prednisolone / Generic mfg. - LARVOL DELTA

P097 Atypical pemphigoid and an acneiform eruption in a patient with inflammatory bowel disease. (PubMed, Br J Dermatol) - "The differential diagnosis included fungal and bacterial infections, and his scalp responded to terbinafine and ciprofloxacin, with partial improvement of his face and trunk...He responded rapidly to high-dose oral prednisolone, which was tapered over 3 months...His working diagnosis is two concurrent conditions: an atypical pemphigoid and a separate acneiform/pustular eruption possibly on the pyoderma gangrenosum-hidradenitis suppurativa spectrum in the context of irritable bowel disease. He is now well controlled on dapsone and doxycycline, with isotretinoin added recently, given an overarching clinical feature of an acneiform eruption at present."

Journal • Acne Vulgaris • Dermatology • Gastroenterology • Gastrointestinal Disorder • Hidradenitis Suppurativa • Immunology • Infectious Disease • Inflammation • Inflammatory Bowel Disease • Pyoderma Gangrenosum • Ulcerative Colitis

BG07 Usage of dupilumab treatment in generalized bullous pemphigoid in two older Asian patients with favourable outcomes. (PubMed, Br J Dermatol) - "He developed gastritis after initially taking oral prednisolone 20 mg per day. Both patients of East Asian descent responded favourably to the treatment and were able to achieve remission within 8 weeks, which reflected a satisfactory outcome from dupilumab treatment, especially with the absence of adverse events. As a result, dupilumab could be a welcome option in treatment of BP, especially as the typical patient with BP is older and may have multiple existing comorbidities or a preexisting immunocompromised state."

Journal • Bullous Pemphigoid • Cardiovascular • CNS Disorders • Congestive Heart Failure • Dermatology • Dermatopathology • Gastrointestinal Disorder • Heart Failure • Immunology • Movement Disorders • Osteoporosis • Parkinson's Disease • Rheumatology • IL13 • IL4R

CPC01 Eosinophilic cellulitis in the setting of cocaine use. (PubMed, Br J Dermatol) - "Oral prednisolone (0.5 mg kg-1 per day) was commenced, with rapid improvement noted within days. In this case it is also possible that the clinical findings were triggered by a contaminated batch of cocaine, as levamisole-adulterated cocaine can cause autoimmunity syndromes such as drug-induced ANCA. This dangerous recreational drug initiates inflammation through formation of neutrophil extracellular traps, which culminates in pronounced autoimmune responses including ANCA production."

Journal • Cardiovascular • Dermatology • Eosinophilia • Hypotension • Immunology • Infectious Disease • Inflammation • Otorhinolaryngology • Pneumonia • Respiratory Diseases • Sinusitis • CRP

PA17 A challenging case of refractory childhood pemphigus vulgaris. (PubMed, Br J Dermatol) - "He commenced oral prednisolone 20 mg daily, but continued to develop new blisters with 11-kg weight loss due to limited oral intake...Mycophenolate mofetil (MMF) (10 mg kg-1 twice daily) was added, leading to disease stabilization enabling prednisolone tapering...On increasing MMF to 20 mg kg-1 twice daily, disease remission was eventually achieved, and azathioprine and prednisolone were stopped...Almost all cases achieved complete or partial remission after rituximab, mostly without relapse and only minor side-effects. A wide range of dosing regimens were used. Our case highlights the challenges in managing refractory PV in this age group."

Journal • Cushing’s Disease • Dermatology • Endocrine Disorders • Immunology • Oncology • Pemphigus Vulgaris • Steven-Johnson Syndrome

P040 Clinical features, treatment and treatment response of 24 patients with epidermolysis bullosa acquisita. (PubMed, Br J Dermatol) - "All patients were treated initially with oral prednisolone and some patients required oral dapsone (n = 20), intravenous corticosteroids (n = 11), mycophenolate mofetil (n = 19) and azathioprine (n = 7). Overall, 63% (n = 15) of patients were treated with intravenous immunoglobulin (IVIG) and 63% (n = 15) with rituximab...In conclusion, the treatment of EBA can be challenging, and most patients in this series required combination treatment with corticosteroids, dapsone and an intravenous immunosuppressant. The treatment-refractory nature of the disease is also reflected by the high proportion of patients requiring rituximab, and 25% of patients having ongoing active disease despite maximal therapy."

Journal

BI35 A case of dupilumab-induced scalp psoriasis and review of the literature. (PubMed, Br J Dermatol) - "The AD was ineffectively controlled by topical steroids, ultraviolet therapy and abrocitinib. He was trialled on methotrexate (up to 12.5 mg per week), which helped control his eczema but was discontinued because of deranged liver function. He continued to develop severe recurrent flare-ups requiring treatment with short-term oral prednisolone and then ciclosporin...His AD is being managed with lebrikizumab...Hypothetically, the blockade of the T helper (Th)2 response with dupilumab by targeting the IL-4/IL-13 signalling pathway could result in a shift towards a Th1/Th17 phenotype, leading to an inflammatory cytokine cascade and eventually psoriatic skin plaques, as described in this report. Dermatologists should be aware of psoriasis as a potential adverse event with dupilumab."

