Visanne (dienogest) / Mochida, Bayer - LARVOL DELTA

Norethindrone acetate versus dienogest for pain relief in endometriosis related pain: A randomized controlled trial. (PubMed, Eur J Obstet Gynecol Reprod Biol) - P=N/A | "Both progestins effectively reduced pain scores, but NETA achieved a greater reduction in endometrioma size and had a lower dropout rate, potentially due to its higher dose. These findings suggest NETA 5 mg/day may be a better approach instead of dienogest for the endometriosis treatment."

Journal • Endometriosis • Gynecology • Musculoskeletal Pain • Pain • Women's Health

Comparative analysis of the clinical efficacy of conservative treatment for adenomyosis using traditional Chinese medicine and Western medicine. (PubMed, J Health Popul Nutr) - "Dan'e Fukang Decoction is markedly effective in alleviating pain; Goserelin + Mirena exhibits significant efficacy in reducing bleeding."

Clinical • Journal • Endometriosis • Gynecology • Musculoskeletal Pain • Pain • Women's Health

Add-on effect of curcumin to dienogest in patients with endometriosis: a randomized, double-blind, controlled trial. (PubMed, Phytomedicine) - "The combination of curcumin and dienogest significantly reduced pain and improved QOL and sexual function in women with endometriosis, suggesting curcumin as an effective adjunct therapy."

Clinical • Journal • Endometriosis • Gynecology • Musculoskeletal Pain • Pain • Women's Health

D-chiro-inositol effectively counteracts endometriosis in a mouse model. (PubMed, Mol Med) - "By modulating proliferation, EMT transition and aromatase activity, DCI emerges as a promising compound for endometriosis treatment."

Journal • Preclinical • Endometriosis • Gynecology • Infertility • Pain • Sexual Disorders • Transplantation • Women's Health • CD34 • CDH1 • CYP19A1 • PCNA • SIRT1

Reply to 'Critical appraisal of "Comparison of combined oral contraceptives and dienogest for endometriosis-associated pain"'. (PubMed, Eur J Obstet Gynecol Reprod Biol) - No abstract available

Journal • Endometriosis • Gynecology • Pain • Women's Health

Fertility preservation in women with endometriosis: A retrospective non-Inferiority study comparing Dienogest in the PPOS protocol to antagonist and agonist protocols. (PubMed, J Gynecol Obstet Hum Reprod) - "The PPOS protocol with Dienogest appears to be a promising alternative for FP compared to traditional protocols for patients with endometriosis, without adversely affecting the number of mature oocytes retrieved. Larger prospective studies are required to confirm these results."

Head-to-Head • Journal • Retrospective data • Endometriosis • Gynecology • Women's Health

ENDOmiRNA: Salivary microRNA in Endometriosis: Correlation With Response to Progestin Therapy (clinicaltrials.gov) - P=N/A | N=90 | Recruiting | Sponsor: University of Udine | Trial completion date: May 2025 ➔ Dec 2025 | Trial primary completion date: Jan 2025 ➔ Dec 2025

Trial completion date • Trial primary completion date • Endometriosis • Gynecology • Women's Health

Efficacy and safety of hormone therapies for treating adenomyosis-associated pelvic pain: a systematic review and network meta-analysis of randomized controlled trials. (PubMed, Front Endocrinol (Lausanne)) - "Dienogest seems to be the most effective HT for AAPP. However, although rare, it is also related to more adverse effects compared to other HTs. https://www.crd.york.ac.uk/prospero/, identifier CRD42024535472."

Clinical • Journal • Retrospective data • Review • Endometriosis • Gynecology • Long-acting Reversible Contraceptives • Musculoskeletal Pain • Pain • Women's Health

Sequential therapy of dienogest following relugolix for adenomyosis and impact on symptoms and serum CA125 levels: a case series. (PubMed, BMC Womens Health) - "Our findings demonstrate that sequential therapy provides effective symptom management and long-term disease control. Further, CA125 remains a valuable biomarker for monitoring therapeutic success."

