prednisolone / Generic mfg. - LARVOL DELTA

Pembrolizumab-induced pan-airway mucositis with a cobblestone-like appearance: a case report. (PubMed, Jpn J Clin Oncol) - "Her symptoms and endoscopic and radiologic abnormalities resolved after discontinuation of pembrolizumab and initiation of oral prednisolone, and steroids were successfully tapered without recurrence. This case highlights a rare but clinically important pattern of ICI-induced pan-airway mucositis, in which lower-airway inflammation may be initially attenuated by inhaled steroids and later become evident after extension to the upper airway; such airway irAEs should be considered in ICI-treated patients presenting with persistent or atypical upper-airway symptoms."

Journal • Asthma • Dermatology • Immunology • Mucositis • Non Small Cell Lung Cancer • Oncology • Otorhinolaryngology • Pulmonary Disease • Respiratory Diseases • Squamous Cell Carcinoma • CD8

Disseminated Lomentospora prolificans infection in a patient with neutropenia treated with ipilimumab and nivolumab. (PubMed, BMJ Case Rep) - "The neutrophil count only recovered once oral prednisolone was commenced, indicating a haematological irAE. A restaging Positron Emission Tomography scan revealed intramuscular ring-enhancing collections throughout his body, one of which was aspirated and cultured the fungus Lomentospora prolificans He was treated with voriconazole plus terbinafine, both of which were later substituted with olorofim due to a voriconazole-induced rash. After 4 months, the collections had resolved on repeat imaging, and olorofim was ceased due to transaminitis. This case highlights neutropenia as a lesser-known adverse effect of immunotherapy and raises awareness about L. prolificans infection."

Journal • Febrile Neutropenia • Hematological Disorders • Infectious Disease • Melanoma • Neutropenia • Oncology • Solid Tumor

INCIDENCE, RISK FACTORS AND OUTCOMES OF AVASCULAR NECROSIS IN ALLOGENEIC STEM CELL TRANSPLANT RECIPIENTS DEVELOPING GRAFT-VERSUS-HOST DISEASE (EBMT 2026) - "All patients had hip involvement with median ARCO stage II; 4 had shoulder and 1 had wrist involvement(median number of joints involved: 2,range:1-4).Twelve AVN patients required vitamin D supplementation at diagnosis of AVN, and 13 received bisphosphonates(alendronate:11, zoledronate:2)...AVN cases received higher starting dose of systemic steroids for acute GVHD(median:2.19 vs 1.19 mg/kg prednisolone equivalents, p=0.016), but there were no differences in steroid therapy duration, steroid-refractoriness, or use of maintenance prednisolone and oral budesonide... Symptomatic AVN incidence among ASCT recipients who developed GVHD was 6.4%, with 57% requiring surgery. Higher pre-ASCT steroid exposure, higher initial steroid dose for acute GVHD, higher CD3+ cell dose, and pre-ASCT vitamin D deficiency were potentially modifiable risk factors for AVN."

Clinical • Acute Graft versus Host Disease • Chronic Graft versus Host Disease • Graft versus Host Disease • Hematological Malignancies • Hodgkin Lymphoma • Immunology • Lymphoma • Orthopedics • Transplantation

CASE REPORT: CLEARANCE OF TP53 MUTATION POST ALLOGENEIC STEM CELL TRANSPLANT IN THE SETTING OF CHRONIC GVHD, WITH SUBSEQUENT TP53 MYELOID SARCOMA (EBMT 2026) - " A 21-year-old male underwent a reduced intensity conditioning sibling HLA matched allo-HSCT (fludarabine and melphalan) in October 2021 for TP53 (VAF 26%)-mutated myelodysplastic syndrome with marrow fibrosis and excess blasts in the context of Swachman-Diamond Syndrome (SDS)...During ciclosporin wean, the patient developed chronic GVHD of the mouth, eyes and liver. cGVHD was managed with topical steroids and intermediate dose oral prednisolone... Somatic mutations in acute myeloid leukaemia can be monitored as minimal residual disease (MRD) markers pre and post allograft. TP53 is not currently recognised as a valid MRD marker. Typically, persistence of MRD early post-transplant is highly associated with imminent relapse and few cases have described clearance of somatic mutations in the setting of developing cGVHD."

