methylprednisolone acetate / Generic mfg. - LARVOL DELTA

Conservative Treatment in Patients With Supraspinatus Tendon Injury. (clinicaltrials.gov) - P=N/A | N=40 | Recruiting | Sponsor: Medical University of Lodz | Trial primary completion date: Jul 2025 ➔ May 2026

Trial primary completion date • CNS Disorders • Musculoskeletal Pain • Pain • Sleep Disorder

Intra-articular methylprednisolone acetate does not induce hyperinsulinemia or hyperglycemia in metabolically normal horses. (PubMed, J Am Vet Med Assoc) - "Reported practitioner sentiment that IA MPA carries a lower risk for corticosteroid-induced laminitis may relate to the lack of postinjection hyperinsulinemia noted in this study. However, additional work in insulin-dysregulated and/or laminitis-prone horses is required before IA MPA should be considered safe to use in these horses."

Journal • Diabetes

Hoffa's Fat Pad Impingement (HFPI) (clinicaltrials.gov) - P=N/A | N=62 | Not yet recruiting | Sponsor: Boston Children's Hospital

New trial

Glucocorticoid-induced changes of the gut microbiota and metabolic markers in healthy young men: Outcome of a randomized controlled trial. (PubMed, Cell Rep Med) - P1/2 | "In this 7-day trial, we assess glucocorticoid-induced changes in gut microbiota and metabolic markers in 56 healthy men, randomly assigned to three interventions: oral prednisolone (PO group), intramuscular methylprednisolone acetate (IM group), or saline (CTL group)...These findings underscore the route-dependent effects of glucocorticoids on gut microbiota and their potential impact on host metabolism and immunity. The trial was approved by the Danish Medicine Agency (EudraCT protocol number: 2016-001850-16)."

Journal • Metabolic Disorders

Ultrasound guided pain interventions for management of medically challenged Neuropathic Pain- a case series (ASRA-FALL 2025) - "USG guided tibial nerve block with 0.25% bupivacaine and 40 mg depomedrol on each side...Ulnar nerve block with 0.2% Ropivacaine and 80mg of ü methyl prednisolone ü Case 1: ü Patient reported 90% and 100% symptom relief on right and left side respectively immediately after the posterior tibial MIPSI...In all these cases, a variety of neuropathic pain medications were tried, definitive pain interventional procedures were also practiced. However when they did not provide adequate pain relief or in cases of residual pain after the main procedure, ultrasound guided peripheral nerve blocks played a huge role in such refractory challenging chronic pain conditions."

Clinical • Musculoskeletal Diseases • Neuralgia • Orthopedics • Pain

Clemens von Pirquet Award - 2nd Place - Practical Evaluation of Biologic Hypersensitivity in a Drug Allergy Clinic: A 10-Year Review (ACAAI 2025) - "Results Twenty-three unique biologics were implicated (Table), most commonly Ustekinumab (10, 16.1%), Evolocumab (7, 11.3%), and Infliximab (6, 9.7%)...Testing was done in 25 cases (40.3%), including 20 skin tests (18 to excipients, 2 to the biologic), all negative except one positive for methylprednisolone acetate...Most hypersensitivity to biologics seems unlikely to be excipient-related. Premedication, modified use, and alternative biologics can be effectively identified to ensure continued treatment."

Review • Allergy • Cardiovascular • Dermatology • Immunology • Pruritus • Urticaria

Does Intra-Operative Posterior Facet Steroid Injection in Lumbar Laminectomy Decreases Post-Operative Low Back Pain? A randomized Clinical Trial. (PubMed, Arch Bone Jt Surg) - "Patients were randomly allocated into two groups, one receiving a 2-ml injection of 80mg/2ml methylprednisolone acetate into the facets intraoperatively (n=25), the other receiving no injection (n=25)...Our research indicates that combining steroid infiltration of the facet joints with simple laminectomy does not provide significant advantages beyond possibly expediting recovery. Studies with larger sample sizes are needed to reach the best conclusions for patients with lumbar spinal stenosis."

Clinical • Journal • Back Pain • Immunology • Lumbar Back Pain • Musculoskeletal Diseases • Musculoskeletal Pain • Orthopedics • Pain • Rheumatology

Methylprednisolone acetate as a cause of anaphylactic shock [WITHDRAWN] (EUSEM 2025) - "She had type 2 diabetes mellitus being treated with dapagliflozin and sitagliptin, systemic arterial hypertension being treated with telmisartan, nonspecific sleep disorder being treated with escitalopram 20 mg, and bilateral gonarthrosis being treated with NSAIDs.Her current condition began after a consultation with an orthopedic surgeon, who, two hours prior to her admission to the emergency department, administered 40 mg of intra-articular methylprednisolone acetate due to persistent pain and limited ambulation despite management with opioids. Treatment was initiated with solutions and norepinephrine at 0.07 mcg/kg/min. Patient was admitted to the Intensive Care Unit."

