methylprednisolone acetate / Generic mfg. - LARVOL DELTA

taVNS in Veterans With Knee OA (AVAHCS) (clinicaltrials.gov) - P=N/A | N=40 | Not yet recruiting | Sponsor: VA Office of Research and Development

New trial • Immunology • Inflammation • Osteoarthritis • Pain • Rheumatology

From Physicochemical Properties to Rehabilitation Outcomes: Understanding Corticosteroid Injection Adverse Effects. (PubMed, Int J Mol Sci) - "Particulate corticosteroids such as triamcinolone acetonide and methylprednisolone acetate exhibit low aqueous solubility, microcrystal formation, and prolonged intra-articular residence, which translate into sustained anti-inflammatory effects but also higher risks of chondrotoxicity, calcifications, tendinopathy, cutaneous and muscular atrophy, osteonecrosis, nerve injury, infection, and post-injection flare, especially with repeated or high-dose use. In contrast, more soluble preparations like betamethasone and dexamethasone sodium phosphate provide rapid onset and shorter duration of action, with reduced local depot-related complications but a greater propensity for transient systemic effects such as glycemic spikes...Ultrasound guidance significantly improves injection accuracy, optimizes drug deposition of both particulate and non-particulate agents, and may enhance clinical outcomes while limiting complications, thereby representing a relevant component of CSI..."

Adverse events • Journal • Review • Infectious Disease • Muscular Atrophy • Musculoskeletal Diseases

CORTISS: Success Rates and Safety of Steroid Injections in Managing Spinal and Sacro-Iliac Pain (CORTisone Injection Spine Study) (clinicaltrials.gov) - P4 | N=500 | Recruiting | Sponsor: Igor Wilderman. MD

New P4 trial • Back Pain • Immunology • Musculoskeletal Diseases • Musculoskeletal Pain • Orthopedics • Osteoarthritis • Pain • Rheumatology • Seronegative Spondyloarthropathies • Spondylarthritis

Safety, biodistribution, and exploratory clinical outcomes of a novel intra-articular IL-1Ra gene therapy (PCRX-201) in moderate-to-severe knee osteoarthritis: 2-year results of a phase 1 study. (PubMed, Ann Rheum Dis) - P1 | "A single intra-articular injection of PCRX-201 demonstrated safety and localised distribution within the knee. Exploratory patient-reported clinical outcomes suggest promise and support further investigation of PCRX-201."

Clinical data • Journal • P1 data • Gene Therapies • Immunology • Inflammation • Osteoarthritis • Pain • Rheumatology • IL1R1

Clinically relevant intra-articular corticosteroid doses impair equine osteoclast function in vitro. (PubMed, Vet Surg) - "Understanding that intra-articular corticosteroids may influence osteoclast activity, potentially affecting subchondral bone remodeling and repair, is important for guiding judicious use in equine joint management."

Journal • Preclinical • TRAP

Use of ultrasound-guided percutaneous perineural corticosteroid injections for refractory cervical pain secondary to vertebral venous system abnormality in a dog. (PubMed, J Vet Intern Med) - "Three ultrasound-guided perineural glucocorticoid injections (methylprednisolone acetate, 1 mg/kg per site) were performed at right C5-C6, C6-C7, and C7-T1 with improvement noted in lameness and cervical discomfort. No adverse effects were associated with the injections. This case highlights use of ultrasound-guided perineural glucocorticoid injections as a potential option for improving refractory cervical pain secondary to vertebral venous system abnormalities in a dog."

Journal • CNS Disorders • Musculoskeletal Pain • Pain

Effectiveness of ultrasound-guided cyst aspiration and injection of corticosteroid for the treatment of superior glenoid paralabral ganglion cysts (AOSSM 2026) - "A solution containing ~2ml of Bupivacaine 0.5% and 1 ml (40-80mg) of Methylprednisolone acetate was injected into the cyst cavity... Ultrasound-guided aspiration and corticosteroid injection is a safe treatment for symptomatic superior glenoid paralabral cysts with 77% of patients experiencing resolution of symptoms and normal shoulder exam. This approach can be successfully used as a first line of treatment for those patients that wish to avoid surgery."

