MOD06051 / Alivexis - LARVOL DELTA

Cathepsin C inhibition reduces neutrophil serine protease activity and improves activated neutrophil-mediated disorders. (PubMed, Nat Commun) - "Furthermore, MOD06051 dose-dependently ameliorates vasculitis and significantly decreases NETs when administered to a rat model of myeloperoxidase (MPO)-antineutrophil cytoplasmic antibody-associated vasculitis (AAV). These findings suggest that CatC inhibition is a promising strategy to reduce neutrophil activation and improve activated neutrophil-mediated diseases such as MPO-AAV."

Journal • ANCA Vasculitis • Inflammation • Vasculitis • CTSC • ELANE • MPO