SmarT cells / Nanjing Drum Tower Hospital - LARVOL DELTA

Machine learning-assisted colorimetric serum phosphate detection based on sweet potato-derived carbon dots. (PubMed, Mikrochim Acta) - "To decouple these signals from environmental and matrix noise, a smartphone-based imaging system coupled with an machine learning algorithm was deployed for precise color recognition and automated quantitative determination. This integrated platform enables rapid phosphate detection within 60 min, exhibiting a broad linear range of 0.1-5.0 mM, a low limit of detection (LOD) of 0.03 mM, and an exceptional prediction accuracy of 99%. Ultimately, by synergizing chemical stability with analytical precision, this strategy offers a highly practical, low-cost, and robust paradigm for POC clinical phosphorus monitoring."

Journal

Bioinspired Janus Micro/Nanofibrous dressings for unidirectional exudate management and real-time colorimetric monitoring in chronic wounds. (PubMed, J Colloid Interface Sci) - "This smart dressing integrates a pH-responsive hydrophilic viscose outer layer with a hydrophobic polyurethane nanofibrous inner layer...In vivo evaluations confirm that this Janus dressing significantly accelerates tissue regeneration. This bioinspired sense-and-treat dressing offers a sophisticated strategy for the next generation of intelligent chronic wound care."

Journal • Infectious Disease • Inflammation

A scoping review on the application of new technology in the screening and diagnosis of adolescent idiopathic scoliosis. (PubMed, Spine Deform) - "AI-based non-radiological AIS screening demonstrates high diagnostic accuracy and offers a promising alternative to traditional methods by providing accessible, multi-output assessments using smartphone cameras or 3D scanners. Key limitations include small sample sizes, inconsistent validation, and ethical concerns (e.g., data privacy and automation bias). Future research should prioritize randomized controlled trials, standardized protocols, and multi-level stakeholder engagement to facilitate clinical integration."

Journal • Review

Promoter methylation-associated brain-enriched long noncoding RNAs in glioblastoma: a multi-cohort public epigenomic re-analysis. (PubMed, Epigenomics) - "External layers used GSE36278 methylation, CGGA expression/survival, and GSE131928 Smart-seq2 state scores...MEG8 and FAM201A were downregulated in CGGA versus GTEx brain, and FAM201A associated with pseudobulk stemness and mesenchymal scores. This public-data re-analysis prioritizes brain-enriched lncRNAs associated with promoter hypermethylation and lower expression in GBM, but does not establish direct methylation-mediated silencing."

Journal • Brain Cancer • Glioblastoma • Oncology • Solid Tumor • NFIB

Exosomal immune decoy integrates cfDNA scavenging and mTOR inhibition for synergistic lupus nephritis therapy. (PubMed, Theranostics) - "A "smart immune decoy" (RAPA@MEX-PL) was engineered by encapsulating rapamycin (RAPA) in mesenchymal stromal cell-derived exosomes (MEX) and coating the surface with a cationic polylysine (PLL) corona. The RAPA@MEX-PL nanoplatform represents a targeted and effective immunotherapeutic strategy for LN, capable of achieving sufficient immunosuppression without systemic toxicity. These findings emphasize its potential as a favorable candidate for the therapy for autoimmune diseases."

Journal • Glomerulonephritis • Immunology • Inflammation • Inflammatory Arthritis • Lupus • Lupus Nephritis • Nephrology • TLR9

Re-balancing immunity with CRISPR-Cas9: Novel strategies for cancer and autoimmune disorders. (PubMed, Biotechnol Adv) - "We focus on how these six strategies enhance anti-tumor immunity by engineering immune cells to bypass inhibitory checkpoints and the tumor microenvironment, and suppress autoimmunity by restoring immune tolerance through precise genomic and transcriptional interventions. Finally, we discuss translational challenges and future directions, including the adoption of next-generation editors and smart delivery systems, which are poised to maximize the therapeutic potential of CRISPR-based cellular interventions."

