Zirgan (ganciclovir ophthalmic gel) / Bausch Health, Thea Laboratories - LARVOL DELTA

Delayed uveitis after implantable Collamer lens Implantation caused by COVID-19 infection: a case report. (PubMed, Am J Transl Res) - "Treatment with sodium hyaluronate eye drops, ganciclovir ophthalmic gel, and systemic corticosteroids improved symptoms; however, persistent punctate exudates and pigment deposits on the ICL surface exhibited limited resolution. For patients with systemic autoimmune diseases or virus-induced uveitis undergoing ICL implantation, preoperative immunological screening should be actively performed to minimize postoperative complications. Early comprehensive therapy is critical to prevent progressive vision loss and rare transparency alterations of the ICL surface caused by pigment-laden exudates."

Journal • Ankylosing Spondylitis • Immunology • Infectious Disease • Inflammation • Inflammatory Arthritis • Novel Coronavirus Disease • Ocular Inflammation • Ophthalmology • Respiratory Diseases • Rheumatology • Seronegative Spondyloarthropathies • Uveitis

Cytomegalovirus Corneal Endotheliitis Presenting As Bullous Keratopathy: Resolution With Antiviral Therapy Alone. (PubMed, Cureus) - "Consequently, the patient was diagnosed with CMV-related corneal endotheliitis, and treatment with 0.5% ganciclovir eye drops was initiated. This clinical experience underscores the significance of molecular diagnostic approaches in ophthalmic practice, illustrating how targeted antiviral therapy can effectively restore corneal function in cases previously regarded as suitable only for surgical intervention. Sustained visual improvement was documented throughout the one-year follow-up period, suggesting a paradigm shift in managing select cases of bullous keratopathy."

Journal • Cytomegalovirus Infection • Herpes Simplex • Herpes Zoster • Infectious Disease • Ophthalmology • Transplantation • Varicella Zoster

Cytomegalovirus retinitis in an HIV-infected patient: an unexpected ocular manifestation in the era of antiretroviral therapy (SOE 2025) - "Ganciclovir 250 mg every 12 hours and prophylaxis for pneumocystis with bactrim 400/80 mg twice daily were initiated. After two weeks of treatment, including antiretroviral therapy, the patient demonstrated significant improvement in cutaneous lesions and in the fundoscopic, although with no changes on visual acuity. This case report emphasizes the critical importance of correlating ophthalmological findings with the general physical examination for accurate diagnosis and integrated clinical management following appropriate treatment."

Clinical • Ocular Inflammation • Ophthalmology • Retinal Disorders

Cytomegalovirus retinitis: a major threat for immunocompromised patients (SOE 2025) - "Systemic treatment with intravenous ganciclovir was initiated, along with antiretroviral triple therapy... CMV retinitis should be considered in any case of necrotizing retinitis in immunocompromised patients. This case underscores the importance of close and systematic monitoring in patients with severely reduced CD4 counts and/or CMV viremia."

Clinical • Ocular Inflammation • Ophthalmology • Retinal Disorders • CD4

CMV retinitis in HIV-infected patients: Plasma viral load utility in diagnosis. (PubMed, Diagn Microbiol Infect Dis) - "Plasma viral load testing is a valuable diagnostic tool but cannot replace ophthalmic examination. Quantitative PCR aids in effective virological monitoring and timely treatment initiation."

Journal • Cytomegalovirus Infection • Genetic Disorders • Human Immunodeficiency Virus • Infectious Disease • Ocular Inflammation • Ophthalmology • Retinal Disorders

A Phase Ⅱa Study of the Safety, Tolerability and Efficacy of BD111 in Herpes Simplex Virus Type I Stromal Keratitis (clinicaltrials.gov) - P2 | N=40 | Recruiting | Sponsor: Shanghai BDgene Co., Ltd. | Not yet recruiting ➔ Recruiting | Trial completion date: Dec 2026 ➔ Mar 2027 | Initiation date: Sep 2024 ➔ Apr 2025 | Trial primary completion date: Dec 2025 ➔ Dec 2026

Enrollment open • Trial completion date • Trial initiation date • Trial primary completion date • Herpes Simplex • Keratitis • Ocular Inflammation • Ophthalmology

A Study of the Safety, Tolerability and Prelinminary Efficacy of BD111 in Herpes Simplex Virus Type I Stromal Keratitis (clinicaltrials.gov) - P1 | N=16 | Active, not recruiting | Sponsor: Shanghai BDgene Co., Ltd. | Recruiting ➔ Active, not recruiting | Trial completion date: Sep 2025 ➔ Mar 2026

