ciprofol injectable emulsion (HSK3486) / Haisco - LARVOL DELTA

Efficacy and safety of ciprofol versus propofol for sedation in hysteroscopy: a systematic review and meta-analysis. (PubMed, Ther Adv Drug Saf) - "The meta-analysis has been registered with PROSPERO. The registration number is CRD420251091116."

Journal • Retrospective data • Anesthesia • Cardiovascular • CNS Disorders • Depression • Gynecology • Hypotension • Pain • Psychiatry

Efficacy and safety of ciprofol for general anesthesia in pediatric strabismus correction surgery: a prospective, randomized, double-blind, non-inferiority study. (PubMed, Front Med (Lausanne)) - P1 | "For anesthesia induction, Group C received an intravenous injection of ciprofol 0.5 mg/kg, alfentanil 20 μg/kg, and vecuronium bromide 0.05 mg/kg; Group P received an intravenous injection of propofol 2 mg/kg, alfentanil 20 μg/kg, and vecuronium bromide 0.05 mg/kg. Ciprofol can be safely used for general anesthesia in pediatric strabismus correction surgery, with non-inferior anesthesia success rate compared with propofol and a lower incidence of adverse reactions. https://www.chictr.org.cn, identifier ChiCTR2300078654."

Clinical • Head-to-Head • Journal • Anesthesia • Ophthalmology • Pediatrics • Strabismus

Effect of ciprofol with etomidate on the occurrence of hypotension in elderly patients undergoing upper gastrointestinal endoscopy: a prospective randomized controlled study. (PubMed, BMC Anesthesiol) - No abstract available

Journal • Hypotension

Comparison of anesthetic efficacy and safety between ciprofol and propofol in elderly patients undergoing painless gastrointestinal endoscopy. (PubMed, Am J Transl Res) - "For PGE in elderly patients, ciprofol demonstrates significant advantages over propofol in reducing adverse reactions, alleviating pain, and improving patient satisfaction."

Journal • Anesthesia • CNS Disorders • Depression • Pain • Psychiatry

Determination of ED50 and ED95 for Ciprofol in Morbidly Obese Patients During Induction of General Anesthesia: A Single-Center, Up-and-Down Study Based on Lean Body Weight. (PubMed, Drug Des Devel Ther) - "The LBW-scaled ED50 and ED95 of ciprofol for loss of consciousness during the induction of general anesthesia in morbidly obese adults were 0.492 and 0.634 mg kg-1, respectively. Hemodynamics were generally well controlled and adverse events were infrequent."

Clinical • Journal • Anesthesia • Cardiovascular • Genetic Disorders • Hypotension • Obesity

TAPH: Effect of Titrated Administration of Ciprofol on Perioperative Hypotension in Elderly Patients Undergoing Laparoscopic Abdominal Surgery: A Randomized Controlled Trial (clinicaltrials.gov) - P=N/A | N=500 | Recruiting | Sponsor: Sixth Affiliated Hospital, Sun Yat-sen University | Not yet recruiting ➔ Recruiting

Enrollment open • Hypotension

Effects of Voriconazole on the Safety, Pharmacokinetics and Pharmacodynamics of Ciprofol (HSK3486), a Novel Intravenous Anaesthetic, in Healthy Participants: A Prospective, Randomized, Crossover Clinical Trial. (PubMed, Drug Des Devel Ther) - P1 | "The dose of ciprofol is suggested not be adjusted in patients receiving the CYP inhibitor voriconazole based on the PK, PD and safety characteristics. Clinicaltrials.gov, NCT04145583, registered on 25 October 2019."

Clinical • Journal • PK/PD data • Anesthesia • CYP2C9 • CYP3A4

Efficacy and safety of ciprofol compared to propofol during the induction of general anesthesia in burns patients: A double-blind, randomized controlled trial. (PubMed, Burns) - "Ciprofol is safe and effective for anesthesia induction in burn patients, offering acceptable sedation with reduced injection discomfort. Findings support its clinical use and address evidence gaps in burn patient anesthesia management."