Biomarker • Journal • Endometriosis • Gynecology • Musculoskeletal Pain • Pain • Women's Health

Treatment and fertility outcomes of moss-like endometriosis with hemorrhagic ascites: A case report. (PubMed, Medicine (Baltimore)) - "Ascites is a rare manifestation of endometriosis and its diagnosis is difficult. Laparoscopy or exploratory laparotomy is required to confirm this diagnosis. Cyclic dysmenorrhea and abnormal menstruation warrant vigilance and should be investigated carefully. Hysterectomy and bilateral oophorectomy should be avoided as much as possible in patients with fertility needs and age adaptation, and symptoms can be successfully resolved with medical therapy."

Journal • Endometriosis • Gynecology • Hematological Disorders • Oncology • Ovarian Cancer • Women's Health

Concurrent Inguinal Endometriosis and Catamenial Pneumothorax: A Case Report. (PubMed, Cureus) - "Post-surgical hormonal therapy with dienogest resulted in the resolution of both conditions. This case underscores the potential for diverse presentations of extra-pelvic endometriosis and highlights the importance of a multidisciplinary approach to its management."

Journal • Endometriosis • Gynecology • Pain • Pulmonary Disease • Respiratory Diseases • Women's Health

Long-term clinical outcomes of dienogest for perimenopausal women with symptomatic adenomyosis. (PubMed, Sci Rep) - "In perimenopausal women with symptomatic adenomyosis, nearly half of the treated patients benefitted from dienogest. Our informative findings can assist clinicians in pre-treatment counseling and identifying factors correlated with treatment effectiveness."

Clinical data • Journal • Retrospective data • Endometriosis • Gynecology • Musculoskeletal Pain • Pain • Women's Health

Diagnosis and treatment of a serous cystadenofibroma-like tumor potentially arising from urinary tract endometriosis: A case report. (PubMed, Taiwan J Obstet Gynecol) - "Differentiating a such tumors from other malignancies based solely on imaging findings is challenging. It is crucial to judge the degree of surgical intervention through intraoperative macroscopic examination and rapid pathological assessment. The efficacy of gonadotropin-releasing hormone analog (GnRHa) and dienogest (DNG) therapy in preventing the recurrence of such tumors following surgery for endometriosis remains uncertain."

Journal • Endometriosis • Gynecology • Oncology • Ovarian Cancer • Solid Tumor • Women's Health

The present adenomyosis treatment status in Luzhou, China: a small scope observational cross-sectional survey. (PubMed, BMC Womens Health) - "There were treatment delays and treatment selection bias in managing adenomyosis in Luzhou, China. Popular science education and early individualized hormone therapy are needed. Uterine-sparing surgery should be carefully selected."

Journal • Observational data • Endometriosis • Gynecology • Women's Health

Endometriosis in Adolescents: A Closer Look at the Pain Characteristics and Atypical Symptoms: A Prospective Cohort Study. (PubMed, J Clin Med) - " Adolescents with endometriosis often present with earlier menarche, longer menstrual periods, more severe dysmenorrhea, and atypical symptoms. Hormonal contraceptives and dienogest are effective and safe treatments that improve pain and QoL."

Journal • Endometriosis • Gynecology • Musculoskeletal Pain • Pain • Women's Health

Critical appraisal of "Comparison of combined oral contraceptives and dienogest for endometriosis-associated pain". (PubMed, Eur J Obstet Gynecol Reprod Biol) - No abstract available

Journal • Endometriosis • Gynecology • Pain • Women's Health

The effect of dienogest and gonadotropin-releasing hormone agonist on pelvic pain after laparoscopic surgery for endometriosis: An RCT. (PubMed, Int J Reprod Biomed) - "Our results suggested that the effect of GnRH agonists and dienogest in improving pelvic pain for endometriosis is the same after a 3-month treatment period. However, these 2 drugs caused different adverse effects."