Enrollment closed • Trial completion date • Herpes Simplex • Keratitis • Ocular Inflammation • Ophthalmology

In-situ gel bases ocular delivery system of Ganciclovir, in-vivo and in-vitro investigation. (PubMed, BMC Pharmacol Toxicol) - "These findings confirm that the optimized ganciclovir in situ gel preparation improves eye permeation and prolongs ocular retention time, thus enhancing its therapeutic efficacy. Its sustained release and prolonged retention time make it a promising alternative to conventional eye drops, offering better patient compliance and efficacy."

Journal • Preclinical • Infectious Disease • Ocular Infections • Ophthalmology

Congenital cytomegalovirus retinitis of prematurity: a case report and literature review. (PubMed, Front Pediatr) - "Later, antiviral treatment with ganciclovir was provided for 3 weeks. Congenital cytomegalovirus retinitis carries substantial risks. For infants suspected of this condition, early initiation of antiviral therapy is crucial to enable timely intervention, improve prognosis, and enhance the child's quality of life."

Journal • Cytomegalovirus Infection • Genetic Disorders • Hematological Disorders • Infectious Disease • Ocular Inflammation • Ophthalmology • Retinal Disorders • Thrombocytopenia

Efficacy and safety of ROH-101 (0.15% ganciclovir gel) for cytomegalovirus corneal endotheliitis: an open-label, uncontrolled, phase 3 study in Japan. (PubMed, Jpn J Ophthalmol) - "ROH-101 was a safe and efficacious treatment in Japanese patients diagnosed with CMV corneal endotheliitis."

Journal • P3 data • Cytomegalovirus Infection • Inflammation

TO SEE IS TO BELIEVE: A CASE OF INFECTIOUS CEREBRAL VASCULITIS SECONDARY TO LATENT CYTOMEGALOVIRUS REACTIVATION IN AN ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANT PATIENT (EBMT 2025) - "Initial workup attributed these findings to Engraftment Syndrome with capillary leak, and intravenous methylprednisolone therapy provided partial resolution of visual symptoms.On day +23, the patient experienced acute left-sided numbness and weakness...Despite initiation of intravenous ganciclovir, the patient's condition deteriorated, culminating in fatal progression of ischemic strokes on hospital day 41... This case underscores the diagnostic challenges and high morbidity associated with CMV CNS vasculitis in allo-HSCT patients. The early onset of symptoms, particularly visual disturbances, deviates from the typical median onset of CMV encephalitis, which occurs around day 105 post-transplant. This unusual presentation highlights the potential for latent CMV reactivation to manifest atypically and earlier than expected in high-risk individuals."

Clinical • Bone Marrow Transplantation • Cardiovascular • CNS Disorders • Cytomegalovirus Infection • Ischemic stroke • Myelofibrosis • Ophthalmology • Pain • Respiratory Diseases • Transplantation • Vasculitis

CMV RETINITIS AFTER ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION IN CHILDREN (EBMT 2025) - "The median peak CMV PCR levels of the patients were 7.6x105 (range 6.6x104-4.7x106) copies/ml.All patients received systemic ganciclovir and/or foscarnet treatment. CMV retinitis is very rare, and the number of reports focusing on CMV retinitis after allogeneic HSCT is very limited. Therefore, descriptions of CMV retinitis are minimal in the guidelines for managing CMV infection after HSCT. When it comes to children and even infants, who may not be able to communicate their vision problems, it is clear that we need to use screening methods in this regard."

Clinical • Bone Marrow Transplantation • Cytomegalovirus Infection • Genetic Disorders • Immunology • Infectious Disease • Ocular Inflammation • Ophthalmology • Pediatrics • Primary Immunodeficiency • Retinal Disorders • Transplantation

CMV RETINITIS AFTER ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION IN CHILDREN (EBMT 2025) - "The median peak CMV PCR levels of the patients were 7.6x105 (range 6.6x104-4.7x106) copies/ml.All patients received systemic ganciclovir and/or foscarnet treatment. CMV retinitis is very rare, and the number of reports focusing on CMV retinitis after allogeneic HSCT is very limited. Therefore, descriptions of CMV retinitis are minimal in the guidelines for managing CMV infection after HSCT. When it comes to children and even infants, who may not be able to communicate their vision problems, it is clear that we need to use screening methods in this regard."

