triptorelin acetate depot (ISR048) / ISR Immune System Regulation - LARVOL DELTA

Sustained In-Vivo Release of Triptorelin Acetate from a Biodegradable Silica Depot: Comparison to Pamorelin LA. (PubMed, Nanomaterials (Basel)) - "The resulting microparticles were then combined with another silica sol containing silica nanoparticles, which together formed an injectable silica-triptorelin acetate depot. The depot also showed a comparable sustained triptorelin release and equivalent pharmacodynamic effect as the Pamorelin injections. Detectable triptorelin plasma concentrations were seen with the depot after the 91-day study period and testosterone plasma concentrations remained below the human castration limit for the same period."

Journal • Preclinical

Efficacy and Safety of GnRH Analogue Triptorelin for HIV-1 Reservoir Reduction in ART Treated HIV-1 Infected Patients (clinicaltrials.gov) - P2; N=52; Recruiting; Sponsor: Immune System Regulation AB; Trial completion date: Dec 2020 ➔ Dec 2021; Trial primary completion date: Sep 2020 ➔ Aug 2021

Clinical • Trial completion date • Trial primary completion date • Human Immunodeficiency Virus • Infectious Disease

Efficacy and Safety of GnRH Analogue Triptorelin for HIV-1 Reservoir Reduction in ART Treated HIV-1 Infected Patients (clinicaltrials.gov) - P2; N=52; Recruiting; Sponsor: Immune System Regulation AB; Trial completion date: May 2020 ➔ Dec 2020; Trial primary completion date: Feb 2020 ➔ Sep 2020

Clinical • Trial completion date • Trial primary completion date • CD8