pizotifen malate / Generic mfg. - LARVOL DELTA

Anxiety and depression among patients with migraine: A single-center cross-sectional study in Malaysia. (PubMed, PLoS One) - "Anxiety and depression are commonly observed in patients with migraine in Asia. Routine assessments for anxiety and depression should be performed to ensure holistic management of migraine."

Journal • Observational data • Asthma • CNS Disorders • Depression • General Anxiety Disorder • Immunology • Migraine • Mood Disorders • Pain • Psychiatry • Pulmonary Disease • Respiratory Diseases

Disruption of Extracellular Signal-Regulated Kinase Partially Mediates Neonatal Isoflurane Anesthesia-Induced Changes in Dendritic Spines and Cognitive Function in Juvenile Mice. (PubMed, Int J Mol Sci) - "Concurrently, the ERK/CREB pathway, which is crucial for synaptic plasticity and memory consolidation, is supported and maintained by pizotifen, thereby preventing cognitive deficits caused in response to isoflurane or postsynaptic density-95-PDZ2-wildtype peptide exposure. Activation of ERK signaling cascade by pizotifen helps to prevent cognitive impairment and spine loss in response to postsynaptic density-95-PDZ2 domain disruption."

Journal • Preclinical • Alzheimer's Disease • Anesthesia • Cognitive Disorders • Developmental Disorders • DLG4 • TJP1

Neuropharmacological potential of Mimosa tenuiflora in adult zebrafish: An integrated approach to GABAergic and serotonergic neuromodulation. (PubMed, Behav Brain Res) - "The anxiolytic response induced by alcohol withdrawal and the seizure induced by pentylenetetrazole were also tested. The possible mechanisms of anxiolytic and antidepressant actions of FATEM were evaluated through the administration of specific antagonists (Flumazenil, Cyproheptadine, Pizotifen or Granisetron)...FATEM did not present acute toxicity and caused a reduction in locomotor activity (p < 0.0001 vs. Control) similar (p< 0.0001) to Diazepam, indicating a sedative/anxiolytic effect...FATEM also prevented anxious behaviors induced by alcohol withdrawal and exhibited an antidepressant effect in the ZTI (p < 0.0001 vs. Control) similar (p < 0.0001) to the effect of Fluoxetine, which was reversed by serotonergic antagonists. In silico evaluations indicated favorable pharmacokinetic properties and affinity of FATEM with GABAergic and serotonergic receptors. The study reveals that FATEM has adequate physicochemical characteristics to act on the CNS with..."

Journal • CNS Disorders • Depression • Epilepsy • Mood Disorders • Psychiatry

Sustainable, Green, and Sensitive Spectrofluorimetric Approach for Pizotifen Maleate Detection in Tablets and Human Plasma via Photo-Induced Electron Transfer Inhibition. (PubMed, Luminescence) - "This new strategy represents a new and sensitive method for accurate PZM monitoring in different samples. Furthermore, the established fluorimetric method's greenness was evaluated."

Journal • CNS Disorders • Migraine • Pain

Integrative bioinformatics analysis for identifying the mitochondrial-related gene signature associated with immune infiltration in premature ovarian insufficiency. (PubMed, BMC Med) - "Our results highlight the crosstalk between mitochondrial function and the immune response in the development of POI. The identification of MitoDEGs could lead to reliable biomarkers for the early diagnosis, monitoring, and personalized treatment of POI."

Gene Signature • Journal • Immunology • Metabolic Disorders • Women's Health • CFTR • CPT1A • MRPL51

Comparative Efficacy of Escitalopram Monotherapy and Escitalopram in Adjuvant With Pizotifen in Depressive Disorder (clinicaltrials.gov) - P=N/A | N=88 | Recruiting | Sponsor: Riphah International University

New trial • CNS Disorders • Depression • Mood Disorders • Psychiatry

Molecular docking and GC/MS-based approach for identification of anxiolytic alkaloids from Griffinia (Amaryllidaceae) species in a zebrafish model. (PubMed, Chem Biodivers) - "Furthermore, pre-treatment with diazepam and pizotifen drugs was able to reverse the anxiolytic action, indicating involving the GABAergic and serotonergic receptors. Molecular docking showed that the compounds vittatine, lycorine and 11,12-dehydro-2-methoxyassoanine had high affinity with both receptors, suggesting them to be responsible for the anxiolytic effect."

Journal • Mood Disorders • Psychiatry

Preventive treatment of migraine: Non-specific oral agents. (PubMed, Handb Clin Neurol) - "Propranolol, metoprolol, candesartan, topiramate, divalproex, lisinopril, amitriptyline, and venlafaxine have the strongest evidence to support for use. Flunarizine and pizotifen may also be effective. Selection of preventive treatments is based on individual characteristics, comorbid conditions, efficacy, contraindications, side effects, cost, compliance, and drug. An adequate trial of migraine prophylaxis is usually 2 months at the target dose, and it is always important to re-evaluate indication for prophylactic use after a period of time."

