D-penicillamine / Generic mfg. - LARVOL DELTA

CNN-integrated ratiometric fluorescent tag for rapid monitoring of seafood freshness at refrigerated temperatures. (PubMed, Curr Res Food Sci) - "In this study, a ratiometric fluorescent tag was proposed for detecting ammonia to assess seafood freshness, using D-penicillamine-capped silver/copper nanoclusters (DPA-AgCuNCs) and fluorescein isothiocyanate (FITC) as dual-emission probes...For on-site monitoring, the CNN was integrated into a smartphone application (FreshSense), constructing a simple platform for rapid monitoring of seafood freshness. This proof-of-concept system is rapid, on-site, and non-destructive, demonstrating its potential for practical screening in food quality and safety."

Journal

Therapeutic Management of Wilson Disease in Clinical Practice: Multicenter Retrospective Real-World Data from Germany. (PubMed, Z Gastroenterol) - "Chelating agents available include D-penicillamine (DPA) and trientine (TETA-2HCl and TETA-4HCl). These real-world data describe WD treatment management at specialized German centers. The observed dose changes during formulation switches are descriptive and hypothesis-generating, but prospective studies with clinical outcome data are needed before any switch factor can be recommended for routine practice."

Journal • Real-world evidence • Retrospective data • Genetic Disorders • Metabolic Disorders • Movement Disorders • Rare Diseases

Amino-Acid/Protein-Engineered Zr/Ce-MOF Nanozyme for Dual-Channel Smart On-Site Detection of Tetracyclines and d-Penicillamine. (PubMed, ACS Sens) - "The sensing platform exhibits unprecedented analytical performance with limits of detection as low as 3.9 nmol·L-1 for TCs and 0.31 μmol·L-1 for d-PA. This work is validated across multiple food matrices and establishes a machine learning-assisted, structurally constrained biophotonic strategy for broad-scale, high-throughput monitoring."

Journal

Solid-Liquid Dual-Signal Spatial Isolation in High-Spin Iron/Triethanolamine Comodified Silica for Cross-Interference-Free One-Pot Sensing of Chlortetracycline and d-Penicillamine. (PubMed, Anal Chem) - "Thanks to the merits including free from enzymes/chromogenic reagents/initiators, good resistance to dissolved O2, and compatibility within wide pH and temperature ranges, our probe was demonstrated to exhibit robust analytical performance in complex food matrices. Our study not only provides a facile and practical method to track the copollution status of CTC and d-PA leveraging solid-liquid logic-gate signals but also verifies the feasibility of producing mutually independent responses in the same pot to more than one analyte, offering new insights into constructing multiresponse platforms for multiplexed detection."

Journal

A Septuagenarian Surprise: Wilson Disease Presenting as Fulminant Acute Liver Failure in a 70-Year-Old Woman (ACG 2026) - "Case Description/ A 70-year-old woman with rheumatoid arthritis and systemic lupus erythematosus on low-dose methotrexate and hydroxychloroquine presented with confusion, progressive jaundice, nausea, poor oral intake, and fatigue...Viral hepatitis, autoimmune markers, and acetaminophen testing were negative, and she was treated with N-acetylcysteine for possible drug-induced liver injury...Despite D-penicillamine and zinc, she progressed to multiorgan failure...Recognition of this biochemical pattern is crucial, because medical therapy alone is rarely sufficient and survival depends on early liver transplantation evaluation. Figure: Table 1: Laboratory parameters and trends since admission Figure: Figure 1: CT image showing cirrhotic-appearing liver with ascites"

Clinical • Autoimmune Hepatitis • CNS Disorders • Genetic Disorders • Hematological Disorders • Hepatology • Immunology • Infectious Disease • Inflammation • Inflammatory Arthritis • Liver Failure • Lupus • Metabolic Disorders • Movement Disorders • Rheumatoid Arthritis • Systemic Lupus Erythematosus

Multimodal optical coherence tomography assessment of the neck skin in Wilson's Diseasepatients exposed to D-Penicillamine (EADV 2026) - No abstract available

Clinical • Genetic Disorders • Hepatology • Metabolic Disorders • Movement Disorders

Low-dose D-penicillamine in recurrent localized scleroderma: an effective and underused approach (EADV 2026) - No abstract available

Immunology • Scleroderma • Systemic Sclerosis

Restoring Meropenem Activity Against VIM-1-Producing Klebsiella pneumoniae Through Zinc-Binding Ligands. (PubMed, Chembiochem) - "The growing prevalence of metallo-β-lactamase (MBL)-producing bacteria threatens the clinical efficacy of carbapenems such as meropenem. Molecular docking and MD simulations with the VIM-1 enzyme further elucidated the putative binding modes of these inhibitors. These results suggest that repurposing the conventional D-penicillamine and chlorpropamide drugs can effectively counteract MBL-mediated resistance."

