly and cost-effective alternative to conventional adsorbents for removing persistent pharmaceutical compounds from aqueous systems."

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How painful is Implanon NXT® insertion?: A multicenter randomized trial on the use of Acetaminophen, Mefenamic Acid and Diclofenac Sodium for pain management post Implanon NXT® insertion. (PubMed, BMC Womens Health) - "All oral analgesics demonstrated a reduction in pain score. Based on this limited study, the most suitable analgesic for pain management post Implanon NXT® insertion is tablet Mefenamic Acid 250 mg twice daily for up to 2 days. More robust double-blinded studies using placebos as a control are needed to confirm this finding."

Journal • Pain

Beeswax sacrificial support and latex curing for high-fidelity semi-solid extrusion 3D printed sustained-release tablets. (PubMed, J Pharm Sci) - "This approach successfully produced high-fidelity, diclofenac sodium-loaded tablets with tunable release profiles governed by the Eudragit® RL-to-HPMC ratio. These findings present a robust strategy for producing dimensionally stable, mechanically strong, and personalized sustained-release formulations via SSE 3D printing."

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Algerian bee Venom attenuates formaldehyde-induced acute inflammation and oxidative stress in male rats. (PubMed, Environ Anal Health Toxicol) - "One hour later, rats received either subcutaneous bee venom (0.76 mg/kg) or oral diclofenac sodium (10 mg/kg) as a reference drug...The overall protective effects of bee venom were comparable to those of diclofenac. These findings demonstrate that A. mellifera intermissa venom exerts significant anti-inflammatory and antioxidant actions and may represent a promising natural therapeutic candidate for inflammation associated with oxidative stress."

Journal • Preclinical • Inflammation • CAT • CRP

Combined pulse radiofrequency and selective nerve root block for lumbar disc herniation-related neuropathic pain: a retrospective cohort study. (PubMed, Front Med (Lausanne)) - "342 cases were treated with oral diclofenac sodium (Control group), and 215 cases were treated with selective nerve root block using dexamethasone palmitate (Intervention group)...No serious complications or drug side effects were observed in both groups of patients. Compared with oral medication treatment, pulse radiofrequency combined with selective nerve root block using dexamethasone palmitate can more effectively alleviate neuropathic pain caused by lumbar disc herniation, improve quality of life, and promote lumbar functional recovery."

Journal • Retrospective data • Musculoskeletal Diseases • Neuralgia • Pain

Investigation of the drug release modifying property of Pentadesma butyracea gum in diclofenac sodium matrix tablets. (PubMed, PLoS One) - "A matrix system comprising 15%w/w P. butyracea gum and ≥ 20%w/w xanthan gum effectively extended the release of diclofenac sodium over 24 hours, demonstrating its potential application in extended-release formulations."

Journal • Gene Therapies

A comparison of the efficacy of pharmacotherapy and hypnotherapy in patients with primary dysmenorrhoea. (PubMed, J Pak Med Assoc) - "Pharmacotherapy and hypnotherapy were both effective in reducing pain in primary dysmenorrhoea patients, but the effect of pharmacotherapy lasted longer than that of hypnotherapy."

Clinical • Journal • Gynecology • Pain • Women's Health

Evaluation of analgesic efficacy of transdermal patch versus oral diclofenac tablets in orthodontic patients undergoing multiple premolar extractions - A crossover study. (PubMed, Natl J Maxillofac Surg) - "The right maxillary and mandibular first premolars were extracted first and 50 mg oral Diclofenac sodium tablets were prescribed to be taken thrice a day for three days...However, patients reported that they were more comfortable using the transdermal patch particularly due to the once-a-day application and lesser frequency of systemic adverse effects. Transdermal Diclofenac patch provides as potent analgesia as the oral Diclofenac tablets with the added advantage of better patient compliance and may be used for routine post-extraction analgesia."

