prednisolone / Generic mfg. - LARVOL DELTA

CASE REPORT: THROMBOTIC MICROANGIOPATHY SECONDARY TO A HYPERTENSIVE EMERGENCY MIMICKING ATYPICAL HEMOLYTIC UREMIC SYNDROME (ISN-WCN 2026) - "Distinguishing secondary TMA associated with hypertensive emergencies from atypical hemolytic uremic syndrome (aHUS) is often challenging, as both conditions can present with similar hematologic and renal abnormalities.Moreover, aHUS frequently presents with hypertension, and certain complement gene variants are associated with a slowly progressive clinical course, further complicating the differentiation from hypertension-induced TMA.We report a case of secondary TMA triggered by a hypertensive emergency that closely mimicked aHUS.Methods A woman in her 60s with polymyalgia rheumatica, on long-term oral prednisolone (PSL) therapy for eight years, presented with progressive stiffness of the lower legs in late June, year X. The PSL dosage was increased from 1 mg to 15 mg per day in response to her symptoms...Plasma exchange and treatment with ravulizumab were therefore considered...In case of TMA associated with severe hypertension, prompt and strict blood pressure..."

Case report • Clinical • Atypical Hemolytic Uremic Syndrome • Cardiovascular • Complement-mediated Rare Disorders • Gastroenterology • Giant Cell Arteritis • Hepatology • Hypertension • Immunology • Musculoskeletal Pain • Nephrology • Thrombocytopenia • Thrombocytopenic Purpura • Thrombosis • CD46 • HP

TARGETING B CELLS UPFRONT: COMPARING SAFETY AND EFFICACY OF RITUXIMAB AND CORTICOSTEROIDS AS A FIRST LINE THERAPY IN NEWLY DIAGNOSED CASES OF ADULT ONSET MINIMAL CHANGE DISEASE (B-RIPP STUDY) (ISN-WCN 2026) - "We evaluated the efficacy and safety of RTX compared with standard corticosteroid therapy in adult-onset MCD.Methods In this 24-week observational study, biopsy-proven MCD patients were enrolled to receive RTX (1 g × 2 doses, 15 days apart), or received oral prednisolone (1 mg/kg/day for up to 8 weeks, tapered to 5–7.5 mg/day after remission). Given the reduced incidence of steroid-related toxicity RTX represents a viable alternative as a first line agent to conventional steroid therapy. However, long-term data on relapse rates, maintenance therapy strategies, and cost-effectiveness are warranted before establishing RTX as a first-line agent."

Clinical • Glomerulonephritis • Infectious Disease

PGNMID WITH AKI SUCCESSFULLY MANAGED BY CLONE-DIRECTED THERAPY (ISN-WCN 2026) - "We report a case of PGNMID with severe AKI requiring hemodialysis following recovery from infectious enteritis, successfully managed by clone-directed therapy, including daratumumab and bortezomib.Methods A 60-year-old man presented with proteinuria and edema...He was treated with steroid pulse therapy followed by oral prednisolone and an ARB, later combined with cyclosporine and an SGLT2 inhibitor, achieving partial remission...Prospective studies are essential to establish optimal treatment strategies for PGNMID with AKI. The current case indicates that the narrowing of the glomerular capillary lumina, resulting from an increase in inflammatory cells and mesangial matrix expansion, may lead to AKI."

Gastrointestinal Disorder • Glomerulonephritis • Infectious Disease • Lupus Nephritis • Nephrology • Novel Coronavirus Disease • Renal Disease

TREATMENT OUTCOMES AND RELAPSE PREDICTORS IN ADULT MINIMAL CHANGE DISEASE AT A TERTIARY CENTER IN ETHIOPIA (ISN-WCN 2026) - "Younger age (mean 23 ± 5 years, p = 0.047), lower baseline albumin (2.60 ± 0.29 g/dL, p = 0.01), and higher total cholesterol (298 ± 100 mg/dL, p = 0.001) were significantly associated with relapse.VariablesFrequencyPercentage %Oral PrednisoloneYes36100.0%No00.0%Response to initial steroid responsiveYes3288.9%No411.1%Initial Steroid DependentYes822.2%No2877.8%Initial Steroid ResistanceYes411.1%No3288.9%Tx options and duration of tx for steroid dependentCyclosporine225.0%Rituximab675.0%Cyclophosphamide00.0%Other00.0%Tx outcome for steroid dependentCR8100.0%PR00.0%Tx options and duration of tx for steroid resistanceCyclosporine466.7%Cyclophosphamide233.3%Tx outcome for steroid resistanceCR4100.0%PR00.0%Time to complete remission for steroid dependent estimated in weeksMean 7.5 WeeksSD ± 4.2 weeksConclusion One-third of adult MCD patients experienced relapse, with younger age, hypoalbuminemia, and hypercholesterolemia identified as key predictive..."

