Eraxis (anidulafungin) / RaQualia - LARVOL DELTA

Antifungal resistance and poor clinical outcome rates of Candida auris in mainland China: A systematic review and meta-analysis. (PubMed, Front Microbiol) - "The resistance rates of caspofungin, micafungin, and anidulafungin were 3% (95%CI: 0%-11%), 2% (95%CI: 0%-4%), and 1% (95%CI: 0%-3%), respectively...Fluconazole is not an appropriate choice for treating C. auris strains in mainland China, while echinocandins should be the primary treatment option...Patients with C. auris colonization or infection exhibit variable clinical outcomes. Clinical practice should prioritize routine laboratory antifungal susceptibility surveillance, standardized hospital infection control measures, and targeted interventions to improve patient clinical outcomes."

Clinical data • Journal • Retrospective data • Review • Infectious Disease

From Gastric Pneumatosis to Fungal Necrosis: Invasive Candida Gastritis Mimicking Gastric Malignancy (ACG 2026) - "Case Description/ A 51-year-old man with type 1 diabetes on an insulin pump, sarcoidosis on hydroxychloroquine, chronic opioid use, and CAD s/p CABG was admitted weeks earlier for a 1% TBSA hand burn requiring hospitalization and wound care...Anidulafungin was initiated; repeat EGD showed ulcer improvement, tissue biopsies confirmed Candida, and therapy was transitioned to fluconazole for 21 days with clinical recovery...Figure: Figure 2 (A) H&E stain demonstrating a fibrinopurulent ulcer bed with extensive acute inflammation and necrotic debris overlying the gastric mucosa; no viable epithelium is identified. (B) GMS stain highlighting abundant fungal yeast forms and hyphal elements within the necrotic ulcer bed, consistent with invasive Candida gastritis."

Cardiovascular • Diabetes • Gastric Adenocarcinoma • Gastrointestinal Disorder • Immunology • Infectious Disease • Metabolic Disorders • Oncology • Sarcoidosis • Solid Tumor • Type 1 Diabetes Mellitus

In Vitro Activity and In Vivo Efficacy in a Murine Model of Rezafungin, Anidulafungin, Caspofungin, and Micafungin Against the Fifth Clade of Candida (Candidozyma) auris. (PubMed, J Fungi (Basel)) - "Pseudohyphae production was common in controls, but not in echinocandin-treated mice. Rezafungin activity was comparable to or better than the three previously approved echinocandins."

Journal • Preclinical • Infectious Disease

VER02. Sponsored by Verathon: Early Career Anesthesia Provider Airway Management and Lung Isolation Hands-On Workshop: Essentials to Advanced (Non-CME) (ASA 2026) - "During the workshop, real-world scenarios will be explained, practical tips and tricks will be shared by our airway experts, and of course, plenty of hands-on practice opportunities will be provided. SessionLearningObjective1: Apply advanced airway management techniques, including combined hyperangle video laryngoscopy and flexible bronchoscopy, in adult and pediatric difficult airway scenarios.SessionLearningObjective2: Demonstrate effective strategies for lung isolation, including double lumen tube placement and use of endobronchial blockers for one lung ventilation.SessionLearningObjective3: Integrate clinical decision-making for airway assessment, awake tracheal intubation, and rescue techniques in complex, real-world situations."

Metastases • Anesthesia

Candida glabrata species complex in a Brazilian public tertiary hospital: site of infection, identification and antifungal susceptibility profile. (PubMed, J Venom Anim Toxins Incl Trop Dis) - "Minimum inhibitory concentrations (MICs), determined via broth microdilution and according to the European Committee on Antimicrobial Susceptibility Testing (EUCAST) guidelines, showed high susceptibility to amphotericin B (AmB), voriconazole (VRC), and echinocandins (ECNs) [caspofungin (CSF), anidulafungin (ANF), and micafungin (MCF)], as well as uniform susceptibility within the "I" category (susceptible, increased exposure) to fluconazole (FLC). All recovered isolates were confirmed as Candida glabrata sensu stricto and exhibited different susceptibility profiles from reference EUCAST isolates. These findings establish a strong regional baseline, serving as a useful guide for monitoring therapeutic measures and supporting antimicrobial stewardship."

