CC002 / Chupu Chuang (Wuhan) Pharmaceutical Technology - LARVOL DELTA

A New Mouse Model for Ozone Health Effects Research. (PubMed, Environ Health Perspect) - "The CC002/Unc strain provides an improved model to study the effects of acute and repeated O3 exposure due to its enhanced sensitivity vs C57BL/6J and more human-like thermoregulatory response. Further genetic analysis to pinpoint causal genes underlying CC002/Unc's susceptibility will provide new insights into mechanisms of O3-induced lung disease."

Journal • Preclinical • Eosinophilia • Fibrosis • Immunology • Inflammation • Pulmonary Disease • Respiratory Diseases

Risk Assessment of PFAS-Induced Male Reproductive Toxicity: A Comprehensive Evaluation Using the TRAEC Strategy. (PubMed, Environ Health (Wash)) - "Notably, independent in vivo experiments confirmed that PFNA exposure significantly impaired sperm routine parameters and sperm dynamics across multiple mouse strains (including C57BL/6J, CC002, CC037, and CC057 strains). Our study identified PFOS and PFNA as particularly detrimental to male reproductive health across multiple dimensions, underscoring the urgent need for measures to reduce PFAS exposure and mitigate risks to male fertility."

Journal

Genetic variations and their interaction with thirdhand smoke exposure on anxiety and memory in Collaborative Cross mice. (PubMed, Environ Int) - "Memory was tested using passive avoidance: impairments were observed in both sexes in CC016 and CC019, with sex-dependent effects in CC002 and CC051...KEGG pathway analysis identified distinct genetic pathways, including GTPase binding and GTPase regulatory activity, that act as critical molecular switches in the brain that regulate synaptic plasticity, dendritic spine structure, and neuronal signaling, directly influencing anxiety-like behaviors and memory formation. These findings show that THS exposure affects neurobehavioral outcomes in a sex- and genotype-dependent manner, highlighting critical gene-environment interactions and providing a foundation for mechanistic insights into THS neurotoxicity."

Journal • Preclinical • Mood Disorders • Psychiatry

Comparative Analysis of Genetic Risk for Viral-Induced Axonal Loss in Genetically Diverse Mice. (PubMed, Int J Mol Sci) - "However, chronic radiculoneuropathy characterized by axonal degeneration with myelin loss was observed in the CNS of only two strains, CC002 and CC023, which had markedly different immune responses and clinical profiles throughout the course of infection...We used previous results from RNA sequencing of the hippocampus and spinal cord to test our hypothesis that myelin loss in these strains resulted from the convergent biological effects of multiple genetic risk variants, many previously unassociated with TMEV-induced diseases. These findings identify novel genetic targets and demonstrate the utility of genetically diverse models for uncovering complex neuroimmune interactions."

Journal • Preclinical • CNS Disorders • Epstein-Barr Virus Infections • Infectious Disease • Multiple Sclerosis • Pain