ceftriaxone / Generic mfg. - LARVOL DELTA

Abolishing PorB-induced mitophagy enhances gonococcal outer membrane vesicle vaccine efficacy. (PubMed, Emerg Microbes Infect) - "AbstractThe emergence and global spread of ceftriaxone-resistant Neisseria gonorrhoeae underscores the urgent need for an effective vaccine...Therefore, our results identify PorB-induced mitophagy in DCs as a potential immune evasion mechanism that may dampen adaptive immunity. Engineering OMV vaccines to circumvent this process represents a rational strategy to explore for enhancing gonococcal vaccine efficacy."

Journal • Infectious Disease • CD86 • IFNG • TNFA

Gonococcal Dacryoadenitis: A Case Report. (PubMed, Case Rep Ophthalmol) - "Following IV ceftriaxone and flucloxacillin, topical steroid and chloramphenicol eye drops, the patient saw marked clinical improvement. This case demonstrates that NG may present with unusual features, and clinicians should have a low threshold for conjunctival cultures and promptly explore the sexual and social histories of patients presenting with similar symptomology."

Journal • Conjunctivitis • Infectious Disease • Inflammation • Ocular Infections • Ocular Inflammation • Ophthalmology • Pain • Scleritis

Tularemia from a cat bite: Case report and review of the literature. (PubMed, IDCases) - "Prior to admission, she had been treated with ceftriaxone and clindamycin without improvement. She failed to improve on vancomycin and piperacillin-tazobactam...Her antibiotics were switched to ciprofloxacin (for F. tularensis) and oral amoxicillin-clavulanate (for coverage of other feline oral flora) with improvement...She was then treated with six weeks of doxycycline with complete resolution...This case illustrates the importance of considering F. tularensis in cat-related infections not improving with standard antibiotic therapy. The case also underscores the importance of recognizing relapse of F. tularensis infection as a common complication, as well as the importance of engaging with public health authorities to be aware of changes in epidemiology that may affect patient care."

Journal • Infectious Disease

CASE REPORT: FIRST DOCUMENTED DIALYSIS-REQUIRING WEIL'S DISEASE IN GORAKHPUR, EASTERN UTTAR PRADESH — A SENTINEL REPORT OF SEVERE LEPTOSPIRA-ASSOCIATED ACUTE KIDNEY INJURY WITH FULL RECOVERY (ISN-WCN 2026) - "Without waiting for specific test results, the patient was given intravenous ceftriaxone at a dose of 1 gram twice a day, in addition to general supportive care, which included intravenous fluids and pantoprazole...Based on this finding, intravenous doxycycline was started at a dose of 100 mg twice a day...https://doi.org/10.12659/AJCR.897741.[iv] Manocha H, Ghoshal U, Singh SK, Kishore J, Ayyagari A. Frequency of leptospirosis in patients of acute febrile illness in Uttar Pradesh...Conclusion This case highlights the important need for doctors to pay closer attention to leptospirosis in people who have fever and yellowing of the skin for unknown reasons, mainly in eastern Uttar Pradesh. If it is found quickly and treated right away, including getting dialysis when needed, people can fully recover, even if they are very sick. Important situations like this one show that we still struggle to find leptospirosis in North India, which makes it even more important to include..."

Case report • Clinical • Acute Kidney Injury • Dengue Fever • Hepatology • Human Immunodeficiency Virus • Infectious Disease • Inflammation • Malaria • Nephrology • Renal Disease

SEVERE LEPTOSPIROSIS & AKI : A REPORT OF 2 CASES FROM BERMUDA (ISN-WCN 2026) - "Rapid institution of beta lactam antibiotics( Ceftazidime & Ceftriaxone) and Doxycycline, along with supportive care in intensive unit led to good outcomes in both cases. Monthly Communicable Disease Report. Sandiego County, 2024; Vol 8, Issue 2, Page 1."

