FP-300 / Flightpath Biosci - LARVOL DELTA

Behavioural and electrophysiological (event-related potential) determinants of decision-making in individuals with a smoking habit. (PubMed, Front Psychol) - "Neurophysiological processes related to option evaluation, response selection and feedback integration were assessed as the pre-outcome N500 (480-520 ms), the DNP and the post-outcome FRN & fP300 (450-700 ms) ERPs across five blocks of 60 trials during which the selection of advantageous decks, an index of decision making in the IGT, was recorded. Similarly, while the amplitude of the FRP was greater for negative than for positive outcomes across groups, in ISH, this contrast was inversely proportional to the severity of the smoking habit, as assessed with the Fagerström test. These findings together identify biobehavioural determinants of decision making in individuals with a smoking habit that may represent an endophenotype of the impaired insight that characterises individuals with a substance use disorder."

Journal • CNS Disorders • Psychiatry