Clinical • Dyslipidemia • Glomerulonephritis • Metabolic Disorders

DRUG INDUCED TUBULOINTERSTITIAL NEPHRITIS WITH FANCONI SYNDROME POSSIBLY LINKED TO ROSUVASTATIN: A CASE REPORT (ISN-WCN 2026) - "However, there was widespread infiltration of inflammatory cells and tubulitis in the tubulointerstitial area, leading to the diagnosis of tubulointerstitial nephritis.Results Oral prednisolone (40 mg/day) was initiated, which resulted in a marked improvement in renal function. Although there have been a few reports on statin-related interstitial nephritis, the concurrence of Fanconi syndrome has not been documented. The favorable outcomes following drug discontinuation, corticosteroid therapy, and a safe switch to ezetimibe highlight the importance of early diagnosis and appropriate management of this condition."

Case report • Clinical • Anorexia • Cardiovascular • Dyslipidemia • Hypertension • Immunology • Infectious Disease • Metabolic Disorders • Nephrology • Respiratory Diseases

GLUCOCORTICOID DOSE AT DISCHARGE AND THE RISK OF INFECTIOUS COMPLICATIONS AND REHOSPITALIZATION IN RENAL DISEASES (ISN-WCN 2026) - "Adults initiated on oral prednisolone ≥30 mg/day during hospitalization for renal disease were included...In contrast, glucocorticoid pulse therapy, older age and reduced renal function were associated with increased rehospitalization risk.Conclusion Higher discharge doses of oral glucocorticoids did not increase infection or rehospitalization rates. Discharge timing should therefore be individualized based on overall patient risk rather than glucocorticoid dose alone."

Clinical • Cytomegalovirus Infection • Infectious Disease • Nephrology • Pneumonia • Renal Disease • Respiratory Diseases

ADULT FSGS IN INDIA: CLINICAL OUTCOMES AT ONE YEAR – I-TANGIBLE REGISTRY DATA (ISN-WCN 2026) - "We report 1-year outcomes of adults with primary FSGS treated with oral prednisolone and enrolled in the pan-India I-TANGIBLE Registry.Methods I-TANGIBLE is an ICMR-funded collaborative registry across 13 centres in India, enrolling adult patients with biopsy-proven GN...These findings provide important insights into the short-term outcomes of FSGS in India. Nearly one-third required additional immunosuppressive therapy to maintain remission."

Clinical • Clinical data • Chronic Kidney Disease • Focal Segmental Glomerulosclerosis • Glomerulonephritis

INFLUENCE OF EXPANDING THERAPEUTIC OPTIONS ON REMISSION INDUCTION STRATEGIES AND OUTCOMES IN ANCA-ASSOCIATED VASCULITIS: A SINGLE-CENTER RETROSPECTIVE STUDY (ISN-WCN 2026) - "Introduction The therapeutic landscape of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) has evolved considerably following the approval of rituximab (RTX) and, more recently, the introduction of avacopan...The use of steroid pulse therapy became significantly more frequent, whereas the initial and 2-month doses of oral prednisolone did not differ significantly between groups...However, no significant improvement was observed in short-term renal or survival outcomes or in infection risk. These findings suggest that further optimization of treatment regimens, particularly with respect to minimizing glucocorticoid exposure, remains warranted."

Retrospective data • ANCA Vasculitis • Eosinophilic Granulomatosis With Polyangiitis • Infectious Disease • Langerhans Cell Histiocytosis • Rare Diseases • Vasculitis

ADULT ONSET NEPHROTIC SYNDROME PRESENTING AS ACUTE INFLAMMATORY DEMYELINATING POLYNEUROPATHY AS AN ODDITY (ISN-WCN 2026) - "Patient was initiated on tablet prednisolone 80 mg once a day...This possibly increases glomerular permeability to albumin by T-cell clones secreting vascular circulating factor in FSGS. The simultaneous occurrence of both these entities is unique reinforcing the fact that they share a common pathogenesis which needs further research."