Journal • Infectious Disease • Pneumonia

Prevalence of Wilson's disease in Poland. (PubMed, Pol Arch Intern Med) - "Estimated WD prevalence in Poland is comparable to the prevalence in neighboring countries. Many patients remain professionally active. Expanding screening programs may improve early detection."

Journal • Genetic Disorders • Metabolic Disorders • Movement Disorders

A ratiometric fluorescent probe based on peanut-shell-derived CDs and CuNCs for smartphone-assisted detection of methyl orange. (PubMed, Anal Methods) - "The CDs were mixed with D-penicillamine (DPA)/bovine serum albumin (BSA)-stabilized copper nanoclusters (CuNCs) at a controlled volume ratio to form a dual-emission ratiometric fluorescent probe...Recoveries in Mizone beverage, liquor, sugar solution, and tap water ranged from 97.04% to 99.96%, with RSD values below 2.18%. Smartphone-assisted B/R analysis enabled visual semi-quantitative detection using three smartphone models, supporting the feasibility of the platform for on-site MO screening."

Journal

Hierarchical self-assembly of structurally complex chiral hedgehog particles for exosomes trapping | Poster Board #1702 (ACS-Fall 2026) - "These assemblies arise from controlled coordination between gold ions and ligand penicillamine, which introduces both steric and chiral constraints during particle growth...Our findings highlight how subtle variations in temperature, pH and coordination chemistry can guide the emergence of shape complexity and surface roughness at the nanoscale. These Au-pen hedgehogs represent a new class of supramolecular particles with potential for chiroptical sensing, pH-responsive behavior, and tunable surface interactions in biomedical applications."

A Dual-Function Guanidinium Scaffold for Copper sequestration and Redox Protection in Wilson disease Models. (PubMed, Free Radic Biol Med) - "Gua-Cu-3 attenuates oxidative stress in ATP7B-homolog-deficient Caenorhabditis elegans and rescues copper-induced developmental defects in zebrafish, outperforming D-penicillamine, which is currently in use for WD management. These findings establish Gua-Cu-3 with a therapeutic potential that couples-controlled copper sequestration with redox regulation and provides a framework for treating WD and other disorders associated with metal dyshomeostasis and oxidative stress."

Journal • Genetic Disorders • Metabolic Disorders • Movement Disorders • ATP7B

Neurological-dominant Wilson's disease without significant hepatic involvement: evidence from a 40-year follow-up of two siblings (SSIEM 2026) - "Adherence to D-penicillamine treatment was inconsistent, and between ages 12 and 22, he developed dysprosody, dysarthria, hypomimia, orofacial dyskinesias, upper-limb resting and postural tremors, and mild postural instability... The disconnect between neurological and hepatic impairment in these cases supports the idea that individual factors influence the WD phenotype and its severity. Better understanding of these factors could improve prognostic accuracy and help guide more targeted treatments."

Addiction (Opioid and Alcohol) • CNS Disorders • Dystonia • Gastrointestinal Disorder • Genetic Disorders • Hepatology • Metabolic Disorders • Movement Disorders • ATP7B • CP

Copper homeostasis and cuproptosis: New perspectives on the diagnosis and treatment of metabolic diseases. (PubMed, J Trace Elem Med Biol) - "Copper chelators including tetrathiomolybdate and merestinib are primary agents for metabolic tissue preservation, whereas ionophores such as elesclomol are restricted to oncology, with lipid nanoparticle-based delivery platforms essential to overcome the blood-brain barrier challenge, as underscored by the neurological worsening documented in D-penicillamine-treated Wilson disease patients. The interplay between cuproptosis and ferroptosis, sharing GSH depletion but diverging at lipoylated protein aggregation versus glutathione peroxidase 4 (GPX4)-dependent lipid peroxidation, suggests dual-pathway inhibition may be necessary. Future priorities include validation of the metabolic threshold hypothesis, β-cell-specific knockout studies, standardised DLAT oligomerisation diagnostics, tissue-targeted copper modulator delivery, and integration of cuproptosis biomarkers with multi-omics and artificial intelligence for clinically stratified precision medicine."

