Derinat (sodium desoxyribonucleate) / PharmPak - LARVOL DELTA

Derinat extends hair cycle at anagen phase by decreasing the level of TRPCs-mediated intracellular ROS accumulation in skin (ISID 2023) - "Our study demonstrated that Derinat with hair restorer efficacy in mice was due to maintenance of the hair cycle at the anagen phase, relating to the decreased level of TRPCs-mediated intracellular ROS accumulation."

Inflammation

Derinat has an immunomodulatory and anti-inflammatory effect on the model of acute lung injury in male SD rats. (PubMed, Front Pharmacol) - "Thus, the administration of Derinat stimulates the immune response, has a pronounced protective effect against cytokinemia and respiratory failure caused by ALI, has immunomodulatory effect, and also stimulates a local immune response in lung tissues. Thus, Derinat is a promising treatment for ALI."

Immunomodulating • Journal • Preclinical • Acute Lung Injury • Hematological Disorders • Immune Modulation • Inflammation • Respiratory Diseases

Experimental Study of the Efficacy of Sodium Deoxyribonucleate Used in Combination with Co-Transplantation of Mesenchymal and Hematopoietic Stem Cells after Exposure to γ-Radiation. (PubMed, Bull Exp Biol Med) - "Single or double administration of Derinat prior to irradiation was ineffective. The optimal result was obtained when the following scheme was applied: MSC→HSC with an interval of 48 h starting during the first hours after irradiation and triple administration of Derinat (in 10-15 min, 3 and 7 days after irradiation) in a dose of 3 mg/mouse."

Clinical • Combination therapy • Journal • Aplastic Anemia • Hematological Disorders • Immune Modulation • Inflammation • Transplantation