ciprofol injectable emulsion (HSK3486) / Haisco - LARVOL DELTA

Recovery Profiles and Well-Being Outcomes in Patients Undergoing Various Anaesthesia Techniques: A Systematic Review. (PubMed, Health Sci Rep) - "Intravenous anesthetics such as propofol and newer agents like remimazolam and ciprofol are associated with improved recovery rates in high-risk patients, providing hemodynamic stability and reducing the risk of postoperative nausea and vomiting. Furthermore, Opioid-sparing and xenon-based anesthetics also contributed to better recovery profiles. Anesthesia choice plays a critical role in patient recovery, with tailored techniques enhancing outcomes and reducing adverse effects."

Journal • Review • Anesthesia • Pain

Efficacy and Safety of Ciprofol Alone versus Ciprofol with Fentanyl for Upper Gastrointestinal Endoscopy: A Randomized, Double-Blind, Controlled Trial. (PubMed, Drug Des Devel Ther) - "Ciprofol alone is non-inferior to ciprofol with fentanyl for sedation in upper gastrointestinal endoscopy and offers advantages in respiratory and hemodynamic stability. However, it is associated with increased coughing, minor delays in induction and recovery, and more postoperative dizziness."

Clinical • Journal • Anesthesia • CNS Disorders • Depression • Hypotension • Psychiatry

CP-MINS: Effects of Ciprofol on Myocardial Injury After Non-cardiac Surgery in Video-Assisted Thoracoscopic Surgery (clinicaltrials.gov) - P4 | N=1058 | Not yet recruiting | Sponsor: Tongji Hospital

New P4 trial • Cardiovascular

Effective Dosage of Ciprofol for the Induction of General Anesthesia Across Diverse Age Groups in Adults: A Single-Center, Prospective, Non-Randomized Sequential Trial. (PubMed, J Pain Res) - "Ciprofol is safe and effective for anesthesia induction across age groups, with lower doses required for elderly patients. NTI reduction was dose-dependent and slower in elderly patients."

Clinical • Journal • Anesthesia

Efficacy and safety of ciprofol for sedation/anesthesia in patients undergoing hysteroscopy: a prospective, randomized, non-inferiority trial. (PubMed, Ann Med) - P=N/A | "Despite slightly longer induction and recovery times, ciprofol results in lower instances of injection pain and less impact on respiration and circulation compared to propofol. Clinical trial Registration Identifier: NCT06172140."

Clinical • Head-to-Head • Journal • Anesthesia • Cardiovascular • CNS Disorders • Depression • Gynecology • Hypotension • Pain • Psychiatry

Ciprofol versus propofol sedation in ICU patients and norepinephrine requirements: a single-center prospective cohort study. (PubMed, Crit Care) - No abstract available

Journal • Anesthesia

Half effective dose and clinical efficacy of continuous infusion of ciprofol with compound ketamine for ESD surgery of colon polyps in elderly patients (ChiCTR) - P4 | N=50 | Not yet recruiting | Sponsor: Shanghai Xuhui Central Hospital; Shanghai Xuhui Central Hospital

New P4 trial • Colonic Polyps • Gastroenterology • Gastrointestinal Disorder

Effects of Ciprofol versus Propofol on Blood Pressure after Anesthesia Induction in Patients with Acute Type A Aortic Dissection: A Randomized Controlled Trial (ChiCTR) - P4 | N=404 | Not yet recruiting | Sponsor: Beijing Anzhen Hospital, Capital Medical University; Xiangya Hospital, Central South University

New P4 trial • Anesthesia

Efficacy and safety of ciprofol as an adjunctive sedative during spinal anesthesia (ChiCTR) - P4 | N=60 | Not yet recruiting | Sponsor: Affiliated Hospital of Guizhou Medical University; Affiliated Hospital of Guizhou Medical University

New P4 trial • Anesthesia

The effect of ciprofol induction on the dosage of propofol in propofol-remifentanil total intravenous anesthesia (ChiCTR) - P=N/A | N=26 | Not yet recruiting | Sponsor: The First Affiliated Hospital of Sun Yat-sen University; The First Affiliated Hospital of Sun Yat-sen University

New trial • Anesthesia • Immunology • Osteoarthritis • Pain • Rheumatology

Comparison of the Effects of Three Intravenous Anesthetics on Early Postoperative Recovery Quality in Elderly Patients Undergoing Thoracoscopic Lung Surgery: A Randomized Clinical Trial (ChiCTR) - P=N/A | N=459 | Not yet recruiting | Sponsor: West China Hospital, Sichuan University; West China Hospital, Sichuan University

New trial • Anesthesia

Effect of Ciprofol on emergence agitation after tonsillectomy and adenoidectomy in children: a randomised controlled trial (ChiCTR) - P=N/A | N=80 | Not yet recruiting | Sponsor: The Third Affiliated Hospital of Zhengzhou University; The Third Affiliated Hospital of Zhengzhou University

