Boostrix (tetanus toxoid, reduced diphtheria toxoid and acellular pertussis vaccine) / GSK - LARVOL DELTA

The COVID-19 VaccinE Response and Co-Administration in Rheumatology Patients (COVER-CoAd) (clinicaltrials.gov) - P4 | N=129 | Terminated | Sponsor: Oregon Health and Science University | Active, not recruiting ➔ Terminated; Low enrollment.

Trial termination • Infectious Disease • Novel Coronavirus Disease • Psoriatic Arthritis • Rheumatology • IL17A • IL23A

A Study on the Immune Response and Safety of a Combined Vaccine Against Diphtheria, Tetanus and Acellular Pertussis (dTpa) in Japanese Healthy Pregnant Women (clinicaltrials.gov) - P3 | N=102 | Active, not recruiting | Sponsor: GlaxoSmithKline | Recruiting ➔ Active, not recruiting

Enrollment closed • Infectious Disease • Pertussis • Respiratory Diseases • Tetanus

Adult immunization. (PubMed, Med Lett Drugs Ther) - No abstract available

Journal • Hepatitis B • Herpes Zoster • Infectious Disease • Inflammation • Influenza • Measles • Meningococcal Infections • Pertussis • Pneumococcal Infections • Respiratory Diseases • Respiratory Syncytial Virus Infections • Tetanus • Varicella Zoster

Comparison chart: Some vaccines for adults. (PubMed, Med Lett Drugs Ther) - No abstract available

Journal • Hepatitis B • Infectious Disease • Inflammation • Influenza • Measles • Meningococcal Infections • Pertussis • Pneumococcal Infections • Respiratory Diseases • Respiratory Syncytial Virus Infections • Tetanus

Antibody persistence following primary and toddler booster vaccination of a hexavalent DTaP-IPV-HB-PRP∼T vaccine and immunogenicity of a school-age aP-containing booster vaccine in term and preterm infants born to women vaccinated with Tdap during pregnancy. (PubMed, Vaccine) - P=N/A | "These data support current maternal Tdap vaccination strategies and childhood booster vaccination policies in Belgium."

Journal • Infectious Disease • Pertussis • Respiratory Diseases • Tetanus

A Study on the Immune Response and Safety of a Combined Vaccine Against Diphtheria, Tetanus and Acellular Pertussis (dTpa) in Japanese Healthy Pregnant Women (clinicaltrials.gov) - P3 | N=95 | Recruiting | Sponsor: GlaxoSmithKline | Not yet recruiting ➔ Recruiting

Enrollment open • Infectious Disease • Pertussis • Respiratory Diseases • Tetanus

A Study on the Safety and Immune Responses to the GVGH altSonflex1-2-3 Vaccine Against Shigellosis in Adults, Children, and Infants (clinicaltrials.gov) - P1/2 | N=551 | Completed | Sponsor: GlaxoSmithKline | Phase classification: P1 ➔ P1/2

Phase classification

REPEATED MATERNAL TDAP VACCINATION DURING PREGNANCY – EFFECTS ON NEONATAL ANTIBODY LEVELS (ESPID 2026) - "Methods Women previously enrolled in the MATIMMUNE-study received a second Tdap vaccination in a subsequent pregnancy (N=40) with PREG1: Triaxis and PREG2: Boostrix, slightly different in antigen content...Immune responses were attenuated across antigens assessed, less so for PT and FHA, although responses were lower than expected given the higher antigen content in the second vaccine. Nevertheless, repeated Tdap vaccination in successive pregnancies still induced robust immune responses, highlighting the benefit of vaccinating during each pregnancy."

Infectious Disease • Pertussis • Tetanus

A Study on the Immune Response and Safety of a Combined Vaccine Against Diphtheria, Tetanus and Acellular Pertussis (dTpa) in Japanese Healthy Pregnant Women (clinicaltrials.gov) - P3 | N=95 | Not yet recruiting | Sponsor: GlaxoSmithKline

New P3 trial • Infectious Disease • Pertussis • Respiratory Diseases • Tetanus

The Effect of Maternal Pertussis Vaccination on Neonatal Health Outcomes in the Dutch Pregnancy Drug Register. (PubMed, Birth Defects Res) - "The maternal pertussis vaccination did not increase the risk of several adverse neonatal health outcomes, confirming the safety of pertussis vaccination during pregnancy with respect to neonatal health outcomes."

HEOR • Journal • Cough • Critical care • Infectious Disease • Pertussis • Respiratory Diseases • Small for Gestational Age

CosTaR: Concurrent Versus Sequential Administration of Tdap and RSV Vaccines in Pregnancy (clinicaltrials.gov) - P4 | N=60 | Recruiting | Sponsor: Canadian Immunization Research Network | Trial primary completion date: Jan 2026 ➔ May 2026

Trial primary completion date • Infectious Disease • Pertussis • Respiratory Diseases • Respiratory Syncytial Virus Infections • Tetanus

A Study on the Safety and Immune Responses to the GVGH altSonflex1-2-3 Vaccine Against Shigellosis in Adults, Children, and Infants (clinicaltrials.gov) - P1 | N=551 | Completed | Sponsor: GlaxoSmithKline | Active, not recruiting ➔ Completed

Trial completion

A Study to Evaluate Safety, Reactogenicity, and Immune Response of GVGH iNTS-TCV Vaccine Against Invasive Nontyphoidal Salmonella and Typhoid Fever (clinicaltrials.gov) - P1/2 | N=155 | Completed | Sponsor: GlaxoSmithKline | Recruiting ➔ Completed

