pizotifen malate / Generic mfg. - LARVOL DELTA

Specialist transition headache clinic from an UK perspective: From children to young adults (EHF-EHC 2025) - "The most common preventive treatments tried were pizotifen, propranolol and amitriptyline. A structured transition headache clinic can successfully bridge the gap and provide continuity of care during a pivotal time in the young adult"s lives, both academically and developmentally. As more patients access novel treatments in adulthood, continued follow-up will be crucial to assess long-term outcomes."

Clinical • CNS Disorders • Migraine • Pain

Comparative Efficacy of Escitalopram Monotherapy and Escitalopram in Adjuvant With Pizotifen in Depressive Disorder (clinicaltrials.gov) - P=N/A | N=88 | Completed | Sponsor: Riphah International University | Recruiting ➔ Completed

Monotherapy • Trial completion • CNS Disorders • Depression • Mood Disorders • Psychiatry

Real-world data on Rimegepant for prophylaxis of episodic and chronic migraine in patients with at least three treatment failures. (IHC 2025) - "Patients with CM had tried amitriptyline, propranolol, candesartan, topiramate, pizotifen, venlafaxine, flunarazine, sodium valproate, onabotulinumtoxinA, CGRP mAbs and atogepant unless contraindicated with a minmum of 8 and maximum of 11 treatment failures. Conclusion Rimegepant is a well tolerated and effective prophylactic treatment option for EM and CM. Currently the data is on a small number of patients and we aim to report on a large cohort of patients in due course."

Clinical • Real-world • Real-world evidence • CNS Disorders • Migraine

Response to intravenous dihydroergotamine (DHE) for the treatment of refractory chronic migraine in adolescent patients (IHC 2025) - "Pre-infusion ondansetron 150 mcg/kg and prochlorperazine 5 mg/kg were administered PRN...For management, 54% (14/26) used sumatriptan,19% (5/26) used rizatriptan, 23% (6/26) used zolmitriptan, and 4% (1/26) used eletriptan. Preventively, 31% (8/26) had used propranolol, 23% (6/26) topiramate, 23% (6/26) amitriptyline, and 23% (6/26) pizotifen...This may include infusion slowing and increasing anti-emetic breadth and doses. Larger longer-term follow up studies are needed."

Clinical • CNS Disorders • Migraine

Response to Atogepant in refractory chronic migraine patients: a real world data from Hull Migraine Clinic. (IHC 2025) - "Patients had failed an average of 7.5 (range 5-11) treatments including amitriptyline 93%, propranolol 89%, candesartan 88%, topiramate 72%, pizotifen 39%, flunarazine 25%, venlafaxine 23%, sodium valproate 8% and all (100%) failed onabotulinumtoxinA and CGRP mAbs. It will be interesting to see a response in those with few treatment failures. Atogepant is an effective prophylaxis even in those non-responsive to other treatments."

Clinical • Real-world • Real-world evidence • CNS Disorders • Migraine

Cephalalgia heterotopica: a case series of lower-half-face migraine (IHC 2025) - "One patient reported significant pain relief with rizatriptan and another with sumatriptan. Preventive treatment, including pizotifen, propranolol, flunarizine, amitriptyline, divalproex sodium, and pregabalin, proved to be effective...A proper case definition of this rare clinical presentation may provide new insights into understanding the mechanisms of migraine. Keywords: facial pain, migraine, lower-half-face migraine."

Clinical • CNS Disorders • Migraine

Efficacy and Tolerance of Pizotifen for the Migraine Treatment in a Group of Children in a Brazilian Amazon's City: A Retrospective Study. (PubMed, Neurol India) - "Pizotifen proved to be effective in reducing the frequency and intensity of migraine attacks and had an acceptable tolerance profile, which makes it a good therapeutic option. Randomized clinical trials with a larger number of participants are needed to confirm our findings."

Clinical • Journal • Retrospective data • CNS Disorders • Migraine • Pain

Anxiety and depression among patients with migraine: A single-center cross-sectional study in Malaysia. (PubMed, PLoS One) - "Anxiety and depression are commonly observed in patients with migraine in Asia. Routine assessments for anxiety and depression should be performed to ensure holistic management of migraine."

Journal • Observational data • Asthma • CNS Disorders • Depression • General Anxiety Disorder • Immunology • Migraine • Mood Disorders • Pain • Psychiatry • Pulmonary Disease • Respiratory Diseases

Disruption of Extracellular Signal-Regulated Kinase Partially Mediates Neonatal Isoflurane Anesthesia-Induced Changes in Dendritic Spines and Cognitive Function in Juvenile Mice. (PubMed, Int J Mol Sci) - "Concurrently, the ERK/CREB pathway, which is crucial for synaptic plasticity and memory consolidation, is supported and maintained by pizotifen, thereby preventing cognitive deficits caused in response to isoflurane or postsynaptic density-95-PDZ2-wildtype peptide exposure. Activation of ERK signaling cascade by pizotifen helps to prevent cognitive impairment and spine loss in response to postsynaptic density-95-PDZ2 domain disruption."

