LTC004
/ Leto Laboratories
- LARVOL DELTA
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July 08, 2024
Study of LTC004 Combine With Toripalimab in Patient With Solid Tumors Resistant to Immunotherapy
(clinicaltrials.gov)
- P2 | N=10 | Recruiting | Sponsor: Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Combination therapy • Metastases • New P2 trial • Oncology • Solid Tumor
April 25, 2024
A phase I open-label study of a novel IL-2Rβ/γ cytokine agonist, LTC004, in patients with advanced or metastatic solid tumors.
(ASCO 2024)
- P1 | "A confirmed PR was achieved in a pMMR/MSS CRC patient with prior therapies including fluoropyrimidines, irinotecan, oxaliplatin, targeted therapy and TKI. LTC004 demonstrated encouraging anti-tumor efficacy including cold tumor, and well tolerated in patients with advanced or metastatic solid tumors. The further dose expansion in selected tumor types is ongoing, and evaluations in combination with other agents are being planned."
Clinical • Metastases • P1 data • Anemia • Colorectal Cancer • Gastric Cancer • Gastrointestinal Cancer • Hematological Disorders • Hypotension • Lung Cancer • Melanoma • Non Small Cell Lung Cancer • Oncology • Ovarian Cancer • Sarcoma • Solid Tumor • Thymic Carcinoma • Thymus Cancer • CD8
April 25, 2024
Phase II Clinical Study of LTC004 in Patients With mCRC
(clinicaltrials.gov)
- P1/2 | N=30 | Not yet recruiting | Sponsor: Letolab
Metastases • Monotherapy • New P1/2 trial • Colorectal Cancer • Gastrointestinal Cancer • Oncology • Solid Tumor
April 25, 2024
Phase II Clinical Study of LTC004 in Patients With Advanced Sarcoma
(clinicaltrials.gov)
- P1/2 | N=30 | Not yet recruiting | Sponsor: Letolab
Metastases • New P1/2 trial • Oncology • Sarcoma • Solid Tumor
March 21, 2024
Combination of LTC004 and Regorafenib to Treat Patients With Advanced/Metastatic CRC
(clinicaltrials.gov)
- P2 | N=20 | Not yet recruiting | Sponsor: Tianjin Medical University Cancer Institute and Hospital
Combination therapy • Metastases • New P2 trial • Colorectal Cancer • Gastrointestinal Cancer • Oncology • Solid Tumor
February 26, 2024
A Phase I Study of LTC004 Combin With FC in Patients With Advanced/Metastatic Malignancies Tumor
(clinicaltrials.gov)
- P1 | N=48 | Not yet recruiting | Sponsor: Letolab
Combination therapy • Metastases • New P1 trial • Oncology • Solid Tumor
February 16, 2024
LTC004-01: Clinical Trial for Advanced or Metastatic Pancreatic Cancer
(clinicaltrials.gov)
- P2 | N=26 | Not yet recruiting | Sponsor: Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Combination therapy • Metastases • New P2 trial • Gastrointestinal Cancer • Hepatology • Oncology • Pancreatic Cancer • Solid Tumor
December 28, 2022
Study of LTC004 in Subjects With Advanced Malignant Tumors
(clinicaltrials.gov)
- P1 | N=368 | Not yet recruiting | Sponsor: Letolab
Metastases • New P1 trial • Oncology • Solid Tumor • IL1B • IL6
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