Natacyn (natamycin) / Harrow Health, Clinigen, Santen - LARVOL DELTA

Efficacy of natamycin monotherapy versus combination therapy with voriconazole for fungal keratitis: a randomised clinical trial. (PubMed, Br J Ophthalmol) - P2/3 | "Adjunctive topical voriconazole did not significantly improve clinical outcomes compared with natamycin monotherapy. Natamycin 5% remains an effective first-line treatment, particularly in non-Aspergillus keratitis. Further studies are warranted to explore targeted roles for combination therapy."

Journal • Monotherapy • Infectious Disease • Keratitis • Ocular Inflammation • Ophthalmology • Transplantation

Malassezia pachydermatis Acquires Resistance to Polyenes in the Laboratory Model. (PubMed, Pathogens) - "This study presents a model investigation into the development of tolerance to polyene antifungal drugs (nystatin and natamycin) in strains of Malassezia pachydermatis. Such an approach may support targeted therapy development and help identify strains predisposed to drug adaptation. These findings hold promise for assessing therapeutic risk in immunosuppressed patients and for building resistance datasets that can support artificial intelligence algorithms in predicting fungal resistance mechanisms."

Journal • Gastrointestinal Disorder • Infectious Disease

Clinical profile and outcomes of dematiaceous fungal keratitis - data from a secondary center in rural North India. (PubMed, J Ophthalmic Inflamm Infect) - "Despite prolonged healing, DFK has a high resolution rate with appropriate medical therapy, minor procedures, and complete debridement. Poor prognostic factors include large and deep infiltrates, hypopyon, and prior steroid use."

Journal • Keratitis • Mood Disorders • Ocular Inflammation • Ophthalmology • Transplantation

Fungal keratitis: Does antifungal Resistance Influence the outcome? (PubMed, Int Ophthalmol) - "Although the outcomes are multifactorial, antifungal resistance seems to influence the prognosis of fungal keratitis."

Journal • Retrospective data • Keratitis • Ocular Inflammation • Ophthalmology • Transplantation

Fluorescent Probes Derived from the Polyene Class of Antifungal Drugs Reveal Distinct Localization Patterns and Resistance-Associated Vacuolar Sequestration in Candida Species. (PubMed, Angew Chem Int Ed Engl) - "Amphotericin B, nystatin, and natamycin are the only polyene antifungals in clinical use and remain last-resort therapies for severe fungal infections. These findings suggest that vacuolar sequestration contributes to polyene resistance and may represent an unrecognized aspect of the fungal stress response. More broadly, this work provides the first direct visual evidence that polyene structure dictates subcellular distribution patterns in fungal cells."

Journal • Infectious Disease

A review of technological advances in the management of bacterial, fungal, viral, and Acanthamoeba keratitis. (PubMed, Clin Exp Optom) - "For fungal keratitis, ocular natamycin, with oral ketoconazole or voriconazole treatments, offer improved outcomes for severe cases. Beyond antibiotics, photoactivated chromophores for keratitis-corneal collagen cross-linking and photodynamic therapy have been successfully used. Therapies for large ulcers or scarring include corneal gluing, tissue scaffolds such as amniotic membrane or conjunctival flaps, and tissue replacement through penetrating or lamellar keratoplasty."

Journal • Review • Infectious Disease • Keratitis • Mood Disorders • Ocular Infections • Ocular Inflammation • Ophthalmology • Transplantation

Development and Validation of a QuEChERS-Based LC-MS/MS Method for Natamycin in Imported Agricultural Commodities in Korea. (PubMed, Foods) - "Matrix effects were classified as "soft" for mandarin (|ME| < 20%) and "medium" for soybean, hulled rice, green pepper, and potato (20% ≤;ME| < 50%). The analytical method for natamycin was validated as suitable for regulatory safety monitoring under the Korean PLS."

Journal

Abundant organic nitrogen enhances natamycin biosynthesis by increasing NAD(P) metabolic pathway activity in Streptomyces gilvosporeus F607. (PubMed, Front Microbiol) - "Supplementation of S. gilvosporeus F607 with 10 mg/L NMN and overexpression of a site-directed mutant enzyme (NadDsgRYKK, at positions of R17Y20K26R168) promoted natamycin biosynthesis by 43.1%, increasing production from 4.67 g/L to 6.68 g/L. These findings indicate that an abundance of organic nitrogen primarily enhances natamycin biosynthesis by elevating NAD(P) levels, providing valuable insights for medium optimization and strain engineering toward high-yield natamycin production."