Clinical • Journal • CNS Disorders • Endometriosis • Gynecology • Musculoskeletal Diseases • Musculoskeletal Pain • Orthopedics • Pain • Women's Health

Letter to editor: Comparison of the effectiveness of levonorgestrel intrauterine system and dienogest in the management of adenomyosis: A systematic review and meta-analysis. (PubMed, Eur J Obstet Gynecol Reprod Biol) - No abstract available

Journal • Retrospective data • Endometriosis • Women's Health

Re: Letter to the editor: Comparison of the effectiveness of levonorgestrel intrauterine system and dienogest in the management of adenomyosis: A systematic review and meta-analysis. (PubMed, Eur J Obstet Gynecol Reprod Biol) - No abstract available

Journal • Retrospective data • Endometriosis • Women's Health

Non-inferiority study to compare the efficacy of relugolix with dienogest for endometriosis-associated pain and usefulness of administering relugolix prior to dienogest (READY study): study protocol for a multicenter randomized controlled study. (PubMed, Trials) - "This study will determine the efficacy of relugolix for improving endometriosis-associated pain and dienogest-induced abnormal uterine bleeding. The results will support treatment decisions regarding endometriosis-associated pain, and the introduction of new treatments to reduce dienogest-induced abnormal uterine bleeding."

Head-to-Head • Journal • Endometriosis • Gynecology • Infertility • Musculoskeletal Pain • Pain • Sexual Disorders • Women's Health

Azurocidin is Associated with Dienogest-resistance in Ovarian Endometriotic Cysts. (PubMed, Reprod Sci) - "Azurocidin concentrations in the blood and urine were higher in patients resistant to DNG therapy than in other patients. Thus, azurocidin may be associated with DNG resistance in OMAs."

Journal • Endometriosis • Gynecology • Infertility • Sexual Disorders • Women's Health • CXCL8 • ER • IL6 • PGR

Pathogenesis, Diagnosis, and Management of Inguinal Endometriosis: A Case Series of Six Patients. (PubMed, Reprod Sci) - "Complete resection is often performed; however, hormonal therapy is administered to patients who do not undergo surgery, or to avoid recurrence. In our cases, dienogest was effective in reducing inguinal endometriotic lesions, improving pain, and preventing recurrence."

Journal • Endometriosis • Gastroenterology • Gynecology • Pain • Women's Health

A Case of Familial Mediterranean Fever With Severe Attacks During Withdrawal Bleeding After Controlled Ovarian Hyperstimulation. (PubMed, Cureus) - "To prevent further FMF attacks during the waiting period before embryo transfer, colchicine or dienogest was administered, effectively suppressing additional episodes. It underscores the importance of prophylactic therapy with colchicine or other agents during assisted reproductive technology (ART). Furthermore, when prophylactic treatment is not feasible, alternative strategies such as fresh embryo transfer should be considered."

Journal • Endometriosis • Genetic Disorders • Gynecology • Immunology • Infertility • Inflammation • Musculoskeletal Diseases • Musculoskeletal Pain • Orthopedics • Pain • Rheumatology • Sexual Disorders • Women's Health

Preoperative Medication for Ovarian Endometrioma Reduces Cyst Size and PainBut Not rASRM score. (PubMed, J Minim Invasive Gynecol) - "Preoperative hormonal medication can reduce the size of ovarian endometriomas but does not significantly affect the overall operative findings. Nevertheless, preoperative medication is helpful in reducing pain in patients before surgery."

Journal • Endometriosis • Gynecology • Pain

VISAGE: A Study to Learn More About How Safe Dienogest is and How Well it Works Under Real World Conditions in Indian Women With Endometriosis (clinicaltrials.gov) - P=N/A | N=160 | Completed | Sponsor: Bayer | Active, not recruiting ➔ Completed | Trial completion date: Dec 2024 ➔ Sep 2024

Real-world evidence • Trial completion • Trial completion date • Endometriosis • Gynecology • Musculoskeletal Pain • Pain • Women's Health