Journal • Review • Diabetes • Genetic Disorders • Hepatology • Metabolic Disorders • Metabolic Dysfunction-Associated Steatotic Liver Disease • Movement Disorders • Obesity • Oncology • Type 2 Diabetes Mellitus • ATP7B • DLAT • FDX1 • GPX4 • LIAS • LIPT1

Unable to walk or eat without assistance in pregnancy-Wilson's disease in a resource-limited and conflict-affected setting: a case report. (PubMed, J Med Case Rep) - "A thorough physical examination remains essential for neurological presentations in resource-limited and conflict-affected settings remains key to diagnosis and life-saving treatment, including for Wilson's disease."

Journal • CNS Disorders • Genetic Disorders • Hepatology • Liver Failure • Metabolic Disorders • Movement Disorders • Vascular Neurology

Chirality transfer from penicillamine to gold nanoparticles enables enantioselective electrochemical sensing of cysteine. (PubMed, Nanoscale) - "The presence of L- or D-penicillamine induces chirality during nanoparticle growth, and its extent is examined at different growth stages using SEM...This enantioselective interaction between enantio-matched pairs demonstrates that the encoded chirality influences molecular recognition processes at the electrode interface. Overall, this study establishes penicillamine-induced chiral AuNPs as versatile, label-free platforms for enantioselective electrochemical sensing."

Journal

Sodium-Glucose Linked Transporter-2 (SGLT-2) Inhibitor-Associated Unmasking of Myasthenia Gravis in a Patient With Undiagnosed Thymic Follicular Hyperplasia: The First Reported Case. (PubMed, Cureus) - "Myasthenia gravis induced by drugs has been reported with D-penicillamine and immune checkpoint inhibitors, but never with the sodium-glucose linked transporter-2 inhibitors. We report a case of a 62-year-old man with type 2 diabetes presenting with progressive, fluctuating bilateral ptosis, binocular diplopia, dysarthria, and dysphagia occurring eight weeks after starting treatment with 10 mg daily of empagliflozin...Pyridostigmine and prednisone 40 mg daily were started, with full resolution of his symptoms...This case represents the first description of the unmasking of acetylcholine receptor-positive myasthenia gravis by sodium-glucose linked transporter-2 inhibitors in a patient with thymic follicular hyperplasia. Myasthenia gravis should be considered in patients with newly acquired fatigable ptosis, diplopia, or bulbar symptoms who are being treated with sodium-glucose linked transporter-2 inhibitors."

Journal • CNS Disorders • Diabetes • Gastrointestinal Disorder • Immunology • Infectious Disease • Metabolic Disorders • Myasthenia Gravis • Oncology • Type 2 Diabetes Mellitus

Expanding the spectrum of the giant panda sign: a bright-eye variant in Wilson disease. (PubMed, Radiol Case Rep) - "The patient started D-penicillamine treatment and showed clinical improvement. Radiologists need to recognize both common and rare MRI features of Wilson disease, especially when neuropsychiatric symptoms are present. Spotting the "panda with bright eyes" sign can help with early diagnosis, guide metabolic testing, and allow prompt chelation therapy, which can improve neurological outcomes."

Journal • Genetic Disorders • Hepatology • Metabolic Disorders • Movement Disorders • Psychiatry • ATP7B

Nano-hydrogel-based delivery system for dihydroartemisinin to enhance cuproptosis and synergize with anti-PD-1 therapy in triple-negative breast cancer. (PubMed, J Nanobiotechnology) - "Copper chelators tetrathiomolybdate (TTM) and D-penicillamine (DPA) could significantly reverse the antitumor effects of Lip-DHA-CuS@Gel in TNBC. In the 4T1 tumor-bearing BALB/c mice, Lip-DHA-CuS@Gel synergistically potentiated the antitumor immunity of PD-1 blockade by inducing the release of damage-associated molecular patterns (DAMPs) and promoting intra-tumoral infiltration of CD8⁺ T cells. Taken together, these findings suggested that Lip-DHA-CuS@Gel highlights significant therapeutic potential to induce cuproptosis and enhance immunotherapy responsiveness in TNBC."

Journal • Breast Cancer • Oncology • Solid Tumor • Triple Negative Breast Cancer • CD8

Cystine-binding medication is poorly accessible for the treatment of cystinuria. (PubMed, Kidney Blood Press Res) - "When lifestyle modification and urine alkalinization fail, cystine-binding medication such as tiopronin and D-penicillamine are indicated...Discussion Cystine-binding medication is poorly and inconsistently accessible across Europe. Coordinated efforts are urgently needed to stabilize supply and ensure equitable, affordable access."

