Humalog Mix 50/50 (insulin lispro protamine 50% + insulin lispro 50%) / Eli Lilly - LARVOL DELTA

Humalog Mix50wmassive overdose for suicidal purpose: a case report (ECE 2017) - "The dose is correlated with a prolonged hypoglycemic risk higher than that deduced from the pharmacokinetics of insulin administered. To our knowledge this case represents the largest overdose with Humalog Mix50wever reported."

Clinical • Biosimilar • Cardiovascular • Depression • Diabetes • Diabetic Nephropathy • Obesity

Injection force and dose accuracy of FlexTouch for the delivery of a new basal insulin (Expert Opin Drug Deliv) - "...all tested doses from KP filled with insulin lispro mix 75/25 100 U/ml were within ISO limits, while some doses from SS filled with insulin glargine 100 U/ml were outside ISO limits. FT had a significantly lower injection force than SS and KP (p < 0.05)."

Clinical • Diabetes

Sexual Differences in response to Mid- or Low-Premixed Insulin Analogue in Patients with Type 2 Diabetes. (PubMed, J Diabetes Res) - "After screening, patients with longstanding T2D receive a 7-day continuous subcutaneous insulin infusion (CSII) therapy, and then subjects were randomly assigned 1 : 1 into two groups receiving Novo Mix 30 or Humalog Mix 50 regimen for a 2-day phage, followed by a 4-day cross-over period. Our data indicate that male patients with T2D receiving mid-premixed insulin analogue regimen may have a potential benefit of improvement in glycemic control compared to female patients. This trial is registered with ClinicalTrials.gov ChiCTR-IPR-15007340."

Clinical • Journal

Comparison of analog insulin mix 50:50 with human insulin mix 30:70 in persons with type 2 diabetes during Ramadan. (PubMed, Int J Clin Pract) - "Switching from human insulin mix 30:70 to analog insulin mix 50:50 results in better post main meal control in Ramadan, without affecting HbA1c, or increasing the incidence of hypoglycaemia."

Journal

COST-MINIMIZATION ANALYSIS OF INSULIN LISPRO 50/50 VERSUS INSULIN ASPART 30/70 PREMIXED FORMULATIONS IN TYPE II DIABETES (ISPOR-EU 2019) - "Insulin Mix Lispro 50/50 would be a dominant strategy compared to Insulin Mix Aspart 30/70 assuming the same product price."

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