Clinical • Chronic Kidney Disease • Complement-mediated Rare Disorders • Focal Segmental Glomerulosclerosis • Glomerulonephritis • Immunology • Nephrology • Pain • Renal Disease

A CASE OF GRANULOMATOSIS WITH POLYANGIITIS PRESENTING WITH ABDOMINAL PAIN AND IGA DEPOSITION IN CUTANEOUS VESSEL WALLS, MIMICKING IGA VASCULITIS (ISN-WCN 2026) - "Oral prednisolone was initiated, which improved abdominal pain and arthralgia...The patient was treated with high-dose intravenous steroids, avacopan, rituximab, and plasma exchange therapy...The mechanism of IgA deposition in the skin remains unclear; however, chronic mucosal inflammation, as seen in patients with chronic sinusitis or allergic rhinitis, may lead to alterations in IgA structure or metabolism, which could in turn contribute to its deposition within small dermal vessels.Conclusion This case highlights that GPA can present with abdominal pain and IgA deposition in the skin, findings that are atypical for GPA and mimic IgA vasculitis. In such cases, kidney biopsy is crucial for accurate diagnosis and timely initiation of appropriate immunosuppressive therapy."

Clinical • Allergic Rhinitis • Glomerulonephritis • Inflammation • Lupus Nephritis • Mucositis • Musculoskeletal Pain • Nephrology • Otorhinolaryngology • Pain • Rare Diseases • Renal Disease • Respiratory Diseases • Sinusitis • Vasculitis

VANISHING BILE DUCT SYNDROME RELATED TO AVACOPAN THERAPY IN A PATIENT WITH ANCA-ASSOCIATED VASCULITIS. (ISN-WCN 2026) - "Following steroid pulse therapy, she started oral prednisolone 40 mg daily, combined with avacopan. At a post-discharge outpatient visit (day 32 of avacopan administration), marked elevation of liver enzymes was noted, requiring readmission.Results The patient was diagnosed with liver injury due to abacavir and abacavir was discontinued...Treatment with plasma exchange resulted in improvement of the liver injury, and the patient was discharged.Conclusion To avoid progression to severe liver dysfunction, strict monitoring of liver function is required during treatment. Plasma exchange may be useful for improving liver dysfunction caused by avacopan.We presented atThe 55th Western Regianal Meeting of the Japanese Society of Nephrology."

Clinical • ANCA Vasculitis • Glomerulonephritis • Hepatology • Liver Failure • Lupus Nephritis • Nephrology • Renal Disease • Vasculitis

Abiraterone acetate and prednisolone with or without enzalutamide for high-risk non-metastatic prostate cancer: a meta-analysis of primary results from two randomised controlled phase 3 trials of the STAMPEDE platform protocol. (PubMed, Lancet) - P2/3 | "Among men with high-risk non-metastatic prostate cancer, combination therapy is associated with significantly higher rates of metastasis-free survival compared with ADT alone. Abiraterone acetate with prednisolone should be considered a new standard treatment for this population."

Journal • P3 data • Retrospective data • Colorectal Adenocarcinoma • Colorectal Cancer • Gastrointestinal Cancer • Genito-urinary Cancer • Hypertension • Oncology • Prostate Cancer • Respiratory Diseases • Septic Shock • Solid Tumor

Systemic Low Dose Corticosteroid Improves Early Postoperative Knee Function and Pain Intensity in Patients Undergoing Unilateral Total Knee Arthroplasty: A Blinded Controlled Randomized Clinical Trial. (PubMed, JB JS Open Access) - "A total of 102 patients who underwent primary unilateral TKA were randomized to receive either 400 mg of celecoxib plus 10 mg of oral prednisolone daily or 400 mg of celecoxib alone. To optimize dosing regimens and assess the long-term effects of oral corticosteroids in TKA recovery protocols, large-scale randomized controlled trials are necessary. Therapeutic Level I. See Instructions for Authors for a complete description of levels of evidence."

Clinical • Journal • Orthopedics • Pain

IgG4-Related Prostatitis Detected by Whole-Body Diffusion-Weighted Imaging With Background Body Signal Suppression (DWIBS). (PubMed, Cureus) - "Herein, we present a rare case of IgG4-related prostatitis, which was detected by whole-body diffusion-weighted imaging with background body signal suppression (DWIBS) and was pathologically diagnosed by MRI-fusion target biopsy, accompanied by IgG4-related dacryoadenitis/sialadenitis and multiple lymphadenopathies. Oral prednisolone relieved symptoms including general malaise, weight loss, and LUTS, with decreases in serum IgG4 levels. At the same time, DWIBS showed a remarkable signal reduction in the prostate and other involved organs. The present case suggests the usefulness of DWIBS in detecting and monitoring IgG4-RD including IgG4-related prostatitis."