Case report • Clinical • Acute Myelogenous Leukemia • Bone Marrow Transplantation • Chronic Graft versus Host Disease • Fibrosis • Graft versus Host Disease • Hematological Malignancies • Immunology • Leukemia • Myelodysplastic Syndrome • Sarcoma • Solid Tumor • Transplantation • ANPEP • CD33 • CD34 • KIT • NRAS • RUNX1 • TP53

Four versus six cycles of CHOP chemotherapy in combination with six applications of rituximab in patients with aggressive B-cell lymphoma with favourable prognosis (FLYER): a randomised, phase 3, non-inferiority trial. (PubMed, Lancet) - P3; "In young patients with aggressive B-cell non-Hodgkin lymphoma and favourable prognosis, four cycles of R-CHOP is non-inferior to six cycles of R-CHOP, with relevant reduction of toxic effects. Thus, chemotherapy can be reduced without compromising outcomes in this population."

Clinical • Combination therapy • Head-to-Head • Journal • P3 data • Hematological Disorders • Hematological Malignancies • Lymphoma • Non-Hodgkin’s Lymphoma • Oncology

Eosinophilic Colitis in an Adult Ethiopian Patient. (PubMed, Case Rep Gastrointest Med) - "Diagnostic colonoscopy with biopsy confirmed EC, supported by peripheral eosinophilia and histological findings. The patient was treated with oral prednisolone, leading to complete symptom resolution."

Journal • Eosinophilia • Fatigue • Gastroenterology • Gastrointestinal Disorder • Immunology • Pain

Bilateral Idiopathic Pyoderma Gangrenosum: A Case Report of an Atypical Presentation. (PubMed, Clin Case Rep) - "The patient was treated with oral prednisolone and local saline dressings, resulting in significant improvement within 2 weeks and complete healing without recurrence. PG can occur even in the absence of systemic diseases and may mimic infectious or vascular ulcers. Awareness about atypical presentations, early biopsy and timely initiation of corticosteroid therapy is essential to avoid misdiagnosis and achieve favorable outcomes."

Journal • Dermatology • Hematological Disorders • Immunology • Infectious Disease • Mood Disorders • Pain • Pyoderma Gangrenosum • Vasculitis • CRP

Continuous enzalutamide after progression of metastatic castration-resistant prostate cancer treated with docetaxel (PRESIDE): an international, randomised, phase 3b study. (PubMed, Lancet Oncol) - P3 | "PRESIDE met its primary endpoint and showed that continuing enzalutamide with docetaxel plus androgen deprivation therapy delayed time to progression compared with docetaxel plus androgen deprivation therapy alone, supporting the hypothesis that enzalutamide maintenance could control persistent androgen-dependent clones in men with mCRPC who progress after treatment with enzalutamide alone."

Journal • P3 data • Genito-urinary Cancer • Hematological Disorders • Neuroendocrine Tumor • Neutropenia • Oncology • Prostate Cancer • Renal Disease • Septic Shock • Solid Tumor

Abiraterone acetate and prednisolone with or without enzalutamide for high-risk non-metastatic prostate cancer: a meta-analysis of primary results from two randomised controlled phase 3 trials of the STAMPEDE platform protocol. (PubMed, Lancet) - P2/3 | "Among men with high-risk non-metastatic prostate cancer, combination therapy is associated with significantly higher rates of metastasis-free survival compared with ADT alone. Abiraterone acetate with prednisolone should be considered a new standard treatment for this population."

Journal • P3 data • Retrospective data • Colorectal Adenocarcinoma • Colorectal Cancer • Gastrointestinal Cancer • Genito-urinary Cancer • Hypertension • Oncology • Prostate Cancer • Respiratory Diseases • Septic Shock • Solid Tumor

Paracentral Acute Middle Maculopathy Associated With Dengue Fever. (PubMed, Cureus) - "He was treated with oral prednisolone 40 mg/day with tapering every week...The onset of a central scotoma may suggest the onset of PAMM, and this requires a comprehensive ocular evaluation, and if required, an OCT test to rule out this possibility. Ophthalmologists should be aware of this differential diagnosis."