Clinical • Acute Kidney Injury • Cardiovascular • Chronic Kidney Disease • CNS Disorders • Epilepsy • Hematological Disorders • Hepatitis B • Hepatitis C • Hepatology • Human Immunodeficiency Virus • Infectious Disease • Inflammation • Malaria • Musculoskeletal Pain • Nephrology • Renal Disease • Septic Shock • Thrombocytopenia • Vasculitis

PD PERITONITIS WITH NEISSERIA CINEREA (ISN-WCN 2026) - "Peritoneal fluid Gram stain revealed 2+ WBC, and no organisms were seen.The patient was started initially on empiric intraperitoneal vancomycin and cefipime. When PD fluid culture grew Neisseria cinerea, antibiotics were broadened to intraperitoneal ceftriaxone 2 gm IV q 24 hrs and Ciprofloxacin 500 mg PO q 24 hrs for double coverage of Neisseria species.We did request sensitivities on the Neisseria cinerea, but they are not routinely run on this organism and will be a send out so expecting that it will take at least 1 week, if not more...Repeat cell count from the peritoneal fluid remained normal and repeat peritoneal fluid culture was negative and she completed both antibiotics for a total of 21 days and remained asymptomatic. On follow up, she did not have any further episodes of PD peritonitis since this event.Conclusion Take home pointsNeisseria Cinerea is a common commensal in nasal and oropharyngeal secretions and can result in PD peritonitis.Usually needs double..."

Infectious Disease

CASE REPORT : PERITONEAL DIALYSIS-ASSOCIATED PERITONITIS DUE TO S. AUREUS VS P. AERUGINOSA IN DIFFERENT PATIENTS (ISN-WCN 2026) - "We gave 14 days of ip ceftriaxone and gentamycin, followed by oral ciprofloxacin for 7 days to patient one...On patient two, after 5 days of being given ip ceftazidime and gentamycin, he showed refractory response. When comparing MSSA with P. aeruginosa peritonitis in CAPD patients, Pseudomonas is associated with a significantly worse prognosis. It leads to higher rates of treatment failure, catheter removal, and transfer to HD."

Case report • Clinical • Infectious Disease

BARTONELLA ENDOCARDITIS MIMICKING ANCA-ASSOCIATED VASCULITIS (ISN-WCN 2026) - "Given his cat exposure, Bartonella endocarditis was suspected, and antibiotic therapy with rifampicin, doxycycline, and ceftriaxone was initiated. These immune responses complicate differentiation from autoimmune vasculitis.Conclusion Bartonella henselae endocarditis can mimic ANCA-associated vasculitis with immune-complex nephritis. Thorough clinical evaluation and molecular diagnostic testing are essential to avoid misdiagnosis and to guide appropriate antimicrobial therapy."

Acute Kidney Injury • ANCA Vasculitis • Cardiovascular • Glomerulonephritis • Infectious Disease • Inflammation • Inflammatory Arthritis • Lupus • Lupus Nephritis • Nephrology • Renal Disease • Vasculitis • TLR9

A CASE OF CEFTRIAXONE-ASSOCIATED ENCEPHALOPATHY IN A PATIENT UNDERGOING PERITONEAL DIALYSIS (ISN-WCN 2026) - "CTRX-associated encephalopathy was suspected, and CTRX was discontinued on day 4 and replaced with ampicillin/sulbactam. This case highlights the importance of recognizing AAE as a potential cause of acute consciousness disturbance during antibiotic therapy. Early diagnosis, discontinuation of the offending agent, and consideration of dialysis are crucial for favorable outcomes in high-risk populations."

Clinical • Cardiovascular • Chronic Kidney Disease • CNS Disorders • Diabetes • Diabetic Nephropathy • Epilepsy • Hypertension • Infectious Disease • Metabolic Disorders • Movement Disorders • Nephrology • Renal Disease

SEVERE ICTERIC LEPTOSPIROSIS LEADING TO ACUTE KIDNEY FAILURE AND MULTI-ORGAN DYSFUNCTION: A 10-YEAR CASE SERIES FROM A TERTIARY CENTER IN TAIWAN (ISN-WCN 2026) - "All patients received an IgM serology assay within 3 days of admission and appropriate antibiotic therapy with ceftriaxone, after which their renal function improved and they were successfully extubated...Early recognition of its characteristic clinical features and timely initiation of appropriate antibiotic therapy are critical for improving patient outcomes. The rapid IgM serology assay serves as a useful screening tool for early detection due to its simplicity and quick turnaround time."

