Salicyn-30 / Sorrento - LARVOL DELTA

Associations of plasma GFAP and P-tau217 with imaging ATN markers and cognitive decline across Centiloid scales. (PubMed, Lancet Reg Health West Pac) - "2018SHZDZX01), STI2030-Major Projects (Grant No. 2022ZD0213800), and Shanghai Medical Innovation and Development Foundation "Brain Health Youth Fund-Precision Diagnosis and Treatment Research on Alzheimer's Disease" (Grant No. SMIDF-150-2025A30)."

Journal • Alzheimer's Disease • CNS Disorders • Cognitive Disorders • Dementia • GFAP

Short tandem repeat expansions in patients with neurodegenerative dementia. (PubMed, EBioMedicine) - "Our findings provide evidence for the clinical pleiotropy of STRs in NDD and their involvement in NDD pathogenesis."

Journal • Alzheimer's Disease • CNS Disorders • Dementia • Frontotemporal Lobar Degeneration • Lewy Body Disease • Movement Disorders • Progressive Supranuclear Palsy • ATXN8OS • CACNA1A • PPP2R2B

Efficacy and safety of perospirone as adjunctive therapy in major depressive disorder patients with inadequate response to antidepressants: a randomized clinical trial. (PubMed, EClinicalMedicine) - P4 | "Adjunctive therapy with a second-generation antipsychotic (SGA) represents a treatment option for major depressive disorder (MDD) patients with inadequate response to antidepressants. Further confirmatory randomized controlled trials are warranted to validate these findings. The study was supported by the STI2030-Major Projects (grant 2021ZD0202000), National Natural Science Foundation of China (grant 82201693 and 82471555), Hunan Provincial Natural Science Outstanding Youth Foundation (grant 2025JJ20093), Science and Technology Innovation Program of Hunan Province (grant 2024RC3057), Sanming Project of Medicine in Shenzhen (grant SZSM202311025), and Reboscience (Zhuhai) Pharmaceutical Research Co., Ltd., and sponsored by Livzon Pharmaceutical Group Inc."

Clinical • Journal • CNS Disorders • Depression • Major Depressive Disorder • Mood Disorders • Psychiatry

Anti-BCMA CAR-T cell therapy in relapsed/refractory chronic inflammatory demyelinating polyneuropathy. (PubMed, Med) - P1 | "This study demonstrates the safety and potential of anti-BCMA CAR-T cell therapy in treating refractory CIDP and provides insights into the molecular mechanisms underlying patient responses (ClinicalTrials.gov: NCT04561557)."

Journal • Infectious Disease • Novel Coronavirus Disease • Pain

Development and validation of machine learning models with blood-based digital biomarkers for Alzheimer's disease diagnosis: a multicohort diagnostic study. (PubMed, EClinicalMedicine) - "These spectral features serve as digital biomarkers, providing valuable support in the early screening and diagnosis of AD. The National Natural Science Foundation of China, STI2030-Major Projects, National Key R&D Program of China, Outstanding Youth Fund of Hunan Provincial Natural Science Foundation, Hunan Health Commission Grant, Science and Technology Major Project of Hunan Province, Hunan Innovative Province Construction Project, Grant of National Clinical Research Center for Geriatric Disorders, Xiangya Hospital and Postdoctoral Fellowship Program of CPSF."

Biomarker • Journal • Alzheimer's Disease • CNS Disorders • Cognitive Disorders • Dementia • Frontotemporal Lobar Degeneration • Geriatric Disorders • Lewy Body Disease • Movement Disorders • Progressive Supranuclear Palsy • GFAP

Heterogeneity of TSPO-PET Distribution Patterns Among Patients with Temporal Lobe Epilepsy (AES 2024) - "82272039, 82021002, 82394434 and 81971641); STI2030-Major Projects (2022ZD0211600)... The majority of TLE patients exhibit higher uptake of [18F]DPA-714 in the ipsilateral hemisphere with the clinically-defined epileptic focus, indicating ongoing neuroinflammation. But its distribution patterns may vary among patients. The outcome of TSPO-PET may be influenced by some clinical factors such as interval from last seizure to PET scan and seizure frequency."

Clinical • Heterogeneity • CNS Disorders • Epilepsy • Inflammation

Excessive Excitatory Synapses Drive Pathological Neurons to Hyperexcitability in a Mouse Model of Focal Cortical Dysplasia (AES 2024) - "Funding: This abstrat was supported by STI2030-Major Projects (2021ZD0202500, Y.S.), National Natural Science Foundation of China (32130044 and T2241002, Y.S.; 32100930, Q.H.), Program of Shanghai Academic/Technology Research Leader (21XD1400100, Y.S.), and China Postdoctoral Science Foundation (2020M681160, Q.H.)... Our results strongly suggest that excessive excitatory synaptic inputs may counteract with the low excitability in mutant neurons, leading to hyperexcitability in FCD."

Preclinical • CNS Disorders • Epilepsy • PIK3CA

Super-resolution ultrasound imaging reveals temporal cerebrovascular changes with disease progression in female 5×FAD mouse model of Alzheimer's disease: correlation with pathological impairments. (PubMed, EBioMedicine) - "Through high-resolution, in vivo imaging of cerebrovasculature, this study reveals significant spatiotemporal dysfunction in cerebrovascular dynamics accompanying disease progression in a mouse model of AD, enhancing our understanding of its pathophysiology."

Journal • Preclinical • Alzheimer's Disease • CNS Disorders

Uncovering distinct progression patterns of tau deposition in progressive supranuclear palsy using [F]Florzolotau PET imaging and subtype/stage inference algorithm. (PubMed, EBioMedicine) - "We present the evidence of distinct in vivo spatiotemporal tau trajectories in PSP. Our findings can contribute to precision medicine advancements for PSP."

Journal • CNS Disorders • Movement Disorders • Progressive Supranuclear Palsy

Non-suicidal self-injury in Chinese population: a scoping review of prevalence, method, risk factors and preventive interventions. (PubMed, Lancet Reg Health West Pac) - "This review was supported by Humanity and Social Science Youth foundation of Ministry of Education (22YJCZH018), Science and Technology Innovation 2030 (STI2030-Major Projects:2021ZD0200702), National Natural Science Foundation of China (81825009), and Shuimu Tsinghua Scholar. No funding agencies were involved in the data collection, data analysis, and writing of this paper."

Journal • Review