Journal • Dental Disorders • Pain

Development and Optimization of Sustained-Release Matrix Tablets of Diclofenac Sodium Using Carboxymethylated Chitosan Through Systematic Application of Design of Experiments. (PubMed, Drug Metab Bioanal Lett) - "The study successfully developed a sustained-release matrix tablet of diclofenac sodium using CMCS as the primary matrix material. The optimized formulation demonstrated a dissolution profile comparable to the marketed product (>90% release in 8 hours), with f2 > 50 and f1 < 15, suggesting its potential as a generically equivalent alternative. Moreover, the findings indicate that CMCS is an effective carrier for sustainedrelease formulations and can potentially be applied to other drugs requiring controlled release."

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Effectiveness of Pulse Intravenous Infusion of Methylprednisolone on Pain in Patients with Lumbar Disc Herniation: A Randomized Controlled Trial. (PubMed, Anesth Pain Med) - "The control group received common painkillers (diclofenac sodium tablets 100 mg), while the experimental group received a single dose of 500 mg methylprednisolone sodium succinate (intravenous injection in 500 cc normal saline). Analysis of variance indicated that methylprednisolone significantly reduced pain in patients with LDH (P = 0.000, F = 660.668). Given the effectiveness of intravenous pulse infusion of 500 mg methylprednisolone compared to common NSAIDs in relieving pain and improving clinical outcomes for patients with lumbar disc herniation, the use of this drug is recommended for pain reduction in these patients."

Journal • Musculoskeletal Diseases • Pain

3D Printable Self-Healing Mineralized Hydrogels Loaded With Diclofenac Sodium: In Vitro and In Vivo Assessment. (PubMed, Biotechnol Bioeng) - "The in vitro drug release study demonstrated that the 3% w/w diclofenac sodium-loaded oral films printed at 2 mm/sec exhibited a faster release profile. Furthermore, considerable bioavailability of diclofenac sodium (DS) was achieved from the 3D-printed oral films during the in vivo study. These results can be effectively used to develop a drug delivery system that can release medications accurately and consistently, either in a targeted area or systemically."

Journal • Preclinical

Clinical efficacy of Fu's subcutaneous needling based on "multi-joint muscle spiral balance chain" theory for cervical vertigo and its effect on blood flow velocity of vertebral artery (PubMed, Zhongguo Zhen Jiu) - "Fu's subcutaneous needling based on the "multi-joint muscle spiral balance chain" theory can effectively alleviate the vertigo and neck pain, and improve the blood flow velocity of vertebral artery in CV patients, and has a long-term therapeutic effect."

Clinical • Journal • Musculoskeletal Pain • Otorhinolaryngology • Pain • Vertigo

Investigation of the effects of a new transdermal formulation of systemic diclofenac on the upper gastrointestinal mucosa in patients with low back pain: A comparative study with oral diclofenac. (PubMed, J Gastroenterol Hepatol) - "DSSP is associated with a lower risk of gastrointestinal mucosal damage than DST, which has the same active ingredient but uses a different route of administration, in patients with LBP."

Journal • Back Pain • Gastrointestinal Disorder • Lumbar Back Pain • Musculoskeletal Pain • Pain • Peptic Ulcer

Comparison of Bromelain and Diclofenac in the Management of Postoperative Pain and Quality of Life Following Root Canal Therapy: A Randomized Controlled Trial. (PubMed, Cureus) - "After access opening, preparation of the root canal and temporization, Group I (n=50) patients received oral bromelain 200 mg and Group II (n=50) received oral diclofenac sodium 50 mg, respectively. Conclusions When compared to diclofenac, bromelain has the same analgesic efficacy after 12 hours but a lower risk of adverse effects in patients receiving root canal therapy for postoperative pain. Diclofenac is more effective in immediate postoperative pain relief and improvement in quality of life for patients with moderate to severe pain."

HEOR • Journal • Dental Disorders • Pain

Characterization of Taro (Colocasia esculenta) stolon polysaccharide and evaluation of its potential as a tablet binder in the formulation of matrix tablet. (PubMed, Int J Biol Macromol) - "The release-exponent value above 0.89 indicated a super case II drug transport combining matrix erosion and diffusion. Optimum tablet hardness and very low friability, even at 2.5 % binder concentration, suggested the potential application of the novel TSP as a tablet binder in the formulation of the tablets."