Clinical • Acute Kidney Injury • Hepatology • Nephrology • Renal Disease • Respiratory Diseases

A CASE REPORT ON WUNDERLICH SYNDROME IN A 32-YEAR-OLD MALE: DIAGNOSTIC AND CLINICAL CHALLENGES (ISN-WCN 2026) - "Perirenal abscess formation was considered at this time and Ceftriaxone was shifted to Meropenem pending blood culture results...On hospital day 6, repeat CT scan of the whole abdomen with contrast was ordered but due to financial limitations, the patient opted to go home and continue with oral antibiotic Cefixime to complete 2 weeks.One week after discharge, CBC was done showing no further decline of hemoglobin and a follow up abdominal ultrasound showed right perinephric hematoma measuring 11.3 cm x 9.5 cm x 4.1 cm with an estimated volume of 231.51 mL with complete resolution of the pateint's fever...The characteristic Lenk triad of flank mass, a flank pain, and hypovolemic shock is appreciated in only an estimated 20% of patients with WS...Conservative management with follow-up imaging is a good approach to avoid unnecessary surgery. By delving into this rare occurence and its characteristics and clinical outcomes, the goal is to shed insights on the complexities..."

Case report • Clinical • Anorexia • Cardiovascular • Gastroenterology • Gastrointestinal Disorder • Genito-urinary Cancer • Infectious Disease • Kidney Cancer • Nephrology • Renal Calculi • Renal Cell Carcinoma • Renal Disease • Solid Tumor • Vasculitis

BEYOND CATHETERS: A MULTISOURCE MICROBIAL AND RESISTANCE LANDSCAPE AMONG DIALYSIS PATIENTS (ISN-WCN 2026) - "We observed very high resistance to 3rd-generation cephalosporins and fluoroquinolones (≈90–100%) but remained fully susceptible to carbapenems and amikacin in E. coli. While K. pneumoniae shows moderate–high resistance to ceftriaxone (58.3%) and aztreonam (66.7%), but lower aminoglycoside resistance (16.7%). Half of S. aureus was MRSA (oxacillin/cefoxitin 50%) with vancomycin still susceptible and low clindamycin(9.1%) and erythromycin(18.2%) resistance.Download: Download high-res image (252KB)Download: Download full-size imageIn exploratory modeling, organism type was the principal driver of resistance, though most organisms–antibiotic effects had wide confidence intervals. The most reliable association was lower tetracycline resistance in S. epidermidis (OR 0.012, 95% CI 0.0003–0.49; p=0.020)...Organism type showed significant relations to resistance rather than dialysis modality or specimen source. The importance of empirical therapy based on organisms are..."

Clinical • Chronic Kidney Disease • Infectious Disease • Nephrology • Pneumonia • Renal Disease

FROM RASH TO RENAL RUIN: A CASE REPORT ON RAPIDLY PROGRESSIVE GLOMERULONEPHRITIS SECONDARY TO IMMUNOGLOBULIN A VASCULITIS IN AN ELDERLY FEMALE (ISN-WCN 2026) - "She later developed hypogastric pain and dysuria, for which she was treated with cefuroxime 500 mg tablet twice daily for two days for urinary tract infection (UTI)...Ceftriaxone was discontinued, renal replacement therapy was initiated, and pulse methylprednisolone therapy followed by oral prednisone was given...While not a substitute for renal biopsy, skin biopsy may be a valuable tool in selected vasculitis cases especially in resource-limited settings. Early intervention is critical to prevent irreversible renal damage and to improve long-term outcomes.This abstract was also submitted in the 45th Annual Meeting of the Korean Society of Nephrology."

