prednisolone / Generic mfg. - LARVOL DELTA

Maintenance of Minimal Manifestation Status with Individualized-Interval Efgartigimod in Generalized Myasthenia Gravis: Study Protocol for a Single-Arm, Open-Label Clinical Trial. (PubMed, Neurol Ther) - "We designed a prospective study to evaluate maintenance of MM with low-dose oral prednisolone (PSL) ≤ 5 mg/day (MM-5 mg) under interval-adjusted efgartigimod administration. Graphical Abstract available for this article. Japan Registry of Clinical Trials (jRCT): jRCTs031260127 (prospectively registered on 14 May 2026)."

Journal • CNS Disorders • Immunology • Myasthenia Gravis

A Case of Recurrent Delayed Bleeding During Steroid-Based Stricture Prophylaxis After Circumferential Pyloric Endoscopic Submucosal Dissection for Early Gastric Cancer (ACG 2026) - "Case Description/ An 89-year-old woman taking apixaban for atrial fibrillation was referred for a 40-mm early gastric cancer extending from the antrum to the pyloric ring...Triamcinolone acetonide 50 mg was injected into the ulcer base, and oral prednisolone 30 mg/day was started postoperatively for stricture prophylaxis...This case highlights the balance between stricture prevention and bleeding risk after circumferential pyloric ESD. In patients requiring anticoagulation, steroid therapy should be carefully individualized."

Clinical • Atrial Fibrillation • Gastric Cancer • Oncology • Solid Tumor

Strongyloides stercoralis Masquerading as Crohn's Disease (ACG 2026) - "Patient was started on budesonide while pathology reports were pending, which did not improve his symptoms...There are documented cases of hyper infection after courses of steroids for six days and with oral prednisolone doses as low as 20 mg daily...Figure: Figure 2. Colonoscopy revealing patchy colitis with erosions in descending colon, initially raising concern for Crohn's colitis."

Cardiovascular • Coronary Artery Disease • Crohn's disease • Diabetes • Gastroenterology • Gastrointestinal Disorder • Immunology • Infectious Disease • Inflammation • Inflammatory Bowel Disease • Metabolic Disorders • Type 2 Diabetes Mellitus

Immunoglobulin G4 (IgG4)-Related Disease With a Biphasic Clinical Course of Spontaneous Remission and Relapse: A Case Report of Diagnostic Reasoning. (PubMed, Cureus) - "Treatment with oral prednisolone (PSL; 40 mg/day) was initiated, resulting in rapid biochemical, morphological, and clinical improvement. During the steroid tapering phase, the patient developed trimethoprim-sulfamethoxazole-induced liver injury...This case highlights an uncommon biphasic and metachronous course of IgG4-RD. It underscores the importance of precise diagnostic reasoning by integrating the patient's previous clinical history, recognizing enzyme dissociation patterns, and astutely differentiating drug-induced liver injury to prevent unnecessary steroid escalation during long-term management."

Journal • Hepatology • Immunology • Infectious Disease • Liver Failure • Novel Coronavirus Disease • Oncology • Pancreatic Cancer • Pancreatitis

Prevalence of corticosteroid-induced cataracts in children with nephrotic syndrome: a cross-sectional study in Pakistan. (PubMed, Child Kidney Dis) - "The study included 150 children with NS, aged 2-16 years, who had received oral prednisolone for more than 6 months...Our findings underscore the importance of routine ophthalmologic screening. Individual susceptibility, including potential genetic factors, might play a role in cataract development and warrant further investigation."

Journal • Observational data • Cardiovascular • Cataract • Glomerulonephritis • Hypertension • Nephrology • Ophthalmology • Pediatrics • Renal Disease

Randomized Controlled Trial of Corticosteroid Tapering in Steroid-Sensitive Podocytopathy. (PubMed, Kidney Int Rep) - "After achieving remission, participants were randomized to 1 of the 2 following predefined tapering regimens: a short course (oral prednisolone tapered over 2-months) or a standard course (oral prednisolone tapered over 4-months)...Adverse events occurred in 12 (24.5%) patients in the short-course group and 24 (53.3%) in the standard-course group (P = 0.003). These findings suggest that a shorter course of corticosteroid tapering is noninferior to a prolonged taper in preventing relapses in adults with steroid-sensitive podocytopathy, with a lower incidence of adverse events."