Trial completion • Infectious Disease

CosTaR: Concurrent Versus Sequential Administration of Tdap and RSV Vaccines in Pregnancy (clinicaltrials.gov) - P4 | N=60 | Recruiting | Sponsor: Canadian Immunization Research Network | Not yet recruiting ➔ Recruiting

Enrollment open • Infectious Disease • Pertussis • Respiratory Diseases • Respiratory Syncytial Virus Infections • Tetanus

Safety Evaluation of Tetanus, Diphtheria, and Acellular Pertussis Vaccine (Tdap) During Pregnancy Among Vietnamese Women. (PubMed, Vaccines (Basel)) - "Background: In Vietnam, the Ministry of Health recently approved the use of Tdap vaccines-Boostrix (2022) and Adacel (2024)-for administration during pregnancy, aiming to provide passive antibody transfer to protect newborns against pertussis and tetanus from birth. This first large-scale Vietnamese cohort provides reassuring evidence on the safety of Tdap vaccination during pregnancy. These findings support broader implementation of maternal Tdap immunization, including concomitant administration with IIV4, to protect both mothers and infants."

Journal • Dermatology • Fatigue • Infectious Disease • Influenza • Obstetrics • Pain • Pertussis • Respiratory Diseases • Tetanus

The COVID-19 VaccinE Response and Co-Administration in Rheumatology Patients (COVER-CoAd) (clinicaltrials.gov) - P4 | N=129 | Active, not recruiting | Sponsor: Oregon Health and Science University | Trial completion date: Dec 2025 ➔ Aug 2026 | Trial primary completion date: Jan 2025 ➔ Apr 2025

Trial completion date • Trial primary completion date • Infectious Disease • Novel Coronavirus Disease • Psoriatic Arthritis • Rheumatology • IL17A • IL23A

Should Japanese athletes undergo booster vaccination for pertussis? (PubMed, IJID Reg) - "However, DTaP (diphtheria, tetanus, and acellular pertussis) (TRIBIKⓇ) is the only available vaccine in Japan, which contains higher antigen concentrations than the internationally used Tdap (tetanus, diphtheria, pertussis) vaccines (ADACEL™ and BOOSTRIXⓇ): the antigen contents of pertussis toxin, filamentous hemagglutinin, and diphtheria toxin in TRIBIKⓇ, ADACEL™, and BOOSTRIXⓇ are 23.5 µg/23.5 µg/≤15 µg, 2.5 µg/5 µg/2 µg, and 8 µg/8 µg/2.5 µg, respectively. These differences result in more severe local adverse effects in vaccinees and would complicate booster strategies in Japan. Aligning Japan's immunization policies with international practices represents a critical step toward ensuring individual health and public safety in increasingly globalized sports environments."

Journal • Chronic Cough • Cough • Infectious Disease • Novel Coronavirus Disease • Pertussis • Respiratory Diseases • Tetanus

CosTaR: Concurrent Versus Sequential Administration of Tdap and RSV Vaccines in Pregnancy (clinicaltrials.gov) - P4 | N=60 | Not yet recruiting | Sponsor: Canadian Immunization Research Network

New P4 trial • Infectious Disease • Pertussis • Respiratory Diseases • Respiratory Syncytial Virus Infections • Tetanus

A Phase I/II Study to Evaluate the Safety and Immunogenicity of GC3111B in Healthy Adults (clinicaltrials.gov) - P1/2 | N=120 | Recruiting | Sponsor: GC Biopharma Corp | Not yet recruiting ➔ Recruiting

Enrollment open • Infectious Disease • Pertussis • Respiratory Diseases • Tetanus

A Phase I/II Study to Evaluate the Safety and Immunogenicity of GC3111B in Healthy Adults (clinicaltrials.gov) - P1/2 | N=120 | Not yet recruiting | Sponsor: GC Biopharma Corp

New P1/2 trial • Infectious Disease • Pertussis • Respiratory Diseases • Tetanus

Extension study of DV2-TDAP-01 to assess immunogenicity of Tdap-1018 to pertussis antigens. (ANZCTR) - P=N/A | N=57 | Completed | Sponsor: Dynavax Technologies Corporation | Recruiting ➔ Completed

Trial completion • Infectious Disease • Pertussis • Respiratory Diseases • Tetanus

Acellular Pertussis Vaccine Given in the Week After Birth Does Not Impair Antibody Responses to Later Childhood Doses. (PubMed, Pediatr Infect Dis J) - "A birth dose of acellular pertussis vaccine does not impair antibody responses to booster doses of pertussis vaccines and may be an alternative for protection against early infant pertussis when pertussis booster has not been administered during pregnancy."

Journal • Hepatitis B • Hepatology • Infectious Disease • Inflammation • Pertussis • Respiratory Diseases • Tetanus

A Study on the Safety and Immune Responses to the GVGH altSonflex1-2-3 Vaccine Against Shigellosis in Adults, Children, and Infants (clinicaltrials.gov) - P1 | N=552 | Active, not recruiting | Sponsor: GlaxoSmithKline | Recruiting ➔ Active, not recruiting | Phase classification: P1/2 ➔ P1

Enrollment closed • Phase classification

Safety and Immunogenicity of a Novel Conjugate Vaccine Against Salmonella Typhi and Salmonella Paratyphi A in Healthy Adults (clinicaltrials.gov) - P1 | N=97 | Completed | Sponsor: GlaxoSmithKline | Recruiting ➔ Completed

Trial completion • Infectious Disease

Immunogenicity and Safety of BPZE1 Intranasal Pertussis Vaccine in Healthy School-age Children (clinicaltrials.gov) - P2 | N=367 | Completed | Sponsor: ILiAD Biotechnologies | Active, not recruiting ➔ Completed

Trial completion • Cough • Infectious Disease • Pertussis • Respiratory Diseases