Pandel (hydrocortisone probutate) / Novartis - LARVOL DELTA

Geometric morphometrics analysis of forensically important Sarcophaga species. (PubMed, Forensic Sci Res) - "We collected a total of 80 wings (both left and right) from male individuals representing nine species (Sarcophaga africa, Sarcophaga argyrostoma, Sarcophaga hirticrus, Sarcophaga jacobsoni, Sarcophaga lehmanni, Sarcophaga melanura, Sarcophaga pandellei, Sarcophaga portschinskyi, and Sarcophaga teretirostris)...The results demonstrated effective differentiation among seven species, representing significant progress in the expedited identification of Sarcophaga species. Due to its speed, affordability, and user-friendly nature, the wing landmark-based geometric morphometrics, when combined with taxonomy, can enhance the robustness of Sarcophagidae analyses and prove to be useful for discriminating flesh flies in forensic contexts."

Journal

Heroic actions of dermatologists during the Holocaust (EADV 2024) - "A recent study identified five non- Jewish dermatologists – Emanuele Stablum (Italy) , Erzsebet Heintz (Hungary) , Lubbertus Leopold (Holland) , Pandelis Kallinikides (Greece) and Antun Vuletic (Croatia) – who have been awarded the title “ Righteous Among the Nations ” for saving Jews in the Holocaust... Just as we acknowledge eminent dermatologists for research and clinical contributions, it is important to sometimes recognise dermatologists for other reasons. The courage and heroic actions of the five dermatologists warrant recognition, and occupy a special strand of the history of our field.**"

Dermatology • Infectious Disease

Salt-tolerance mechanisms in quinoa: Is glycinebetaine the missing piece of the puzzle? (PubMed, Plant Physiol Biochem) - "We show that the differential distribution of sodium in plants depends on the variety, observing that varieties such as Pandela Rosada limit the passage transit of sodium to the aerial part of the plant, a mechanism that seems to be regulated by sodium transporters such as HKT1s or SOS1...The compound with a higher presence was glycinebetaine, which makes up 6% of the leaf dry matter under saline conditions. Our findings suggest that glycinebetaine can act as an osmolyte and/or osmoprotectant, facilitating plant development under high saline ambient."

Journal

PanDelos-frags: A methodology for discovering pangenomic content of incomplete microbial assemblies. (PubMed, J Biomed Inform) - "PanDelos-frags outperforms state-of-the-art approaches in reconstructing gene families in synthetic benchmarks and in a real use case of metagenomics. PanDelos-frags is publicly available at https://github.com/InfOmics/PanDelos-frags."

Journal

Discovery of novel inhibitor of 11 beta-hydroxysteroid dehydrogenase type 1 using in silico structure-based screening approach for the treatment of type 2 diabetes. (PubMed, J Diabetes Metab Disord) - "The binding energies of hydrocortisone succinate, medroxyprogesterone acetate, testolactone, hydrocortisone cypionate, deoxycorticosterone acetate, and hydrocortisone probutate were lower than that of substrate corticosterone...The docking study revealed that hydrocortisone cypionate has a higher binding affinity than carbenoxolone and its other analogs...These findings indicate the potential use of this FDA approved drug in the treatment of type 2 diabetes. However, validation by in vitro inhibitory studies and clinical trials on type 2 diabetes patients is essential to confirm the current findings."

Journal • Diabetes • Metabolic Disorders • Type 2 Diabetes Mellitus

Diversity of flesh flies (Sarcophagidae, Sarcophaginae) of pond habitats in rural areas in the Croatian part of Baranja. (PubMed, Zookeys) - "The diversity of grey flesh flies (Sarcophagidae: Sarcophaginae) from the Croatian part of Baranja was studied during 2019 to 2021, resulting in 37 species, of which the following are new for the area: Raviniapernix (Harris, 1780); Sarcophaga (Het.) depressifrons Zetterstedt, 1845; S. (Het.) filia Rondani, 1860; S. (Het.) haemorrhoides Böttcher, 1913; S. (Het.) pumila Meigen, 1826; S. (Het.) vagans Meigen, 1826; S. (Lis.) dux Thomson, 1869; S. (Lis.) tuberosa Pandellé, 1896; S. (Meh.) sexpunctata (Fabricius, 1805); S. (Pan.) protuberans Pandellé, 1896; S. (Sar.) carnaria (Linnaeus, 1758); S. (Sar.) variegata (Scopoli, 1763), and S. (Pse.) spinosa Villeneuve, 1912...Combined with previous records, 42 species of flesh flies have been recorded from Croatian Baranja, which comprise 27% of the flesh flies known to occur in Croatia. The total number of species of the family Sarcophagidae currently known in Croatia has increased to 156."