Journal • Focal Segmental Glomerulosclerosis • Glomerulonephritis • Infectious Disease

Efficacy and safety of add-on glucocorticoid pulse therapy during remission induction in patients with ANCA-associated vasculitis: a target trial emulation study (ACR Convergence 2026) - "In this study, we aimed to evaluate the efficacy and safety of GC pulse therapy in induction treatment of AAV using a target trial emulation framework. This multicenter cohort study included patients with active granulomatosis with polyangiitis (GPA) or microscopic polyangiitis (MPA) who received induction therapy with either rituximab (RTX) or intravenous cyclophosphamide (CYC) between 2004 and 2024...The primary outcome was remission at 12 months, defined as a Birmingham Vasculitis Activity Score (BVAS) of 0 and an oral prednisolone dose of ≤10 mg/day... In patients with AAV receiving RTX- or CYC-based induction therapy, add-on GC pulse therapy showed no additional benefit in achieving remission at 12 months, but was associated with a higher risk of serious infection."

Clinical • ANCA Vasculitis • Diabetes • Infectious Disease • Metabolic Disorders • Rare Diseases • Vasculitis

Neutropenia in Patients With Castration-Resistant Prostate Cancer Treated Using Cabazitaxel and Prophylactic Administration of Pegfilgrastim. (PubMed, Adv Urol) - "Cabazitaxel was administered every 3-4 weeks at doses determined by the treating physicians, generally 20-25 mg/m2, with daily oral prednisolone...A longer interval from CRPC diagnosis to cabazitaxel initiation showed a consistent trend toward association with FN risk in Japanese patients across analyses. These findings provide real-world safety data and highlight the importance of careful hematologic monitoring, particularly in patients treated later in the CRPC disease course."

Journal • Castration-Resistant Prostate Cancer • Febrile Neutropenia • Genito-urinary Cancer • Hematological Disorders • Neutropenia • Oncology • Prostate Cancer • Solid Tumor

Nintedanib for progressive pulmonary fibrosis associated with sarcoidosis: a retrospective preliminary observational report. (PubMed, Respir Investig) - "Our exploratory study yielded two hypotheses; a potential benefit of nintedanib on the FVC annual decline and a possible role for chest CT findings predicting nintedanib efficacy. Unexpected adverse events were not observed."

Journal • Retrospective data • Bronchiectasis • Idiopathic Pulmonary Fibrosis • Immunology • Pulmonary Disease • Respiratory Diseases • Sarcoidosis

Continuous enzalutamide after progression of metastatic castration-resistant prostate cancer treated with docetaxel (PRESIDE): an international, randomised, phase 3b study. (PubMed, Lancet Oncol) - P3 | "PRESIDE met its primary endpoint and showed that continuing enzalutamide with docetaxel plus androgen deprivation therapy delayed time to progression compared with docetaxel plus androgen deprivation therapy alone, supporting the hypothesis that enzalutamide maintenance could control persistent androgen-dependent clones in men with mCRPC who progress after treatment with enzalutamide alone."

Journal • P3 data • Genito-urinary Cancer • Hematological Disorders • Neuroendocrine Tumor • Neutropenia • Oncology • Prostate Cancer • Renal Disease • Septic Shock • Solid Tumor

Abiraterone acetate and prednisolone with or without enzalutamide for high-risk non-metastatic prostate cancer: a meta-analysis of primary results from two randomised controlled phase 3 trials of the STAMPEDE platform protocol. (PubMed, Lancet) - P2/3 | "Among men with high-risk non-metastatic prostate cancer, combination therapy is associated with significantly higher rates of metastasis-free survival compared with ADT alone. Abiraterone acetate with prednisolone should be considered a new standard treatment for this population."

Journal • P3 data • Retrospective data • Colorectal Adenocarcinoma • Colorectal Cancer • Gastrointestinal Cancer • Genito-urinary Cancer • Hypertension • Oncology • Prostate Cancer • Respiratory Diseases • Septic Shock • Solid Tumor

Incidence and Clinical Course of Intraocular Inflammation Following Pharmacy-Compounded Intravitreal Aflibercept 8mg for Neovascular AMD: A Real-World Cohort Study. (PubMed, Clin Ophthalmol) - "To evaluate the incidence and clinical course of intraocular inflammation (IOI) after intravitreal aflibercept 8 mg (Eylea 8 mg - E8) injection in patients with neovascular age-related macular degeneration (nAMD) in Poland...All cases were managed with topical corticosteroids, 16/20 additionally received sub-Tenon triamcinolone, and 6 required oral prednisolone; 1 patient required pars plana vitrectomy...In this first Polish cohort study, the incidence of IOI after E8 injection (2.31% per eye/patient) was higher than reported in registration trials, though episodes were generally mild and self-limited, without long-term visual impact. These findings may help inform clinical monitoring for patients receiving E8 for nAMD."