Cardiovascular • CNS Disorders • Diabetes • Metabolic Disorders • Orthopedics • Osteoarthritis • Pulmonary Arterial Hypertension • Sleep Disorder • Type 2 Diabetes Mellitus

Comparison of Efficacy of Autologous Blood Injection versus Steroid Injection in Treatment of Lateral Epicondylitis: A Comparative Study. (PubMed, J Orthop Case Rep) - "Using simple randomization, patients were assigned to Group A (methylprednisolone acetate 40 mg with 1 mL 2% lignocaine) or Group B (2 mL autologous venous blood from the opposite arm). Pain relief stratified by age, sex, symptom duration, and baseline VAS score showed significant improvement in both groups, with greater improvement in Group B. No acute or late complications were observed. AB injection provides superior and more sustained pain relief than steroid injection in patients with lateral epicondylitis."

Journal • Musculoskeletal Diseases • Musculoskeletal Pain • Orthopedics • Pain

Effectiveness of Epidural Methylprednisolone Injection in Management of Lumbar Prolapsed Intervertebral Disc: A Comparison of Caudal, Transforaminal and Interlaminar Routes. (PubMed, J Orthop Case Rep) - "All patients received methylprednisolone acetate injections under fluoroscopic guidance. Transforaminal ESI with methylprednisolone provides superior pain relief and functional recovery compared to caudal and interlaminar routes. Route selection should consider anatomical precision and patient-specific factors."

Journal • Pain

Comparative efficacy of polyacrylamide hydrogel versus hyaluronic acid and corticosteroids in knee osteoarthritis: A retrospective cohort study. (PubMed, Medicine (Baltimore)) - "This retrospective cohort study included primary KOA patients (Kellgren-Lawrence grade II-IV) treated between January 2023 and December 2024 with 1 of 3 intra-articular injections: iPAAG (6 mL Arthrosamid), HA (2 mL, 60 mg Artroaid), and Steroid (40 mg methylprednisolone acetate, Arhropan)...It may be a complementary option in individualized osteoarthritis management. Further prospective studies are needed to define its optimal use."

Clinical • Journal • Observational data • Retrospective data • Immunology • Osteoarthritis • Pain • Rheumatology

Corticosteroid Injections for Pain Relief and Range of Motion in Adhesive Capsulitis. (PubMed, Cureus) - "Intra-articular corticosteroid injections are moderately effective in the treatment of adhesive capsulitis, with just over half of the patients experiencing positive outcomes."

Journal • Musculoskeletal Pain • Orthopedics • Pain

Inguinal endometriosis: a rare entity of a common condition . (PubMed, BMJ Case Rep) - "Initial treatment with depot methylprednisolone acetate injection was ineffective...A multidisciplinary approach involving a surgeon was employed for excision surgery, with meticulous attention given to avoiding femoral vein injury.This case study underscores the importance of collaboration between specialties for accurate diagnosis and effective surgical management of inguinal endometriosis. Preoperative imaging is useful, but the final diagnosis can be confirmed only after surgical excision and histopathology."

Journal • Endometriosis • Gynecology • Obstetrics • Pain • Women's Health

Anterior Quadratus Lumborum Block for Microvascular Free-Flap Breast Reconstruction: A Propensity-Score-Weighted Study. (PubMed, A A Pract) - "When compared to intraoperative sTAP with liposomal bupivacaine, pre-operative ultrasound-guided aQLB with DXP and MPA is an effective alternative, leading to similar opioid consumption and earlier ambulation for DIEP flap reconstruction."

Journal • Anesthesia • Pain

Effectiveness of betamethasone dipropionate versus methylprednisolone acetate intra-articular injection in the management of pain in primary osteoarthritis of the knee. (PubMed, Ghana Med J) - "Both steroid injections provided symptom relief; however, Betamethasone Dipropionate demonstrated superior long-term effectiveness compared to Methylprednisolone Acetate, offering better sustained pain relief beyond eight weeks. None declared."

Clinical • Journal • Immunology • Orthopedics • Osteoarthritis • Pain • Rheumatology

A Second Look at the Use of VersaWrap® Nerve Protector in Spine Surgery: A Case Report. (PubMed, Cureus) - "The presence of severe epidural fibrosis (EF) during a spinal revision procedure increases the risk of interoperative complications and post-operative success. We present a retrospective series of one surgeon's standard of care application of VersaWrap® Nerve Protector (Alafair Biosciences, Inc., Austin, TX, USA) in 169 lumbar decompressions in conjunction with Depo-Medrol (80 mg) and Marcaine/epinephrine (1 mL) to manage scar tissue tethering of the nerve root to the surrounding tissues. Of the 169 total lumbar decompression procedures, there were zero (0) complications reported for VersaWrap in conjunction with the medicinal agents in the dosages reported. A representative case of a patient who later underwent a revision procedure is highlighted to allow a second-look assessment of the initial VersaWrap application. The surgeon's experience was that VersaWrap bioresorbed completely and that any scar tissue present was easy to..."

