gp96-Ig vaccine / Sylvester Comprehensive Cancer Center - LARVOL DELTA

"All for One and One for All": The Secreted Heat Shock Protein gp96-Ig Based Vaccines. (PubMed, Cells) - "In this review, we will highlight three major principles of the gp96-Ig vaccine strategy: (1) presentation of pathogenic antigens to T cells (specificity); (2) activation of innate immune responses (adjuvanticity); (3) priming of T cells to home to the epithelial compartments (mucosal immunity). In summary, we provide a paradigm for a vaccine approach that can be rapidly engineered and customized for any future pathogens that require induction of effective tissue-resident memory responses in epithelial tissues."

Journal • Review • Infectious Disease • Oncology

Secreted heat shock protein gp96-Ig and OX40L-Fc combination vaccine enhances SARS-CoV-2 Spike (S) protein-specific B and T cell immune responses. (PubMed, Vaccine X) - "Thus, a cell-based gp96-Ig vaccine/OX40-L fusion protein regimen provides encouraging translational data that this vaccine platform induces pathogen-specific CD8+, CD4+ T and B cell responses, and may cohesively work as a booster for FDA-approved vaccines. Our vaccine platform can be rapidly engineered and customized based on other current and future pathogen sequences."

Journal • Immune Modulation • Infectious Disease • Inflammation • Novel Coronavirus Disease • Oncology • Respiratory Diseases • CD4 • CD8 • PROS1

[VIRTUAL] Development of a gp96-Ig vaccine for COVID-19 (IMMUNOLOGY 2021) - "We showed that our vaccine platform effectively stimulates a robust cellular immune response against protein S. Moreover, we confirmed that gp96-Ig, secreted from allogeneic cells expressing full-length protein S, generates powerful, protein S polyepitope-specific CD4+ and CD8+ T cell responses in both lung interstitium and airways. These findings were further strengthened by the observation that protein-S -specific CD8+ T cells were induced in human leukocyte antigen (HLA)-A2-02-01 transgenic mice thus providing encouraging translational data that the vaccine is likely to work in humans, in the context of SARS-CoV-2 antigen presentation."

Human Immunodeficiency Virus • Infectious Disease • Interstitial Lung Disease • Lung Cancer • Malaria • Non Small Cell Lung Cancer • Novel Coronavirus Disease • Oncology • Respiratory Diseases • Solid Tumor • CD4 • CD8 • PROS1

Secreted heat shock protein gp96-Ig vaccine induces malaria specific intrahepatic CD8 T cell responses (IMMUNOLOGY 2020) - "Also, we found an increased frequency of intrahepatic CD8+ T cells secreting IL-2, which is relevant for maintenance of effective memory responses. Our findings are strongly supportive of a novel gp96-Ig-based malaria vaccine as a unique systemic and liver-homing, liver-stage antigen-specific CD8+ cytotoxic T lymphocyte (CTL) vaccine strategy."

CD8 • IL2