Journal • Real-world evidence • Age-related Macular Degeneration • Inflammation • Macular Degeneration • Ocular Inflammation • Ophthalmology • Retinal Disorders • Uveitis • Vasculitis • Wet Age-related Macular Degeneration

Papilledema With Facial and Vestibulocochlear Nerve Involvement in Idiopathic Intracranial Hypertension: An Unusual Case. (PubMed, Case Rep Ophthalmol Med) - "A 5-day course of oral prednisolone for presumed Bell's palsy yielded no improvement...Acetazolamide was started on Day 13 together with a structured weight-management program...Yet, progressive visual field loss may ensue despite stable papilledema, revealing the optic disc as an unreliable proxy for neuronal integrity. Only spectral-domain OCT-by quantifying inner retinal layer loss-can expose silent axonal degeneration and must therefore become the cornerstone of long-term monitoring, independent of clinical appearance."

Journal • Cardiovascular • CNS Disorders • Hematological Disorders • Hypertension • Obesity • Ocular Inflammation • Ophthalmology • Otorhinolaryngology • Pain • Thrombosis

Non-suppurative Destructive Cholangitis After Avacopan Therapy in Myeloperoxidase-Antineutrophil Cytoplasmic Antibody (MPO-ANCA)-Associated Glomerulonephritis: A Case Report and Review of the Literature. (PubMed, Cureus) - "A 55-year-old obese female with myeloperoxidase-antineutrophil cytoplasmic antibody (MPO-ANCA)-associated crescentic glomerulonephritis achieved remission via steroid pulse therapy, oral prednisolone (PSL), and rituximab. Seven weeks before admission, avacopan and ursodeoxycholic acid (UDCA) were initiated...To the best of our knowledge, this is the first report describing a comprehensive immunohistochemical evaluation of the periportal microenvironment in avacopan-induced biliary injury. This case highlights that severe cholangitis can occur regardless of baseline risk profiles or disease activity, underscoring the need for vigilant, long-term monitoring of liver enzymes and bilirubin levels during avacopan therapy."

Journal • Glomerulonephritis • Hepatology • Liver Failure • Lupus Nephritis • Nephrology • Obesity • CD4 • CD68 • CK19 • KRT19 • MPO

Recurrent Intravenous Contrast-Induced Submandibular Sialadenitis: A Case Report and Literature Review. (PubMed, Am J Case Rep) - "Because she reported a prior episode of bilateral neck and submandibular swelling shortly after intravenous contrast administration 10 years earlier, premedication with oral prednisolone was prescribed...CONCLUSIONS Iodinated contrast-induced sialadenitis is a rare, self-limited delayed reaction to iodinated contrast media that can recur after re-exposure. Recognition of its characteristic clinical and imaging findings is important to aid diagnosis and avoid misdiagnosis and unnecessary contrast exposure, premedication, investigations, and treatment."

Journal • Review • Bronchiectasis • Chronic Kidney Disease • Dermatology • Infectious Disease • Mumps • Nephrology • Otorhinolaryngology • Pain • Pulmonary Disease • Renal Disease • Respiratory Diseases

Long-term developmental outcome in infantile epileptic spasms syndrome after high-dose prednisolone and vigabatrin treatment. (PubMed, Epilepsia Open) - "Infantile epileptic spasms syndrome (IESS) is a severe epilepsy of infancy that often leads to lasting developmental problems. In this study of 236 children with IESS treated with a stepwise vigabatrin and prednisolone protocol, developmental outcome at age 3 was mainly associated with the underlying cause of IESS and response to treatment. Children without an identified underlying cause and those who responded to treatment had better developmental outcomes than children with a structural or genetic cause or those who did not respond. These findings emphasize the importance of careful evaluation and individualized treatment in children with IESS."

Journal • CNS Disorders • Epilepsy

Recurrent kimura disease of unilateral parotid gland: the magnetic resonance imaging findings. (PubMed, BMJ Case Rep) - "Fine-needle aspiration cytology showed a benign lymphoid proliferation with marked eosinophilia, revealing recurrent KD. Combined therapy with oral prednisolone, cyclosporine and surgery led to significant improvement."

Journal • Eosinophilia • Inflammation • Otorhinolaryngology • Pain

Unmasking a Hidden Burden: Chemotherapy-Induced and Exacerbated Diabetes in Paediatric Cancer: A Report of Two Cases. (PubMed, Niger Med J) - "A 4-year-old female with newly diagnosed Acute Lymphoblastic Leukaemia (ALL) was commenced on chemotherapy with prednisolone, 6-mercaptopurine, vincristine, doxorubicin, cyclophosphamide, L-asparaginase and cytarabine...An 11-year-old male was diagnosed with NHL, and chemotherapy was initiated with a regimen consisting of cyclophosphamide, vincristine, oral prednisolone, intrathecal methotrexate, and hydrocortisone...Treatment was commenced with metformin 500mg nocte. The FBG has normalized.These cases demonstrate that early detection of hyperglycaemia during childhood cancer chemotherapy is a low-cost, high-impact intervention that can prevent life-threatening complications such as DKA and its associated morbidity and mortality, especially in resource-constrained settings."

