Optiquel (B27PD) / National Eye Institute, Enzo - LARVOL DELTA

Immunology of Uveitis - From Bench to Bedside. (PubMed, Klin Monbl Augenheilkd) - "The discovery of the tolerance-inducing but non-pathogenic mimicry epitope B27PD made it possible to treat therapy-refractory uveitis patients by inducing oral tolerance. These new animal models also enabled the development of a small molecule dihydroorotate dehydrogenase (DHODH) inhibitor PP-001/KIO-100 for the treatment of uveitis, which inhibits lymphocytes but has no toxic effects on intraocular cells (in vivo: rat) and human retinal pigment epithelial cells (RPE, in vitro). This was followed by a successful phase I trial for patients with non-infectious posterior uveitis, by intraocular application of PP-001/KIO-100 - without side effects, but with improvement of visual acuity and reduction in inflammation and CME."

Journal • Immunology • Inflammation • Ocular Inflammation • Ophthalmology • Uveitis