Journal • CNS Disorders • Migraine • Pain

Comparison of Efficacy Between Combination of Amitriptyline-propranolol and Pizotifen for Migraine Prophylaxis. (clinicaltrials.gov) - P2 | N=140 | Active, not recruiting | Sponsor: Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh

New P2 trial • CNS Disorders • Migraine • Pain

Pharmaceutical residues in stranded dolphins in the Bay of Biscay. (PubMed, Sci Total Environ) - "Very low concentrations (<1 ng/g) of orphenadrine and pizotifen were found in liver and promethazine in blubber. Herein, the gap in the knowledge regarding the study organisms and marine environments with respect to pharmaceutical pollution, which demands further research to understand if pharmaceuticals are a threat for these apex predators, is highlighted and discussed."

Journal

Anxiolytic-like effects of Pseudospondias microcarpa hydroethanolic leaf extract in zebrafish: Possible involvement of GABAergic and serotonergic pathways. (PubMed, Nat Prod Bioprospect) - "The zebrafish light dark test (LDT) and novel tank test (NTT) were employed to assess the anxiolytic-like effects of PME (0.1, 0.3, 1.0 mg mL), fluoxetine (3 × 10 mg mL) and diazepam (1.5 × 10 mg mL)...The potential mechanisms of anxiolytic action of the extract was evaluated after pre-treated with flumazenil, granisetron, methysergide, or pizotifen, all at 1 × 10 mg mL...In addition, PME treatment significantly reversed CUS-induced anxiety behaviours in zebrafish. Results show that PME possesses anxiolytic-like effects possibly through interaction with serotonergic and gamma-aminobutyric acid mediated pathways."

Journal • CNS Disorders • Mood Disorders • Psychiatry

Anxiolytic effects of N-(4,5-dihydro-5-oxo-1,2-dithiolo-[4,3,b]-pyrrole-6-yl)-N-methylformamide, a pyrroloformamide isolated from a marine Streptomyces sp., in adult zebrafish by the 5-HT system. (PubMed, J Biomol Struct Dyn) - "This effect was reduced by a pretreatment with pizotifen and granisetron, and was not reversed after treatment with cyproheptadine. Molecular docking and dynamics studies confirmed the interaction of PFD with the 5-HT receptor.Communicated by Ramaswamy H. Sarma."

Journal • CNS Disorders • General Anxiety Disorder • Mood Disorders • Psychiatry

Synthesis and anxiolytic effect of europium metallic complex containing lapachol [Eu(DBM). LAP] in adult zebrafish through serotonergic neurotransmission: in vivo and in silico approach. (PubMed, J Biomol Struct Dyn) - "Anxiety-related mental health problems are estimated at 3.6% globally, benzodiazepines (BZDs) are the class of drugs indicated for the treatment of anxiety, including lorazepam and diazepam...The complex was characterized using spectrometric techniques, and the anxiolytic effect of complex may be involved the neuromodulation of receptors 5-HT3A/3B, since the pre-treatment with pizotifen and cyproheptadine did not block the anxiolytic effect of [Eu(DBM). LAP], unlike fluoxetine had its anxiolytic effect reversed...LAP] and 5HT receptor with binding energy -7.8 kcal/mol and the ADMET study showed that complex has low toxic risk. It is expected that the beginning of this study will allow the application of the new anxiolytic drugs, given the pharmacological potential of the lapachol complex.Communicated by Ramaswamy H. Sarma."

Journal • Preclinical • Mood Disorders • Psychiatry

Repurposed pizotifen malate targeting NRF2 exhibits anti-tumor activity through inducing ferroptosis in esophageal squamous cell carcinoma. (PubMed, Oncogene) - "Our study illustrates that the over expression of NRF2 indicates poor prognosis and promotes tumor proliferation in ESCC. PZM, as a novel NRF2 inhibitor, inhibits the tumor growth by inducing ferroptosis and elucidates a potent NRF2-based therapy strategy for patients with ESCC."

Journal • Esophageal Cancer • Esophageal Squamous Cell Carcinoma • Oncology • Squamous Cell Carcinoma • GPX4

Gastrulation Screening to Identify Anti-metastasis Drugs in Zebrafish Embryos. (PubMed, Bio Protoc) - "A previous study subjected 1,280 FDA-approved drugs to the screen and identified adrenosterone and pizotifen as epiboly-interrupting drugs...Therefore, this screen could be converted into a chemical genetic screening platform for identification of metastasis-promoting genes. Graphical abstract."

Journal • Breast Cancer • Oncology • Solid Tumor

Consensus of the Brazilian Headache Society (SBCe) for prophylactic treatment of episodic migraine: Part II. (PubMed, Arq Neuropsiquiatr) - " Despite an effort by the scientific community to find really effective drugs in the treatment of migraine, given the large number of drugs tested for this purpose, we still have few therapeutic options."