Journal • Cardiovascular • Dengue Fever • Genetic Disorders • Hematological Disorders • Macular Degeneration • Ocular Inflammation • Ophthalmology • Pain • Retinal Disorders • Uveitis

An Adrenal Crisis After Denosumab Use in a Patient With Addison's Disease: A Case Report. (PubMed, Cureus) - "A 69-year-old female patient with a 35-year history of primary adrenal insufficiency was on stable replacement therapy with 5 mg of oral prednisolone daily...She was successfully treated with intravenous hydrocortisone and fluid resuscitation, with full clinical recovery. To our knowledge, this is the first reported case of adrenal crisis temporally linked to denosumab use in a female patient with Addison's disease, suggesting a possible association rather than definite causality, particularly when stress-dose glucocorticoids are not provided. Clinicians should be aware of this potential association and consider individualized risk assessment, pre-treatment glucocorticoid dose adjustments, and close monitoring in patients with adrenal insufficiency receiving denosumab."

Journal • Cardiovascular • Chronic Kidney Disease • Endocrine Disorders • Fatigue • Heart Failure • Hypotension • Nephrology • Osteoporosis • Rare Diseases • Renal Disease • Rheumatology

IgG4-related pulmonary pseudotumor and pleuritis mimicking lung cancer and asbestos plaque: A case report. (PubMed, Respir Med Case Rep) - "The patient was treated with oral prednisolone, resulting in resolution of the lung mass, symptom improvement, and a decline in serum IgG4 levels...This case highlights the diagnostic challenges posed by IgG4-related lung disease, which can mimic malignancy and asbestos-related pathology, underscoring the importance of biopsy for accurate diagnosis. It also suggests a possible association between asbestos exposure and IgG4-RD development."

Journal • Cough • Fibrosis • Immunology • Lung Cancer • Oncology • Pulmonary Disease • Respiratory Diseases • Solid Tumor

Intracerebral Hemorrhage During the Chronic Phase of Eosinophilic Granulomatosis With Polyangiitis: A Case Report Emphasizing Cerebrovascular Vulnerability. (PubMed, Clin Case Rep) - "After receiving high-dose corticosteroids (Day-165) and edoxaban for subacute distal deep vein thrombosis (Day-158), her eosinophil count steadily decreased, and she was discharged without hypertension on oral prednisolone 40 mg/day (Day-144). Current guidelines do not address this risk, underscoring the need for individualized risk assessment. This case may indicate that brain imaging, including SWI, could be considered prior to initiating anticoagulation therapy in patients with EGPA."

Journal • Asthma • Cardiovascular • Cerebral Hemorrhage • Eosinophilia • Eosinophilic Granulomatosis With Polyangiitis • Hematological Disorders • Hypertension • Immunology • Inflammation • Langerhans Cell Histiocytosis • Pulmonary Disease • Rare Diseases • Respiratory Diseases • Rheumatology • Thrombosis • Vasculitis

Unilateral Ptosis and Bulbar Symptoms as the Initial Presentation of Late-Onset Acetylcholine Receptor Antibody-Positive Myasthenia Gravis Mimicking Acute Ischemic Stroke in an 82-Year-Old Man. (PubMed, Cureus) - "He was treated with pyridostigmine and oral prednisolone with gastric and bone protection and close monitoring of glycaemic control...As most cases classically present before the age of 50-60 years, this presentation in an 82-year-old man also illustrates very late-onset acetylcholine receptor antibody-positive disease. This case highlights that unilateral ocular involvement does not exclude myasthenia gravis and that close attention to fatigability and symptom evolution can prevent misdiagnosis and support timely, appropriate treatment."