Journal • Infectious Disease

Identification and characterization of anti-chikungunya virus compounds using a biosafe toolkit. (PubMed, Virol Sin) - "A virus replicon particle (VRP) system for CHIKV was first constructed and applied to compound library screening, resulting in the identification of three candidate antiviral compounds: MDL-12330A, bazedoxifene acetate, and anidulafungin...Using these complementary systems, we systematically evaluated the antiviral profiles of the three candidate compounds across multiple stages of the CHIKV life cycle. This analysis revealed distinct stage-specific inhibitory patterns and provided insights into their potential antiviral mechanisms, which warrant validation using authentic CHIKV infection to assess their translational potential."

Journal • Chikungunya • Hematological Malignancies • Infectious Disease • Leukemia • Oncology

Clinical Outcomes of Micafungin and Anidulafungin in Candidozyma auris (Formerly Candida auris) Candidemia: A Propensity Score-Matched Retrospective Cohort Study. (PubMed, J Fungi (Basel)) - "RUCAM-based hepatic safety profiles were descriptively comparable. Micafungin and anidulafungin showed comparable observed outcomes in C. auris candidemia in this cohort."

Clinical data • Journal • Retrospective data • Hepatology • Liver Failure

Clinical Outcomes of Candida auris Versus Other Candida Species Bloodstream Infections: An IPTW-Adjusted Cohort Study in South Korea. (PubMed, J Fungi (Basel)) - "Among 423 patients, C. auris accounted for 6.9% of cases and was uniformly fluconazole non-susceptible, with frequent high-level caspofungin resistance but preserved micafungin and anidulafungin susceptibility. Residual confounding by unmeasured illness severity and limited precision preclude concluding equivalence. Continued surveillance, molecular characterisation, and infection control remain essential."

Clinical data • Journal • Infectious Disease • Septic Shock

Intraocular protothecosis: a case report and literature review. (PubMed, Rev Iberoam Micol) - "To date, there have been very few reported cases of protothecosis affecting the eye. The most common sample is usually a corneal scraping, and the microbiological diagnosis is based on the macro- and microscopic morphological features of the alga, confirmed using proteomic or molecular techniques. Treatment combines surgical techniques, antifungals, and steroids, with good outcomes in most cases."

Journal • Cataract • Infectious Disease • Ocular Inflammation • Ophthalmology

Podospora bulbillosa keratitis: A Case Series with Molecular Confirmation from North-East India. (PubMed, Indian J Med Microbiol) - "Antifungal susceptibility testing showed lower MICs for voriconazole, amphotericin B, and anidulafungin than for natamycin. Treatment with topical and systemic antifungal and surgical interventions resulted in healing with improved vision in one patient only. A review of the available literature indicates that these are the first reported cases of P. bulbillosa keratitis from Northeast India."

Journal • Keratitis • Ocular Inflammation • Ophthalmology

Comparative real-world safety profiles of caspofungin, micafungin, and anidulafungin: a disproportionality analysis based on FAERS and VigiAccess databases. (PubMed, Front Pharmacol) - "This study provides a comparative pharmacovigilance overview of the safety profiles of three echinocandins using FAERS and VigiAccess data. Further prospective studies are needed to validate these observations."

Journal • Real-world evidence • Candidiasis • Eosinophilia • Hepatology • Liver Failure • Renal Disease

Antifungal Susceptibility of Rare Yeasts Causing Vulvovaginal Candidiasis in the Acidic Vaginal Environment. (PubMed, Infect Drug Resist) - "The antifungal agents most affected by a lower pH were terconazole (3 two-fold dilutions higher, MIC >0.5-8 mg/L) for all yeast isolates, followed by amphotericin B (2 two-fold dilutions higher, MIC >2 mg/L) for 93% of isolates, nystatin (2 two-fold dilutions higher, MIC >4-8 mg/L) for 95% of isolates, and micafungin (2 two-fold dilutions higher, MIC >0.125-1 mg/L) for 50% of isolates, compared with those at pH 7.0, indicating a high percentage of low activity against the yeast species. Fluconazole, voriconazole, miconazole, and clotrimazole were the least affected, while anidulafungin, caspofungin, and 5-flucytosine were not affected significantly by pH, showing activity against most rare yeast species at both pH levels...Considering the influence of acidic pH, our results reveal apparently drug-specific and genus-specific trends in antifungal susceptibility. The variability of rare yeasts with regard to antifungal susceptibility at acidic pH warrants..."

