SmarT cells / Nanjing Drum Tower Hospital - LARVOL DELTA

Clinical outcomes of bowel preparation education strategies in colonoscopy: An evidence map of systematic reviews. (PubMed, Medicine (Baltimore)) - "A multi-method combination has significant practical potential. This study proposes personalized combination strategies based on the characteristics of different populations, and their effectiveness needs to be further verified by more high-quality research in the future. Additionally, this study pioneers the visualization of the evidence landscape through an evidence map, establishing a direct mapping between educational strategies and outcome measures to provide a framework for optimizing clinical decision-making. These findings call for high-quality research to compare the efficacy and generalizability of strategy combinations, while exploring tailored approaches for diverse populations to advance clinical application of personalized, precision-based bowel preparation education programs."

Clinical data • Journal • Colorectal Cancer • Infectious Disease • Oncology • Solid Tumor

Efficient 3D Biomedical Image Segmentation by Parallelly Multiscale Transformer-CNN Aggregation Network. (PubMed, Chem Biomed Imaging) - "Although the burgeoning of deep learning technologies has fostered smart segmentators, the successive and simultaneous garnering global and local features still remains challenging, which is essential for an exact and efficient imageological assay...Meanwhile, MPSTrans outperforms other mainstream methods (Swin UNETR, UNETR, nnU-Net, PHTrans, and 3D U-Net) on three public multiorgan (aorta, gallbladder, kidney, liver, pancreas, spleen, stomach, etc.) and multimodal (CT, PET-CT, and MRI) data sets of medical segmentation decathlon (MSD) brain tumor, multiatlas labeling beyond cranial vault (BCV), and automated cardiac diagnosis challenge (ACDC), accentuating its adaptability. These results reflect the potential of MPSTrans to advance the state-of-the-art in biomedical imaging analysis, which would offer a robust tool for enhanced diagnostic capacity."

Journal • Brain Cancer • Colon Cancer • Colorectal Cancer • Oncology • Solid Tumor

Adaptive Nanoplasmonics Controlled by Soft Polymers. (PubMed, ACS Appl Mater Interfaces) - "This perspective focuses on the dynamic control of both individual plasmonic nanoparticles and their aggregates or assemblies at biological interfaces through the use of smart polymer ligands...We also discuss the underlying molecular mechanisms driving these responses. Finally, we provide a summary of the field and offer perspectives on future directions for soft, stimuli-responsive nanoplasmonics at biointerfaces."

Journal • Review

Application of ChatGPT-based artificial intelligence in the diagnosis and management of polycystic ovary syndrome. (PubMed, BMC Med Inform Decis Mak) - "It holds promise for improving standardization in diagnosis and treatment, empowering patient self-management, enhancing access to high-quality healthcare resources, and offering comprehensive health management for PCOS patients. This innovation promotes the development of smart healthcare, benefiting women's health."

Journal • Polycystic Ovary Syndrome • Women's Health

SmarT cell combined with PD-1 blockade and SOX as first-line treatment for patients with advanced gastric/gastroesophageal junction adenocarcinoma. (ASCO 2025) - P1/2 | "Patients were assigned to PD-1 mAb plus chemotherapy (Tegafur and oxaliplatin every 3 weeks), or PD-1 mAb plus chemotherapy. SmarT cell shows superior ORR along with PFS benefit and an acceptable safety profile, in combination with PD-1 mAb plus chemotherapy versus PD-1 mAb plus chemotherapy in previously untreated patients with advanced gastric or gastroesophageal junction adenocarcinoma."

Clinical • IO biomarker • Metastases • Esophageal Cancer • Gastric Cancer • Gastroesophageal Junction Adenocarcinoma • Hematological Malignancies • Leukemia • Oncology • Solid Tumor • HER-2 • PD-L1

Clinical applicability and accuracy of population pharmacokinetic model in guiding individualized use of Vancomycin (ChiCTR) - P4 | N=360 | Not yet recruiting | Sponsor: Nanjing Drum Tower Hospital Group Suqian Hospital; Nanjing Drum Tower Hospital Group Suqian Hospital

New P4 trial

Stroke Management and Analysis Risk Tool (SMART): An interpretable clinical application for diabetes-related stroke prediction. (PubMed, Nutr Metab Cardiovasc Dis) - "An interpretable stroke-predictive model was created for patients with diabetes. This model proposes that standard clinical and laboratory parameters can predict the stroke risk in individuals with diabetes."

Journal • Cardiovascular • Diabetes • Metabolic Disorders • Type 2 Diabetes Mellitus

Colorimetric aptasensor coupled with a deep-learning-powered smartphone app for programmed death ligand-1 expressing extracellular vesicles. (PubMed, Front Immunol) - "This combined approach offers a simple, sensitive, and specific tool for lung cancer detection using PD-L1@EVs. The addition of a CNN-powered smartphone app further eliminates the need for specialized equipment, making the colorimetric aptasensor more accessible for low-resource settings."

Biomarker • IO biomarker • Journal • Lung Cancer • Oncology • Solid Tumor • PD-L1

Glycyrrhizic Acid Hydrogel Microparticles Encapsulated with Mesenchymal Stem Cell Exosomes for Wound Healing. (PubMed, Research (Wash D C)) - "Current trends focus on the integration of bioactive matrix and their smart stimulus-responsive release to meet the complex demand of regeneration in diabetic wound...Besides, they could also markedly accelerate the wound healing process by down-regulating inflammation and promoting collagen deposition and angiogenesis in bacteria-infected in vivo diabetic wound. These results indicate that the proposed exosome-integrated GA hydrogel microparticles present great potential for clinical diabetic wound treatment."