Journal

"Congrats!!! @Pandelela_R Olahragawati Kebangsaan 2021 #ASN2021 #DemiMalaysia" (@AtletMalaysia)

"Azizulhasni, Pandelela crowned Sportsman and Sportswoman for year 2021 https://t.co/B3MJwdgWKG #TMRSports #TMRNews #ASN2021" (@TMReserve)

"Thanks, Lexi Pandell for a good interview and a good piece on trauma: How trauma became the word of the decade https://t.co/JH3Z5ECXPU via @voxdotcom" (@m_scheeringa)

Interview • Mood Disorders

Contribution to the knowledge of the bee fauna (Hymenoptera, Apoidea, Anthophila) in Serbia. (PubMed, Zookeys) - "Fourteen species, collected in the last three years, are the first published records of these taxa from Serbia: Andrenabarbareae (Panzer, 1805), A.clarkella (Kirby, 1802), A.fulvicornis (Schenck, 1853), A.intermedia (Thomson, 1870), A.lapponica (Zetterstedt, 1838), A.pandellei (Pérez, 1895), A.paucisquama (Noskiewicz, 1924), A.simillima (Smith, 1851), Panurginusherzi (Morawitz, 1892), Epeoloidescoecutiens (Fabricius, 1775), Nomadaleucophthalma (Kirby, 1802), Chelostomanasutum (Pérez, 1895), Hoplitisclaviventris (Thomson, 1872), and Dasypodapyrotrichia (Förster, 1855)...This study contributes to the knowledge of the distribution of bee species in Europe. The present work provides a baseline for future research of wild bee diversity in Serbia and neighbouring regions at the local and regional levels, and a basis for their conservation."

Journal • Ophthalmology

Isolation, identification, and pathogenicity of Steinernema carpocapsae and its bacterial symbiont in Cauca-Colombia. (PubMed, J Nematol) - "Susceptibility of Epitrix cucumeris and Pandeleteius cinereus adults was evaluated by individually exposing adults to 50 infective juveniles...Adults of both pests were susceptible to S. carpocapsae indicating this EPN potential for its management. The results of this study constitute the first record of S. carpocapsae in Colombia and the susceptibility of P. cinereus to this EPN."

Journal

Cuticular hydrocarbons for identifying Sarcophagidae (Diptera). (PubMed, Sci Rep) - "Here, we analysed the CHC chemical profiles of adult males and females of eleven species of flesh flies belonging to the genus Sarcophaga Meigen (Sarcophagidae), namely Sarcophaga africa (Wiedemann), S. agnata Rondani, S. argyrostoma Robineau-Desvoidy, S. carnaria (Linnaeus), S. crassipalpis Macquart, S. melanura Meigen, S. pumila Meigen, S. teretirostris Pandellé, S. subvicina Rohdendorf, S. vagans Meigen and S. variegata (Scopoli)...Time of preservation prior to extraction ranged between a few weeks to over one hundred years. CHC profiles (1) allowed reliable identification of a large majority of specimens, (2) differed between males and females of the same species, (3) reliably associated males and females of the same species, provided sufficient replicates (up to 10) of each sex were analysed, and (4) identified specimens preserved for up to over one hundred years prior to extraction."

Journal

Two new records of flies causing myiasis from Saudi Arabia with a survey of flies parasitizing goats and sheep in Jazan Region. (PubMed, Trop Biomed) - "Two of these species were recorded for the first time for Saudi Arabia, namely Hemipyrella pulchra (Wiedemann, 1830) and Sarcophaga (Liosarcophaga) exuberans Pandellé, 1896...The results expand the knowledge of geographical distribution, fauna, and habitat of the myiasis-causing flies in Saudi Arabia. Biological information and world-wide geographical distribution of these species are included together with some taxonomic remarks."

Journal

Drugs for atopic dermatitis. (PubMed, Med Lett Drugs Ther) - No abstract available

Journal • Atopic Dermatitis • Dermatitis • Dermatology • Immunology

"@JeremyTurling @b_law16 @AbbateAntonio @Mikekontos1 @kriskrao @KeyurBShahRIC @VCU_IMRes @VCUInternalMed @Adnan_KhanMD @MESternberg @ETKirtonDavis @jaypark_is_here @alex_pandelidis @sammyd56702583 @sratanapo" (@AjayPMD)

Aerobic microbe community and necrophagous insects associated with decomposition of pig carrion poisoned with lead. (PubMed, Leg Med (Tokyo)) - "The necrophagous insects collected consisted of three orders: Coleoptera, Diptera, and Hymenoptera which included insects like Chrysomya chloropyga Wiedemann, 1818, Musca domesticaLinnaeus, 1758, Sarcophaga exuberansPandelle, 1896, Necrobia rufipesDe Geer, 1775, Dermestes maculatusDe Geer, 1774, Camponotus sericeusFabricius, 1798 and Camponotus perrisiiForel, 1886...Spectrophotometric analysis of insect larvae collected from decomposing pigs revealed they had presence of lead. Insect larvae and microbes identified are good entomotoxicological tools in crimes associates with lead poisoning."