Journal • Fibrosis • Immunology • Orthopedics

Effectiveness of Subacromial Methylprednisolone Acetate Injection With Lignocaine in Rotator Cuff Tendonitis. (PubMed, Cureus) - "The intervention was effective in 81 (93%) patients. Conclusions Subacromial methylprednisolone acetate injection with lignocaine demonstrated a high rate of short-term symptom improvement (93%) in managing rotator cuff tendonitis."

Journal • Orthopedics • Pain

Comparison of the Efficacy of Two Different Suprascapular Nerve Block Techniques in Patients With Chronic Shoulder Pain (clinicaltrials.gov) - P=N/A | N=80 | Completed | Sponsor: TC Erciyes University | Recruiting ➔ Completed

Trial completion • Musculoskeletal Pain • Pain

Yale SEVEN: Yale Steroid Enhanced Versus Exparel Nerveblock TKA Part 2 (clinicaltrials.gov) - P2 | N=66 | Recruiting | Sponsor: Yale University | Trial completion date: Mar 2026 ➔ Mar 2028 | Trial primary completion date: Mar 2025 ➔ Sep 2027

Trial completion date • Trial primary completion date • Musculoskeletal Diseases • Orthopedics • Pain

Yale SEVEN: Yale Steroid Enhanced Versus Exparel Nerveblock TKA RCT Study (clinicaltrials.gov) - P2 | N=250 | Recruiting | Sponsor: Yale University | Trial completion date: Mar 2026 ➔ Mar 2028 | Trial primary completion date: Mar 2025 ➔ Sep 2027

Trial completion date • Trial primary completion date • Musculoskeletal Diseases • Orthopedics • Pain

ANTERIOR QUADRATUS LUMBORUM BLOCK FOR MICROVASCULAR FREE-FLAP BREAST RECONSTRUCTION: A PROPENSITY-SCORE WEIGHTED STUDY (ASRA-SPRING 2025) - "Materials and Methods A total of 413 patients were examined in this Continuous Quality Improvement (CQI) project, including baseline [N=254, with surgeon-placed intraoperative transverse abdominal plane (TAP) blocks using bupivacaine plus liposomal bupivacaine) and pilot (N=159, with preoperative bilateral aQLB using bupivacaine plus dexamethasone sodium phosphate (DXP) and methylprednisolone acetate (MPA)] patients. Pre-operative ultrasound guided aQLB with DXP and MPA is an effective alternative to the surgeon-placed LIA with liposomal bupivacaine leading to the ability to ambulate sooner for DIEP flapreconstruction immediately after unilateral or bilateral mastectomy."

Anesthesia • Pain

The Use of Intra-articular Corticosteroid Injection to Treat Osteoarthritis of the Carpometacarpal Joint (clinicaltrials.gov) - P4 | N=90 | Active, not recruiting | Sponsor: University of Alberta | Recruiting ➔ Active, not recruiting

Enrollment closed • Immunology • Osteoarthritis • Pain • Rheumatology

Radiofrequency Ablation of the First Carpometacarpal Joint for Osteoarthritis: A Technical Report. (PubMed, Pain Med) - "This unique approach highlights using RFA as a safe, minimally invasive alternative for refractory CMC joint pain. With ultrasound guidance and fluoroscopy confirmation, RFA may offer a valuable option for patients who have exhausted traditional treatments with little to no improvement in functionality."

Journal • Immunology • Musculoskeletal Diseases • Musculoskeletal Pain • Orthopedics • Osteoarthritis • Pain • Rheumatology

MAGIC V: MAGIC Ruxolitinib for aGVHD (clinicaltrials.gov) - P2 | N=98 | Recruiting | Sponsor: John Levine

New P2 trial • Acute Graft versus Host Disease • Bone Marrow Transplantation • Graft versus Host Disease • Immunology • Transplantation

Preoperative image-guided pudendal nerve blocks to optimize short-term and functional recovery from gender-affirming vaginoplasty (AUA 2025) - "PNB was administered in the outpatient setting days to weeks prior to surgery using fluoroscopic guidance and combination low-volume bupivacaine and methylprednisolone acetate mixture...Mean total inpatient morphine milligram equivalent (MME) was 160.0 (range: 6-371.75)... Our preliminary experience demonstrates outpatient preoperative PNB is safe and feasible with excellent inpatient and intermediate-term outcomes, particularly regarding time to goal dilation and return to sexual function. Further prospective trials will further clarify the role of preoperative PNB in recovery from GAV."

Pain