Journal • Inflammation

Beyond Antibody Titers: Corticosteroid Effects on IgG Avidity Dynamics in Experimental Strongyloidiasis. (PubMed, Microb Pathog) - "Oral dexamethasone allowed transient IgG detection 8 dpi, with seroconversion only 21 dpi, while subcutaneous dexamethasone nearly eliminated the response/detection. Oral prednisolone caused delayed seroconversion, with full positivity only 30 dpi...These findings show that corticosteroids suppress antibody levels but may not impair, and can even enhance, antibody maturation. Avidity testing may improve serodiagnosis and risk assessment in immunocompromised individuals with suspected strongyloidiasis."

Journal • Infectious Disease

A Study of Adeno-Associated Virus Serotype 8-Mediated Gene Transfer of Glucose-6-Phosphatase in Patients With Glycogen Storage Disease Type Ia (GSDIa) (clinicaltrials.gov) - P3 | N=49 | Completed | Sponsor: Ultragenyx Pharmaceutical Inc | Active, not recruiting ➔ Completed

Trial completion • Gene Therapies • Metabolic Disorders

Comparison of polydipsia and polyuria in dogs treated with once-daily or divided twice-daily oral prednisolone in 12 dogs. (PubMed, J Small Anim Pract) - "Once-daily rather than divided-daily dosing is a reasonable option in dogs treated with oral prednisolone to reduce excessive water intake in the clinical setting. Urine specific gravity and osmolality can be used interchangeably for the assessment of urine concentration."

Journal

External Ear Vasculitis Beyond Levamisole and Autoimmunity: An Infection-Associated Case (AAD 2026) - "We present the case of a 76-year-old woman from Medellín, Colombia, with a history of seropositive rheumatoid arthritis diagnosed in 2003, treated with methotrexate, chloroquine, leflunomide, and low-dose oral prednisolone. Varicella is an uncommon and underrecognized etiology of vasculitis in adults, and its overlap with autoimmune and levamisole-induced vasculitis poses a diagnostic challenge. To our knowledge, small-vessel vasculitis due to varicella is exceedingly rare, underscoring the value of tissue biopsy and reminding clinicians that not all vasculitis are autoimmune in origin."

Clinical • Cardiovascular • Immunology • Infectious Disease • Inflammatory Arthritis • Rheumatoid Arthritis • Varicella Zoster • Vasculitis

Evaluation of side effects and evidence of systemic absorption in patients with IgA Nephropathy treated with targeted-release budesonide (Kinpeygo) (UKKW 2026) - "Budesonide is a highly potent steroid; 16mg is equivalent to oral prednisolone 213mg1. Future work to evaluate the longer-term effects of TRf-budesonide in different ethnic populations, including effects on the hypothalamic-pituitary-adrenal axis and adverse effects is required. References: 1: Equivalent dosage of commonly used steroids (Journal of Allergy and Clinical Immunology): https://www.jacionline.org/cms/10.1016/j.jaci.2015.07.046/attachment/9e6d93c6-b64b- 4468-8cf5-38a0e9b551e9/mmc2.pdf"

Adverse events • Clinical • Acne Vulgaris • Glomerulonephritis • Hematological Malignancies • IgA Nephropathy • Immunology • Infectious Disease • Lupus Nephritis • Lymphoma • Metabolic Disorders • Nephrology • Pneumonia • Renal Disease • Respiratory Diseases • Retinal Disorders • CYP3A4

INCIDENCE, RISK FACTORS AND OUTCOMES OF AVASCULAR NECROSIS IN ALLOGENEIC STEM CELL TRANSPLANT RECIPIENTS DEVELOPING GRAFT-VERSUS-HOST DISEASE (EBMT 2026) - "All patients had hip involvement with median ARCO stage II; 4 had shoulder and 1 had wrist involvement(median number of joints involved: 2,range:1-4).Twelve AVN patients required vitamin D supplementation at diagnosis of AVN, and 13 received bisphosphonates(alendronate:11, zoledronate:2)...AVN cases received higher starting dose of systemic steroids for acute GVHD(median:2.19 vs 1.19 mg/kg prednisolone equivalents, p=0.016), but there were no differences in steroid therapy duration, steroid-refractoriness, or use of maintenance prednisolone and oral budesonide... Symptomatic AVN incidence among ASCT recipients who developed GVHD was 6.4%, with 57% requiring surgery. Higher pre-ASCT steroid exposure, higher initial steroid dose for acute GVHD, higher CD3+ cell dose, and pre-ASCT vitamin D deficiency were potentially modifiable risk factors for AVN."

