CC002 / Chupu Chuang (Wuhan) Pharmaceutical Technology - LARVOL DELTA

Comparative Analysis of Genetic Risk for Viral-Induced Axonal Loss in Genetically Diverse Mice. (PubMed, Int J Mol Sci) - "However, chronic radiculoneuropathy characterized by axonal degeneration with myelin loss was observed in the CNS of only two strains, CC002 and CC023, which had markedly different immune responses and clinical profiles throughout the course of infection...We used previous results from RNA sequencing of the hippocampus and spinal cord to test our hypothesis that myelin loss in these strains resulted from the convergent biological effects of multiple genetic risk variants, many previously unassociated with TMEV-induced diseases. These findings identify novel genetic targets and demonstrate the utility of genetically diverse models for uncovering complex neuroimmune interactions."

Journal • Preclinical • CNS Disorders • Epstein-Barr Virus Infections • Infectious Disease • Multiple Sclerosis • Pain