Natacyn (natamycin) / Novartis - LARVOL DELTA

Randomised controlled trial of topical combination therapy chlorhexidine 0.2% and natamycin 5% versus topical natamycin 5% alone for fungal keratitis in East Africa: study protocol. (PubMed, Wellcome Open Res) - "Primary analysis (intention-to-treat) will be by linear regression, with treatment arm and baseline BSCVA pre-specified covariates. Secondary outcomes include epithelial healing time, scar/infiltrate size, ulcer depth, hypopyon size, perforation and/or therapeutic penetrating keratoplasty, and positive re-culture rate."

Journal • Infectious Disease • Keratitis • Ocular Infections • Ocular Inflammation • Ophthalmology • Transplantation

Moderation of cross linkage of sodium alginate-polyethylene oxide films loaded with natamycin for treatment of Aspergillus fumigatus keratitis. (PubMed, J Mater Sci Mater Med) - "SA-PEO membranes could reduce the inflammatory response. Conclusively, NATA-SA-PEO films could be considered a useful approach to prolong ocular natamycin maintenance and improve the outcome of fungal keratitis."

Journal • Inflammation • Keratitis • Ocular Inflammation • Ophthalmology

SARS-CoV-2 infection enhancement by amphotericin B: implications for disease management. (PubMed, J Virol) - "Subsequently, we investigated the impact of AmB, nystatin, natamycin, fluconazole, and caspofungin on SARS-CoV-2 infection and replication in vitro. The magnitude of enhancement could be up to 10- or 100-fold, depending on cell lines used. These findings indicate that AmB and nystatin have the potential to enhance disease when given to patients infected with SARS-CoV-2 and therefore should not be used for treatment of fungal infections in active COVID-19 cases."

Journal • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases • IFITM3

Efficacy of natamycin to reduce adhesion and biofilm formation of multispecies yeast biofilms on variable flow conditions. (PubMed, Biofouling) - "This highlights the importance of preventing initial adhesion for controlling biofilm development. Additionally, these findings underscore the importance of evaluating antimicrobial agents in dynamic flow conditions that closely mimic real-world applications."

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Pectin and natamycin coating improves the quality and fungal diversity of jujube. (PubMed, Int J Biol Macromol) - "Consequently, PNC demonstrated potential in effectively enhancing the physicochemical properties and modulating the fungal community composition of jujube during refrigeration. The outcomes of this study will offer valuable insights for strategies in fruit preservation."

Journal • Infectious Disease

Deep Fungal Stromal Keratitis After Cataract Surgery: A Case Report. (PubMed, Cureus) - "Initial treatment with natamycin and fluconazole was ineffective, and the infection progressed despite topical and systemic voriconazole. This case illustrates the diagnostic value of in vivo confocal microscopy in deep stromal fungal keratitis. It emphasizes the importance of selecting appropriate antifungal agents when first-line treatments are ineffective."

Journal • Cataract • Infectious Disease • Keratitis • Ocular Inflammation • Ophthalmology • Transplantation

Clinical and microbiological profile of patients with fungal keratitis demonstrating unusual yeast-like structures in potassium hydroxide with calcofluor white preparation of corneal scraping. (PubMed, J Ophthalmic Inflamm Infect) - "Atypical structures resembling yeast-like cells detected in direct smear examination in the absence of growth in culture media should raise the suspicion of a fungal etiology and warrant further investigations to establish the diagnosis."

Journal • Keratitis • Ocular Infections • Ocular Inflammation • Ophthalmology • Transplantation

Retrospective Review of Fungal Keratitis at Two Tertiary Hospitals in Perth, Western Australia Between 2006 and 2022. (PubMed, Mycoses) - "Results were largely consistent with previous studies in the Australian context. Fusarium species and Candida albicans were the most common pathogens isolated. Prior topical corticosteroid use was the most common predisposing risk factor, followed closely by contact lens wear and ocular surface disease. A large proportion of patients experienced corneal perforations and required penetrating keratoplasty."

Journal • Retrospective data • Keratitis • Mood Disorders • Ocular Inflammation • Ophthalmology • Transplantation

Macrophomina phaseolina keratitis: treatment approach for poor response to topical natamycin. (PubMed, BMJ Case Rep) - "Corneal scraping showed fungal hyphae on smears and was later identified as Macrophomina phaseolina Despite hourly topical natamycin 5% and oral ketoconazole, the infiltrates progressed in a migrating ring pattern. After 5 months, the infiltrate resolved without recurrence. This case highlights Macrophomina keratitis which mimicked Nocardia and Pythium infections and demonstrates successful treatment with topical voriconazole."

