ofloxacin/ornidazole / Generic mfg. - LARVOL DELTA

A simple patch test (empty tablet cover patch test) demonstrating ornidazone as offending agent in a patient of fixed drug eruption: Report of a clinical case, a new modified technique and systematic review of literature. (PubMed, Indian J Pharmacol) - "A 49-year-old male presented with the complaints of sudden-onset redness and watering of both the eyes following the intake of fixed drug combination of ofloxacin-ornidazole for diarrhea...We also conducted a systematic review of FDEs associated with ornidazole exposure. We searched PubMed and Google Scholar with specific keywords to finally retrieve 14 case reports of ofloxacin induced FDEs, which were further reviewed."

Journal • Review

Point-Prevalence Survey of Antimicrobial Use in Benin Hospitals: The Need for Antimicrobial Stewardship Programs. (PubMed, Antibiotics (Basel)) - "In four prescriptions, hospital A used a non-recommended association of antibiotics, such as ceftriaxone + sulbactam and ofloxacin + ornidazole. While hospital A prescribed predominantly amoxicillin + clavulanic acid (19/92; 21%) and ceftriaxone (14/92; 15%), hospital B prescribed ampicillin (24/120; 20%) and cefuroxime (14/120; n = 12%)...In patients in intensive care units, prolonged prophylaxis (>1 day, SP3) accounted for all postoperative prescriptions. These findings highlight the critical need for implementing antimicrobial stewardship programs, expanding diagnostic laboratory capacity to minimize empirical prescribing, and strengthening medical student training to ensure quality and rational antibiotic use, thereby addressing the growing challenge of resistance in resource-limited settings."

Journal • Critical care

Comparative Study of Postoperative Healing Outcomes With and Without Medicated Cavity Packing Following Canal Wall Down (CWD) Mastoidectomy. (PubMed, Cureus) - "Group A (n=62) received medicated mastoid cavity packing containing ofloxacin, ornidazole, clobetasone propionate, and itraconazole on postoperative days 0, 10, and 20. It offers particular benefits in low-resource settings by enhancing healing and reducing follow-up needs. Larger studies are warranted to establish standardized postoperative care protocols."

Journal • Otorhinolaryngology

Digital platform for prescription analytics and antibiotic surveillance in an outpatient department setup. (PubMed, Indian J Pharmacol) - "Using the VaidyaRx digital platform, real-time prescription analysis was possible which helped in enhancing medication safety and antimicrobial stewardship. Suitable interventions are needed to reduce polypharmacy, increase generic prescribing, ensure rational antibiotic use, and improve prescribing practices."

Journal • Musculoskeletal Diseases • Orthopedics • Pediatrics

Three developed spectrophotometric methods for determination of a mixture of ofloxacin and ornidazole; application of greenness assessment tools. (PubMed, BMC Chem) - "The developed methods were validated according to ICH guidelines. All techniques were statistically compared to either an official method for OFL or a reported method for ORN and the results indicate that there were not any significant differences."

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TLC-smartphone in antibiotics determination and low-quality pharmaceuticals detection. (PubMed, RSC Adv) - "The recorded images were processed to calculate the R values (R values for ofloxacin and ornidazole were 0.12 and 0.76, respectively) which provide identity of the drugs while spot intensity was calculated using a commercially available smartphone app and employed for quantitative analysis of the antibiotics and "acetaminophen" as an example of a counterfeit substance. The limit of detection was found to be 0.8 μg/spot for ofloxacin and 1.1 μg/spot for ornidazole. The proposed method has been successfully applied for the determination of ofloxacin and ornidazole present in more than one pharmaceutical dosage form and was comparable to the densitometric method."

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