CTPH-03 / Celltrion - LARVOL DELTA

A novel synergistic dual-payload TROP2 ADC (CTPH-03) delivering enhanced safety by increased MTD (AACR 2026) - "Although there are two FDA-approved ADCs, Trodelvy and Datroway, anti-tumor efficacy from these TROP2 ADCs have been subpar due to dose-limiting toxicities. We have developed a novel TROP2-targeting dual-payload ADC (AD2C) by using MMAE-based dual-payload combination to address this unmet need. The presentation highlights advantages of the synergistic dual-payload TROP2 ADC over known single-payload ADCs or other dual-payload ADC formats by demonstrating, (1) in vitro cytotoxicity for cancer cells having different TROP2 expression levels (2) in vivo efficacy in various CDX(cancer-cell derived xenograft) models (3) in vivo ADC stability in rats and monkeys by PK(pharmacokinetics) studies, and (4) preliminary toxicity studies conducted in mice and monkeys.In due course, we are currently in preparation of PDX efficacy studies for further confirming its in vivo efficacy over various patient-derived tumor cells, and IND-enabling toxicology studies in order to quickly move..."

ADC • Clinical • Oncology • TACSTD2