Case report • Clinical • Chronic Kidney Disease • Glomerulonephritis • IgA Nephropathy • Infectious Disease • Lupus Nephritis • Musculoskeletal Pain • Nephrology • Vasculitis

ADJUNCTIVE HEMOADSORPTION WITH DNA 230 IN SEVERE SYSTEMIC LUPUS ERYTHEMATOSUS WITH MULTIORGAN INVOLVEMENT: A CASE REPORT (ISN-WCN 2026) - "She exhibited SLE activity in renal, mucocutaneous, serosal, hematologic, and immunologic domains.She was started on ceftriaxone, paracetamol, N-acetylcysteine, hydrocortisone, calcium + vitamin D, losartan, and atorvastatin. She was discharged stable on day 25 on tapering corticosteroids with a scheduled renal biopsy.Renal, liver and inflammatory markersConclusion This case highlights the potential role of DNA 230 hemoadsorption as an adjunct to standard immunosuppression and dialysis in severe lupus with multiorgan involvement. By facilitating removal of cytokines and inflammatory mediators, hemoadsorption may accelerate recovery and improve organ function during lupus flares."

Case report • Clinical • Acute Kidney Injury • Cardiovascular • CNS Disorders • Epilepsy • Glomerulonephritis • Heart Failure • Hematological Disorders • Immunology • Inflammatory Arthritis • Lupus • Lupus Nephritis • Metabolic Disorders • Nephrology • Pulmonary Disease • Renal Disease • Respiratory Diseases • Systemic Lupus Erythematosus

SODIUM THIOSULPHATE POTENTIAL RARE ADVERSE EFFECTS (ISN-WCN 2026) - "Patient was treated empirically with ceftriaxone and doxycycline to cover for possible pneumonia. Given the time course and resolution of symptoms after discontinuation of STS, it is safe to attribute it to STS. More studies are needed to establish full spectrum of direct and indirect STS adverse effects for its safe use in dialysis patients."

Adverse events • Calciphylaxis • Cardiomyopathy • Cardiovascular • Chronic Kidney Disease • CNS Disorders • Eosinophilia • Hepatology • Hypertension • Immunology • Infectious Disease • Inflammation • Liver Failure • Metabolic Disorders • Nephrology • Pneumonia • Rare Diseases • Renal Disease • Respiratory Diseases • Septic Shock

Prevalence of Missed Medication Doses and Outcomes of Hospitalized Patients Living with HIV in Uganda. (PubMed, Drug Healthc Patient Saf) - "Missed doses were common across nearly all medications, with omission rates exceeding 80% for ceftriaxone, paracetamol, metronidazole, omeprazole, metoclopramide, and levofloxacin, and approaching 100% for furosemide, co-amoxiclav, ondansetron, enoxaparin, albumin, and artesunate. Missed parenteral medication doses are highly prevalent among hospitalized PLHIV in Uganda. Strengthening medication administration and documentation systems is urgently needed to improve patient safety and outcomes."

Journal • Human Immunodeficiency Virus • Infectious Disease

Unlocking the potential of Pseudomonas aeruginosa QS intermediates as antimicrobial synergists against three multidrug-resistant enteric bacteria. (PubMed, Front Microbiol) - "Pyocyanin showed the highest synergistic effect, with a 300% increase in the inhibition zone when combined with sulfamethoxazole/trimethoprim (23.75/1.25 µg/mL) against S. Typhimurium-W20. Rhamnolipids exhibited a 106% increase in synergy with ceftriaxone (30 μg/mL) against E. coli-SS1, whereas HHQ (10 μg/mL) showed a 257% increase with ampicillin (10 μg/mL) against E. coli-SS1. PQS displayed the highest synergistic effect of 109% with amoxicillin clavulanic acid (30 μg/mL) against E. coli-SS1. Moreover, growth curve analysis revealed a dose-dependent reduction in bacterial growth with sub-inhibitory concentrations of antimicrobials, particularly for the combinations exhibiting the highest synergy across the QS effectors. These findings demonstrate the potential of the QS effectors in reducing the required dosage of antibiotics against resistant Enterobacteriaceae strains and highlight the need to develop a comprehensive understanding of the underlying mechanisms..."

Journal

Detection of Finegoldia magna in Cyst Secretions from a Non-Lutating Female Breast: A Case Report. (PubMed, Infect Drug Resist) - "In vitro drug susceptibility testing showed that the strain was susceptible to penicillin, ampicillin, ceftriaxone, and imipenem, but resistant to clindamycin. The empyema cavity was irrigated with gentamicin saline, and local dressing changes were performed, leading to good wound healing and discharge. This case suggests that clinicians should pay attention to the possibility of anaerobic bacterial infections after breast surgery, especially when routine bacterial cultures are negative, necessitating timely anaerobic culture. Combined with mass spectrometry identification and drug susceptibility test results, this approach guides precise treatment."