Journal

Towards elucidating the solar instability of the anti-fungal food preservative natamycin: insights from spectroscopy. (PubMed, Phys Chem Chem Phys) - "A photoproduct was isolated and characterised, and identified as being formed through a combination of isomerisation and epoxide ring-opening pathways. The insight garnered into the photodynamics of natamycin may facilitate design of next generation UV photostabilisers which protect natamycin against UV-induced degradation."

Journal

Cost-effective natamycin production by Streptomyces lydicus JCK-6019 via solid-state fermentation and development of a bioproduct with fungicidal and plant growth-promoting activities. (PubMed, Pest Manag Sci) - "This study showed a cost-effective and eco-friendly approach for natamycin production from agro-industrial by-products, highlighting its SSF product potential as a stable biofungicide and plant growth promoter in sustainable agriculture."

HEOR • Journal

A Case Report and Global Perspective on Fusarium Superficial Keratitis in the Pediatric Population. (PubMed, Cureus) - "Treatment with topical natamycin and voriconazole led to complete healing without surgery. This case highlights the need for early recognition, rapid microbiological confirmation, and appropriate antifungal therapy in pediatric fungal keratitis, while underscoring the dangers of unsupervised corticosteroid use in endemic regions."

Journal • CNS Disorders • Infectious Disease • Keratitis • Ocular Inflammation • Ophthalmology • Pediatrics

Biomimetic Nanomicelles: Utilizing Peptide Transporters to Overcome Corneal Barrier for Treating Fungal Infection. (PubMed, Mol Pharm) - "PeNatcel showed comparable activity against Candida albicans at 4 times a day dosing frequency compared to 12 times a day marketed 5% natamycin suspension. Consequently, the developed peptide transporter-specific ligand-conjugated nanomicelles delivery system can also be explored further for other water-insoluble and poorly permeable drugs."

Journal • Infectious Disease

Trial to Evaluate the Efficacy And Safety of IVIEW-1201 In the Treatment of Fungal Keratitis (clinicaltrials.gov) - P2 | N=60 | Not yet recruiting | Sponsor: IVIEW Therapeutics Inc. | Trial completion date: Dec 2026 ➔ Dec 2027 | Trial primary completion date: Dec 2026 ➔ Dec 2027

Trial completion date • Trial primary completion date • Keratitis • Ocular Inflammation • Ophthalmology

Molecular characterization and antifungal susceptibility profile of Podospora bulbillosa keratitis: case series and review of literature. (PubMed, J Mycol Med) - "Notably, all five P. bulbillosa isolates clustered within a single subclade, indicating close genetic relatedness. Podospora bulbillosa keratitis responds well to standard antifungal agents. Molecular tools are crucial for accurate identification of rare, non-sporulating fungal pathogens."

Journal • Infectious Disease • Keratitis • Mood Disorders • Ocular Inflammation • Ophthalmology

An experimental study of the investigation of post-harvest fungal control potential of natamycin-loaded chitosan nanoparticles: synthesis, characterization, and antifungal activity analyses. (PubMed, 3 Biotech) - "In situ tests on apple wounds demonstrated a reduction in fungal growth ranging from 24 to 30% at a concentration of 20 mg/L, with protection lasting up to 5 days. These findings highlight the potential of Nat-Chi-NPs as an effective and eco-friendly nanobiotechnological system for the control of post-harvest fungal infections in fruits and vegetables."

Journal • Infectious Disease

FANCY: Fungal Ulcer Treatment Augmented With Natamycin and Cyclosporine A (clinicaltrials.gov) - P3 | N=150 | Recruiting | Sponsor: University of California, San Francisco | Not yet recruiting ➔ Recruiting | Trial completion date: Jun 2027 ➔ Sep 2027 | Initiation date: Jun 2025 ➔ Sep 2025 | Trial primary completion date: Jun 2027 ➔ Sep 2027

Enrollment open • Trial completion date • Trial initiation date • Trial primary completion date • Keratitis • Ocular Inflammation • Ophthalmology

Pathogenesis and treatment strategies for infectious keratitis: Exploring antibiotics, antimicrobial peptides, nanotechnology, and emerging therapies. (PubMed, J Pharm Anal) - "This review examines standard therapeutic agents for treating IK, including broad-spectrum empiric antibiotics for bacterial keratitis (BK), antifungals such as voriconazole and natamycin for fungal infections, and antiviral nucleoside analogues for viral keratitis (VK). Furthermore, methods of Photodynamic Antimicrobial Therapy (PDAT) are explored. This review underscores the importance of integrating novel and traditional therapies to tackle drug resistance and enhance drug delivery, with the goal of advancing treatment strategies for IK."