Journal • Review • Allergic Rhinitis • Alopecia • Asthma • Atopic Dermatitis • Dermatitis • Dermatology • Immunology • Inflammation • Mood Disorders • Psoriasis • Psychiatry • Pulmonary Disease • Respiratory Diseases • IL13 • IL4

BI21 Intermittent and progressive pustular psoriasis during chemotherapy cycles in a toddler. (PubMed, Br J Dermatol) - "Just before his next chemotherapy cycle (cisplatin and etoposide), the rash recurred as a pruritic pustular eruption across the frontal and retroauricular scalp; skin biopsy suggested nonspecific subacute eczematous dermatitis...Topical ivermectin and ketoconazole did not help...A second biopsy was taken due to clinical suspicion of psoriasis, and 10 days of oral prednisolone was given to try to clear his skin for autologous stem cell transplantation (HSCT)...He was treated with topical calcipotriol and mometasone 0.1%, with consideration of acitretin should he not improve. Fortunately, the rash settled with topical therapy and time. After completing proton radiotherapy prior to tumour resection, he had six cycles of maintenance immunotherapy (dinutuximab) with no recurrence of the rash, despite monthly GCSF, and good cell counts, and has now completed his oncological therapy."

Journal • Atopic Dermatitis • Bone Marrow Transplantation • Contact Dermatitis • Dermatitis • Dermatology • Epstein-Barr Virus Infections • Herpes Simplex • Herpes Zoster • Immunology • Neuroblastoma • Oncology • Psoriasis • Pustular Psoriasis • Solid Tumor • Transplantation • Varicella Zoster

BI27 Treatment of recalcitrant eczema in a patient with B-cell and natural killer cell lymphopenia of unknown cause. (PubMed, Br J Dermatol) - "He had tried superpotent topical corticosteroids and oral prednisolone, as well as emollients, none of which had improved his symptoms...Tralokinumab was trialled for 12 weeks, as this has a single therapeutic target (interleukin-13), but unfortunately there was no improvement. Following discussion with the immunologists, he was commenced on upadacitinib as this was felt to have a more targeted immunosuppressive effect above agents such as methotrexate and dupilumab. We await his next follow-up appointment to assess response. This case highlights the complexity of treating an immunocompromised individual with immunosuppressive agents, when the cause of their immunosuppression is unknown."

Journal • Atopic Dermatitis • Cutaneous T-cell Lymphoma • Dermatitis • Dermatology • Herpes Zoster • Immunology • Infectious Disease • Mycosis Fungoides • Oncology • Solid Tumor • Thymoma • Thymus Cancer • Varicella Zoster • BTK • GATA2 • IL13

P099 Spesolimab use in effective treatment of generalized pustular psoriasis: a case report. (PubMed, Br J Dermatol) - "He was managed as an inpatient with topical treatment and oral prednisolone...He received oral methotrexate therapy but upon readmission with pustulation flare, diagnosis of GPP was confirmed and acitretin commenced...The patient then experienced widespread desquamative eruption and incipient pustulation, and as it was not possible to secure further compassionate funding for spesolimab as maintenance therapy, he commenced secukinumab therapy...In our patient with GPP spesolimab was a highly effective treatment modality, leading to lasting skin clearance when used as monotherapy from its induction, but unavailable for maintenance therapy. We await NICE appraisal, due March 2025, to consider its use within NHS care."

Journal • Dermatology • Gastroenterology • Hepatology • Immunology • Keratitis • Pancreatitis • Psoriasis • Pustular Psoriasis

BG11 Neutrophilic dermatosis: an unexpected pathway to diagnosing rheumatoid arthritis in a 73-year-old woman. (PubMed, Br J Dermatol) - "Treatment with oral prednisolone, 30 mg daily for 1 week, with a slow taper and dapsone 100 mg once daily was commenced. This case highlights the challenges in managing neutrophilic dermatosis in older patients, particularly when complicated by comorbidities. The patient's evolving clinical picture, including the possibility of rheumatoid arthritis contributing to both her skin and pulmonary manifestations, underscores the importance of a multidisciplinary approach in diagnosing and managing complex dermatological cases in older patients."