Journal • Acute Lymphocytic Leukemia • Cardiovascular • Diabetes • Hematological Malignancies • Hypertension • Hypoglycemia • Leukemia • Lymphoma • Metabolic Disorders • Obesity • Oncology • Pediatrics

Four versus six cycles of CHOP chemotherapy in combination with six applications of rituximab in patients with aggressive B-cell lymphoma with favourable prognosis (FLYER): a randomised, phase 3, non-inferiority trial. (PubMed, Lancet) - P3; "In young patients with aggressive B-cell non-Hodgkin lymphoma and favourable prognosis, four cycles of R-CHOP is non-inferior to six cycles of R-CHOP, with relevant reduction of toxic effects. Thus, chemotherapy can be reduced without compromising outcomes in this population."

Clinical • Combination therapy • Head-to-Head • Journal • P3 data • Hematological Disorders • Hematological Malignancies • Lymphoma • Non-Hodgkin’s Lymphoma • Oncology

Pustulotic arthro-osteitis complicated by polyarteritis nodosa: a case report. (PubMed, Mod Rheumatol Case Rep) - "The patient was diagnosed with exacerbation of PAO complicated by PAN and was treated with oral prednisolone followed by methotrexate, resulting in rapid normalization of inflammatory markers and improvement in osteoarticular symptoms, purpura, and finger paresthesia, although lower-extremity neurological symptoms persisted at discharge. When patients with PAO develop atypical features such as purpura or neuropathic symptoms suggestive of mononeuritis multiplex, concomitant vasculitis, including PAN, should be considered in the differential diagnosis."

Journal • Immunology • Inflammation • Musculoskeletal Diseases • Pain • Psoriasis • Vasculitis • MPO

Comparison of oral prednisolone and ACTH therapies in infantile epileptic spasms syndrome: using BASED and E-Chess scores. (PubMed, Brain Dev) - "High-dose oral prednisolone and ACTH therapies demonstrated comparable efficacy in reducing electrographic and clinical seizure burden in children with IESS. Improvement in epileptiform activity, as reflected by reductions in the BASED score, is strongly associated with better clinical outcomes. Additionally, a high pretreatment medication burden may serve as an early indicator of a refractory clinical course."

Journal • CNS Disorders • Epilepsy

Oral steroids in sciatica: The OASIS Randomised Controlled Trial (ANZCTR) - P4 | N=390 | Active, not recruiting | Sponsor: The University of Sydney | Recruiting ➔ Active, not recruiting | N=200 ➔ 390

Enrollment change • Enrollment closed • Musculoskeletal Pain • Pain

Persistent Periorbital Edema as the Initial Manifestation of Probable Systemic Lupus Erythematosus With Suspected Protein-Losing Enteropathy or Lupus Serositis in an Adolescent: A Case Report. (PubMed, Cureus) - "The patient received oral prednisolone at 1 mg/kg/day based on a documented body weight of 50 kg...This case illustrates that isolated periorbital edema may be an initial manifestation of systemic lupus erythematosus in adolescents, and the presence of hypoalbuminemia with ascites in the absence of proteinuria should prompt consideration of protein-losing enteropathy or serositis in the differential diagnosis. Early immunological evaluation and corticosteroid therapy were associated with favorable clinical and biochemical outcomes."

Journal • Dermatology • Hematological Disorders • Immunology • Inflammation • Inflammatory Arthritis • Lupus • Pain • Renal Disease • Respiratory Diseases • Systemic Lupus Erythematosus

Cytokine Release Syndrome Induced by Neoadjuvant Pembrolizumab in Early Triple-Negative Breast Cancer: A Case Report with Implications for Early Diagnosis and Management. (PubMed, Case Rep Oncol) - "Suspecting CRS, the patient was admitted to the intensive care unit (ICU) and treated with tocilizumab and steroid pulse therapy, resulting in rapid clinical improvement...She was started on oral prednisolone with gradual tapering; however, she experienced CRS recurrence...At 20 months postoperatively, neither breast cancer relapse nor CRS recurrence was observed. Early diagnosis and treatment of CRS are crucial to prevent severe multi-organ failure."

Journal • Breast Cancer • Critical care • Hypotension • Nephrology • Oncology • Pain • Renal Disease • Solid Tumor • Triple Negative Breast Cancer

AZD2265 Compared With Standard of Care in PSMA-positive Metastatic Castration-resistant Prostate Cancer (VECTRA-01) (clinicaltrials.gov) - P3 | N=670 | Recruiting | Sponsor: AstraZeneca | Trial completion date: Dec 2029 ➔ Jun 2030 | Trial primary completion date: Feb 2029 ➔ Jun 2029

Trial completion date • Trial primary completion date • Castration-Resistant Prostate Cancer • Genito-urinary Cancer • Oncology • Prostate Adenocarcinoma • Prostate Cancer • Solid Tumor