Musculoskeletal Diseases • Musculoskeletal Pain • Orthopedics

Ultrasound-Guided Intra-Articular Infiltration of Hyaluronic Acid, Lidocaine, and Methylprednisolone in Patients with Temporomandibular Disorders (TMD): A Preliminary Pilot Case Series. (PubMed, Clin Pract) - "The ultrasound-guided infiltration technique, combined with personalized interocclusal support, demonstrated preliminary feasibility and short-term temporal improvement in pain and joint clicking in this specific patient cohort. Due to the lack of a control group and the multimodal nature of the intervention, these findings should be considered preliminary and do not allow for causal inferences regarding the efficacy of individual components."

Journal • Musculoskeletal Diseases • Musculoskeletal Pain • Otorhinolaryngology • Pain • Vertigo

In Vitro Cytotoxicity and Inflammatory Response of Local Anaesthetics and Corticosteroids in Canine Fibroblast-Like Synoviocytes. (PubMed, Cartilage) - "Lidocaine, methylprednisolone, and methylprednisolone acetate suppressed TNF-α-induced IL-6 expression.ConclusionsCommonly used intra-articular agents induce dose-dependent cytotoxic effects on canine FLS at clinically relevant concentrations. This study provides the first evidence of species-specific responses for mepivacaine, levobupivacaine, and dexamethasone in canine FLS, highlighting mediator-specific and concentration-dependent effects crucial for optimizing intra-articular therapies in veterinary and translational medicine."

Journal • Preclinical • Anesthesia • Immunology • Inflammation • Osteoarthritis • Pain • Rheumatology • IL6 • MMP9 • TNFA

The ASPIRE Trial: AchilleS tendinoPathy Treated With cortIcosteRoid injEctions (clinicaltrials.gov) - P3 | N=276 | Recruiting | Sponsor: Erasmus Medical Center

New P3 trial

Investigating a Sprague-Dawley rat-based anthelmintic assay using Trichostrongylus colubriformis. (PubMed, J Helminthol) - "Group 1 received unmedicated feed (negative control), while Groups 2, 3, and 4 received hydrocortisone acetate (HCA) in their diet at 60 ppm, 80 ppm, and a two-phase regimen of 200 ppm followed by 60 ppm, respectively. Group 5 received intramuscular methylprednisolone acetate (MPA) on three occasions...There was insufficient evidence to support the Sprague-Dawley rat-T. colubriformis model but, given the results of this study, further investigation and development are warranted."

Journal • Preclinical • Infectious Disease

Percutaneous balloon compression followed by perineural methylprednisolone for trigeminal neuralgia: A 50-patient retrospective series with 12-month outcomes. (PubMed, Clin Neurol Neurosurg) - "In this retrospective single-arm series, a combined protocol of PBC followed by perineural methylprednisolone was associated with rapid early pain relief, attenuation of benefit by 12 months, and an acceptable safety profile. Because no comparator group was included, the incremental value of methylprednisolone beyond standard PBC cannot be determined. These findings should therefore be regarded as exploratory and hypothesis-generating and support prospective controlled studies comparing PBC with and without adjunct steroid."

Journal • Retrospective data • Neuralgia • Pain

Synovial fluid fibroblast-like synoviocytes from patients with inflammatory arthritis are selectively attenuated by glucocorticoids: an in vitro study (EULAR 2026) - "We then evaluated the effects of: GC (methylprednisolone acetate, 5μg/ml), MTX (Methotrexate, 0.05 μg/ml), IFX (infliximab, 10μg/ml), SEC (secukinumab, 10μg/ml) and TOFA (Tofacitinib, 10ng/ml) on modulation of inflammatory gene expression in SF-FLS by qPCR. (E) Heatmap illustrating gene expression in response to each drug. Gene expression levels were normalized to GAPDH, *p<0.04, **p<0.02, ***p<0.001."