Journal • Preclinical • Alzheimer's Disease • Anesthesia • Cognitive Disorders • Developmental Disorders • DLG4 • TJP1

Neuropharmacological potential of Mimosa tenuiflora in adult zebrafish: An integrated approach to GABAergic and serotonergic neuromodulation. (PubMed, Behav Brain Res) - "The anxiolytic response induced by alcohol withdrawal and the seizure induced by pentylenetetrazole were also tested. The possible mechanisms of anxiolytic and antidepressant actions of FATEM were evaluated through the administration of specific antagonists (Flumazenil, Cyproheptadine, Pizotifen or Granisetron)...FATEM did not present acute toxicity and caused a reduction in locomotor activity (p < 0.0001 vs. Control) similar (p< 0.0001) to Diazepam, indicating a sedative/anxiolytic effect...FATEM also prevented anxious behaviors induced by alcohol withdrawal and exhibited an antidepressant effect in the ZTI (p < 0.0001 vs. Control) similar (p < 0.0001) to the effect of Fluoxetine, which was reversed by serotonergic antagonists. In silico evaluations indicated favorable pharmacokinetic properties and affinity of FATEM with GABAergic and serotonergic receptors. The study reveals that FATEM has adequate physicochemical characteristics to act on the CNS with..."

Journal • CNS Disorders • Depression • Epilepsy • Mood Disorders • Psychiatry

Sustainable, Green, and Sensitive Spectrofluorimetric Approach for Pizotifen Maleate Detection in Tablets and Human Plasma via Photo-Induced Electron Transfer Inhibition. (PubMed, Luminescence) - "This new strategy represents a new and sensitive method for accurate PZM monitoring in different samples. Furthermore, the established fluorimetric method's greenness was evaluated."

Journal • CNS Disorders • Migraine • Pain

Integrative bioinformatics analysis for identifying the mitochondrial-related gene signature associated with immune infiltration in premature ovarian insufficiency. (PubMed, BMC Med) - "Our results highlight the crosstalk between mitochondrial function and the immune response in the development of POI. The identification of MitoDEGs could lead to reliable biomarkers for the early diagnosis, monitoring, and personalized treatment of POI."

Gene Signature • Journal • Immunology • Metabolic Disorders • Women's Health • CFTR • CPT1A • MRPL51

Comparative Efficacy of Escitalopram Monotherapy and Escitalopram in Adjuvant With Pizotifen in Depressive Disorder (clinicaltrials.gov) - P=N/A | N=88 | Recruiting | Sponsor: Riphah International University

New trial • CNS Disorders • Depression • Mood Disorders • Psychiatry

Molecular docking and GC/MS-based approach for identification of anxiolytic alkaloids from Griffinia (Amaryllidaceae) species in a zebrafish model. (PubMed, Chem Biodivers) - "Furthermore, pre-treatment with diazepam and pizotifen drugs was able to reverse the anxiolytic action, indicating involving the GABAergic and serotonergic receptors. Molecular docking showed that the compounds vittatine, lycorine and 11,12-dehydro-2-methoxyassoanine had high affinity with both receptors, suggesting them to be responsible for the anxiolytic effect."

Journal • Mood Disorders • Psychiatry

Preventive treatment of migraine: Non-specific oral agents. (PubMed, Handb Clin Neurol) - "Propranolol, metoprolol, candesartan, topiramate, divalproex, lisinopril, amitriptyline, and venlafaxine have the strongest evidence to support for use. Flunarizine and pizotifen may also be effective. Selection of preventive treatments is based on individual characteristics, comorbid conditions, efficacy, contraindications, side effects, cost, compliance, and drug. An adequate trial of migraine prophylaxis is usually 2 months at the target dose, and it is always important to re-evaluate indication for prophylactic use after a period of time."

Journal • CNS Disorders • Migraine • Pain

Comparison of Efficacy Between Combination of Amitriptyline-propranolol and Pizotifen for Migraine Prophylaxis. (clinicaltrials.gov) - P2 | N=140 | Active, not recruiting | Sponsor: Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh

New P2 trial • CNS Disorders • Migraine • Pain

Pharmaceutical residues in stranded dolphins in the Bay of Biscay. (PubMed, Sci Total Environ) - "Very low concentrations (<1 ng/g) of orphenadrine and pizotifen were found in liver and promethazine in blubber. Herein, the gap in the knowledge regarding the study organisms and marine environments with respect to pharmaceutical pollution, which demands further research to understand if pharmaceuticals are a threat for these apex predators, is highlighted and discussed."

