latanoprost punctal plug delivery system (L-PPDS) / Mati Therap - LARVOL DELTA

Near-Infrared Broadband Absorbing Polymer Acceptors for Flexible All-Polymer Photodetectors with High Detectivity. (PubMed, ACS Appl Mater Interfaces) - "Compared to conventional inorganic detectors, all-polymer photodetectors (all-PPDs) have attracted significant attention in the field of flexible and wearable electronics owing to their unique mechanical properties...Moreover, it demonstrated a low dark current density (5.5 × 10-11 A·cm-2), a wide linear dynamic range (109.0 dB), and a fast response time (rise time/fall time = 2.12/3.59 μs), outperforming many existing acceptor materials. Benefiting from the excellent mechanical properties of the all-polymer blend film, P1-TT can be used to fabricate flexible device, and it also delivered a superior detectivity of 3.3 × 1013 Jones at 700 nm under a bias of -0.1 V. Practical application tests further verified its potential in optical communications, infrared signal detection, and biometric monitoring, demonstrating its promise for use in next-generation flexible optoelectronic systems."

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Assessment of age-related eye morphology and aqueous humor flow dynamics in the DBA/2J mouse model of pigmentary glaucoma using ocular MRI and anterior chamber iPerfusion systems (ARVO 2016) - "...9-mo DBA animals showed a decrease in Gd accumulation (Diff 10.33 ± 2.779, p<0.01) and peak Gd intensity. Facility in DBA2J shows an average of 46% reduction from 9 to 6 mo (N=4)."

Preclinical • Glaucoma • Ophthalmology

Comparison of Latanoprost PPDS With Timolol Maleate GFS in Subjects With Ocular Hypertension or Open-Angle Glaucoma (clinicaltrials.gov) - P2; N=86; Active, not recruiting; Sponsor: Mati Therapeutics Inc.; Completed ➔ Active, not recruiting; Trial primary completion date: Jul 2016 ➔ Dec 2016

Enrollment closed • Trial primary completion date • Biosimilar • Cardiovascular • Glaucoma • Ophthalmology

Long-term safety and intraocular pressure lowering efficacy of latanoprostene bunod 0.024% in Japanese subjects with open-angle glaucoma or ocular hypertension: the JUPITER study (ARVO 2016) - P3, N=130; JUPITER (NCT01895972); "Results from this 1-year study demonstrate that LBN 0.024% qPM was safe and well tolerated and provided robust and sustained long-term IOP lowering in Japanese subjects with OAG or OHT."

P3 data • Glaucoma • Ophthalmology

High Performance All-Polymer Photodetectors via Thick Photoactive Layer Strategy. (PubMed, ACS Appl Mater Interfaces) - "More importantly, the resultant all-PPDs exhibited a high working frequency over 10 kHz associated with a large linear dynamic range. These findings demonstrate the great potential for practical applications of the all-PPDs developed in this work."

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