Vicodin CR (acetaminophen/hydrocodone) / AbbVie - LARVOL DELTA

"Ban Vicodin and Percocet.The benefits of these do not outweigh its risks @FDArecalls @US_FDA @FDA_Drug_Info @NPR" (@MauricioAngie1)

[VIRTUAL] Neuropathy After Heparin-induced Thrombocytopenia And A Nerve Block To Improve Pain (ASA 2020) - "Treatments (Vicodin, Gabapentin, Cymbalta, Tylenol, Baclofen, and Tizanidine) were unsuccessful in alleviating her pain. Due to these treatments failing, the patient had bilateral ultrasound guided saphenous nerve blocks with 0.25% bupivacaine and dexamethasone. The patient felt immediate relief in the recovery room, increased range of motion and continues to improve."

Cardiovascular • Heart Failure • Hematological Disorders • Pain • Thrombocytopenia

[VIRTUAL] Characteristics and Predictors of Hydrocodone Misuse: Results from the 2018 National Survey on Drug Use and Health. (EUSEM 2020) - "According to the Monitoring the Future survey, prevalence of the past year Vicodin misuse were 0.9% and 1.1% for 8th and 10th graders respectively... The results indicate a high prevalence of hydrocodone misuse within a nationally representative sample of survey respondents. The use and misuse of substances and underlying mental health conditions were important predictors of hydrocodone misuse. Appropriately directed harm reduction strategies must be developed focusing on these predictors"

CNS Disorders • Depression • Mood Disorders • Psychiatry • Suicidal Ideation

The Vicodin Abuse Problem: A Mathematical Approach. (PubMed, J Theor Biol) - "Our results demonstrate that relying solely on rehabilitation and other treatment programs is not enough to combat the prescription drug problem in the United States. We anticipate that implementing preventative measures in both prescribers and patients will reduce the number of Vicodin abusers."

Journal • Pain

"What's the correct term please? (Off of Vicodin but it was my friend.)" (@cancerisSOFUNNY)

"Before vicodin was rescheduled to C II" (@pinky_or_brain)

Sex differences in prescription opioid use patterns assessed through a community engagement program in Florida. (PubMed, Drug Alcohol Depend) - "The risk factors identified in this community sample provide additional information not accounted for by national studies. Future examinations of the consequences of concomitant opioid and sedative use, especially among women, are needed."

Journal • Oncology

"Vicodin works for pain to call me dr.fckin house!" (@DIESELPATRIOT1)

Pain

Assessment of Opioid-Prescribing Practices in Breast Augmentation: Future Directions for Prescribing Guidelines. (PubMed, Ann Plast Surg) - "Considerable variability exists among prescribing patterns after breast augmentation. Societal guidelines aimed at providers and patients may serve a future role in opioid prescribing."

Journal • Aesthetic Medicine • Pain

Machine Learning to Detect Prescription Opioid Abuse Promotion and Access via Twitter. (PubMed, Am J Public Health) - "Our methodology can identify illegal online sale of prescription opioids from large volumes of tweets. Our results indicate that controlled substances are trafficked online via different strategies and vendors. Public Health Implications. Our methodology can be used to identify illegal online sellers in criminal violation of the Ryan Haight Online Pharmacy Consumer Protection Act."

Journal • Biosimilar

Increasing availability of illicit and prescription opioids among people who inject drugs in a Canadian setting, 2010-2014. (PubMed, Am J Drug Alcohol Abuse) - "The availability of most prescription opioids had continued to increase in recent years among our sample of PWID in Vancouver. Concurrent increases in the availability of heroin were also observed, raising concerns regarding combination of both illicit and prescription opioid use among PWID that could potentially increase the risk of overdose."

Journal • Addiction (Opioid and Alcohol) • Biosimilar

"Yep. All the post surgery: moprphine, demoral, Vicodin. And I've taken naproxen. AND excedrin migraine. I give up." (@crystalsloth)

Biosimilar • Migraine

" #Scientology make from the drug #Humira made by @abbvie who also make #Vicodin Thanks wealthy Scn donors! #hypo" (@kellykels_melbs)

Biosimilar

Stigmatization of opioid addiction based on prescription, sex and age. (PubMed, Addict Behav) - "To assess which opioid users are stigmatized most, we administered an experimenter-created vignette that experimentally manipulated the type of opioid (Prescribed Vicodin vs. Non-prescribed Vicodin vs. heroin) as well as the sex of the opioid user (Male vs. Female) and the age of the user (23 years-old vs. 53 years-old) to 4300 people on Amazon's Mechanical Turk (a survey hosting website)...Lastly, young male opioid users were stigmatized more than any other group. Results are discussed."