Journal • Candidiasis • Vaginitis

Adaptive susceptibility shifts in Candidozyma auris following biocidal exposure: Exploratory effects on antifungal and biocidal susceptibility. (PubMed, Eur J Clin Microbiol Infect Dis) - "C. auris demonstrates dynamic and mostly reversible tolerance patterns affecting both antifungals and biocides. R6G assays provided indirect functional observations consistent with altered membrane transport dynamics following biocidal exposure, which may have contributed to the observed adaptive susceptibility shifts. The observed susceptibility shifts highlights the adaptive potential of this pathogen under disinfection stress and underscores the need to consider cross-tolerance when designing infection control strategies in healthcare settings."

Journal • Infectious Disease

LaeA Orchestrates Iron-Heme Supply and P450 Catalytic Efficiency for Enhanced Echinocandin B Biosynthesis in Aspergillus nidulans. (PubMed, Biotechnol J) - "Echinocandin B (ECB), a fungal non-ribosomal lipopeptide, serves as the exclusive natural precursor of the front-line antifungal anidulafungin...Co-expression of CPR2 with bacterial hemoglobin VHb achieved synergistic enhancement, improving the ECB titer to 3170 ± 41 mg/L. This study provided a practical strategy for improving ECB production and offering insights into the versatile regulatory modes of global secondary metabolite regulators."

Journal

Radiolabeled Antimicrobials for Infection Imaging: A Scoping Review. (PubMed, Int J Mol Sci) - "Among preclinical studies, radiolabeled plazomicin and echinocandins (caspofungin and anidulafungin) exhibited the greatest number of preferred characteristics. Many radioligands demonstrate good tissue penetration but suboptimal washout, limiting their diagnostic value. In vivo pharmacokinetic applications during active infections are promising, though significant challenges remain for infection imaging."

Journal • Review • Infectious Disease

Predictors of Candida auris Infection in Previously Colonized Patients: A Retrospective Cohort Study from a Large Tertiary Reference Center. (PubMed, J Fungi (Basel)) - "All 40 tested isolates had high fluconazole minimum inhibitory concentration (MIC) values; micafungin susceptibility was 92.5%, while anidulafungin resistance was observed in 32.5% of isolates. Our findings demonstrate that nearly half of colonized patients developed BSI, with no identifiable safe window for intervention, underscoring the necessity of sustained infection control measures and susceptibility-guided antifungal therapy."

Journal • Retrospective data • Critical care • Diabetes • Infectious Disease • Metabolic Disorders

Refractory Candida orthopsilosis endocarditis in a hemodialysis patient: The role of species-level identification and surgical source control. (PubMed, Diagn Microbiol Infect Dis) - "MALDI-TOF-guided species identification, susceptibility-directed echinocandin therapy, and timely surgical source control constitute an effective management framework for Candida endocarditis, achieving complete microbiological clearance despite severe systemic complications."

Journal • Cardiovascular • Chronic Kidney Disease • Diabetes • Infectious Disease • Metabolic Disorders • Nephrology • Pulmonary Embolism • Renal Disease • Respiratory Diseases

Clinical characteristics, healthcare-associated exposures, and antifungal susceptibility patterns of Candida auris colonization and invasive infections: a retrospective observational study at a single center in Turkey. (PubMed, BMC Infect Dis) - "Accurate identification of C. auris and continuous antifungal susceptibility surveillance are essential for infection control. Older age was the only variable significantly associated with invasive infection, while other clinical and healthcare-associated exposures were common in both groups but did not differ significantly. All isolates were resistant to fluconazole, and echinocandin resistance emerged in two isolates. Amphotericin B susceptibility findings should be interpreted cautiously, as the use of Sensititre YeastOne without confirmatory reference testing may have overestimated resistance. Larger multicenter studies are needed to better define factors independently associated with invasive infection."