Preclinical • Ankylosing Spondylitis • Immunology • Inflammation • Inflammatory Arthritis • Psoriatic Arthritis • Rheumatoid Arthritis • Rheumatology • Seronegative Spondyloarthropathies • Spondylarthritis • COL1A1 • GAPDH • IL17A • IL2 • IL6 • MMP9 • THY1

Anaphylactic Reaction to Methylprednisolone Acetate in a Young Adult (EAACI 2026) - "Results S kin prick and intradermal tests were performed for hydrocortisone succinate, methylprednisolone succinate, methylprednisolone acetate, and dexamethasone phosphate. Conclusion The findings indicate that the anaphylactic reaction was likely caused by the acetate ester component of methylprednisolone acetate rather than the corticosteroid molecule itself. Clinicians should be aware of ester-specific corticosteroid hypersensitivity when managing patients requiring steroid therapy."

Clinical • Late-breaking abstract • Immunology • Inflammation

Rediscovering Intramuscular Glucocorticoids: A Forgotten Strategy in Rheumatology? A Systematic Scoping Review of Historical Use, Current Evidence and Future Perspectives (EULAR 2026) - "Agents included methylprednisolone acetate (MPA), triamcinolone acetonide (TActn), triamcinolone diacetate (TDac), and prednisolone, administered as single or repeated injections. However, the existing literature is heterogeneous, largely outdated, and methodologically limited, precluding firm conclusions on long-term safety or comparative effectiveness. Modern, adequately powered randomized controlled trials are urgently needed to clarify optimal dosing strategies, long-term outcomes, and the role of IM-GCs within current treat-to-target and combination therapeutic frameworks."

Review • Cardiovascular • Gout • Immunology • Infectious Disease • Inflammatory Arthritis • Novel Coronavirus Disease • Osteoporosis • Rheumatoid Arthritis • Rheumatology

Synovial lining fibroblast molecular endotypes relate to divergent phenotypes in rheumatoid and psoriatic arthritis (EULAR 2026) - "Single nucleus RNA sequencing was performed on knee synovial tissue biopsies from 4 patients with RA and 4 patients with PsA, before and 4 weeks after 80 mg intra-articular methylprednisolone acetate injection (Figure 1a)...(c) UMAP depicting all annotated cell types in the single nucleus RNA sequencing data from pre- and post-treatment RA and PsA samples. (d) Differential gene expression in pre-treatment lining fibroblasts in RA and PsA."

Immunology • Inflammatory Arthritis • Orthopedics • Osteoarthritis • Psoriatic Arthritis • Rheumatoid Arthritis • Rheumatology • Seronegative Spondyloarthropathies • MGP

Effectiveness Of Fluoroscopic Guided Sacroiliac Joint Injections In Managing Sacroiliac Joint Pain Of Varying Etiology (ACSM 2026) - "The intra-articular space was injected with 2.5mL of 0.25% Bupivacaine HCl and 40mg/ml of methylprednisolone acetate injectable suspension... Fluoroscopic SI joint injections are an effective method of treating pain of sacroiliac origin. There is limited evidence to determine if the etiology of SI joint pain impacts the effectiveness of SI joint injections. Our study determined that the inflammatory arthritis group had a superior response, while the lumbar fusion and trauma groups had decreased response rates."

Immunology • Inflammatory Arthritis • Mood Disorders • Musculoskeletal Diseases • Musculoskeletal Pain • Orthopedics • Pain

Glucocorticoid-Enhanced Fascial Plane and Peripheral Nerve Blocks Versus Periarticular and Local Infiltration Analgesia in Total Hip Arthroplasty: A Prospective Randomized Controlled Trial. (PubMed, J Bone Joint Surg Am) - "Patients who received aQLB+LFCNB with dual glucocorticoids and those who received PALIA with dual glucocorticoids demonstrated no significant differences in daily opioid consumption, pain score, or functional recovery following THA."