Journal • Age-related Macular Degeneration • Cardiovascular • Cataract • Chronic Kidney Disease • CNS Disorders • Diabetes • Gastrointestinal Disorder • Immunology • Ischemic stroke • Macular Degeneration • Metabolic Disorders • Myasthenia Gravis • Nephrology • Ophthalmology • Renal Disease • Retinal Disorders • Solid Tumor • Thymoma • Thymus Cancer • Type 2 Diabetes Mellitus

Comparative Efficacy and Safety of Upadacitinib Versus Oral Prednisolone for the Induction of Remission in Ulcerative Colitis: A Prospective, Multicenter, Open-label, Randomized Controlled Trial (PREDUPA Trial) Protocol (ECCO-IBD 2026) - "This study aims to determine whether upadacitinib can serve as a safer alternative to corticosteroids. Findings from this RCT could significantly inform clinical guidelines and improve treatment outcomes for patients who do not respond to conventional therapies."

Clinical • Immunology • Inflammatory Bowel Disease • Ulcerative Colitis

Severe Short Stature, Pathological Fracture, and Avascular Necrosis Due to Prolonged Over-the-Counter Steroid Use in an Adolescent Patient. (PubMed, Cureus) - "We present a case of an 18-year-old male patient with a 10-year history of self-medicating with oral prednisolone for joint pain, without medical supervision...This case underscores the devastating consequences of unregulated GC use during adolescence, resulting in growth failure, delayed puberty, osteoporosis, adrenal insufficiency, and AVN. It highlights the need for clinician vigilance, public education, and policy-level regulation of OTC steroid access to prevent such avoidable endocrinopathies."

Journal • Cushing’s Disease • Endocrine Disorders • Musculoskeletal Diseases • Musculoskeletal Pain • Nephrology • Orthopedics • Osteoporosis • Pain • Renal Disease • Rheumatology

Efficacy and Safety of AC102 Compared to Steroids in Adults With Idiopathic Sudden Sensorineural Hearing Loss (ISSNHL) (clinicaltrials.gov) - P2 | N=210 | Active, not recruiting | Sponsor: AudioCure Pharma GmbH | Recruiting ➔ Active, not recruiting | Trial completion date: Dec 2025 ➔ Jul 2026

Enrollment closed • Trial completion date • Otorhinolaryngology

A Rare Case of Sarcoidosis Presenting With Endobronchial Mass. (PubMed, Cureus) - "The patient was diagnosed with sarcoidosis and was initiated on oral prednisolone. This case highlights the importance of considering sarcoidosis in the differential diagnosis to ensure timely and appropriate management."

Journal • Cough • Immunology • Inflammation • Oncology • Respiratory Diseases • Sarcoidosis

Neuropathy of the infraorbital area following rapid palatal expansion: A case report. (PubMed, Medicine (Baltimore)) - "This case illustrates that MARPE, while effective and generally safe, can occasionally induce neuropathic complications extending beyond palatal branches to involve the infraorbital pathway. Mechanical stress redistribution in skeletally mature patients likely contributes to this outcome. Careful monitoring for atypical sensory changes, early recognition, and timely pharmacological intervention are essential to optimize prognosis. Further research is warranted to clarify biomechanical mechanisms and risk factors for trigeminal nerve injury during orthodontic maxillary expansion."

Journal • Neuralgia • Pain • Xerostomia

VEXAS Syndrome with Vibrio vulnificus Sepsis During Treatment with Tocilizumab: A Case Report. (PubMed, Intern Med) - "He was treated with tocilizumab, oral prednisolone, and regular blood transfusions...A blood culture confirmed V. vulnificus infection, which resolved after tazobactam/piperacillin treatment...vulnificus infections can be facilitated by iron overload resulting from frequent blood transfusions. Since patients with VEXAS syndrome often require regular transfusions, clinicians should monitor for this potentially fatal infection."