Journal • Infectious Disease

Newfangled Combination Azilsartan and Ceftriaxone Exhibited Potential Effects in In-Vitro and In-Vivo Models of Cerebral Ischemia: A Comprehensive Pharmacological Investigation. (PubMed, Ann Neurosci) - "The above combination significantly reversed the behavioural dysfunction in ischemic rats, which evidences the beneficial effects. The repurposing of anti-hypertensive, Azi, and antibiotic Cef combination demonstrated an excellent neuroprotective potential, mediating through ameliorating neuroinflammation, excitotoxicity and oxidative stress in in vitro OGD-induced astrocyte-neuron co-culture as well as cerebral ischemic rat model."

Journal • Preclinical • Cardiovascular • CNS Disorders • Inflammation

Single point mutations in global regulatory genes restore cephalosporin resistance in a low-MIC Enterococcus faecium natural isolate. (PubMed, Antimicrob Agents Chemother) - "At Parc Taulí University Hospital, we identified a clinical isolate of ampicillin-susceptible E. faecium (Efm5) that exhibited unusually low MICs to cefotaxime (1 mg/L), ceftriaxone (3 mg/L), and ceftaroline (0.19 mg/L). Transcriptional profiling showed upregulation of the pbp5 operon, which includes ftsW, psr, and pbp5, in the croS variants. This study provides evidence that E. faecium isolates with low MICs to CPH can arise in clinical settings without laboratory manipulation, enabling further investigation of resistance pathways."

Journal

The Hidden Face of Lyme Disease: Neuroinfection With Cranial Nerve Involvement. (PubMed, Cureus) - "After starting antibiotic therapy with ceftriaxone, the patient showed significant clinical improvement after a few days. It should be remembered that in the course of Lyme disease, the nervous system can often be involved, resulting in many bothersome and unusual symptoms, which often make it difficult to make a correct diagnosis."

Journal • Infectious Disease • Inflammatory Arthritis • Lyme Disease • Pain

Ceftriaxone-Induced Immune Hemolytic Anemia and Subsequent Disseminated Intravascular Coagulation. (PubMed, Cureus) - "Laboratory studies confirmed ceftriaxone-dependent antibodies and a positive direct antiglobulin test (DAT), establishing the diagnosis of ceftriaxone-induced DIIHA with secondary DIC. This case underscores the fulminant and often fatal course of ceftriaxone-induced hemolytic anemia and highlights the critical importance of swift recognition and discontinuation of suspected offending agents in patients presenting with acute hemolysis and coagulopathy following antibiotic therapy."

Journal • Anemia • Cognitive Disorders • Hematological Disorders • Infectious Disease • Pneumonia • Respiratory Diseases

Factors predicting STI-positive cervicitis and pelvic inflammatory disease, and implications on antibiotic use: a cross-sectional analysis. (PubMed, Sex Health) - "This study identified several characteristics that predicted STI-positive cervicitis and PID. However, none predicted STI-positivity with high degrees of confidence. Presumptive treatment leads to significant unnecessary antibiotic use, but ceftriaxone may have additional coverage beyond gonorrhoea. Rapid molecular point-of-care testing should be trialled to reduce unnecessary antibiotics for these syndromes - starting with cervicitis."

Journal • Infectious Disease • Inflammation

Pneumomediastinum and breakthrough bacteraemia: an atypical Streptococcus oralis infection with acquired ceftriaxone resistance (ESCMID Global 2026) - No abstract available

Infectious Disease

A five-step infection control bundle for the permanent containment of a ceftriaxone-susceptible but gentamicin- and piperacillin/tazobactam-non-susceptible hypervirulent ST39 Klebsiella pneumoniae outbreak in a neonatal intensive care unit (NICU) (ESCMID Global 2026) - No abstract available

Critical care • Infectious Disease • Pneumonia