Journal • Observational data • Retrospective data • Critical care • Infectious Disease • Palliative care

SAFETY AND EFFECTIVENESS OF OUTPATIENT INTRAVENOUS ANTIFUNGAL THERAPY IN PEDIATRIC PATIENTS: EXPERIENCE FROM A SINGLE- CENTER COHORT (ESPID 2026) - "Antifungals included liposomal-amphotericin B (3), micafungin (3), anidulafungin (3), isavuconazole (1); 3 received combination dual therapy. All achieved complete response. Conclusions/Learning Points OPAT antifungal therapy was safe and effective in pediatric patients, including those immunocompromised and with relatively long therapies, both administered by parents/guardians and by Hospital at Home service."

Clinical • Infectious Disease

A LETHAL ALLIANCE: PERSISTENT CANDIDA KRUSEI CANDIDEMIA IN A CHILD SUPPORTED WITH A VENTRICULAR ASSIST DEVICE (ESPID 2026) - "Empirical voriconazole therapy was changed to anidulafungin, and all vascular catheters were replaced; however, device exchange was not possible. Due to persistent fungemia, antifungal therapy was escalated to liposomal amphotericin B. Despite prolonged antifungal treatment, blood cultures remained positive for two months, and the patient ultimately died...Candida krusei candidemia is associated with persistent infection, limited therapeutic options, and poor outcomes, particularly when device removal is not feasible. Early recognition, aggressive antifungal therapy, and preventive strategies are critical to improving outcomes in this high-risk population."

Clinical • Infectious Disease

Candidozyma auris susceptibility from Michigan hospitals to manogepix, rezafungin and nine other antifungal agents. (PubMed, JAC Antimicrob Resist) - "MIC was determined by microdilution testing for amphotericin B, anidulafungin, caspofungin, manogepix, micafungin, rezafungin and five triazoles...The MIC90 demonstrated values of ≤0.5 mg/L for isavuconazole, itraconazole and posaconazole...Amphotericin B demonstrated greater activity compared with published studies. Fluconazole has poor activity; the activity of other triazoles remains unclear."

Journal • Infectious Disease

Candida (Candidozyma) auris in pediatric population: risk factors, clinical presentation, and outcomes. (PubMed, J Mycol Med) - "C. auris in pediatric patients represents a growing challenge, especially in preterm neonates, due to high antifungal resistance and diagnostic difficulties."

Journal • Review • Critical care • Infectious Disease • Pediatrics

Intravitreal rezafungin and anidulafungin in a rabbit model of Aspergillus fumigatus endophthalmitis. (PubMed, Sci Rep) - "Rezafungin (RZF) and anidulafungin (AFG) are echinocandins with potential for treating Aspergillus fumigatus endophthalmitis. RZF and AFG showed low minimum effective concentrations, inhibited biofilm formation, disrupted fungal cell wall and membrane integrity in vitro and significantly reduced intraocular inflammation, fungal burden and aqueous humor TNF-α in vivo, with overall efficacy comparable to that of liposomal amphotericin B and voriconazole. These findings support RZF and AFG as promising alternative agents for intravitreal therapy of A. fumigatus endophthalmitis."

Journal • Preclinical • Infectious Disease • Inflammation • Ocular Infections • Ocular Inflammation • Ophthalmology • IL1B • TNFA

Multicenter evaluation of low inoculum and a colorimetric assay for antifungal susceptibility testing of Aspergillus fumigatus to echinocandins with the EUCAST E.Def 9.4. (PubMed, J Clin Microbiol) - "The upper MEC and MIC-2 limits of wild-type (WT) isolates were 0.03 mg/L for both anidulafungin and micafungin, whereas non-WT isolates had MEC and MIC-2 >0.125 mg/L. The low inoculum facilitated echinocandin MEC determination, and the XTT assay increased objectivity and enabled automation for the separation of WT and non-WT A. fumigatus isolates with the EUCAST method."

Clinical • Journal • CD9 • GDF15

Ergosterol-depleted clinical isolates of Nakaseomyces glabratus can develop multi-drug resistance without severe fitness defects or attenuated virulence in an invertebrate infection model. (PubMed, mBio) - "We performed whole-genome sequencing and sterol profiling on nine clinical N. glabratus isolates, which were resistant to ANF and displayed resistance or low susceptibility to fluconazole (FLU) and AMB. The underlying ergosterol depletion contributed to low azole susceptibility and was associated with anidulafungin resistance. These findings demonstrate how fast MDR can evolve in N. glabratus and underline the need for close resistance monitoring."

Journal • Candidiasis • Infectious Disease