New trial

Comparison of the effects of ciprofol and propofol on hypoxemia in obese patients underwent sedative gastrointestinal endoscopy: a multicenter randomized controlled clinical trial (ChiCTR) - P=N/A | N=266 | Not yet recruiting | Sponsor: The Seventh Affiliated Hospital of Sun Yat-Sen University; The Seventh Affiliated Hospital of Sun Yat-Sen University

New trial • Genetic Disorders • Obesity

Analysis of the anesthetic effects of alfentanil combined with ciprofol for gynecological outpatient short operation (ChiCTR) - P=N/A | N=192 | Not yet recruiting | Sponsor: The First Affiliated Hospital of Jinan University; The First Affiliated Hospital of Jinan University

New trial • Anesthesia

The Effects of Ciprofol and Etomidate Combination Solution on Intraoperative Hypoxemia and Hypotension in Elderly Patients Undergoing Painless Gastrointestinal Endoscopy: A Randomized Controlled Trial (ChiCTR) - P=N/A | N=210 | Not yet recruiting | Sponsor: The First Affiliated Hospital of Zhengzhou University; The First Affiliated Hospital of Zhengzhou University

New trial • Hypotension • Pain

Observation of the Clinical Efficacy of Ciprofol in the Induction of General Anesthesia in Hypertensive Patients (ChiCTR) - P4 | N=96 | Not yet recruiting | Sponsor: Weifang People's Hospital; Weifang People's Hospital

New P4 trial • Anesthesia • Cardiovascular • Hypertension

Comparison of the cardiovascular stability of etomidate, remimazolam and ciprofol during the induction of general anesthesia in elderly patients: a multicenter randomized controlled study (ChiCTR) - P=N/A | N=156 | Not yet recruiting | Sponsor: The Third Affiliated Hospital of Zhengzhou University; The Third Affiliated Hospital of Zhengzhou University

New trial • Anesthesia • Cardiovascular • Hypotension

Clinical investigation of postoperative euphoria and perioperative mood changes and adverse events after painless gastroenteroscopy with ciprofol (ChiCTR) - P=N/A | N=346 | Not yet recruiting | Sponsor: Northern Jiangsu People's Hospital; Northern Jiangsu People's Hospital

Adverse events • New trial • Pain

A study on the median effective dose of ciprofol for laryngeal mask anesthesia in children of different age groups (ChiCTR) - P=N/A | N=60 | Not yet recruiting | Sponsor: Women and Children's Medical Center Affiliated to Guangzhou Medical University; Women and Children's Medical Center Affiliated to Guangzhou Medical Un

New trial • Anesthesia

Effect of ciprofol versus etomidate on hypotension after anesthetic induction in frail patients undergoing transcatheter cardiac radiofrequency ablation: A randomized controlled trial (ChiCTR) - P=N/A | N=106 | Not yet recruiting | Sponsor: People's Hospital of Ningxia Hui Autonomous Region; People's Hospital of Ningxia Hui Autonomous Region

New trial • Anesthesia • Hypotension

Effects of Ciprofol on Intraoperative Hypotension, Carotid Artery Hemodynamics, and Postoperative Negative Emotions in Patients Undergoing Laparoscopic Surgery (ChiCTR) - P=N/A | N=260 | Not yet recruiting | Sponsor: Women's Hospital, Zhejiang University School of Medicine; Women's Hospital, Zhejiang University School of Medicine

New trial • Hypotension

The Clinical Application of Ciprofol in General Anesthesia (ChiCTR) - P4 | N=300 | Not yet recruiting | Sponsor: Nanjing Stomatological hospital; Nanjing Stomatological hospital

New P4 trial • Anesthesia

Effects of three intravenous anesthetic drugs on Early Recovery Quality After TAVR: A Randomized Trial (ChiCTR) - P=N/A | N=678 | Not yet recruiting | Sponsor: West China Hospital of Sichuan University; West China Hospital of Sichuan University

New trial • Anesthesia

Induction of general anesthesia during elective surgery in adults: A randomized, double-blind, phase 3 study of HSK3486 vs propofol (HSK3486-309) (Euroanaesthesia 2025) - P3 | "HSK3486 was associated with significantly less pain on injection vs propofol. HSK3486 and propofol had similar success rates for induction in subgroups."

Clinical • P3 data • Surgery • Anesthesia • Pain

Should we divide the preoperative ASA 2 group into smaller subgroups to better evaluate our patients? (Euroanaesthesia 2025) - "More studies have already focused on a new drug, ciprofol, that causes more stable hemodynamic parameters in elderly patients (1).Materials and We analyzed retrospectively patients' preoperative data and their anesthesia induction parameters...However, as we compared the sub-parameters of the score systems, a significant difference was visible only in the cardiac function and the kidney parameters (CN GI: 4±1, GII: 7±3 mmol/l, p=0.02) besides age.Conclusion(s): We differentiated two in their parameters significantly different groups within the ASA 2 patients based on their age. Parameters representing patients' age and frailty need to be identified and a new score system should be designed to predict intraoperative management difficulties."

Clinical • Anesthesia • Hypotension