ciprofol injectable emulsion (HSK3486) / Haisco - LARVOL DELTA

Comments on "The 95% effective dose of ciprofol-assisted sedation for knee arthroplasty in elderly patients: a prospective cohort study". (PubMed, Int J Surg) - No abstract available

Journal • Anesthesia • Orthopedics

Effects of Different Anesthetic Drugs on Immune Function in Healthy Volunteers (clinicaltrials.gov) - P=N/A | N=80 | Enrolling by invitation | Sponsor: Henan Provincial People's Hospital

New trial • Anesthesia

Optimal dosing of ciprofol for gastrointestinal endoscopy: a systematic review and network meta-analysis. (PubMed, BMC Gastroenterol) - "A dose of 0.4 mg/kg of ciprofol may represent the optimal dose for endoscopic sedation, as it can reduce the incidence of injection pain, respiratory depression, and hypotension. However, most included studies focus on Chinese populations, which limits the global applicability of the findings. Future RCTs conducted in more countries are warranted."

Clinical • Journal • Retrospective data • Review • Anesthesia • Cardiovascular • CNS Disorders • Depression • Hypotension • Pain • Psychiatry

Comparison of ciprofol and propofol on dreaming and emotional response during painless gastroscopy: a single-center randomized controlled trial. (PubMed, Expert Opin Drug Saf) - P4 | "However, this does not impact patient satisfaction with the procedure. www.chictr.org.cn; identifier: ChiCTR2400082655."

Journal • Anesthesia • Pain

Comparing the safety and efficacy of propofol, ciprofol, and remimazolam in general anesthesia. (PubMed, Chin Med J (Engl)) - No abstract available

Journal • Anesthesia

Chinese clinical practice guidelines for total intravenous anaesthesia: a systematic review and expert consensus-based recommendations☆. (PubMed, Br J Anaesth) - "After collection and selection of clinical questions, the working group conducted rigorous searches of the literature, formulated recommendations, and finally reached a consensus. A total of 22 recommendations were made on 12 clinical issues, including the indications, contraindications, and advantages of TIVA, use of depth of anaesthesia monitoring during implementation, pharmacological characteristics of available i.v. anaesthetic drugs, selection and use of drugs in target- and nontarget-controlled infusion modes, and precautions for application of TIVA in special populations, thus providing guidance for anaesthetists to standardise implementation of TIVA."

Clinical guideline • Journal • Anesthesia

Effects of Remimazolam and Ciprofol TIVA on PRAE in Pediatric Tonsillectomy and Adenoidectomy (clinicaltrials.gov) - P4 | N=114 | Recruiting | Sponsor: Tongji Hospital | Not yet recruiting ➔ Recruiting | Trial completion date: Dec 2025 ➔ Aug 2026 | Trial primary completion date: Dec 2025 ➔ Aug 2026

Adverse events • Enrollment open • Trial completion date • Trial primary completion date • Anesthesia • Pediatrics

Jiancheng Dual-Channel vs. i-gel Laryngeal Mask Airway for Fiberoptic Bronchoscopy: A Randomized Trial. (PubMed, Anaesth Crit Care Pain Med) - P=N/A | "The Jiancheng dual-channel LMA is associated with higher first-attempt success for airway insertion and bronchoscopy compared to the i-gel LMA, warranting consideration for broader clinical application."

Journal • Anesthesia • Cardiovascular • Hypertension • Hypotension

Ciprofol Versus Propofol for Tracheal Intubation in ICU (clinicaltrials.gov) - P4 | N=100 | Completed | Sponsor: Shanghai Zhongshan Hospital | Recruiting ➔ Completed | Trial completion date: Dec 2026 ➔ Oct 2025 | Trial primary completion date: May 2026 ➔ Oct 2025

Intubation • Trial completion • Trial completion date • Trial primary completion date

Ciprofol versus propofol for sedation in colonoscopy: a systematic review and meta-analysis of randomized controlled trials. (PubMed, Braz J Anesthesiol) - "Ciprofol provides comparable efficacy to propofol for colonoscopy sedation, with a lower incidence of respiratory depression, injection pain, and hypotension. Patient satisfaction was slightly higher with ciprofol, while bradycardia occurrence was similar. These findings suggest ciprofol as a promising alternative, though further large-scale studies are needed to confirm its clinical benefits."

Journal • Retrospective data • Review • Anesthesia • Cardiovascular • CNS Disorders • Depression • Hypotension • Pain • Psychiatry

Comparison of ciprofol versus propofol on gastrointestinal motility in patients undergoing laparoscopic radical resection for colorectal cancer: study protocol for a randomised controlled trial. (PubMed, BMJ Open) - P=N/A | "Results will be published in peer-reviewed journals and presented at scientific conferences. ChiCTR2400093434."

Journal • Anesthesia • Colorectal Cancer • Gastrointestinal Cancer • Oncology • Solid Tumor

The effects of ciprofol and propofol on hypoxemia during gastrointestinal endoscopy in overweight and obese patients: a randomized controlled trial. (PubMed, BMC Anesthesiol) - P=N/A | "The findings of this study indicate that ciprofol offers sedation effects comparable to those of propofol, without significantly altering the incidence of hypoxemia in overweight and obese patients undergoing gastrointestinal endoscopy. However, additional evidence is required to validate these findings due to the limitations posed by the sample size."

