TTRNA-DCs / University of Florida - LARVOL DELTA

MATCHPOINT: Adoptive T Cell Therapy, DC Vaccines, and Hematopoietic Stem Cells Combined With Immune checkPOINT Blockade in Patients With Medulloblastoma (clinicaltrials.gov) - P1 | N=12 | Recruiting | Sponsor: University of Florida | Active, not recruiting ➔ Recruiting

Checkpoint inhibition • Enrollment open • Brain Cancer • Medulloblastoma • Oncology • Solid Tumor

MATCHPOINT: Adoptive T Cell Therapy, DC Vaccines, and Hematopoietic Stem Cells Combined With Immune checkPOINT Blockade in Patients With Medulloblastoma (clinicaltrials.gov) - P1 | N=12 | Active, not recruiting | Sponsor: University of Florida | Recruiting ➔ Active, not recruiting

Enrollment closed • Brain Cancer • Medulloblastoma • Oncology • Solid Tumor

BRAVO: Brain Stem Gliomas Treated With Adoptive Cellular Therapy During Focal Radiotherapy Recovery Alone or With Dose-intensified Temozolomide (Phase I) (clinicaltrials.gov) - P1 | N=11 | Terminated | Sponsor: University of Florida | N=21 ➔ 11 | Trial completion date: Dec 2025 ➔ Mar 2025 | Active, not recruiting ➔ Terminated; Not feasible to accrue due to competing studies

Enrollment change • Trial completion date • Trial termination • Brain Cancer • CNS Tumor • Diffuse Intrinsic Pontine Glioma • Glioma • Oncology • Solid Tumor

MATCHPOINT: Adoptive T Cell Therapy, DC Vaccines, and Hematopoietic Stem Cells Combined With Immune checkPOINT Blockade in Patients With Medulloblastoma (clinicaltrials.gov) - P1 | N=12 | Recruiting | Sponsor: University of Florida | Not yet recruiting ➔ Recruiting

Checkpoint inhibition • Enrollment open • Brain Cancer • Medulloblastoma • Oncology • Solid Tumor

MATCHPOINT: Adoptive T Cell Therapy, DC Vaccines, and Hematopoietic Stem Cells Combined With Immune checkPOINT Blockade in Patients With Medulloblastoma (clinicaltrials.gov) - P1 | N=12 | Not yet recruiting | Sponsor: University of Florida | Initiation date: Dec 2024 ➔ Mar 2025

Checkpoint inhibition • Trial initiation date • Brain Cancer • Medulloblastoma • Oncology • Solid Tumor

BRAVO: Brain Stem Gliomas Treated With Adoptive Cellular Therapy During Focal Radiotherapy Recovery Alone or With Dose-intensified Temozolomide (Phase I) (clinicaltrials.gov) - P1 | N=21 | Active, not recruiting | Sponsor: University of Florida | Trial completion date: Jun 2025 ➔ Dec 2025 | Trial primary completion date: Dec 2024 ➔ Jun 2025

Trial completion date • Trial primary completion date • Brain Cancer • CNS Tumor • Diffuse Intrinsic Pontine Glioma • Glioma • Oncology • Solid Tumor

MATCHPOINT: Adoptive T Cell Therapy, DC Vaccines, and Hematopoietic Stem Cells Combined With Immune checkPOINT Blockade in Patients With Medulloblastoma (clinicaltrials.gov) - P1 | N=12 | Not yet recruiting | Sponsor: University of Florida | Initiation date: Sep 2024 ➔ Dec 2024

Checkpoint block • Checkpoint inhibition • Trial initiation date • Brain Cancer • Medulloblastoma • Oncology • Solid Tumor

MATCHPOINT: Adoptive T Cell Therapy, DC Vaccines, and Hematopoietic Stem Cells Combined With Immune checkPOINT Blockade in Patients With Medulloblastoma (clinicaltrials.gov) - P1 | N=12 | Not yet recruiting | Sponsor: University of Florida

Checkpoint block • Checkpoint inhibition • New P1 trial • Brain Cancer • Medulloblastoma • Oncology • Solid Tumor

BRAVO: Brain Stem Gliomas Treated With Adoptive Cellular Therapy During Focal Radiotherapy Recovery Alone or With Dose-intensified Temozolomide (Phase I) (clinicaltrials.gov) - P1 | N=21 | Active, not recruiting | Sponsor: University of Florida

Trial completion date • Trial primary completion date • Brain Cancer • CNS Tumor • Diffuse Intrinsic Pontine Glioma • Glioma • Oncology • Solid Tumor

BRAVO: Brain Stem Gliomas Treated With Adoptive Cellular Therapy During Focal Radiotherapy Recovery Alone or With Dose-intensified Temozolomide (Phase I) (clinicaltrials.gov) - P1 | N=21 | Active, not recruiting | Sponsor: University of Florida | Recruiting ➔ Active, not recruiting

Enrollment closed • Brain Cancer • CNS Tumor • Diffuse Intrinsic Pontine Glioma • Glioma • Oncology • Solid Tumor

BRAVO: Brain Stem Gliomas Treated With Adoptive Cellular Therapy During Focal Radiotherapy Recovery Alone or With Dose-intensified Temozolomide (Phase I) (clinicaltrials.gov) - P1 | N=21 | Recruiting | Sponsor: University of Florida | Trial completion date: Jun 2024 ➔ Jun 2025 | Trial primary completion date: Dec 2023 ➔ Dec 2024

Trial completion date • Trial primary completion date • Brain Cancer • CNS Tumor • Diffuse Intrinsic Pontine Glioma • Glioma • Oncology • Solid Tumor

BRAVO: Brain Stem Gliomas Treated With Adoptive Cellular Therapy During Focal Radiotherapy Recovery Alone or With Dose-intensified Temozolomide (Phase I) (clinicaltrials.gov) - P1 | N=21 | Recruiting | Sponsor: University of Florida | Trial primary completion date: Dec 2022 ➔ Dec 2023

Trial primary completion date • Brain Cancer • Diffuse Intrinsic Pontine Glioma • Glioma • Oncology • Solid Tumor