Journal • Addiction (Opioid and Alcohol) • CNS Disorders • Pain

DEA publishes proposal to reschedule hydrocodone products (Medscape) - "The US Drug Enforcement Administration (DEA) has published in the Federal Register a formal proposal to reschedule hydrocodone combination products (HCPs) from Schedule III to Schedule II...The DEA's action on February 27 follows recent recommendations to reschedule HCPs from the Assistant Secretary for Health and Human Services (HHS) and a Food and Drug Administration (FDA) advisory committee...The DEA's own evaluation of relevant data on HCPs, which include Vicodin (AbbVie Inc), 'supports the action,' the agency said in a statement."

Regulatory • Pain

The FDA is pushing for greater restrictions on prescription painkillers: Now what (PR Web) - "According to George Catlin of Withdrawal Ease, the FDA's new restrictions on painkillers are not without risk...If these recommendations are approved by the DEA, the new regulations to go into effect in 2014."

Anticipated regulatory • Pain

Hydrocodone/acetaminophen not superior to codeine/acetaminophen for acute pain (Medscape) - P=NA, N=181; "...the pain score before the most recent dose of pain medication was the same for both groups: 7.6. A high pain score was expected as that would prompt patients to take the prescribed pain medication. Patients reported the mean decrease in the pain scores 2 hours after pain medications to be 3.9 in the hydrocodone/acetaminophen group and 3.5 in the codeine/acetaminophen group, for a between-group difference of only 0.4."

Clinical data • Pain

Pharmacokinetic evaluation of hydrocodone/acetaminophen for pain management (J Opioid Manag) - PMID: 23709306; "This review summarizes the current knowledge of the pharmacokinetics, pharmacodynamics, and metabolism of hydrocodone...The available clinical trials for the use of hydrocodone in the management of acute, chronic, and cancer pain are presented."

Review • Pain

"Correct; Vicodin & Bloody Mary is much better combo..." (@docwill121)

"No, give him xarelto and Vicodin" (@Chapermann)

Adolescent Nonmedical Use of Opioids and Alcohol Mixed with Energy Drinks. (PubMed, Am J Health Behav) - "Results Greater frequency of AmED use was associated with greater frequency of nonmedical Oxycontin (r = 0.391, p < .001) and Vicodin (r = 0.379, p < .001) use with moderate effect sizes. Conclusion Our results highlight the need to improve understanding of the relationship between nonmedical prescription opioid, energy drink and AmED use. AmED use appears to be associated with increased nonmedical prescription opioid use."

Journal

"Start by HELPNG #CPP. MFG decent generic pain meds. #percocet #vicodin et al with correct quantities of opiates. We are #patientsNOTaddicts @potus @FLOTUS @DanLairdMD @ThomasKlineMD" (@dhoomonyou)

Clinical

"U do not neee Vicodin after a vasectomy. Good lord." (@daviesbj)

The deadliest drugs in Florida are still opioids, despite a rosy interim report from the state - "'We're seeing the tail of what got started many years ago. There was a massive liberalization of opioid prescribing that had its inception probably in the late '80s, really started to gain momentum in the mid-'90s and went on into the early 2000s. Probably around 2011 you began to see a much bigger public awareness regarding the number of deaths,' Rosenquist says. 'People in 2004 weren't talking about it, but in 2011 they were'...Rosenquist says, just so they wouldn't have to contact the doctor for a refill. These tablets most likely came in the form of hydrocodone or oxycodone, the most popular being Vicodin, OxyContin and Percocet."

Media quote

An Innovative Solution to Detect, Classify, and Report Illicit Online Marketing and Sales of Controlled Substances via Twitter: Project Finalist at HHS Opioid Code-a-Thon. (PubMed, J Med Internet Res) - "Results of this study confirm prior studies that have identified social media platforms, including Twitter, as a potential conduit for supply and sale of illicit opioids. To translate these results into action, authors also developed a prototype wireframe for the purposes of detecting, classifying, and reporting illicit online pharmacy tweets selling controlled substances illegally to the U.S. Food and Drug Administration and U.S. Drug Enforcement Agency. Further development of solutions based on these methods has the potential to proactively alert regulators and law enforcement agencies of illegal opioid sales, while also making the online environment safer for the public."

Journal