Journal • Cardiovascular • Cough • Dermatology • Dyslipidemia • Fatigue • Fibrosis • Hematological Disorders • Hypertension • Immunology • Infectious Disease • Inflammatory Arthritis • Ischemic stroke • Novel Coronavirus Disease • Oncology • Respiratory Diseases • Rheumatoid Arthritis • Rheumatology • CRP

CPC06 Darier-Roussy disease (subcutaneous sarcoidosis): a rare presentation of cutaneous nodules in pulmonary sarcoidosis. (PubMed, Br J Dermatol) - "Treatment involved a weaning course of oral prednisolone combined with topical clobetasol propionate, resulting in significant symptom improvement. This case is notable as subcutaneous nodules are a rare manifestation of sarcoidosis. Documenting such presentations enhances understanding of this uncommon condition and aids in distinguishing it from other differential diagnoses, such as panniculitis or lipomas."

Journal • Cardiovascular • Dermatitis • Dermatology • Fatigue • Gastrointestinal Disorder • Immunology • Infectious Disease • Pain • Sarcoidosis

A case of steroid-responsive late deterioration in Cryptococcus meningoencephalitis followed by longitudinal extensive transverse myelitis (PubMed, Rinsho Shinkeigaku) - "Steroid pulse therapy was administered, followed by post-therapy with oral prednisolone...While late deterioration in CM after antifungal treatment is known, effectiveness of steroid therapy for late-onset myelitis has not been reported so far. This case suggests usefulness of steroid therapy for longitudinal extensive transverse myelitis as late deterioration."

Journal • CNS Disorders • Infectious Disease • Musculoskeletal Pain • Pain

Effective Use of Mepolizumab in a Rare Case of Eosinophilic Granulomatosis With Polyangiitis Complicated by Pulmonary Tuberculosis. (PubMed, Cureus) - "She received oral prednisolone (PSL) monotherapy (10 mg/day) for these symptoms from her previous physician. In the present case, mepolizumab was effective in treating EGPA and preventing pulmonary TB exacerbation. This is a valuable report suggesting the crucial role of mepolizumab in combined cases of both conditions."

Journal • Asthma • Dermatology • Eosinophilic Granulomatosis With Polyangiitis • Immunology • Infectious Disease • Inflammation • Langerhans Cell Histiocytosis • Otorhinolaryngology • Pain • Pulmonary Disease • Rare Diseases • Respiratory Diseases • Sinusitis • Tuberculosis • Vasculitis • IL5

Drug Reaction With Eosinophilia and Systemic Symptoms (DRESS) Syndrome Caused by Pola-R-CHOP: A Case Report. (PubMed, Cureus) - "The patient also had a history of CMV reactivation and was on ganciclovir...With infection ruled out, IV hydrocortisone was started, followed by a switch to oral prednisolone (1 mg/kg), leading to clinical improvement...This case report highlights that DRESS syndrome, although rare, should be part of the differential in oncology patients receiving multi-agent therapies who present with systemic symptoms and rash. Early identification and management are crucial to reducing morbidity and mortality."

Journal • B Cell Lymphoma • Breast Cancer • Cytomegalovirus Infection • Dermatology • Diffuse Large B Cell Lymphoma • Eosinophilia • Hematological Disorders • Hematological Malignancies • Hypotension • Infectious Disease • Lymphoma • Nephrology • Non-Hodgkin’s Lymphoma • Oncology • Renal Disease • Solid Tumor

SUNCT-like headache secondary to herpes zoster in the ipsilateral ophthalmic nerve distribution: A case report (EHF-EHC 2025) - "A 52-year-old Sri Lankan male developed painful vesicular eruptions over the right ophthalmic dermatome and was treated with oral acyclovir (800 mg, five times daily)...Treatment included oral prednisolone (15 mg/day, tapered by 5 mg/week), carbamazepine (100 mg t.d.s., increased to 200 mg t.d.s. from week two), pregabalin (75 mg nocte), and tramadol (50 mg nocte)...This case underscores a SUNCT-like syndrome following ophthalmic zoster, which appears more pharmacoresponsive than primary SUNCT. Immunosuppressive states like diabetes, should be considered underlying zoster reactivation."

Case report • Clinical • Diabetes • Herpes Zoster • Metabolic Disorders • Ophthalmology • Pain • Varicella Zoster

Retinal phlebitis complicated by punctate inner choroidopathy-like lesions: a case report. (PubMed, Am J Ophthalmol Case Rep) - "Treatment with oral prednisolone and sub-Tenon triamcinolone acetonide injections controlled the inflammation, and intravitreal aflibercept injections managed the CNV. At the two-year follow-up, the corrected visual acuity improved to 1.2. The distribution of lesions along the retinal veins suggests that this case represents a presentation of PIC-like lesions secondary to retinal phlebitis."