Journal

Anxiolytic-like effects of Pseudospondias microcarpa hydroethanolic leaf extract in zebrafish: Possible involvement of GABAergic and serotonergic pathways. (PubMed, Nat Prod Bioprospect) - "The zebrafish light dark test (LDT) and novel tank test (NTT) were employed to assess the anxiolytic-like effects of PME (0.1, 0.3, 1.0 mg mL), fluoxetine (3 × 10 mg mL) and diazepam (1.5 × 10 mg mL)...The potential mechanisms of anxiolytic action of the extract was evaluated after pre-treated with flumazenil, granisetron, methysergide, or pizotifen, all at 1 × 10 mg mL...In addition, PME treatment significantly reversed CUS-induced anxiety behaviours in zebrafish. Results show that PME possesses anxiolytic-like effects possibly through interaction with serotonergic and gamma-aminobutyric acid mediated pathways."

Journal • CNS Disorders • Mood Disorders • Psychiatry

Anxiolytic effects of N-(4,5-dihydro-5-oxo-1,2-dithiolo-[4,3,b]-pyrrole-6-yl)-N-methylformamide, a pyrroloformamide isolated from a marine Streptomyces sp., in adult zebrafish by the 5-HT system. (PubMed, J Biomol Struct Dyn) - "This effect was reduced by a pretreatment with pizotifen and granisetron, and was not reversed after treatment with cyproheptadine. Molecular docking and dynamics studies confirmed the interaction of PFD with the 5-HT receptor.Communicated by Ramaswamy H. Sarma."

Journal • CNS Disorders • General Anxiety Disorder • Mood Disorders • Psychiatry

Synthesis and anxiolytic effect of europium metallic complex containing lapachol [Eu(DBM). LAP] in adult zebrafish through serotonergic neurotransmission: in vivo and in silico approach. (PubMed, J Biomol Struct Dyn) - "Anxiety-related mental health problems are estimated at 3.6% globally, benzodiazepines (BZDs) are the class of drugs indicated for the treatment of anxiety, including lorazepam and diazepam...The complex was characterized using spectrometric techniques, and the anxiolytic effect of complex may be involved the neuromodulation of receptors 5-HT3A/3B, since the pre-treatment with pizotifen and cyproheptadine did not block the anxiolytic effect of [Eu(DBM). LAP], unlike fluoxetine had its anxiolytic effect reversed...LAP] and 5HT receptor with binding energy -7.8 kcal/mol and the ADMET study showed that complex has low toxic risk. It is expected that the beginning of this study will allow the application of the new anxiolytic drugs, given the pharmacological potential of the lapachol complex.Communicated by Ramaswamy H. Sarma."

Journal • Preclinical • Mood Disorders • Psychiatry

Repurposed pizotifen malate targeting NRF2 exhibits anti-tumor activity through inducing ferroptosis in esophageal squamous cell carcinoma. (PubMed, Oncogene) - "Our study illustrates that the over expression of NRF2 indicates poor prognosis and promotes tumor proliferation in ESCC. PZM, as a novel NRF2 inhibitor, inhibits the tumor growth by inducing ferroptosis and elucidates a potent NRF2-based therapy strategy for patients with ESCC."

Journal • Esophageal Cancer • Esophageal Squamous Cell Carcinoma • Oncology • Squamous Cell Carcinoma • GPX4

Gastrulation Screening to Identify Anti-metastasis Drugs in Zebrafish Embryos. (PubMed, Bio Protoc) - "A previous study subjected 1,280 FDA-approved drugs to the screen and identified adrenosterone and pizotifen as epiboly-interrupting drugs...Therefore, this screen could be converted into a chemical genetic screening platform for identification of metastasis-promoting genes. Graphical abstract."

Journal • Breast Cancer • Oncology • Solid Tumor

Consensus of the Brazilian Headache Society (SBCe) for prophylactic treatment of episodic migraine: Part II. (PubMed, Arq Neuropsiquiatr) - " Despite an effort by the scientific community to find really effective drugs in the treatment of migraine, given the large number of drugs tested for this purpose, we still have few therapeutic options."

Journal • CNS Disorders • Migraine • Pain

Prophylactic Therapy Response in Children with Abdominal Migraine: A Single Centre Experience in Oman. (PubMed, Pediatr Gastroenterol Hepatol Nutr) - "We found a favorable response to various modalities and combination treatments with riboflavin, pizotifen, and propranolol in children with AM. In addition, the presence of vomiting may predict treatment response."

Journal • CNS Disorders • Gastroenterology • Gastrointestinal Disorder • Migraine • Pain

Intrathecally administered pizotifen alleviates neuropathic and inflammatory pain in mice by enhancing GABAergic inhibition. (PubMed, Neurosci Lett) - "Tricyclic antidepressants (TCA) such as amitriptyline are classical 5-HT reuptake inhibitors, are recommended as the first-line treatment for chronic pain. Furthermore, high dose of pizotifen (5μg) weakly affected motor performance and did not influence the locomotor activity in normal animals. In summary, our findings suggest that pizotifen strengthens the inhibitory synaptic transmission and exerts antinociceptive effect on both neuropathic pain and inflammatory pain in the spinal cord, and may serve as a promising remedy for chronic pain."

Journal • Preclinical • Migraine • Neuralgia • Pain