Journal • Infectious Disease • Keratitis • Mood Disorders • Ocular Infections • Ocular Inflammation • Ophthalmology • Pain

Advancing fungal keratitis treatment: transitioning from conventional amphotericin B therapy to nanocarrier-based delivery systems. (PubMed, Naunyn Schmiedebergs Arch Pharmacol) - "Commercially available topical antifungal formulations are natamycin (5%), voriconazole (1%), fluconazole (0.2-0.5%), itraconazole (1%), and amphotericin B (0.15%). It discusses various nanocarrier strategies, their pharmacokinetics, and preclinical and clinical advancements. By bridging the gap between conventional treatments and modern nanotechnology, this review underscores the potential of nanocarriers to revolutionize FK treatment, offering more effective and patient-friendly therapeutic solutions."

Journal • Review • Infectious Disease • Keratitis • Ocular Infections • Ocular Inflammation • Ophthalmology

In vitro activity of novel antifungals, natamycin, and terbinafine against Fusarium. (PubMed, Antimicrob Agents Chemother) - "In this article, we assessed the in vitro activity of the novel antifungals olorofim, manogepix, rezafungin, and ibrexafungerp, as well as the established but nonstandard drugs, natamycin and terbinafine, against a large set of molecularly identified clinical Fusarium isolates via EUCAST microdilution. Furthermore, we report specific susceptibilities for terbinafine against FDSC, FFSC, and FOSC species. These findings of complex- and species-specific olorofim and terbinafine in vitro susceptibilities highlight the need for diagnostics below genus level."

Journal • Preclinical • Infectious Disease • Keratitis • Ocular Infections • Ocular Inflammation • Ophthalmology

Profiling Drug Susceptibility and Species Identification of Aspergillus Isolates From Patients With Superficial Infection. (PubMed, Mycoses) - "Multi-gene sequencing outperformed MALDI-TOF for Aspergillus identification. A. terreus dominance and micafungin resistance highlight regional epidemiological trends. Natamycin and nystatin remain cost-effective first-line topical options. Enhanced surveillance in trauma-prone and environmentally exposed populations is warranted."

Journal • Infectious Disease • Mood Disorders • Pulmonary Disease • Respiratory Diseases

Antifungal susceptibility and clinical efficacy of chlorhexidine combined with topical ophthalmic medications against Fusarium species isolated from corneal samples. (PubMed, Front Cell Infect Microbiol) - "This study investigated the susceptibility of various Fusarium fungi to five topical antifungal agents: natamycin, voriconazole, chlorhexidine, natamycin combined with chlorhexidine, and voriconazole combined with chlorhexidine. The findings of this study provide valuable guidance for establishing the epidemiological cutoff and clinical MIC values for Fusarium spp. This study paves the way for future multicenter studies on the treatment of FK with natamycin and chlorhexidine."

Journal • Infectious Disease • Keratitis • Ocular Inflammation • Ophthalmology • Transplantation

Therapeutic Efficacy of Ultraviolet C Light on Fungal Keratitis-In Vitro and Ex Vivo Studies. (PubMed, Antibiotics (Basel)) - "Two treatment groups were tested: (1) UVC exposure (265 nm, 1.93 mW/cm2) for durations of 0 s, 5 s, 10 s, 15 s, 30 s, 60 s, or 120 s, and (2) UVC combined with antifungal drugs (Amphotericin B and Natamycin) at their minimum inhibitory concentrations (MICs), determined in YPD broth...Ex vivo, 15 s and 30 s UVC inhibited growth (p = 0.0476), but no differences were seen between groups (all p > 0.05). UVC demonstrated strong antifungal efficacy, with supplementary benefits from combining UVC with low doses of antifungal drugs."

Journal • Preclinical • Infectious Disease • Keratitis • Ocular Infections • Ocular Inflammation • Ophthalmology

Preparation and Application of Edible Chitosan Coating Incorporating Natamycin. (PubMed, Polymers (Basel)) - "The malondialdehyde (MDA) content and peroxidase (POD) activity were decreased by 19.38% and 28.03%, respectively. Based on the significant preservation effect of the composite coating, it is expected to be widely used in the preservation of fruits and vegetables with skin morphologies similar to cherry tomatoes."

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Lasiodiplodia keratitis: A case series of 27 patients. (PubMed, Indian J Ophthalmol) - "Medical management with natamycin was effective in treating patients with Lasiodiplodia keratitis. However, advanced cases necessitated surgical intervention for complete resolution."

Journal • Infectious Disease • Keratitis • Mood Disorders • Ocular Infections • Ocular Inflammation • Ophthalmology

A case of corneal infection with Clonostachys rosea. (PubMed, BMC Infect Dis) - "Herein, we describe a case of corneal infection attributed to Clonostachys rosea. We outline the development and treatment of this infection to enhance clinical comprehension and management of similar cases."