Clinical • Bone Marrow Transplantation • Cytomegalovirus Infection • Genetic Disorders • Immunology • Infectious Disease • Ocular Inflammation • Ophthalmology • Pediatrics • Primary Immunodeficiency • Retinal Disorders • Transplantation

Hexokinase-2 as a Therapeutic Target: Alleviating Herpes Simplex Keratitis through Metabolic Reprogramming (ARVO 2025) - "Additionally, we compared the therapeutic efficacy of lonidamine with that of the classic antiviral agent ganciclovir ophthalmic gel (GCV) using both monotherapy and combination therapy approaches...By targeting a key enzyme involved in cell energy production, called hexokinase-2, we found that we can reduce the virus's ability to replicate and cause damage to the eye. This discovery could lead to more effective treatments for this eye infection, helping to preserve vision and improve patients' quality of life."

Keratitis • Ocular Infections • Ocular Inflammation • Ophthalmology • HK2

Travel – associated emissions of intravitreal injections (ARVO 2025) - "Medication included anti-VEGF agents (94%), dexamethasone intravitreal implants (4%), triamcinolone (0.3%), and ganciclovir (2%). Layman Abstract (optional): Provide a 50-200 word description of your work that non-scientists can understand. Describe the big picture and the implications of your findings, not the study itself and the associated details."

Age-related Macular Degeneration • Diabetic Macular Edema • Ophthalmology • Wet Age-related Macular Degeneration

CMV Retinitis Linked to Prolonged Daratumumab Therapy (ARVO 2025) - "Imaging modalities, including optical coherence tomography (OCT) and fluorescein angiography (FA), were utilized to document retinal findings and therapeutic responses to intravitreal foscarnet and systemic valganciclovir...Our findings emphasize the importance of regular eye exams and close monitoring of patients taking daratumumab in order to catch potential complications early on. This preventive strategy could be able to spare sight and enhance the quality of care for patients undergoing this life-saving treatment."

Ocular Inflammation • Ophthalmology • Retinal Disorders • Uveitis

Necrotizing Herpetic Retinopathy - An Atypical and Severe Case of Acute Retinal Necrosis in a patient with Uncontrolled Diabetes Mellitus (ARVO 2025) - "The patient was placed on standard ARN treatment with IV acyclovir 3 times a day, ophthalmic prednisolone drops 2-4 times a day and a single dose intravitreal ganciclovir injection...Although correct treatment was used, he still developed complications including compelte vision loss in that eye. This report suggests that his diabetes, its complications, and smoking may have caused and made his condition worse, implying that a connection between these factors must be made to better understand this disease."

Clinical • Diabetic Retinopathy • Ophthalmology • Retinal Disorders

Congenital cytomegalovirus screening in neonates born after 35 weeks gestation-is targeted screening beneficial? (PubMed, Front Pediatr) - "All infected neonates were started on Valganciclovir. We demonstrated the feasibility of targeted cCMV screening, which complements universal newborn hearing screening in a tertiary neonatal center in Singapore. Targeted cCMV screening can be implemented cost-effectively during the neonatal period, enabling early detection and intervention."

Journal • Cytomegalovirus Infection • Hematological Disorders • Infectious Disease • Ophthalmology • Otorhinolaryngology • Small for Gestational Age

Retinitis linked to human herpesvirus type 6: a case study in a splenectomised patient. (PubMed, J Ophthalmic Inflamm Infect) - "He was treated with topical corticosteroid eyedrops, cyclopentolate, and prednisolone acetate ointment and systemically with intravenous ganciclovir 5 mg/kg bid for 14 days and then oral valganciclovir 900 mg bid for 4 weeks. The diagnosis was promptly presumed, enabling the early initiation of appropriate treatment and contributing to the preservation of the good visual acuity initially observed."

Journal • Epstein-Barr Virus Infections • Genetic Disorders • Infectious Disease • Ocular Infections • Ocular Inflammation • Ophthalmology • Pneumococcal Infections • Retinal Disorders • Uveitis

Varicella Zoster Virus-induced Acute Retinal Necrosis Following Acute Meningoencephalitis in a Patient with Presumed COVID-19. (PubMed, J Ophthalmic Vis Res) - "The patient received a single intravitreal ganciclovir injection and 10 days of intravenous ganciclovir, followed by oral acyclovir. A case of VZV-induced ARN following acute meningoencephalitis was observed in association with presumed COVID-19. This could be an incidental finding during the COVID-19 pandemic; however, it could also suggest that COVID-19 might trigger ARN in cases with latent herpes family viruses."