Journal • Allergy • Anesthesia • Pain • Thermal Injury

Ciprofol injection in patients receiving non-invasive positive pressure ventilation: a retrospective study. (PubMed, Front Pharmacol) - "For patients undergoing NPPV, ciprofol provides sedation efficacy comparable to propofol while demonstrating a superior safety profile, faster recovery, and enhanced injection tolerability. This combination of advantages makes ciprofol a preferable alternative for sedation in this clinical setting."

Journal • Retrospective data • Anesthesia • CNS Disorders • Depression • Hypotension • Pain • Psychiatry

EC50 via TCI: A Study on Median Effective Concentration of Ciprofol Combined With Remifentanil Via Target-controlled Infusion for Inhibiting Tracheal Intubation Stimulation Under qNOX Index Monitoring (clinicaltrials.gov) - P=N/A | N=70 | Active, not recruiting | Sponsor: Guangzhou General Hospital of Guangzhou Military Command

Intubation • New trial

Ciprofol-lidocaine combination for sedation in gastrointestinal endoscopy: a systematic review and meta-analysis protocol. (PubMed, Anaesth Rep) - "Data will be synthesised using fixed or random effects models as dictated by the degree of heterogeneity, with risk of bias appraised using the RoB 2.0 tool and certainty of evidence graded according to the GRADE framework. This review will be the first comprehensive synthesis of the evidence pertaining to the efficacy and safety of intravenous lidocaine as an adjunct to ciprofol-based sedation, thereby informing future multimodal sedation strategies and clinical practice."

Journal • Retrospective data • Anesthesia

Changes of Ciprofol Dosage and Bispectral Index Required for Loss of Consciousness in Patients of Different Ages (clinicaltrials.gov) - P=N/A | N=125 | Completed | Sponsor: General Hospital of Ningxia Medical University | Not yet recruiting ➔ Completed

Trial completion

Exploring the median effective dose of ciprofol for anesthesia induction in patients with heart valve disease: a prospective, single-arm, single-centre study. (PubMed, BMC Anesthesiol) - No abstract available

Journal • Anesthesia • Cardiovascular

Ciprofol versus propofol and the risk of hemodynamic adverse events: a meta-analysis with trial sequential analysis of randomized controlled trials. (PubMed, BMC Anesthesiol) - "Ciprofol was associated with a reduced incidence of intraoperative hypotension compared with propofol, with comparable anesthetic efficacy. Nevertheless, due to heterogeneity and overall low-to-moderate certainty of evidence, these findings should be interpreted with caution. Further large-scale, well-designed randomized controlled trials are warranted to validate these results and delineate the clinical benefits of ciprofol."

Adverse events • Journal • Retrospective data • Review • Anesthesia • CNS Disorders • Depression • Hypotension • Pain • Psychiatry

Advantages of Ciprofol with Special Consideration of Pediatric Anesthesia. (PubMed, Children (Basel)) - "In recent years, the introduction of ciprofol has marked a major breakthrough in the pharmacological field, following the introduction of dexmedetomidine. Although studies on children are still limited, the literature on adults is now substantial and of high quality. The potential advantages of using ciprofol in pediatric anesthesia include pain-free induction, hemodynamic stability, less respiratory depression, and a lower incidence of emergence delirium."

Journal • Review • Anesthesia • CNS Disorders • Depression • Pain • Pediatrics • Psychiatry

Effect of ciprofol on the incidence of hypotension during induction of general anesthesia in elderly patients undergoing total hip arthroplasty: single-center retrospective study. (PubMed, Front Med (Lausanne)) - "Subgroup analyses demonstrated that the advantages of ciprofol remained consistent across all pre-specified subgroups, with prominent differences noted in patients aged under 90 years, those with an aCCI of ≤4, a CFS score of ≤4, and baseline blood pressure (BP) of <140/90 mmHg. Ciprofol reduces PIH risk, improves haemodynamic stability, and decreases vasoactive agent use and injection pain compared with propofol in elderly patients, independent of baseline characteristics, indicating suitability for anesthetic management in this population."

