ONESTX-01 / ONESTX - LARVOL DELTA

A STEROID SULFATASE INHIBITOR, ONESTX -01, AS A NOVEL TREATMENT FOR NEURODEGENERATIVE DISEASES: EFFECT IN PROGRESSION IN HUNTINGTON DISEASE MODELS (ADPD 2025) - "Aims: ONESTX-01 (formerly Irosustat) is a small molecule that blocks steroid sulfatase (STS), increasing the ratio of sulfated to free steroids in both animals and humans. Preliminary data suggest ONESTX -1 treatment could be a new approach to reversing or alleviating key symptoms in HD patients. The beneficial effect of ONESTX -01 in proteinopathies may be conserved accross evolutionary distant animal models."

Alzheimer's Disease • CNS Disorders • Cognitive Disorders • Genetic Disorders • Huntington's Disease • Inflammation • Movement Disorders • Proteinopathy