Journal

A new species of Sarcophaga (Pandelleisca) (Diptera, Sarcophagidae) from Turkey. (PubMed, Zookeys) - "The species is compared with the two most similar species, Sarcophaga (Pandelleisca) baudeti (Lehrer) and Sarcophaga (Pandelleisca) theodori (Lehrer), both known from Israel. A key is provided to the western Palaearctic species of Pandelleisca Rohdendorf."

Journal

Comparative analysis of mitochondrial genomes among the subfamily Sarcophaginae (Diptera: Sarcophagidae) and phylogenetic implications. (PubMed, Int J Biol Macromol) - "Moreover, the molecular phylogenetic relationships among the subgenera Helicophagella, Kozlovea, Kramerea, Pandelleisca, Phallocheira, Pseudothyrsocnema, Sinonipponia and Seniorwhitea were rarely put forward prior to this study. This study provides insight into the population genetics, molecular biology, and phylogeny for the subfamily Sarcophaginae, especially for the subgeneric classification of Sarcophaga. However, compared with the enormous species diversity of flesh flies, the available mitogenomes are still limited for recovering the phylogeny of Sarcophaginae."

Journal

Exploring genetic targets of psoriasis using genome wide association studies (GWAS) for drug repurposing. (PubMed, 3 Biotech) - "Hence we propose drug repurposing strategy to use existing drugs for new therapies. Therefore, the drug pandel could be explored further and repurposed to treat psoriasis."

Journal • IL13

DNA barcodes reveal 63 overlooked species of Canadian beetles (Insecta, Coleoptera). (PubMed, Zookeys) - "Two new synonymies are established: Mycetoporus triangulatus Campbell, 1991 (Staphylinidae) is a junior synonym of Mycetoporus reichei Pandellé, 1869, syn...The previously suggested move of Ctenicera tigrina (Fall, 1901) to the genus Pseudanostirus Dolin, 1964 (Elateridae) is formalized, resulting in Pseudanostirus tigrinus (Fall, 1901), comb. nov."

Journal

Four new species of Estheria Robineau-Desvoidy (Diptera: Tachinidae) from China and Nepal, with a review of the East Palearctic and Oriental species. (PubMed, Zootaxa) - "Eighteen species are recognized: the fourteen previously described, E. acuta (Portschinsky, 1881), E. alticola Mesnil, 1967, E. bucharensis (Kolomiets, 1974), E. cinerella Mesnil, 1967, E. cristata (Meigen, 1826), E. decolor (Pandellé, 1896), E. flavipennis Herting, 1968, E. lacteipennis Mesnil, 1967, E. maculipennis Herting, 1968, E. magna (Baranov, 1935), E. nigripes (Villeneuve, 1920), E. pallicornis (Loew, 1873), E. petiolata (Bonsdorff, 1866) and E. picta (Meigen, 1826), and four species described as new to science, E. hirtinerva Zhang Shima sp...Estheria acuta and E. decolor are newly recorded for China, E. magna is newly recorded for Malaysia, Pakistan and Vietnam, and E. pallicornis is newly recorded for Nepal. An identification key to the 18 species of Estheria so far known from the East Palearctic and Oriental regions is included, together with 126 figures of heads and habitus of males and females, and male terminalia and known distributions."

Journal

A key to the Mexican genera of Tanymecini (Coleoptera: Curculionidae). (PubMed, Zootaxa) - "A brief synopsis of each genus is included as well as a list of the species recorded for Mexico. The species Minyomerus languidus Horn and Pandeleteius championi Howden are newly recorded for Mexico."

Journal

"@harvardmed @blancaruizdada @Insights_2019 @julesantosER @MPilarLpez1 @jamescantbhf @DrDudenbostel @pediatric_ccrn @ChuckCairns @DavidPandelet @BiegkDavid @ozlembilen2 @DrLaxmiMehta @nieves_tarin @vivian_orte @SamRRazaMD @WoncaEurope @andonimendoz @DrSheilaSahni" (@jaraglezjose)

Clinical

"@harvardmed @blancaruizdada @Insights_2019 @julesantosER @MPilarLpez1 @jamescantbhf @DrDudenbostel @pediatric_ccrn @ChuckCairns @DavidPandelet @BiegkDavid @DrLaxmiMehta @nieves_tarin @vivian_orte @SamRRazaMD @WoncaEurope @andonimendoz @DrSheilaSahni" (@jaraglezjose)

Clinical

"@harvardmed @blancaruizdada @Insights_2019 @julesantosER @MPilarLpez1 @jamescantbhf @DrDudenbostel @pediatric_ccrn @ChuckCairns @DavidPandelet @BiegkDavid @ozlembilen2 @DrLaxmiMehta @nieves_tarin @vivian_orte @SamRRazaMD @WoncaEurope @andonimendoz @DrSheilaSahni" (@jaraglezjose)

Clinical