latanoprost punctal plug delivery system (L-PPDS) / Mati Therap - LARVOL DELTA

Assessment of age-related eye morphology and aqueous humor flow dynamics in the DBA/2J mouse model of pigmentary glaucoma using ocular MRI and anterior chamber iPerfusion systems (ARVO 2016) - "...9-mo DBA animals showed a decrease in Gd accumulation (Diff 10.33 ± 2.779, p<0.01) and peak Gd intensity. Facility in DBA2J shows an average of 46% reduction from 9 to 6 mo (N=4)."

Preclinical • Glaucoma • Ophthalmology

Comparison of Latanoprost PPDS With Timolol Maleate GFS in Subjects With Ocular Hypertension or Open-Angle Glaucoma (clinicaltrials.gov) - P2; N=86; Active, not recruiting; Sponsor: Mati Therapeutics Inc.; Completed ➔ Active, not recruiting; Trial primary completion date: Jul 2016 ➔ Dec 2016

Enrollment closed • Trial primary completion date • Biosimilar • Cardiovascular • Glaucoma • Ophthalmology

Long-term safety and intraocular pressure lowering efficacy of latanoprostene bunod 0.024% in Japanese subjects with open-angle glaucoma or ocular hypertension: the JUPITER study (ARVO 2016) - P3, N=130; JUPITER (NCT01895972); "Results from this 1-year study demonstrate that LBN 0.024% qPM was safe and well tolerated and provided robust and sustained long-term IOP lowering in Japanese subjects with OAG or OHT."

P3 data • Glaucoma • Ophthalmology

High Performance All-Polymer Photodetectors via Thick Photoactive Layer Strategy. (PubMed, ACS Appl Mater Interfaces) - "More importantly, the resultant all-PPDs exhibited a high working frequency over 10 kHz associated with a large linear dynamic range. These findings demonstrate the great potential for practical applications of the all-PPDs developed in this work."

Journal