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NIH HEAL Initiative Preclinical Screening Platform for Pain Program and Data Sharing (IASP 2024) - "(PGI), carbamazepine (3-300 mg/kg, PO), celecoxib (3-100 mg/kg, PO), diazepam (1-30 mg/kg, PO), diclofenac sodium (1-100 mg/kg, PO), duloxetine hydrochloride (3-100 mg/kg, PO), gabapentin (10-300 mg/kg, PO), ketoprofen (0.3-10 mg/kg, PO), morphine sulfate (0.3-10 mg/kg, SC), naproxen sodium (1-100 mg/kg, PO), nalfurafine hydrochloride (1-3,000 µg/kg, SC), pregabalin (10-100 mg/kg, PO), and resatorvid (1-100 mg/kg, SC) were evaluated using the PSPP workflow, including in vitro assessment of safety and abuse liability and protein binding and in vivo assessment of pharmacokinetics, side effect profile, efficacy in pain-related models, and/or abuse liability. The PSPP program and public-facing website (https://pspp.ninds.nih.gov/) are resources available to the global community developing potential pain therapeutics with the goal of accelerating the development of new, non-opioid, non-addictive pain therapeutics. The program website details the optimized and validated..."

Preclinical • Addiction (Opioid and Alcohol) • CNS Disorders • Pain • Psychiatry

NIH HEAL Initiative Preclinical Screening Platform for Pain program (AHS 2024) - "(PGI), carbamazepine (3–300 mg/kg, PO), celecoxib (3–100 mg/kg, PO), diazepam (1–30 mg/kg, PO), diclofenac sodium (1–100 mg/kg, PO), duloxetine hydrochloride (3–100 mg/kg, PO), gabapentin (10–300 mg/kg, PO), ketoprofen (0.3–10 mg/kg, PO), morphine sulfate (0.3–10 mg/kg, SC), naproxen sodium (1–100 mg/kg, PO), nalfurafine hydrochloride (1–3000 μg/kg, SC), pregabalin (10–100 mg/kg, PO), and resatorvid (1–100 mg/kg, SC) were evaluated using the PSPP workflow, including in vitro assessment of safety and abuse liability and protein binding and in vivo assessment of pharmacokinetics, side effect profile, efficacy in pain-related models, and/or abuse liability. The PSPP program aims to accelerate the development of new, non-opioid, non-addictive pain therapeutics, including therapeutics for headache and migraine. The program offers rigorous preclinical evaluation of potential pain therapeutics at no cost to program participants. PSPP has developed a website detailing the..."

Preclinical • Addiction (Opioid and Alcohol) • CNS Disorders • Migraine • Pain • Psychiatry

Formulation and Evaluation of Cola acuminata Gum-based Mucoadhesive Sustained-release. (PubMed, Recent Adv Drug Deliv Formul) - "This study showed that CAG could be useful for mucoadhesive sustained drug delivery."

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Evaluation of Cassia fistula seed galactomannan as tablet-binder in formulation of diclofenac sodium-loaded monolithic matrix tablet. (PubMed, Int J Biol Macromol) - "Other tablet properties were also found to be within the Pharmacopoeial compliance limit. The tablets with a minimum concentration of CFSG (2.5%w/w) as binder showed appreciable mechanical strength and faster drug release, which ratifies CFSG as an alternative tablet binder."

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Comparative Evaluation of Efficacy of Ketoprofen and Diclofenac Transdermal Patches with Oral Diclofenac Tablet on Postoperative Endodontic Pain- A Randomized Clinical Trial. (PubMed, Patient Prefer Adherence) - "Groups A and B received transdermal patches with Ketoprofen and diclofenac sodium, respectively, applied to the right forearm for 24 hours, with an additional patch on the left forearm for the next day. Group C received four diclofenac sodium oral tablets, twice daily for two days...Notably, the Ketoprofen patch group exhibited superior performance compared to the diclofenac transdermal patch and oral diclofenac tablet groups at 48 hours, with statistical significance (p=0.047). The present evidence substantiates the efficacy of transdermal patches containing diclofenac and ketoprofen in managing postoperative pain arising from symptomatic irreversible pulpitis in single-rooted teeth. By avoiding the use of oral NSAIDs, these patches provide effective pain relief while minimizing the risk of adverse effects, presenting a favorable option for patients."