Journal • Inflammation • Ophthalmology • Retinal Disorders

Effect of benralizumab on airway function measured by impulse oscillometry during eosinophilic exacerbations: results from the ABRA study (BTS WM 2025) - "Benralizumab alone or in combination was associated with consistent improvements in reactance parameters, reinforcing previously observed findings, 1 while oral prednisolone alone appeared less effective in restoring peripheral airway function. Benralizumab: from the basic mechanism of action to the potential use in the biological therapy of severe eosinophilic asthma. BioMed Research International 2018(1):4839230."

Asthma • Chronic Obstructive Pulmonary Disease • Immunology • Inflammation • Respiratory Diseases

Determinants of dynamic troponin rise within 30 days of moderate COPD exacerbation (BTS WM 2025) - "Blood eosinophil-guided oral prednisolone for COPD exacerbations in primary care (STARR2). Lancet Respir Med . 2024."

Cardiovascular • Chronic Obstructive Pulmonary Disease • Genetic Disorders • Immunology • Obesity • Respiratory Diseases

Relationship of cardiac biomarkers in COPD at stable state and exacerbation (BTS WM 2025) - "Blood eosinophil-guided oral prednisolone for COPD exacerbations in primary care in the UK (STARR2). Lancet Respir Med . 2024."

Biomarker • Atrial Fibrillation • Cardiovascular • Chronic Obstructive Pulmonary Disease • Congestive Heart Failure • Heart Failure • Immunology • Respiratory Diseases

VEXAS syndrome with eosinophilia and pathologically mimicking histiocytosis: A case report. (PubMed, Mod Rheumatol Case Rep) - "The patient responded favourably to the oral prednisolone therapy...Clinicians should be aware of these potential atypical manifestations to prevent delays in the diagnosis and treatment of VEXAS syndrome. Further research is warranted to delineate the full spectrum of clinical and pathological presentations of VEXAS."

Journal • Dermatology • Eosinophilia • Hematological Malignancies • Immunology • Inflammation • Myelodysplastic Syndrome • Ocular Inflammation • Oncology • Ophthalmology • Rare Diseases • Scleritis • CD68

Intravenous Immunoglobulin and Prednisolone for RPL After ART. (clinicaltrials.gov) - P2 | N=80 | Completed | Sponsor: Aalborg University Hospital | Recruiting ➔ Completed

Trial completion

Oral Prednisolone for Postoperative Analgesia Management in Paediatrics Tonsillectomy: A Meta-Analysis of Published Studies. (PubMed, Anaesth Crit Care Pain Med) - "The current meta-analysis indicates that the administration of oral prednisolone postoperatively does not decrease postoperative pain in paediatric patients following tonsillectomy. In conclusion, the paucity of studies, the high heterogeneity of results, and the low grade of evidence mandatory to perform further studies to confirm the results of the current review."

Journal • Retrospective data • Review • Pain • Pediatrics

Necrobiotic Lung Nodules—A Rare Extraintestinal Manifestation of Ulcerative Colitis (APSR 2025) - "While on oral prednisolone, serial CXRs showed progressive reduction in size of the opacities, with the CXR 14 weeks later showing significantly smaller nodular opacities. Discussion : Necrobiotic lung nodules should be considered as a differential diagnosis of lung nodules in IBD patients, but it is important to exclude infectious, autoimmune and granulomatous etiologies with similar clinical and radiological presentation."

Autoimmune Hepatitis • Cardiovascular • Gastroenterology • Gastrointestinal Disorder • Hepatitis C • Hepatology • Immunology • Infectious Disease • Inflammation • Inflammatory Bowel Disease • Portal Hypertension • Ulcerative Colitis

Intravenous immunoglobulin and prednisolone to women with unexplained recurrent pregnancy loss after assisted reproductive technology treatment: a randomised, double-blind, placebo-controlled trial. (PubMed, BMJ Open) - P2 | "The combination of oral corticosteroids and IVIg did not improve overall pregnancy rates in women with RPL after ART. However, among those who achieved pregnancy after embryo transfer, the risk of pregnancy loss appeared reduced. Larger randomised trials are needed to confirm these findings."

Clinical • Journal • Infertility

Utilizing a Confronting Upside-Down Approach for IgG4-Related Posterior Mediastinal Fibrosis: A Report of a Rare Case. (PubMed, Cureus) - "Five days post-surgery, oral prednisolone (PSL) therapy was initiated at 50 mg/day. This resulted in a significant improvement in visual acuity, with further recovery observed over three months as the PSL dose was tapered.  IgG4-related posterior mediastinal fibrosis is an uncommon condition, requiring biopsy for an accurate diagnosis. The confronting upside-down VATS technique ensures safe, precise tissue sampling with minimal complications, offering better visualization and access to challenging thoracic areas, making it a valuable approach for both biopsy and broader thoracic surgeries."

Journal • Fibrosis • Immunology • Inflammation • Oncology • Thoracic Cancer