tetradecanoylphorbol acetate (PD-616) / Biosuccess Biotech, Rich Pharma - LARVOL DELTA

CD4+T cells in ageing-associated interstitial lung abnormalities show evidence of pro-inflammatory phenotypic and functional profile. (PubMed, Thorax) - "CD4+T cells from ILA subjects are highly proliferative and show an excessive functional activity, likely related to the loss of KLRG1 expression, which may contribute to an inflammatory state and the development of ILA."

Journal • Immune Modulation • Immunology • Inflammation • Respiratory Diseases • CD8 • CDH1 • IFNG • IL6

Improving the Efficacy of EGFR Inhibitors by Topical Treatment of Cutaneous Squamous Cell Carcinoma with miR-634 Ointment. (PubMed, Mol Ther Oncolytics) - "Epidermal growth factor receptor (EGFR) plays a key role in the development of cSCC, but EGFR tyrosine kinase inhibitors (TKIs), such as gefitinib, have shown only partial clinical benefit in this disease...In the present study, we found that topical application of an ointment containing miR-634 inhibited in vivo tumor growth without toxicity in a cSCC xenograft mouse model and a 7,12-dimethylbenz[a]anthracene (DMBA)/12-O-tetradecanoylphorbol-13-acetate (TPA)-induced papilloma mouse model...Furthermore, overexpression of miR-634 synergistically enhanced TKI-induced cytotoxicity by triggering severe energetic stress in vitro and in vivo. Thus, we propose that topical treatment with miR-634 ointment is a useful strategy for improving for EGFR TKI-based therapy for cSCC."

Clinical • Journal • Genetic Disorders • Oncology • Skin Cancer • Squamous Cell Carcinoma • Squamous Cell Skin Cancer • EGFR

[VIRTUAL] Transcription Factor RUNX1 Regulates Factor FXIIIA Subunit (F13A1) Expression in Megakaryocytic Cells and Platelet F13A1 Expression is Downregulated in RUNX1 Haplodeficiency (ASH 2020) - "We studied the regulation of F13A by RUNX1 in human erythroleukemia (HEL) cells treated with phorbol myristate acetate (PMA) to induce megakaryocytic transformation... Overall, these studies provide the first evidence that hematopoietic transcription factor RUNX1 regulates expression of F13A1 in megakaryocytic cells and that platelet expression of F13A1 is decreased in platelets from patients with RUNX1 haplodeficiency. The decreased expression of F13A1 in RHD may contribute to the platelet dysfunction in RHD. These findings are particularly interesting because they reflect regulation of a coagulation protein (FXIIIA) by hematopoietic transcription factor RUNX1."

Hematological Disorders • Hematological Malignancies • Leukemia • Oncology • Thrombocytopenia • F13A1 • F13A1 • F13B • RUNX1

Jasmine (Jasminum grandiflorum Linn.) flower extracts reduced tetradecanoylphorbol-acetate-induced mouse ear skin inflammation (ACS-Sp 2020) - "Acute mouse ear edema was induced by tetradecanoylphorbol-acetate (TPA; 125 µg/mL) and treated with jasmine flower extracts (100 mg/mL) or dexamethasone (DEX; 6.25 mg/mL; as a positive control). Their anti-inflammatory effects were supported by the immunohistochemical analysis of mice skin tissue. Data from this in vivo study demonstrate that jasmine flower extracts reduced TPA-induced skin inflammation in a mouse model."

Preclinical

Downregulating NF-κB signaling pathway with triterpenoids for attenuating inflammation: in vitro and in vivo studies. (PubMed, Food Funct) - "Furthermore, in a tetradecanoylphorbolacetate (TPA)-treated mouse model, AA and IA could effectively attenuate mouse ear edema and pathological damage and reduced levels of cytokines including iNOS, COX-2, TNF-α, and IL-1β. Taken together, AA and IA, being of natural origin, are promising anti-inflammatory agents and may contribute to the overall anti-inflammatory effect of A. trifoliatus."

Journal • Preclinical

A two-step multicomponent synthetic approach and anti-inflammatory evaluation of N-substituted 2-oxopyrazines. (PubMed, ChemMedChem) - "This series of compounds were tested for their potential anti-inflammatory capacity in an in vivo murine model, and four compounds were identified to inhibit tetradecanoylphorbol acetate (TPA)-induced edema by more than 75 %. The series was tested for its potential anti-inflammatory capacity in an in vivo murine model, where 4 compounds were identified that inhibited tetradecanoylphorbol acetate-induced (TPA) edema more than 75%. The two most active compounds having a methyl (10o) and trifluoromehtyl (10x) groups were also able to reduce the MPO activity and leukocyte infiltration; Moreover, 10x promoted the reduction of the thickness of TPA-treated ear as observed in the histological analysis of tissues."

Journal

Comparison of the anti-inflammatory effects of Sinapis alba and Brassica juncea in mouse models of inflammation. (PubMed, Phytomedicine) - "Our results revealed that both EWSS and EYSS are effective anti-inflammatory agents against acute and chronic inflammatory processes, and EWSS possess more potent anti-inflammatory effect than EYSS. The anti-inflammatory effect of the two herbs may be mediated, at least in part, by suppressing the mRNA expression of a panel of inflammatory mediators including TNF-α, IL-6 and IL-1β."

Journal • Preclinical