nifedipine modified release / Generic mfg. - LARVOL DELTA

Population Pharmacokinetics of Nifedipine in High-Altitude and Plain Patients With Hypertension. (PubMed, J Clin Pharmacol) - "The interindividual variability of CL was reduced from 36.26% to 31.91%, and the CL of patients in the plateau area was about 1.35 times higher than that in the plain area. This study may contribute to the rational use of nifedipine in the plateau area."

Journal • PK/PD data • Cardiovascular • Hypertension

A case of malignant hypertension due to sarcoidosis. (PubMed, J Hypertens) - "This is the first reported case of malignant hypertension due to renal sarcoidosis. Therefore, sarcoidosis should be considered as a differential diagnosis in patients with malignant hypertension."

Journal • Cardiovascular • Hypertension • Immunology • Nephrology • Pain • Renal Disease • Retinal Disorders • Sarcoidosis

Pharmacokinetic, bioequivalence, and safety assessments of two brands of 30-mg nifedipine controlled-release formulations in Chinese healthy subjects. (PubMed, Int J Clin Pharmacol Ther) - "Under both the fasting and postprandial states, the two nifedipine controlled-release formulations were bioequivalent and safe in healthy Chinese subjects."

Journal • PK/PD data

Economic evaluation of Annao Pills combined with antihypertensive drugs in treatment of primary hypertension: a study based on decision tree model (PubMed, Zhongguo Zhong Yao Za Zhi) - "The experimental group was treated with Annao Pills combined with anti-hypertensive drugs(nifedipine controlled-release tablets + losartan potassium tablets), and the control group was treated with anti-hypertensive drugs(nifedipine controlled-release tablets + losartan potassium tablets). The probability sensitivity results showed that when the patient's personal willingness to pay the price was higher than 2 650 yuan, the probability of the regimen in the experimental group was higher, which was consistent with the results of the basic analysis. In conclusion, when the price was higher than 2 650 yuan, Annao Pills combined with anti-hypertensive drugs was more economical than anti-hypertensive drugs alone in terms of improving the response rate of the patients with primary hypertension."

HEOR • Journal • Cardiovascular • Hypertension

Comparative Bioequivalence and Food Effect of Two Formulations of 30-mg Nifedipine Controlled-Release Tablets in Healthy Chinese Adults. (PubMed, Clin Pharmacol Drug Dev) - "An important observation with food coadministration was that systemic exposure to nifedipine (based on area under the curve, AUC0-∞ ) was reduced by approximately 12%. The bioequivalence of the test product and reference drug under fasting/fed conditions in healthy subjects in China was demonstrated by the study results."

Journal

Tongue Edema Caused by Taking Nifedipine Controlled-Release Tablets. (PubMed, Neurol India) - No abstract available

Journal

Effects of intravenous nicardipine followed by oral labetalol in combination with nifedipine controlled-release tablet on severe peripartum hypertension. (PubMed, Ginekol Pol) - "Intravenous nicardipine rapidly and safely lowered severe peripartum hypertension. As subsequent therapy, oral labetalol combined with nifedipine controlled-release tablet protocol may be applied to effectively maintain a target BP."

Combination therapy • Journal • Cardiovascular • Hypertension

Late-onset non-obstructive mesenteric ischemia (NOMI) resulting from delayed absorption of overdosed antihypertensive drugs: An autopsy case report. (PubMed, Forensic Sci Med Pathol) - "The formulation of nifedipine was a controlled-release tablet, and the low water solubility of cilostazol may have caused the tablets to adhere and remain in the stomach. Therefore, the drugs had been released into the blood stream several days after hospitalization, leading to delayed-onset NOMI. In cases of overdose, it is crucial to consider the formulation and properties of the involved drugs when determining medical treatment."

Journal • Cardiovascular • Critical care • Gastrointestinal Disorder • Hypotension • Thrombosis

Therapeutic improvements of nifedipine controlled-release tablets combined with sacubitril valsartan on patients with diabetic nephropathy complicated with hypertension. (PubMed, Int Immunopharmacol) - "After three-months treatment, the levels of clinical indexes (glycosylated hemoglobin, fasting blood glucose, systolic and diastolic blood pressure), renal function indicators (urinary albumin excretion rate, blood urea nitrogen, serum creatinine and cystatin C), endothelial function indicators (microalbumin, angiotensin II, thrombomodulin and cartilage oligomeric matrix protein) and inflammatory response factors (interleukin-6 and tumor necrosis factor-α) in the observation group were significantly lower than those in the control group. Nifedipine controlled-release tablets combined with sacubitril valsartan could effectively alleviate the progression of DN combined with hypertension."

Journal • Cardiovascular • Diabetic Nephropathy • Hypertension • Inflammation • Nephrology • Oncology • Renal Disease • CST3 • IL6 • TNFA

Pharmacokinetics and Bioequivalence of 2 Nifedipine Controlled-Release Tablets: A Randomized, Single-Dose, 2-Period Crossover Study in Healthy Chinese Volunteers Under Fasting and Fed Conditions. (PubMed, Clin Pharmacol Drug Dev) - "No serious adverse events were reported throughout the study and no adverse events led to withdrawal from the study. Food effects were found in both the test and reference products, with mean maximum plasma concentration, AUC from time 0 to the last measurable concentration, and AUC from time 0 to infinity increased by 23.7%, 20.7%, and 20.5%, respectively, for the test product and 35.2%, 13.4%, and 14.7% for the reference product after a high-fat and high-calorie breakfast."

Journal • PK/PD data

Analysis of the improvement of serological indexes in patients with diabetic nephropathy and hypertension using Valsartan combined with Nifedipine controlled-release regimen. (PubMed, Pak J Med Sci) - "The levels of adiponectin (APN), aldosterone (ALD) and gastric growth promoting factor (ghrelin) in the observation group after the treatment were lower than those in the control group (P<0.05). A combination of valsartan and nifedipine controlled-release tablets in DN patients with hypertension can effectively control blood glucose and blood pressure, improve the serological indexes such as COMP, TM, mAlb, Ang-1, Hcy, CysC, TGF-β1, APN, ALD and ghrelin, and potentially reduce and delay renal function damage."

Journal • Cardiovascular • Diabetic Nephropathy • Hypertension • Nephrology • Renal Disease • ANGPT1 • CST3 • TGFB1

Exploration of the effect of the alkaloid colchicine on Ca handling and its related physiology in human oral cancer cells. (PubMed, Arch Oral Biol) - "In OC2 cells, colchicine induced [Ca] rises by evoking PLC-dependent Ca release from the endoplasmic reticulum and Ca entry via PKC-sensitive store-operated Ca entry. Furthermore, colchicine caused cell death that was not triggered by preceding [Ca] rises."

Journal