Journal • Inflammation

Conditional generative adversarial network-assisted system for radiation-free evaluation of scoliosis using a single smartphone photograph: a model development and validation study. (PubMed, EClinicalMedicine) - "However, limited data quality and quantity, a homogeneous participant population, and rotational errors during imaging may affect the applicability and accuracy of the system, requiring further improvement in the future. National Key R&D Program of China, Natural Science Foundation of Jiangsu Province, China Postdoctoral Science Foundation, Nanjing Medical Science and Technology Development Foundation, Jiangsu Provincial Key Research and Development Program, and Jiangsu Provincial Medical Innovation Centre of Orthopedic Surgery."

Journal • CNS Disorders • Orthopedics

Reversible Electrochemical Swelling of Straight Carbon Nanotube Yarns for High-Performance Linear Actuation. (PubMed, Small) - "Remarkably, the CNT artificial muscle yarn generates a contractile stroke of 8.8% and an isometric stress of 7.5 MPa under 2.5 V actuation voltages, demonstrating its potential for applications requiring low energy consumption while maintaining high operational efficiency. This study highlights the crucial impact of CNT orientation on the effectiveness of electrochemically-driven artificial muscles, signaling new possibilities in smart material and biomechanical system development."

Journal • Cardiovascular

Smart Molecular Imaging and Theranostic Probes by Enzymatic Molecular In Situ Self-Assembly. (PubMed, JACS Au) - "In this Perspective, we discuss the general principle of controlling in situ self-assembly of synthetic small molecules by an enzyme and then discuss the applications for the construction of "smart" imaging and theranostic probes against cancers and bacteria. Finally, we discuss the current challenges and perspectives in utilizing the E-MISA strategy for disease diagnoses and therapies, particularly for clinical translation."

Journal • Review • Oncology

In Situ Aggregated Nanomanganese Enhances Radiation-Induced Antitumor Immunity. (PubMed, ACS Appl Mater Interfaces) - "Additionally, the pH-responsive disassembly of MnAuNP-C&B triggers the release of Mn2+, further promoting RT-induced activation of the STING pathway and eliciting robust antitumor immunity. Overall, our study presents a smart strategy wherein in situ aggregation of nanomanganese effectively inhibits tumor growth through radiosensitization and the activation of antitumor immunity."

Journal • Oncology

Molecular orbital breaking in photo-mediated organosilicon Schiff base ferroelectric crystals. (PubMed, Nat Commun) - "This process brings about photo-mediated bistability with multiple physical channels such as dielectric, second-harmonic generation, and ferroelectric polarization. This work further explores this newly developed mechanism of ferroelectric phase transition and highlights the significance of photo-mediated ferroelectric materials for photo-controlled smart devices and bio-sensors."

Journal

The effect of nomophobic behaviors among nurses on their clinical decision-making perceptions. (PubMed, Nurse Educ Pract) - "Nomophobic behaviors can hamper nurses' perception of clinical decision-making, potentially leading to inaccuracies or errors. Nurses must use mobile phones judiciously, practice self-regulation and mitigate the disruptive effects of nomophobia on their decision-making. In addition, medical institutions should foster relevant education or craft policies to regularize mobile phone use, augmenting nurses' efficiency and decision-making prowess, enhancing patient care quality, diminishing medical errors and ensuring patient health and safety."

Journal • CNS Disorders • Mood Disorders • Psychiatry

A Reconfigurable DNA Framework Nanotube-Assisted Antiangiogenic Therapy. (PubMed, JACS Au) - "Here, we develop a smart DNA-based nanodrug, termed Endo-rDFN, by precisely assembling the antiangiogenic agent, endostar (Endo), into a reconfigurable DNA framework nanotube (rDFN) that could recognize tumor-overexpressed nucleolin to achieve the targeted delivery and controllable release of Endo. Endo-rDFN can not only effectively enhance the tumor-targeting capability of Endo and maintain its efficient accumulation in tumor tissues but also achieve on-demand release of Endo at tumor sites via the specific DNA aptamer for tumor-overexpressed nucleolin, named AS1411. We also found that Endo-rDFN exhibited significant inhibition of angiogenesis and tumor growth, while also providing effective protection against multiorgan injury (heart, liver, spleen, kidney, lung, etc.) to some extent, without compromising the function of these organs. Our study demonstrates that rDFN represents a promising vector for reducing antiangiogenic therapy-induced multiorgan injury,..."

Journal • Liver Failure • Oncology • NCL

A first-in-human, multiple dose and dose escalation phase I study to investigate the safety, tolerability and antitumor activity of SmarT cells plus PD-1 blocking antibodies in patients with far advanced/metastatic solid tumors (ESMO Asia 2023) - "The median progressive free survival time (mPFS) was 71 days and the median overall survival time (mOS) was 201 days. Conclusions These initial results suggest that SmarT cells has promising efficacy with an acceptable safety profile in patients with heavily pretreated solid cancers."

Clinical • Metastases • P1 data • Oncology • Solid Tumor