Journal • Anesthesia • CNS Disorders • Depression • Genetic Disorders • Hypotension • Obesity • Pain • Psychiatry

Comparison of the Incidence of Hypotension Between Ciprofol and Propofol in Hypertensive Patients Undergoing Painless Gastrointestinal Endoscopy (ChiCTR) - P=N/A | N=84 | Not yet recruiting | Sponsor: Affiliated Hospital of Guangdong Medical University; Affiliated Hospital of Guangdong Medical University

New trial • Cardiovascular • Hypertension • Hypotension • Pain

The 90% effective doses of ciprofol combined with dexmedetomidine nasal spray for inhibiting responses to gastroscope insertion in obese and non-obese patients:a dose-finding experiment using a biased-coin design (ChiCTR) - P=N/A | N=108 | Not yet recruiting | Sponsor: Hefei First People's Hospital; Hefei First People's Hospital

New trial • Gastroenterology • Gastroesophageal Reflux Disease • Gastrointestinal Disorder • Obesity • Pain

Comparative study of ciprofol vs. propofol in carotid endarterectomy: focusing on mean arterial pressure, vasoactive drug use, and postoperative complications. (PubMed, Front Med (Lausanne)) - P=N/A | "Ciprofol may be the preferable anesthetic agent in carotid artery-related procedures. https://www.chictr.org.cn/, identifier ChiCTR2500104162."

Journal • Anesthesia • Cardiovascular • Cognitive Disorders

Efficacy of Cyclopofol versus Propofol Combined with Lidocaine Oropharyngeal Spray Anesthesia for Gastroscopy in School-age Children (ChiCTR) - P4 | N=120 | Not yet recruiting | Sponsor: The Second Affiliated Hospital of Wenzhou Medical University; The Second Affiliated Hospital of Wenzhou Medical University

New P4 trial • Anemia • Anesthesia • Gastrointestinal Disorder • Hematological Disorders • Pain • Peptic Ulcer

Comparison of the Effects of Propofol and Ciprofol on Hemodynamics during Anesthetic Induction in Patients Undergoing Radical Resection of Gastrointestinal Tumors (ChiCTR) - P4 | N=120 | Not yet recruiting | Sponsor: The First Affiliated Hospital of Zhengzhou University; The First Affiliated Hospital of Zhengzhou University

New P4 trial • Anesthesia • Gastrointestinal Cancer • Hypotension • Solid Tumor

Application of different anesthesia regimens in painless gastroscopy for elderly patients (ChiCTR) - P=N/A | N=320 | Not yet recruiting | Sponsor: People's Hospital of Ningxia Hui Autonomous Region; People's Hospital of Ningxia Hui Autonomous Region

New trial • Anesthesia • Pain

The optimal dosage of ciprofol combined with esketamine and sufentanil for general anesthesia induction and intubation in elderly patients (ChiCTR) - P=N/A | N=75 | Not yet recruiting | Sponsor: Hainan General Hospital; Hainan General Hospital

Intubation • New trial • Anesthesia

Effects of ciprofol versus propofol total intravenous anesthesia on regional cerebral oxygen saturation and cerebral blood flow in elderly patients undergoing carotid endarterectomy (ChiCTR) - P4 | N=120 | Not yet recruiting | Sponsor: Xuanwu Hospital, Capital Medical University; Xuanwu Hospital, Capital Medical University

New P4 trial • Anesthesia • Cardiovascular

Comparison of Ciprofol, Remimazolam, and Propofol on Arrhythmia Inducibility in Pediatric Supraventricular Tachycardia: A Retrospective Study (ChiCTR) - P=N/A | N=173 | Not yet recruiting | Sponsor: Women's and Children's Hospital affiliated to Qingdao University; Women's and Children's Hospital affiliated to Qingdao University

New trial • Anesthesia • Cardiovascular • Pediatrics • Ventricular Tachycardia

Application Effect of Ciprofol in Anesthesia for Thoracoscopic Surgery: A Prospective, Randomized, Double-Blind, Controlled Trial (ChiCTR) - P4 | N=120 | Not yet recruiting | Sponsor: Zibo Central Hospital; Zibo Central Hospital

New P4 trial • Anesthesia

The influence of ciprofol on the delayed neurocognitive recovery in elderly patients after laparoscopic colorectal tumor surgery (ChiCTR) - P=N/A | N=130 | Not yet recruiting | Sponsor: Baoding NO.1 central hospital; Baoding No.1 central hospital

New trial • Colorectal Cancer • Solid Tumor

Study on the Effective Dose of Alfentanil Combined with Ciprofol in Inhibiting Intraoperative Body Movement Responses in Patients Undergoing Breast Lump Resection (ChiCTR) - P1 | N=40 | Not yet recruiting | Sponsor: Suzhou Municipal Hospital; Suzhou Municipal Hospital

New P1 trial

The Effect of Oliceridine Infusion on Hemodynamics During ERCP: A Randomized Clinical Trial (ChiCTR) - P=N/A | N=118 | Not yet recruiting | Sponsor: Shanghai East Hospital; Shanghai East Hospital

New trial