Journal • Infectious Disease • Keratitis • Ocular Inflammation • Ophthalmology • Pain

A convenient and rapid LC-MS/MS method for determination of free and liposomal amphotericin B in human plasma by simultaneous separation using SPE. (PubMed, J Pharm Biomed Anal) - "The analyte and internal standard (natamycin) were separated on a ZORBAX Eclise XDB C18 column (2.1 × 50 mm, 3.5 μm) with gradient elution at a flow rate of 0.5 mL/min, employing a mobile phase that consisted of methanol (0.1 % formic acid) and 5 mM ammonium acetate solution (0.1 % formic acid). Using our methodology, we quantified F-AMB and L-AMB without mutual interferences and obtained excellent incurred sample reanalysis (ISR) results for both analytes. The method was also successfully applied to a clinical study in healthy volunteers."

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Keratomycosis: An insight into epidemiology, etiology and antifungal Susceptibility testing of causative agents at a tertiary care centre. (PubMed, Med Mycol) - "Overall, MIC values for natamycin and amphotericin B were high in Aspergillus sp...had high MIC for voriconazole and itraconazole. Candida sp, Curvularia and Alternaria sp had high MIC values for fluconazole. As mycotic keratitis is an infective condition involving healthy eyes, leading to morbid eye conditions and even blindness, strong clinical suspicion of fungal keratitis followed by timely diagnosis and antifungal susceptibility testing based treatment may help the clinicians in better management and improvement of the outcome of patients."

Journal • Keratitis • Mood Disorders • Ocular Infections • Ocular Inflammation • Ophthalmology

Enhanced Natamycin production in Streptomyces gilvosporeus through phosphate tolerance screening and transcriptome-based analysis of high-yielding mechanisms. (PubMed, Microb Cell Fact) - "Our findings suggest that the high production performance of GR-2 is primarily due to the upregulation of the natamycin biosynthetic gene cluster and genes related to precursor supply. Increasing the intracellular supply of valine and glutamate significantly enhanced natamycin production. Additionally, the natamycin biosynthetic gene cluster is likely positively regulated by PhoP and PhoR. Our work presents a novel strategy for strain screening and evolution to improve natamycin production and identifies novel molecular targets for metabolic engineering."

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FANCY: Fungal Ulcer Treatment Augmented With Natamycin and Cyclosporine A (clinicaltrials.gov) - P3 | N=150 | Not yet recruiting | Sponsor: University of California, San Francisco | Trial completion date: Jan 2027 ➔ Jun 2027 | Initiation date: Jan 2025 ➔ Jun 2025 | Trial primary completion date: Jan 2027 ➔ Jun 2027

Trial completion date • Trial initiation date • Trial primary completion date • Keratitis • Ocular Inflammation • Ophthalmology

Simple preparation of biodegradable, superhydrophobic, and antifungal cellulose filter paper for efficient oil/water separation. (PubMed, Int J Biol Macromol) - "The process involved coating a sodium alginate/hydroxyapatite/natamycin (ALG-HA-NA) solution onto a commercial filter paper using a simple vacuum filtration method, followed by CaCl2 crosslinking and beeswax treatment under ambient conditions...The release of NA mass by immersing the ALG-HA-NA-1@C sample in water was fitted to a zero-order kinetic model, exhibiting a diffusion coefficient of 3.43 × 10-10 cm2 s-1. The proposed approach offers an alternative perspective for the fabrication of superhydrophobic paper for environmental remediation and oil spill cleanup."

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Sodium benzoate, potassium sorbate, and natamycin levels in doogh from Sulaymaniyah, Kurdistan region of Iraq and health risk assessment. (PubMed, Food Addit Contam Part B Surveill) - "Hazard quotient (HQ) data of SB and PS in doogh were below 1. Based on these findings, the obtained levels of preservatives in doogh do not pose a health risk to Iraqi consumers."

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Enhancement of natamycin production by combining ARTP mutagenesis with temperature control strategy development in Streptomyces gilvosporeus. (PubMed, Bioprocess Biosyst Eng) - "Under this strategy, the natamycin production reached 14.4 g·L-1, representing a 25.2% increase compared to constant temperature fermentation at 28 ℃. This study provided an efficient production strategy for natamycin."

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Use of Natamycin for the Development of Polymer Systems with Antifungal Activity for Packaging Applications. (PubMed, Polymers (Basel)) - "The results show that PCL with 5% Natamycin represents an effective biodegradable alternative to EVA for inhibiting undesirable filamentous fungi. More specifically, both systems at 5% showed comparable inhibition zones of about 30 mm."

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