dimethylcurcumin (AJ101) / AnnJi Pharma - LARVOL DELTA

ASC-J9 attenuates the metastatic potential of oral cancer cells by downregulating the STAT3/ITGB8 signaling pathway. (PubMed, Eur J Pharmacol) - "These findings suggest that ASC-J9 inhibits ITGB8 in OSCC cells by blocking STAT3 activation, thereby reducing their invasive and migratory capabilities. Collectively, our results support ASC-J9 as a promising therapeutic candidate for the treatment of OSCC."

Journal • Head and Neck Cancer • Oncology • Oral Cancer • Solid Tumor • Squamous Cell Carcinoma • CDH1 • FN1 • SNAI1 • SNAI2 • VIM

Dimethylcurcumin and Copper Sulfate-Loaded Silk Nanoparticles for Synergistic Therapy against Breast Cancer. (PubMed, ACS Biomater Sci Eng) - "Dimethylcurcumin (ASC-J9) is an organic active pharmaceutical ingredient with anti-inflammatory, antioxidant, and antitumor effects...Both in vitro and in vivo experiments demonstrated that the anticancer effect was enhanced by photo thermotherapy. The current study provides a promising strategy for using silk fibroin as nanocarriers for breast cancer therapy."

Journal • Breast Cancer • Oncology • Solid Tumor

Synthesis of curcumin derivatives targeting androgen receptor for castration-resistant prostate cancer therapy. (PubMed, Chem Biol Drug Des) - "In androgen receptor suppression study, compounds 1f and 2g show similar androgen receptor suppression effect as compared to ASC-J9 on C4-2 cells, compound 3c displays significantly enhanced AR suppression effect as compared to ASC-J9, 1f and 2g. Compounds 1a, 1e, 1f, 1h, 2g, 3a and 3c prepared in this work have significant potential for castration-resistant prostate cancer therapy."

Journal • Castration-Resistant Prostate Cancer • Genito-urinary Cancer • Oncology • Prostate Cancer • Solid Tumor • AR

Peptide-functionalised magnetic silk nanoparticles produced by a swirl mixer for enhanced anticancer activity of ASC-J9. (PubMed, Colloids Surf B Biointerfaces) - "Functionalization of nanoparticles with anticancer peptides could be regarded as a new strategy for targeted delivery and enhanced efficiency of anticancer drugs. Furthermore, the microfluidic device introduced in this paper offers a robust and reproducible method for fabrication of small sized homogenous nanoparticles."

Journal • Colorectal Cancer • Gastrointestinal Cancer • Oncology • Solid Tumor

ASC-J9 Blocks Cell Proliferation and Extracellular Matrix Production of Keloid Fibroblasts through Inhibiting STAT3 Signaling. (PubMed, Int J Mol Sci) - "Transmission electron microscopy images revealed that ASC-J9 induced the formation of multilamellar bodies in KFs, which is associated with autophagy-related signaling. These results suggested that inhibiting a vicious cycle of the ROS/STAT3/IL-6 axis by ASC-J9 may represent a potential therapeutic approach to suppress cell proliferation and ECM production in KFs."

Journal • Dermatology • Fibrosis • Immunology • Inflammation • COL1A1 • IL6