Journal • CNS Disorders • Migraine • Pain

Prophylactic Therapy Response in Children with Abdominal Migraine: A Single Centre Experience in Oman. (PubMed, Pediatr Gastroenterol Hepatol Nutr) - "We found a favorable response to various modalities and combination treatments with riboflavin, pizotifen, and propranolol in children with AM. In addition, the presence of vomiting may predict treatment response."

Journal • CNS Disorders • Gastroenterology • Gastrointestinal Disorder • Migraine • Pain

Intrathecally administered pizotifen alleviates neuropathic and inflammatory pain in mice by enhancing GABAergic inhibition. (PubMed, Neurosci Lett) - "Tricyclic antidepressants (TCA) such as amitriptyline are classical 5-HT reuptake inhibitors, are recommended as the first-line treatment for chronic pain. Furthermore, high dose of pizotifen (5μg) weakly affected motor performance and did not influence the locomotor activity in normal animals. In summary, our findings suggest that pizotifen strengthens the inhibitory synaptic transmission and exerts antinociceptive effect on both neuropathic pain and inflammatory pain in the spinal cord, and may serve as a promising remedy for chronic pain."

Journal • Preclinical • Migraine • Neuralgia • Pain

What is new in migraine management in children and young people? (PubMed, Arch Dis Child) - "Recent large trials of established conventional pharmaceuticals such as propranolol, pizotifen, topiramate and amitriptyline for childhood migraine have failed, but the use of a quasi-placebo in future trials could help. We reviewed the evidence for angiotensin antagonists including candesartan in adults, but found a lack of evidence for their use in children. There have been new developments in pharmaceuticals recently, including a more selective 5-HT1F agonist, lasmiditan, an effective acute treatment with no vasoconstrictor activity in adults, currently being tested in children...So, there has been much progress, but mostly for adults. We are in urgent need of more migraine trials in children."

Journal • Review • CNS Disorders • Immunology • Migraine • Pain • Pediatrics

Fishing for drugs. (PubMed, Elife) - "Screening for drugs that disrupt embryonic development in zebrafish can help identify treatments that suppress metastasis."

Journal • Oncology

A chemical screen based on an interruption of zebrafish gastrulation identifies the HTR2C inhibitor Pizotifen as a suppressor of EMT-mediated metastasis. (PubMed, Elife) - "In contrast, HTR2C induced epithelial to mesenchymal transition (EMT) through activation of Wnt-signaling and promoted metastatic dissemination of human cancer cells in a zebrafish xenotransplantation model. Taken together, our concept offers a novel platform for discovery of anti-metastasis drugs."

Journal • Oncology • Transplantation

"Sandomigran è indicato per la prevenzione del mal di testa ricorrente causato da problemi dei vasi sanguigni quali: emicranie tipiche o atipiche (definite anche come emicrania ricorrente con o senza aura) cefalea a grappolo" (@rassegnato1)

Anxiolytic-like effect of natural product 2-hydroxy-3,4,6-trimethoxyacetophenone isolated from Croton anisodontus in adult zebrafish via serotonergic neuromodulation involvement of the 5-HT system. (PubMed, Naunyn Schmiedebergs Arch Pharmacol) - "Pentylenetetrazole (PTZ) was used to induce seizure by immersion...The higher doses (3 and 10 mg/kg; v.o.) produced signs of anxiolytic action in the light/dark test, and this effect was reversed by the pizotifen (antagonist 5HTR and 5HTR), having the potential to form a complex with 5HTR1B. However, the anxiolytic effect of HTMCX has not been abolished by flumazenil (antagonist GABA), cyproheptadine (antagonist 5HTR), and granisetron (antagonist 5HTR). Therefore, HTMCX demonstrated an anxiolytic effect, suggesting that the 5HTR and 5HTR receptors may be involved in the pharmacological performance of this acetophenone in the central nervous system."

Clinical • Journal • CNS Disorders • Epilepsy • Mood Disorders • Psychiatry

Systematic literature review and Bayesian network meta-analysis of episodic cluster headache drugs. (PubMed, Eur Rev Med Pharmacol Sci) - "The results suggest that galcanezumab is more effective compared to verapamil as a prophylaxis treatment for reducing eCH attacks in adults. Further, head-to-head RCTs of galcanezumab vs. treatments using in clinical practice are needed to better assess its comparative efficacy and benefit-risk profile."

Journal • Retrospective data • Review • Pain

Dioclea altissima seed lectin (DAL) prevents anxiety-like behavioral responses in adult zebrafish (Danio rerio): Involvement of GABAergic and 5-HT systems. (PubMed, CNS Neurol Disord Drug Targets) - "DAL was found to have an anxiolytic-like effect mediated by the 5-HT and GABAergic receptors."

Clinical • Journal • Mood Disorders • Psychiatry