Neu-up (nartograstim) / Yakult Honsha - LARVOL DELTA

Nested case-control study utilizing MID-NET on thrombocytopenia associated with pegfilgrastim in patients treated with antineoplastic agents. (PubMed, Clin Pharmacol Ther) - "To investigate the association between G-CSF preparations (filgrastim, nartograstim, lenograstim, and pegfilgrastim) available in Japan and thrombocytopenia in patients treated with antineoplastic agents...Associations of the other G-CSF preparations with thrombocytopenia were unclear due to the inconsistent results among different analyses. A significantly increased risk of thrombocytopenia associated with pegfilgrastim was identified, leading to a revision of precautions in the package inserts of pegfilgrastim as a regulatory safety action."

Clinical • Journal • Hematological Disorders • Oncology • Thrombocytopenia

Development of recombinant human granulocyte colony-stimulating factor (nartograstim) production process in Escherichia coli compatible with industrial scale and with no antibiotics in the culture medium. (PubMed, Appl Microbiol Biotechnol) - "• The process developed led to high purity and reasonable recovery compared to literature. • Nartograstim biological activity was demonstrated in mice using a neutropenia model."

Journal • Hematological Disorders • Neutropenia