Clinical • Acute Graft versus Host Disease • Chronic Graft versus Host Disease • Graft versus Host Disease • Hematological Malignancies • Hodgkin Lymphoma • Immunology • Lymphoma • Orthopedics • Transplantation

INCIDENCE, RISK FACTORS AND OUTCOMES OF AVASCULAR NECROSIS IN ALLOGENEIC STEM CELL TRANSPLANT RECIPIENTS DEVELOPING GRAFT-VERSUS-HOST DISEASE (EBMT 2026) - "All patients had hip involvement with median ARCO stage II; 4 had shoulder and 1 had wrist involvement(median number of joints involved: 2,range:1-4).Twelve AVN patients required vitamin D supplementation at diagnosis of AVN, and 13 received bisphosphonates(alendronate:11, zoledronate:2)...AVN cases received higher starting dose of systemic steroids for acute GVHD(median:2.19 vs 1.19 mg/kg prednisolone equivalents, p=0.016), but there were no differences in steroid therapy duration, steroid-refractoriness, or use of maintenance prednisolone and oral budesonide... Symptomatic AVN incidence among ASCT recipients who developed GVHD was 6.4%, with 57% requiring surgery. Higher pre-ASCT steroid exposure, higher initial steroid dose for acute GVHD, higher CD3+ cell dose, and pre-ASCT vitamin D deficiency were potentially modifiable risk factors for AVN."

Clinical • Acute Graft versus Host Disease • Chronic Graft versus Host Disease • Graft versus Host Disease • Hematological Malignancies • Hodgkin Lymphoma • Immunology • Lymphoma • Orthopedics • Transplantation

CASE REPORT: CLEARANCE OF TP53 MUTATION POST ALLOGENEIC STEM CELL TRANSPLANT IN THE SETTING OF CHRONIC GVHD, WITH SUBSEQUENT TP53 MYELOID SARCOMA (EBMT 2026) - " A 21-year-old male underwent a reduced intensity conditioning sibling HLA matched allo-HSCT (fludarabine and melphalan) in October 2021 for TP53 (VAF 26%)-mutated myelodysplastic syndrome with marrow fibrosis and excess blasts in the context of Swachman-Diamond Syndrome (SDS)...During ciclosporin wean, the patient developed chronic GVHD of the mouth, eyes and liver. cGVHD was managed with topical steroids and intermediate dose oral prednisolone... Somatic mutations in acute myeloid leukaemia can be monitored as minimal residual disease (MRD) markers pre and post allograft. TP53 is not currently recognised as a valid MRD marker. Typically, persistence of MRD early post-transplant is highly associated with imminent relapse and few cases have described clearance of somatic mutations in the setting of developing cGVHD."

Case report • Clinical • Acute Myelogenous Leukemia • Bone Marrow Transplantation • Chronic Graft versus Host Disease • Fibrosis • Graft versus Host Disease • Hematological Malignancies • Immunology • Leukemia • Myelodysplastic Syndrome • Sarcoma • Solid Tumor • Transplantation • ANPEP • CD33 • CD34 • KIT • NRAS • RUNX1 • TP53

Multiple Evanescent White Dot Syndrome After mRNA COVID-19 Vaccination. (PubMed, Cureus) - "Full-field electroretinography (ERG) showed reduced amplitudes of both a- and b-waves...The day after the initial visit, the BCVA in the right eye rapidly declined to 0.01 in decimal units, prompting the initiation of oral prednisolone at 30 mg/day. Eight days later, a sub-Tenon's capsule injection of triamcinolone acetonide (20 mg/0.5 ml) was administered...Oral steroid therapy was tapered, and the visual acuity (VA) improved to 1.0 in decimal units four months later. A case of MEWDS occurring after COVID-19 vaccination showed favorable recovery with oral steroid therapy and sub-Tenon's injection."

Journal • Achromatopsia • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases

Surgically induced necrotizing scleritis after orbital surgery with intraconal tumor excision: a case report. (PubMed, Int Ophthalmol) - "SINS is a rare but potentially sight-threatening complication following orbital surgery with intraconaltumor excision. Persistent pain can be a useful clue before the clinical signs become apparent."

Journal • Cataract • Diabetes • Metabolic Disorders • Ocular Inflammation • Oncology • Ophthalmology • Pain • Scleritis

Efficacy and Safety of Tofacitinib Compared to Cyclophosphamide in Early Diffuse Cutaneous Systemic Sclerosis: A Randomized Controlled Trial. (PubMed, Cureus) - P2 | "Tofacitinib demonstrated significant efficacy in reducing skin thickness (mRSS) in early dcSSc, showing both numerical and statistical advantages over cyclophosphamide at 24 weeks, along with a more favorable safety profile. These findings support further evaluation of tofacitinib as a potential therapeutic option in this patient population."

Clinical • Journal • Hematological Disorders • Immunology • Infectious Disease • Nephrology • Respiratory Diseases • Rheumatology • Scleroderma • Systemic Sclerosis • CRP