IL-12-armored STEAP1 CAR-T / Fred Hutchinson Cancer Center, Promicell Therap - LARVOL DELTA

Collagen-binding IL-12-armored STEAP1 CAR-T cells for advanced prostate cancer (AACR 2026) - "The CAR-T therapy generated durable anti-tumor immune memory to STEAP1 and other antigens. Our findings suggest that CBD fusion can localize potent but toxic immunomodulators such as IL-12 to the tumor site, offering a promising strategy to improve the safety and effectiveness of CAR-T therapies for solid tumors."

CAR T-Cell Therapy • IO biomarker • Metastases • Castration-Resistant Prostate Cancer • Genito-urinary Cancer • Hematological Malignancies • Melanoma • Oncology • Prostate Cancer • Solid Tumor • CD40 • CD80 • CD86 • CSF2 • CXCL12 • CXCL13 • CXCL9 • CXCR4 • CXCR5 • IFNG • IL12A • STEAP1 • TNFSF4