Journal • Hematological Disorders • Infectious Disease • Septic Shock

Renal limited sarcoidosis presenting with non-caseating granulomatous interstitial nephritis in the absence of extrarenal manifestations: a case report and literature review. (PubMed, CEN Case Rep) - "The patient was treated with low dose of oral prednisolone, resulting in significant improvement in renal function and normalization of laboratory parameters. However, in steroid-resistant cases, alternative immunosuppressive agents such as mycophenolate mofetil and infliximab have been employed, though their efficacy and safety require further investigation. In this article, we present this rare case in addition to providing comprehensive literature review of previously cases to summarize clinicopathological characters, treatment strategies, and renal outcomes of renal-limited sarcoidosis for future clinical management."

Journal • Review • Diabetes • Immunology • Infectious Disease • Metabolic Disorders • Nephrology • Oncology • Osteoporosis • Renal Disease • Rheumatology • Sarcoidosis • Solid Tumor • Thyroid Gland Carcinoma • Thyroid Gland Papillary Carcinoma • Type 2 Diabetes Mellitus

SUNCT-like headache secondary to herpes zoster in the ipsilateral ophthalmic nerve distribution: A case report (EHF-EHC 2025) - " A 52-year-old Sri Lankan male developed painful vesicular eruptions over the right ophthalmic dermatome and was treated with oral acyclovir (800 mg, five times daily)...Treatment included oral prednisolone (15 mg/day, tapered by 5 mg/week), carbamazepine (100 mg t.d.s., increased to 200 mg t.d.s. from week two), pregabalin (75 mg nocte), and tramadol (50 mg nocte)... This case underscores a SUNCT-like syndrome following ophthalmic zoster, which appears more pharmacoresponsive than primary SUNCT. Immunosuppressive states like diabetes, should be considered underlying zoster reactivation. Fig."

Case report • Clinical • Diabetes • Herpes Zoster • Metabolic Disorders • Ophthalmology • Pain • Varicella Zoster

Bilateral Optic Sheath Enhancement in Giant Cell Arteritis (GCA) Presenting With Occipital Neuralgia-Like Symptoms. (PubMed, Cureus) - "Although optic nerve signal changes are an uncommon manifestation of giant cell arteritis (GCA), the neurology team commenced high-dose oral prednisolone (60 mg once daily), considering GCA in the differential diagnosis...Subsequent temporal artery ultrasound findings were consistent with GCA, supporting the diagnosis. This case highlights an unusual radiological presentation of GCA and underscores the importance of early empirical treatment to prevent irreversible visual complications."

Journal • CNS Disorders • Giant Cell Arteritis • Immunology • Neuralgia • Neuromyelitis Optica Spectrum Disorder • Ocular Inflammation • Ophthalmology • Optic Neuritis • Pain • Rare Diseases • Solid Tumor • CRP

An Atypical Presentation of Allergic Bronchopulmonary Aspergillosis. (PubMed, Cureus) - "Treatment with oral prednisolone and itraconazole led to full clinical and radiological recovery, with sustained remission under inhaled corticosteroid/long-acting β₂-agonist therapy. This case highlights an uncommon presentation of ABPA with pleural effusion and lobar collapse and emphasizes the importance of considering ABPA in the differential diagnosis of unexplained or eosinophilic pleural effusions."

Journal • Allergic Bronchopulmonary Aspergillosis • Asthma • Cough • Cystic Fibrosis • Eosinophilia • Genetic Disorders • Immunology • Oncology • Pulmonary Disease • Respiratory Diseases

Atypical Posterior Sympathetic Ophthalmia Shortly After PRESERFLO™ MicroShunt Implantation Masquerading as Hypotony Maculopathy: A Case Report. (PubMed, Cureus) - "Oral prednisolone was tapered to 5 mg/day without recurrence. Fundoscopy examination of her right eye was difficult due to long-standing total retinal detachment. This case underscores several atypical features of posterior SO, including very early-onset, posterior-predominant disease without anterior inflammation, and diagnostic challenges in the fellow eye, and highlights the importance of considering SO in atypical postoperative presentations, even after less invasive glaucoma surgery, and the need for early recognition with timely corticosteroid therapy to preserve vision."

Journal • Glaucoma • Inflammation • Macular Degeneration • Ophthalmology • Retinal Disorders