BN-107 / Bionovo - LARVOL DELTA

Natural variation in glycine-rich region of Brassica oleracea cold shock domain protein 5 (BoCSDP5) is associated with low temperature tolerance. (PubMed, Genes Genomics) - "LT-tolerant allele (BoCSDP5v) is dominant and independent of CBF pathway, and sufficient to generate molecular markers to identify LT-tolerant cabbage when it is used in combination with another marker, like BoCCA1-derived one. Production and analysis of overexpressing plants of BoCSDP1, BoCSDP3, BoCSDP5 and BoCSDP5v will be required for elucidating the function of CCHC zinc finger domains in LT-tolerance."

Journal

Bionovo announces publication describing first novel dual mTOR inhibitor, BN107, for the treatment of breast cancer (PipelineReview) - Breast cancer cells lacking ERs are highly sensitive to BN107; Disruption of mTOR signaling mediated by both mTORC1 & mTORC2 complexes is most likely responsible for the anti-tumor effect of BN107

"Dr. Ning Zhou’s #COVID19 #pneumonia #myocarditis 50 yo👨 EF45% incubated, hypoxemia⬆️,put on VV #ECMO BNP1077 cTnl 217 CRP 70 #Yessct👇cleared w ECMO Do VV ECMO before intubation? Early before OI<100? @willsuh76 @atunuguntla1 @DeeDeeWangMD @SVRaoMD @ajaykirtane @arnavkumar" (@iamritu)