Journal • CNS Disorders • Genetic Disorders • Herpes Zoster • Infectious Disease • Inflammation • Novel Coronavirus Disease • Ocular Inflammation • Ophthalmology • Respiratory Diseases • Retinal Disorders • Varicella Zoster

Management of Glaucoma in Cytomegalovirus Uveitis: A Retrospective Case Series of Surgical and Medical Approaches. (PubMed, Cureus) - "They were treated with ganciclovir ophthalmic gel 0.15% for the infection. For IOP control, patients underwent different surgeries, namely microinvasive glaucoma surgery (MIGS) with XEN implant, augmented trabeculectomy (AT), glaucoma drainage device implantation (GDI), and transscleral cyclophotocoagulation (TSCPC). Patients were then followed up for a period ranging from six months to three years post-intervention to monitor for evidence of recurrence, IOP control, number of topical antiglaucoma medications required, and progression of glaucoma as evidenced by optical coherence tomography (OCT) retina nerve fiber layer (RNFL) and Humphrey visual field (HVF)."

Journal • Retrospective data • Cytomegalovirus Infection • Glaucoma • Infectious Disease • Inflammation • Ocular Inflammation • Ophthalmology • Uveitis

Human Herpesvirus 6A Infection-Associated Acute Anterior Uveitis. (PubMed, J Inflamm Res) - "The patient was treated with foscarnet sodium and ganciclovir, showing effective results. Additionally, based on the literature review, the hypothesized mechanism underlying HHV-6A-associated AU was discussed. To the best of our knowledge, this is the first case report of HHV-6A involvement in ocular inflammation and may provide a theoretical basis for further investigations of occurrences of HHV-6A-associated acute AU in clinical settings."

Journal • Bone Marrow Transplantation • Epstein-Barr Virus Infections • Glaucoma • Human Immunodeficiency Virus • Infectious Disease • Inflammation • Ocular Infections • Ocular Inflammation • Ophthalmology • Transplantation • Uveitis

Cytomegalovirus Anterior Uveitis. (PubMed, Cesk Slov Oftalmol) - " CMV anterior uveitis is a rare pathology in our geographic region, but it is important to consider this etiology in cases of recurrent anterior hypertensive uveitis with a low response to local anti-inflammatory medication. Timely verification of the etiological agent with prompt diagnosis and treatment is essential in order to achieve a favorable prognosis. Long-term, low maintenance doses of antiviral therapy with local ganciclovir for several months reduce relapses of uveitis and lead to compensation of IOP."

Journal • Retrospective data • Cytomegalovirus Infection • Glaucoma • Ocular Inflammation • Ophthalmology • Uveitis

Management of Herpes Zoster Ophthalmicus with Optic Neuritis and Cavernous Sinus Involvement: A Case Report. (PubMed, Ocul Immunol Inflamm) - "Following treatment with systemic ganciclovir and intravenous corticosteroids, the patient experienced dramatic improvement in visual acuity, from hand motion to 20/25. This report demonstrates a rare case of HZO optic neuropathy with cavernous sinus involvement that was successfully treated with an unconventional medication regimen."

Journal • Herpes Zoster • Ocular Inflammation • Ophthalmology • Optic Neuritis • Pain • Varicella Zoster

A Case of Cytomegalovirus Gastrosplenic Fistula: A Rare Complication of Acquired Immunodeficiency Syndrome (ACG 2024) - "He was started on IV Ganciclovir...The plan included 6 weeks of anti-CMV treatment, transitioning to oral valganciclovir upon discharge...In conclusion, this case contributes to a small number of documented cases, emphasizing the need for increased awareness among healthcare practitioners regarding potential causes of gastrosplenic fistula and its associated presentations. Figure: Fig.1 CT Abdomen Pelvis with Gastrosplenic fistula, Fig.2 EGD showing Gastrosplenic fistula in gastric fundus."

Clinical • Cytomegalovirus Infection • Gastroenterology • Gastrointestinal Cancer • Gastrointestinal Disorder • Genetic Disorders • Hematological Disorders • Hematological Malignancies • Human Immunodeficiency Virus • Immunology • Lymphoma • Ocular Inflammation • Oncology • Ophthalmology • Pain • Retinal Disorders • CD4