Journal • Orthopedics • Pain

When Cutaneous Sensitization to Polyethylene Glycol (PEG) Goes Beyond Skin Deep: A Case of Anaphylaxis (EADV-Sp 2026) - "He was stabilized in the emergency department where he received IM diphenhydramine and oral prednisolone...Skin prick tests were positive to macrogol 4000 at concentrations of 1:1000, 1:100, 1:10 and methylprednisolone acetate (contains PEG 3350) but negative to methylprednisolone succinate (without PEG). Skin prick and intradermal tests were positive to triamcinolone acetonide (contains polysorbate 80)...Frequently implicated drugs are macrogol laxatives, oral penicillin V, depo-medroxyprogesterone and depo-methylprednisolone2...Conclusions This case depicts a life threatening reaction to PEG following cutaneous sensitization. Awareness of PEG as both a parent compound and an excipient is vital for early recognition to prevent accidental re-exposure."

Clinical • Immunology • Inflammation • Urticaria

Hepatoprotective effects of mitoquinol mesylate in dogs with methylprednisolone acetate-induced steroid hepatopathy: A randomized crossover study. (PubMed, Vet World) - "MitoQ modestly reduced biochemical and histological changes linked to MPA-induced steroid hepatopathy in dogs and may serve as a promising adjunctive hepatoprotective therapy during glucocorticoid use. Larger controlled studies with longer follow-up periods and oxidative stress biomarkers are necessary to verify these initial results."

Journal • Hepatology

Efficacy of Corticosteroid Injection in Shoulder Pain in Indian Population: A Randomized Control Trial. (PubMed, Ann Afr Med) - "Corticosteroid injections offer greater short-term advantages in the management of shoulder discomfort than conservative treatment alone. Nonetheless, after 3 months, we noted no substantial long-term disparities between the two groups."

Journal • Musculoskeletal Pain • Pain

The Use of Intra-articular Corticosteroid Injection to Treat Osteoarthritis of the Carpometacarpal Joint (clinicaltrials.gov) - P4 | N=61 | Completed | Sponsor: University of Alberta | Active, not recruiting ➔ Completed | N=90 ➔ 61 | Trial primary completion date: Dec 2025 ➔ Sep 2025

Enrollment change • Trial completion • Trial primary completion date • Immunology • Osteoarthritis • Pain • Rheumatology

PRIMERA001: Comparing the effectiveness of our tailor-made management approach with routine care from a clinical, patient's as well as an economic point of view. Tailoring of treatment is done by taking the presence of autoantibodies and the quick response to glucocorticoids and JAK inhibitors into account. (clinicaltrialsregister.eu) - P4 | N=300 | Active, not recruiting | Sponsor: Erasmus Universitair Medisch Centrum Rotterdam (Erasmus MC) | Not yet recruiting ➔ Active, not recruiting

Enrollment closed • Immunology • Inflammatory Arthritis • Rheumatoid Arthritis • Rheumatology

Hoffa's Fat Pad Impingement (HFPI) (clinicaltrials.gov) - P4 | N=62 | Recruiting | Sponsor: Boston Children's Hospital | Not yet recruiting ➔ Recruiting | Phase classification: PN/A ➔ P4 | Not yet recruiting ➔ Recruiting

Enrollment open • Phase classification

Therapeutic Evaluation of Intra-articular Platelet-Rich Plasma, Steroid, and Viscosupplement Injections for Sacroiliitis: A Retrospective Comparative Study. (PubMed, Cureus) - "Patients received one of the following treatments: fluoroscopy-guided intra-articular injection of 40 mg methylprednisolone acetate combined with lidocaine (steroid group; n=20), 5 mL of autologous PRP prepared using a standardized double-spin centrifugation protocol (PRP group; n=20), or intra-articular hyaluronic acid viscosupplementation (viscosupplement group; n=20)...Corticosteroids provide rapid early symptom relief, while PRP demonstrates superior mid-term improvement. Viscosupplementation offers sustained clinical benefits and represents a safe and effective therapeutic alternative."

Journal • Retrospective data • Back Pain • Lumbar Back Pain • Musculoskeletal Pain • Orthopedics • Pain