Journal • Retrospective data • Anesthesia • Cardiovascular • Hypertension • Hypotension • Orthopedics • Pain

Compatibility and stability of ciprofol with different concentrations of remifentanil or esketamine. (PubMed, BMC Anesthesiol) - No abstract available

Journal

The effect of ciprofol on the incidence of postoperative delirium in adult surgical patients: a meta-analysis and meta-regression. (PubMed, Front Neurol) - "These findings provide new evidence for perioperative neurocognitive protection. INPLASY International Platform, registration number: INPLASY202610019, DOI: 10.37766/inplasy2026.1.0019."

Journal • Retrospective data • Review • Anesthesia • CNS Disorders • Hypotension

Efficacy and Safety of Ciprofol for Sedation in Critically Ill Patients After Cardiac Surgery: A Single-Center, Prospective, Randomized Controlled Trial. (PubMed, Drug Des Devel Ther) - "Midazolam was administered if additional sedation was required, and remifentanil was used for analgesia. In summary, ciprofol provides non-inferior sedation efficacy and a comparable safety profile to propofol in critically ill patients following cardiac surgery. A numerical trend toward lower hypotension incidence was observed with ciprofol, which warrants further validation in future studies."

Clinical • Journal • Anesthesia • Cardiovascular • CNS Disorders • Critical care • Hypotension • Pain

Incidence of injection pain between ciprofol and propofol after induction of general anesthesia: a systematic review and meta-analysis of randomized controlled trials. (PubMed, Front Med (Lausanne)) - "Trial sequential analysis further supported the robustness of these findings. CRD420251003081."

Journal • Retrospective data • Review • Anesthesia • Cardiovascular • Hypotension • Pain

From pharmacokinetics to precision dosing: optimizing continuous infusion regimens of ciprofol for elderly patients. (PubMed, Front Pharmacol) - "A population PK/PD model for ciprofol in elderly patients was successfully established and validated. The model supports optimized, individualized dosing to achieve target anesthesia depth in this population."

Journal • PK/PD data • Anesthesia

Ciprofol attenuates cerebral Ischemia‒reperfusion injury in rats by inhibiting ferroptosis through upregulating AMPK. (PubMed, Sci Rep) - "From July 2023 and July 2024, fifty male SD rats were randomly divided into five groups: control, model, ciprofol (Ci), erastin (Era), and compound C (CC). Furthermore, the CC rats displayed decreased p-AMPK/T-AMPK activation relative to Ci rats (P < 0.05). Ciprofol ameliorates CIRI in rats by inhibiting ferroptosis and inflammatory factor through upregulating AMPK."

Journal • Preclinical • Cardiovascular • Reperfusion Injury • ACSL4 • AMPK • GPX4 • IL1B • IL6 • TNFA

Impact of low-dose sufentanil on the effective sedative dose of ciprofol for BIS-guided induction in elderly patients: an up-and-down sequential allocation trial. (PubMed, Front Med (Lausanne)) - P4 | "This regimen provides an effective and well-tolerated strategy for anesthesia in elderly patients, particularly in day surgery and outpatient settings. http://www.chictr.org.cn, identifier: ChiCTR2400090926."

Journal • Anesthesia • CNS Disorders • Depression • Hypotension • Psychiatry

What's new in intravenous anaesthesia? (PubMed, Curr Opin Anaesthesiol) - "Over the recent half-decade, the field of intravenous anaesthesia reflects a shift toward personalized, computer-assisted delivery and novel agents with favorable pharmacokinetics. These trends point toward safer, more effective anaesthesia management while paving the way for continued innovation in clinical practice."

Journal • Anesthesia • Cardiovascular • CNS Disorders • Depression • Psychiatry

Optimizing sedation in elderly patients: advantages and challenges of alfentanil-ciprofol for painless gastroscopy. (PubMed, Am J Transl Res) - "The use of the traditional narcotic sedation guidelines like fentanyl and propofol is linked to respiratory and circulatory suppression in this at-risk group. Furthermore, we address the challenges inherent to its use in this age group, such as dose individualization and respiratory management, and propose potential solutions. Lastly, we outline future research directions, emphasizing that individualized dosing strategies based on the principles of precision anesthesia will be central to optimizing outcomes for elderly patients."

Journal • Review • Anesthesia • Pain