Clinical • Journal • Dental Disorders • Musculoskeletal Diseases • Orthopedics • Pain

Chest pain in a patient two hours after treatment of anaphylaxis (EUSEM 2023) - "However, epinephrine use in the treatment of anaphylaxis has also been related...She had taken a tablet of diclofenac sodium for her leg pain thirty minutes prior to coming to our ED...The ECG was immediately done, which revealed ST-segment elevation on inferolateral segments, with intermittent VES occurrence. ECG can be seen in Figure 1.Blood tests revealed Troponin T: 1460 ng/L (normal range is"

Clinical • Acute Coronary Syndrome • Allergy • Cardiovascular • Immunology • Pain • Pruritus

Anti-inflammatory and Anti-arthritic Properties of Mucuna gigantea Plant Extracts: Establishing by Molecular Docking Study. (PubMed, Curr Comput Aided Drug Des) - "Diclofenac sodium (10 mg/kg), prednisolone (5 mg/kg), and methotrexate (0.5 mg/kg) were used as standard...Also, Mucuna gigantea remarkably ameliorated altered WBCs, rheumatoid factor, and positively modified radiographic and histopathological changes. Conclusion Taken together, these results support the traditional use of Mucuna gigantea as a potent anti-inflammatory and anti-arthritic agent that may be proposed for rheumatoid arthritis treatment."

Journal • Immunology • Infertility • Inflammation • Inflammatory Arthritis • Musculoskeletal Diseases • Musculoskeletal Pain • Orthopedics • Pain • Rheumatoid Arthritis • Rheumatology • Sexual Disorders

The Anti-inflammatory and Anti-arthritis Activity of Garcinia travancorica in a Rat Model: A Proof of Concept with Computational Studies. (PubMed, Comb Chem High Throughput Screen) - "Diclofenac sodium (10 mg/kg), prednisolone (5 mg/kg), and methotrexate (0.5 mg/kg) were used as standard... Docking-based in-silico screening of the ligand library has revealed the potential of Polyanxanthone-C as an anti-rheumatoid agent, which is supposed to deliver its therapeutic effect by synergistic targeting of interleukin-1, interleukin-6, and tumor necrosis factor receptor type-1. This plant has the potential to be used in the treatment of arthritis-related disorders."

Journal • Preclinical • Immunology • Inflammation • Inflammatory Arthritis • Oncology • Pain • Rheumatoid Arthritis • Rheumatology • IL6 • TNFA

Modified Baihu decoction therapeutically remodels gut microbiota to inhibit acute gouty arthritis. (PubMed, Front Physiol) - " MBD (5.84, 35 g/kg) was administered orally to AGA rats and diclofenac sodium tablets (DS-tablets) were used as standard treatment control... In summary, MBD is an effective agent for the treatment of AGA, with the potential mechanism being the regulation of intestinal flora to control inflammation. This would help to promote the therapeutic effect of MBD on AGA."

Journal • Gout • Immunology • Inflammation • Inflammatory Arthritis • Rheumatology • IL1B • NLRP3 • TGFB1

Evaluation of Hydroxyethyl Cellulose Grades as the Main Matrix Former to Produce 3D-Printed Controlled-Release Dosage Forms. (PubMed, Pharmaceutics) - "Diclofenac sodium tablets were successfully prepared via hot-melt extrusion (HME) and fused deposition modeling (FDM), using different molecular-weight (Mw) grades of hydroxyethyl cellulose (HEC) as the main excipient...The results indicate that despite being underused in FDM, HEC is a suitable main excipient for 3D-printed dosage forms. More research on underutilized polymers in FDM should be encouraged to increase the limited availability."

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