Journal • Review • Immunology • Oncology

Design and evaluation of a bifunctional fusion polypeptide for targeted delivery of tigecycline against drug-resistant Klebsiella pneumoniae. (PubMed, J Nanobiotechnology) - "This designer polypeptide serves as a smart carrier, capable of efficiently encapsulating the broad-spectrum antibiotic tigecycline (Tig) via reversible temperature-responsive phase transition hydrophobic interaction, resulting in a self-assembled, targeted nano-antibiotic, Tig@Ts-ELP (Tig@TsE). Moreover, the Ts peptide and Tig exhibit marked synergistic antibacterial effects against CRKP. This innovative nano-antibiotic delivery system is designed to increase local drug concentration at the infection site, boost bactericidal activity, and reduce systemic toxicity, thereby presenting a promising therapeutic strategy for the treatment of drug-resistant bacterial pneumonia."

Journal • Infectious Disease • Pneumonia • Respiratory Diseases • MMP9

Smart Functionalization of Acupuncture Needle Enables Molecular Subtyping and Personalized Treatment of Osteoarthritis. (PubMed, ACS Biomater Sci Eng) - "The degradation of each segment triggers the controlled release of a corresponding therapeutic agent: Batimastat, Etodolac, and Docetaxel. After implantation, the needle can be retrieved, and the degradation status of each hydrogel segment assessed by fluorescence imaging, providing a post-treatment readout of the dominant OA molecular subtype. Collectively, this multifunctional platform, termed helical-groove acupuncture needle (HGN), represents a promising strategy to curtail OA progression by simultaneously promoting cartilage restoration and inhibiting fibrotic changes."

Journal • Fibrosis • Genetic Disorders • Immunology • Inflammation • Obesity • Osteoarthritis • Pain • Rheumatology • ADAMTS5 • MMP13 • TGFB1

Deep tumor access via tumor-specific mannose unmasking: Smart heptamannosylated β-cyclodextrin nanoassembly. (PubMed, Colloids Surf B Biointerfaces) - "Ultimately, this chemo-immunotherapy achieved significant tumor growth inhibition in the 4T1 model, alongside robust therapeutic efficacy in the stroma-rich Pan02 model. Our work presents an in situ activable system leveraging endogenous immune cells for precision eradication of deep tumors."

Journal • Oncology

Infection protection, immune regulation and epithelial regeneration trifunctional hydrogel for treatment of burn wounds. (PubMed, Mater Today Bio) - "To address these challenges, we developed an innovative smart hydrogel (Ag-IMP-U@Cur), in which uridine (U) is incorporated as a backbone-forming component via reversible boronate ester bonds with phenylboronic acid, thereby endowing the hydrogel with dual functions of acidic microenvironment responsiveness and promotion of re-epithelialization...In vitro and in vivo studies demonstrate that this hydrogel markedly suppresses infection and inflammation while accelerating wound closure. Collectively, this work introduces an innovative strategy that integrates a nucleoside unit, metal ions, and a phytochemical into a responsive multifunctional hydrogel, offering a promising therapeutic avenue for severe burn injuries."

Journal • Infectious Disease • Inflammation

S-Doped Fe-N-C Single-Atom Nanozyme with Enhanced Oxidase-Like Activity for Colorimetric Detection of Serotonin. (PubMed, ACS Appl Mater Interfaces) - "Furthermore, we established a smartphone-based colorimetric detection platform that quantified 5-HT by correlating its concentration with the grayscale intensity of standard solution images captured by a smartphone. This approach provides a facile strategy for developing point-of-care testing platforms."

Journal • CNS Disorders • Mental Retardation • Psychiatry

Clinical outcomes of bowel preparation education strategies in colonoscopy: An evidence map of systematic reviews. (PubMed, Medicine (Baltimore)) - "A multi-method combination has significant practical potential. This study proposes personalized combination strategies based on the characteristics of different populations, and their effectiveness needs to be further verified by more high-quality research in the future. Additionally, this study pioneers the visualization of the evidence landscape through an evidence map, establishing a direct mapping between educational strategies and outcome measures to provide a framework for optimizing clinical decision-making. These findings call for high-quality research to compare the efficacy and generalizability of strategy combinations, while exploring tailored approaches for diverse populations to advance clinical application of personalized, precision-based bowel preparation education programs."