Journal • Genetic Disorders • Nephrology • Renal Disease

SUBCLİNİCAL EMOTİONAL REGULATİON DEFİCİTS İN CHİLDREN WİTH WİLSON DİSEASE: FOCUS ON IMPULSE CONTROL (ESPGHAN 2026) - "Chelation therapy consisted of D-penicillamine in 64% and trientine in 36% of patients. Integrating structured psychiatric evaluation and longitudinal neurocognitive monitoring into routine follow-up may enable early recognition of emotional dysregulation, inform individualized care and improve overall functioning and quality of life. Contact e-mail address [email protected]"

Genetic Disorders • Hepatology • Metabolic Disorders • Movement Disorders

A case series of 4 patients with elastosis perforans serpiginosa with differing aetiologies (BAD 2026) - "Noted associations with EPS include connective-tissue diseases such as cutis laxa, pseudoxanthoma elasticum, Ehlers–Danlos syndrome (EDS), Marfan syndrome, systemic sclerosis, trisomy 21, Rothmund– Thompson syndrome and medications such as d-penicillamine...Regular medications were notable for tofacitinib to treat her psoriatic arthritis...She had a background history of trisomy 21 and had a history of EPS diagnosed in the paediatric setting. This series highlights the variety of presentations of EPS and the importance of considering it as a differential diagnosis, especially in patients with comorbidities that predispose them to EPS."

Clinical • Genetic Disorders • Hepatology • Hidradenitis Suppurativa • Hurler Syndrome • Immunology • Inflammatory Arthritis • Metabolic Disorders • Movement Disorders • Psoriasis • Psoriatic Arthritis • Scleroderma • Seronegative Spondyloarthropathies • Systemic Sclerosis

A case series of 4 patients with elastosis perforans serpiginosa with differing aetiologies (BAD 2026) - "Noted associations with EPS include connective-tissue diseases such as cutis laxa, pseudoxanthoma elasticum, Ehlers–Danlos syndrome (EDS), Marfan syndrome, systemic sclerosis, trisomy 21, Rothmund– Thompson syndrome and medications such as d-penicillamine...Regular medications were notable for tofacitinib to treat her psoriatic arthritis...She had a background history of trisomy 21 and had a history of EPS diagnosed in the paediatric setting. This series highlights the variety of presentations of EPS and the importance of considering it as a differential diagnosis, especially in patients with comorbidities that predispose them to EPS."

Clinical • Genetic Disorders • Hepatology • Hidradenitis Suppurativa • Hurler Syndrome • Immunology • Inflammatory Arthritis • Metabolic Disorders • Movement Disorders • Psoriasis • Psoriatic Arthritis • Scleroderma • Seronegative Spondyloarthropathies • Systemic Sclerosis

A case series of 4 patients with elastosis perforans serpiginosa with differing predisposing factors (BAD 2026) - "Noted associations with EPS include connective-tissue diseases such as cutis laxa, pseudoxanthoma elasticum, Ehlers–Danlos syndrome (EDS), Marfan syndrome and systemic sclerosis, trisomy 21, Rothmund–Thompson syndrome and medications such as d-penicillamine...Regular medications were notable for tofacitinib to treat her psoriatic arthritis...She had a background history of trisomy 21 and had a history of EPS diagnosed in the paediatric setting. This series highlights the variety of presentations of EPS and the importance of considering it as a differential diagnosis, especially in patients with comorbidities that predispose them to EPS."

Clinical • Genetic Disorders • Hepatology • Hidradenitis Suppurativa • Hurler Syndrome • Immunology • Inflammatory Arthritis • Metabolic Disorders • Movement Disorders • Psoriasis • Psoriatic Arthritis • Scleroderma • Seronegative Spondyloarthropathies • Systemic Sclerosis

Liver-related autoantibodies in Wilson disease: increased prevalence and unclear clinical significance. (PubMed, Adv Med Sci) - "Liver-related autoantibodies were frequently observed in WD and appeared to be markers of immune dysregulation. Further research is needed to clarify the clinical significance of these antibodies and their potential use as biomarkers in the management of WD."

Journal • Autoimmune Hepatitis • Genetic Disorders • Hepatology • Immunology • Inflammation • Liver Failure • Metabolic Disorders • Movement Disorders • Rare Diseases