Journal • Review • Infectious Disease • Inflammation • Keratitis • Mood Disorders • Ocular Infections • Ocular Inflammation • Ophthalmology

Enhancement of natamycin production in Streptomyces gilvosporeus through heavy ion beam mutagenesis and global transcription machinery engineering. (PubMed, J Biotechnol) - "gilvosporeus EP-whiG achieved a natamycin production of 13.1g·L-1 in a 5-L bioreactor within 120h by fed-batch fermentation, which was 61.7% higher than that of the wild-type strain. These results suggest that combining heavy ion beam mutagenesis with global transcription machinery engineering is an effective strategy for strain improvement, laying a theoretical foundation for enhancing the production of secondary metabolites in Streptomyces."

Journal

Predictors of Vision-Related Quality of Life in Patients Treated for Filamentous Fungal Keratitis. (PubMed, Ocul Surf) - "Vision-related QoL after fungal keratitis is significantly influenced by change in visual acuity, need for surgical intervention, and select baseline factors including scar size, initial IND-VFQ score, and presence of hypopyon. Vision-related QoL did not differ by antifungal treatment or adjuvant CXL use."

HEOR • Journal • Infectious Disease • Keratitis • Ocular Inflammation • Ophthalmology

Scedosporium-induced keratitis: insights from a case study. (PubMed, J Ophthalmic Inflamm Infect) - " Pseudallescheria boydii is a soil saprophytic, uncommon fungi entering body via respiratory or penetrating injury. It is often mistaken as Aspergillosis, This fungi shows resistance to amphotericin B, flucytosine and susceptible to triazoles. Surgical resection of lesion shows better outcome. The response of disseminated infection to combination therapy with interferon gamma and antifungal agents is encouraging."

Journal • Infectious Disease • Keratitis • Ocular Inflammation • Ophthalmology • Pain • Pulmonary Disease • Respiratory Diseases • Transplantation • IFNG

Scedosporium apiospermum and Lomentospora prolificans emergent ocular infections in North India. (PubMed, Indian J Ophthalmol) - "Medical management alone with natamycin was successful in two cases, while other patients required surgical intervention in addition to medical management...Oral and topical antifungals along with surgical management (therapeutic penetrating keratoplasty) were successful for the treatment of S. apiospermum/L. prolificans oculomycosis involving the posterior segment of the eye."

Journal • Retrospective data • Infectious Disease • Keratitis • Mood Disorders • Ocular Infections • Ocular Inflammation • Ophthalmology • Transplantation

Correlation between corneal concentration and minimum inhibitory concentration of antifungals in patients undergoing therapeutic keratoplasty for fungal keratitis. (PubMed, Indian J Ophthalmol) - "Despite achieving corneal concentration higher than the MIC-90, cases with recalcitrant fungal keratitis had a poor clinical response to NTM, suggesting other possible reasons, such as poor drug penetration and drug resistance."

Journal • Keratitis • Ocular Inflammation • Ophthalmology • Transplantation

Influence of Geographical Origin and Processing Methods on Biopreservatives, Heavy Metals, Lipid Quality Indices, and Aflatoxin M1 in Imported Cheeses: A Public Health Concern. (PubMed, Food Sci Nutr) - "The findings showed the presence of nisin A and nisin Z presence in a few samples, while natamycin was detected in only one soft cheese in an amount below the regulatory limit...The current study also strongly emphasized the need for improved quality control measures and regular monitoring of dairy products to ensure consumer safety and compliance with international health standards. In addition, it strongly recommends further research to better understand the long-term effects of these pollutants on public health."

Journal

Two Cases of Curvularia geniculata Keratitis Successfully Treated with Natamycin-Based Therapy. (PubMed, Mycopathologia) - "Patient 1 was treated with a combination of topical natamycin and voriconazole, while Patient 2 received natamycin monotherapy. The choice between monotherapy and combination therapy may be guided by clinical severity and antifungal susceptibility testing. This report contributes to the understanding of the clinical features, diagnosis, and management of this rare condition and highlights the potential value of susceptibility testing in guiding treatment decisions."

Journal • Keratitis • Mood Disorders • Ocular Inflammation • Ophthalmology

Comparative Study of Natamycin Encapsulation in Liposomes: Thin-Film vs. Proliposome Methods for Enhanced Stability, Controlled Release, and Efficacy Against Milk Spoilage and Pathogenic Microorganisms. (PubMed, Foods) - "The stability study indicated that these systems were stable over a 60-day storage period, as the zeta potential of all formulations was ~-25 mV. Satisfactory antimicrobial performance of the developed liposomes against Listeria monocytogenes, Yersinia enterocolitica, Candida tropicalis, Candida parapsilosis, and Aspergillus flavus (MIC values from 0.00625 to 4 mg/mL) indicates that loading of natamycin into liposomal carriers was an adequate method for their encapsulation and delivery in the milk industry."

Journal • Gastrointestinal Disorder