Clinical data • Journal • Colorectal Cancer • Infectious Disease • Oncology • Solid Tumor

Efficient 3D Biomedical Image Segmentation by Parallelly Multiscale Transformer-CNN Aggregation Network. (PubMed, Chem Biomed Imaging) - "Although the burgeoning of deep learning technologies has fostered smart segmentators, the successive and simultaneous garnering global and local features still remains challenging, which is essential for an exact and efficient imageological assay...Meanwhile, MPSTrans outperforms other mainstream methods (Swin UNETR, UNETR, nnU-Net, PHTrans, and 3D U-Net) on three public multiorgan (aorta, gallbladder, kidney, liver, pancreas, spleen, stomach, etc.) and multimodal (CT, PET-CT, and MRI) data sets of medical segmentation decathlon (MSD) brain tumor, multiatlas labeling beyond cranial vault (BCV), and automated cardiac diagnosis challenge (ACDC), accentuating its adaptability. These results reflect the potential of MPSTrans to advance the state-of-the-art in biomedical imaging analysis, which would offer a robust tool for enhanced diagnostic capacity."

Journal • Brain Cancer • Colon Cancer • Colorectal Cancer • Oncology • Solid Tumor

Adaptive Nanoplasmonics Controlled by Soft Polymers. (PubMed, ACS Appl Mater Interfaces) - "This perspective focuses on the dynamic control of both individual plasmonic nanoparticles and their aggregates or assemblies at biological interfaces through the use of smart polymer ligands...We also discuss the underlying molecular mechanisms driving these responses. Finally, we provide a summary of the field and offer perspectives on future directions for soft, stimuli-responsive nanoplasmonics at biointerfaces."

Journal • Review

Application of ChatGPT-based artificial intelligence in the diagnosis and management of polycystic ovary syndrome. (PubMed, BMC Med Inform Decis Mak) - "It holds promise for improving standardization in diagnosis and treatment, empowering patient self-management, enhancing access to high-quality healthcare resources, and offering comprehensive health management for PCOS patients. This innovation promotes the development of smart healthcare, benefiting women's health."

Journal • Polycystic Ovary Syndrome • Women's Health

SmarT cell combined with PD-1 blockade and SOX as first-line treatment for patients with advanced gastric/gastroesophageal junction adenocarcinoma. (ASCO 2025) - P1/2 | "Patients were assigned to PD-1 mAb plus chemotherapy (Tegafur and oxaliplatin every 3 weeks), or PD-1 mAb plus chemotherapy. SmarT cell shows superior ORR along with PFS benefit and an acceptable safety profile, in combination with PD-1 mAb plus chemotherapy versus PD-1 mAb plus chemotherapy in previously untreated patients with advanced gastric or gastroesophageal junction adenocarcinoma."

Clinical • IO biomarker • Metastases • Esophageal Cancer • Gastric Cancer • Gastroesophageal Junction Adenocarcinoma • Hematological Malignancies • Leukemia • Oncology • Solid Tumor • HER-2 • PD-L1

Clinical applicability and accuracy of population pharmacokinetic model in guiding individualized use of Vancomycin (ChiCTR) - P4 | N=360 | Not yet recruiting | Sponsor: Nanjing Drum Tower Hospital Group Suqian Hospital; Nanjing Drum Tower Hospital Group Suqian Hospital

New P4 trial

Stroke Management and Analysis Risk Tool (SMART): An interpretable clinical application for diabetes-related stroke prediction. (PubMed, Nutr Metab Cardiovasc Dis) - "An interpretable stroke-predictive model was created for patients with diabetes. This model proposes that standard clinical and laboratory parameters can predict the stroke risk in individuals with diabetes."

