etodolac/thiocolchicoside / Generic mfg. - LARVOL DELTA

VisuMax Femtosecond Laser Small Incision Lenticule Extraction for the Correction of High Myopia (clinicaltrials.gov) - P=N/A; N=187; Active, not recruiting; Sponsor: London Vision Clinic; Recruiting ➔ Active, not recruiting; Trial primary completion date: Sep 2019 ➔ Sep 2020

Enrollment closed • Trial primary completion date

In Vitro Evaluation of the Inhibitory Effect of Topical Ophthalmic Agents on Acanthamoeba Viability. (PubMed, Transl Vis Sci Technol) - "Proxymetacaine, oxybuprocaine, and especially tetracaine were all toxic to the trophozoites and cysts of Acanthamoeba spp., but lidocaine was well tolerated. Ophthalmologists should be aware that certain topical anesthetics and ophthalmic preparations containing BAC prior to specimen sampling may affect the viability of Acanthamoeba spp. in vivo, resulting in false-negative results in diagnostic tests."

Journal • Preclinical

Evaluation of pain during intravitreal ranibizumab injections (EURETINA 2019) - "The pain associated with intravitreal ranibizumab injections and demonstrated that pain associated with intravitreal ranibizumab injections is generally mild and can be ignored."

Adding Dopamine to Proxymetacaine or Oxybuprocaine Solutions Potentiates and Prolongs the Cutaneous Antinociception in Rats. (PubMed, Anesth Analg) - "Oxybuprocaine and proxymetacaine had a higher potency and provoked a shorter duration of sensory block compared with dopamine. The use of dopamine increased the quality and duration of skin antinociception caused by oxybuprocaine and proxymetacaine."

Journal • Preclinical

Serotonin enhances oxybuprocaine- and proxymetacaine-induced cutaneous analgesia in rats. (PubMed, Eur J Pharmacol) - "Oxybuprocaine or proxymetacaine is more potent and has a shorter duration of cutaneous analgesia than serotonin. Serotonin produces a synergistic antinociceptive interaction with oxybuprocaine or proxymetacaine."

Journal • Preclinical

Design by optimization and comparative evaluation of vesicular gels of etodolac for transdermal delivery. (PubMed, Drug Dev Ind Pharm) - "The prepared liposomal gel (ETO-LG) and ethosomal gel (ETO-EG) were optimized and characterized. The vesicular gels showed desirable results compared to other test formulations."

Journal

Bilateral keratopathy due to topical anesthetic abuse, overlooked as microbial keratitis: a case report (ESCRS-WM 2019) - "...Setting: Cornea & External Eye Disease Service, Department of Ophthalmology University Hospital of Heraklion, Crete, Greece Case report Male patient 42 y.o. presented with blurred vision, pain, severe photophobia and irritation in both eyes, due to bilateral non-healing epithelial defects, self treated with proxymetacaine drops... Ophthalmologists should be suspicious of topical anesthetic abuse keratopathy in young males presenting with persistent epithelial defects, ring-shaped keratitis, and accompanying severe ocular pain and photophobia."

Clinical

Regional variation in the administration of fluorescein when performing Goldmann applanation tonometry in the National Health Service, UK (ESCRS-WM 2019) - "Whilst some variation exists in the practice of performing Goldmann applanation tonometry, the majority of departments still perform this by mixing proxymetacaine to fluorescein. The commonest reason sited was to improve comfort to patients. Whilst the combination Minim of proxymetacaine hydrochloride 0.5% with fluorescein sodium 0.25% no longer exists, ophthalmologists continue to manually recreate this to improve comfort to their patients."

VisuMax Femtosecond Laser Small Incision Lenticule Extraction for the Correction of High Myopia (clinicaltrials.gov) - P=N/A; N=187; Recruiting; Sponsor: London Vision Clinic; Trial completion date: Sep 2019 ➔ Sep 2020; Trial primary completion date: Sep 2018 ➔ Sep 2019

Trial completion date • Trial primary completion date