Journal • Cardiovascular • Diabetes • Metabolic Disorders • Type 2 Diabetes Mellitus

Colorimetric aptasensor coupled with a deep-learning-powered smartphone app for programmed death ligand-1 expressing extracellular vesicles. (PubMed, Front Immunol) - "This combined approach offers a simple, sensitive, and specific tool for lung cancer detection using PD-L1@EVs. The addition of a CNN-powered smartphone app further eliminates the need for specialized equipment, making the colorimetric aptasensor more accessible for low-resource settings."

Biomarker • IO biomarker • Journal • Lung Cancer • Oncology • Solid Tumor • PD-L1

Glycyrrhizic Acid Hydrogel Microparticles Encapsulated with Mesenchymal Stem Cell Exosomes for Wound Healing. (PubMed, Research (Wash D C)) - "Current trends focus on the integration of bioactive matrix and their smart stimulus-responsive release to meet the complex demand of regeneration in diabetic wound...Besides, they could also markedly accelerate the wound healing process by down-regulating inflammation and promoting collagen deposition and angiogenesis in bacteria-infected in vivo diabetic wound. These results indicate that the proposed exosome-integrated GA hydrogel microparticles present great potential for clinical diabetic wound treatment."

Journal • Inflammation

Conditional generative adversarial network-assisted system for radiation-free evaluation of scoliosis using a single smartphone photograph: a model development and validation study. (PubMed, EClinicalMedicine) - "However, limited data quality and quantity, a homogeneous participant population, and rotational errors during imaging may affect the applicability and accuracy of the system, requiring further improvement in the future. National Key R&D Program of China, Natural Science Foundation of Jiangsu Province, China Postdoctoral Science Foundation, Nanjing Medical Science and Technology Development Foundation, Jiangsu Provincial Key Research and Development Program, and Jiangsu Provincial Medical Innovation Centre of Orthopedic Surgery."

Journal • CNS Disorders • Orthopedics

Reversible Electrochemical Swelling of Straight Carbon Nanotube Yarns for High-Performance Linear Actuation. (PubMed, Small) - "Remarkably, the CNT artificial muscle yarn generates a contractile stroke of 8.8% and an isometric stress of 7.5 MPa under 2.5 V actuation voltages, demonstrating its potential for applications requiring low energy consumption while maintaining high operational efficiency. This study highlights the crucial impact of CNT orientation on the effectiveness of electrochemically-driven artificial muscles, signaling new possibilities in smart material and biomechanical system development."

Journal • Cardiovascular

Smart Molecular Imaging and Theranostic Probes by Enzymatic Molecular In Situ Self-Assembly. (PubMed, JACS Au) - "In this Perspective, we discuss the general principle of controlling in situ self-assembly of synthetic small molecules by an enzyme and then discuss the applications for the construction of "smart" imaging and theranostic probes against cancers and bacteria. Finally, we discuss the current challenges and perspectives in utilizing the E-MISA strategy for disease diagnoses and therapies, particularly for clinical translation."

Journal • Review • Oncology

In Situ Aggregated Nanomanganese Enhances Radiation-Induced Antitumor Immunity. (PubMed, ACS Appl Mater Interfaces) - "Additionally, the pH-responsive disassembly of MnAuNP-C&B triggers the release of Mn2+, further promoting RT-induced activation of the STING pathway and eliciting robust antitumor immunity. Overall, our study presents a smart strategy wherein in situ aggregation of nanomanganese effectively inhibits tumor growth through radiosensitization and the activation of antitumor immunity."

Journal • Oncology

Molecular orbital breaking in photo-mediated organosilicon Schiff base ferroelectric crystals. (PubMed, Nat Commun) - "This process brings about photo-mediated bistability with multiple physical channels such as dielectric, second-harmonic generation, and ferroelectric polarization. This work further explores this newly developed mechanism of ferroelectric phase transition and highlights the significance of photo-mediated ferroelectric materials for photo-controlled smart devices and bio-sensors."

Journal