human umbilical mesenchymal stem cell therapy (UC-MSCs) / Wuhan Hamilton Biotech, Wuhan Union Hospital - LARVOL DELTA

Human Umbilical Cord Mesenchymal Stem Cells Inhibit the Progression of Osteoarthritis by Suppressing NLRP3-Mediated Synovial Inflammation in the Early Stages of the Disease. (PubMed, Stem Cells Int) - "Experiments in vitro showed that UC-MSCs could inhibit NLRP3-mediated pyroptosis of rat primary synovial cells (Rat-scs). In conclusion, our findings suggest that UC-MSCs exert therapeutic effects on OA, at least in part, through inhibiting NLRP3-mediated synovial inflammation in the early stage of OA."

Journal • Fibrosis • Immunology • Inflammation • Musculoskeletal Diseases • Musculoskeletal Pain • Orthopedics • Osteoarthritis • Pain • Rheumatology • NLRP3

Oral Prednisolone, Apremilast and Human Umbilical Cord Mesenchymal Stem Cells in the Management of Pemphigus Foliaceus. (PubMed, J Inflamm Res) - "The regimen included prednisone, human umbilical cord mesenchymal stem cells (UC-MSCs), and apremilast, showing several advancements: UC-MSCs addressed PF and comorbidities without reported side effects, accelerated steroid tapering substantially compared to apremilast monotherapy, and held superior benefits over hematopoietic stem cells. Over a 4-month follow-up, there was a marked improvement in the patient's condition, normalization of autoantibody levels, and an increase in regulatory T cells. Further research and extended monitoring are warranted to ascertain the findings' validity and applicability."

Journal • Cardiovascular • Dermatology • Diabetes • Hepatitis B • Hepatology • Hypertension • Immunology • Infectious Disease • Inflammation • Metabolic Disorders • Pemphigus Vulgaris

Clusterin-carrying extracellular vesicles derived from human umbilical cord mesenchymal stem cells restore the ovarian function of premature ovarian failure mice through activating the PI3K/AKT pathway. (PubMed, Stem Cell Res Ther) - "Administration of UC-MSCs and UC-MSCs-derived EVs on day 6 of CTX/BUS injection could effectively improve the ovarian function of POF mice. UC-MSCs-derived EVs carrying CLU promoted proliferation and inhibited apoptosis of ovarian granulosa cells through activating the PI3K/AKT pathway. This study identifies a previously unrecognized molecular mechanism of UC-MSCs-mediated protective effects on POF, which pave the way for the use of cell-free therapeutic approach for POF."

Journal • Preclinical • Transplantation • Women's Health • CLU

Phase I Clinical Trial of UC-MSCs in the Treatment of Knee Osteoarthritis (clinicaltrials.gov) - P1 | N=18 | Recruiting | Sponsor: Wuhan Union Hospital, China | Not yet recruiting ➔ Recruiting | Trial completion date: Sep 2025 ➔ Oct 2026 | Trial primary completion date: Jul 2024 ➔ Oct 2024

Enrollment open • Trial completion date • Trial primary completion date • Immunology • Osteoarthritis • Pain • Rheumatology

Phase I Clinical Trial of UC-MSCs in the Treatment of Knee Osteoarthritis (clinicaltrials.gov) - P1 | N=18 | Not yet recruiting | Sponsor: Wuhan Union Hospital, China

New P1 trial • Immunology • Osteoarthritis • Pain • Rheumatology

Human umbilical cord mesenchymal stem cell-derived exosomes ameliorate renal fibrosis in diabetic nephropathy by targeting Hedgehog/SMO signaling. (PubMed, FASEB J) - "In vitro co-culture experiments revealed that UC-MSC-exo reduced EMT of tubular epithelial cells through inhibiting Hedgehog/SMO pathway. Collectively, UC-MSCs inhibit EMT and renal fibrosis by delivering exosomes and targeting Hedgehog/SMO signaling, suggesting that UC-MSCs and their exosomes are novel anti-fibrotic therapeutics for treating DN."

Journal • Chronic Kidney Disease • Diabetic Nephropathy • Fibrosis • Immunology • Nephrology • Renal Disease • SMO

A highly sensitive and specific Homo1-based real-time qPCR method for quantification of human umbilical cord mesenchymal stem cells in rats. (PubMed, Biotechnol J) - "In this study, we establish a highly sensitive and specific Homo1-based real-time quantitative PCR method to quantify the distribution of human UC-MSCs in rats. The method provides guidelines for the safety research of cells in preclinical stages."

Journal • Preclinical • Diabetic Nephropathy • Nephrology • Renal Disease • Transplantation

Human Umbilical Cord Mesenchymal Stem Cells Inhibit Pyroptosis of Renal Tubular Epithelial Cells through miR-342-3p/Caspase1 Signaling Pathway in Diabetic Nephropathy. (PubMed, Stem Cells Int) - "In the present study, we found that human umbilical cord MSCs (UC-MSCs) can effectively ameliorate kidney damage and reduce inflammation in DN rats...Using miRNA mimic transfection, we demonstrated that UC-MSC-derived miR-342-3p inhibited pyroptosis of renal tubular epithelial cells through targeting the NLRP3/Caspase1 pathway. These findings would provide a novel intervention strategy for the use of miRNA-modified cell therapy for kidney diseases."

Journal • Diabetes • Diabetic Nephropathy • Immune Modulation • Inflammation • Metabolic Disorders • Nephrology • Renal Disease • MIR342 • NLRP3

MicroRNA-146a-5p-modified human umbilical cord mesenchymal stem cells enhance protection against diabetic nephropathy in rats through facilitating M2 macrophage polarization. (PubMed, Stem Cell Res Ther) - "Collectively, our findings demonstrate that UC-MSCs-derived miR-146a-5p have the potential to restore renal function in DN rats through facilitating M2 macrophage polarization by targeting TRAF6. This would pave the way for the use of miRNA-modified cell therapy for kidney diseases."

Journal • Preclinical • Chronic Kidney Disease • Diabetes • Diabetic Nephropathy • Immune Modulation • Immunology • Inflammation • Metabolic Disorders • Nephrology • Oncology • Renal Disease • MIR146A • TNFA • TRAF6

Human Umbilical Cord Mesenchymal Stem Cells Promote Macrophage PD-L1 Expression and Attenuate Acute Lung Injury in Mice. (PubMed, Curr Stem Cell Res Ther) - "Our results suggest that UC-MSCs attenuate ALI via PGE2-dependent reprogramming of macrophages to promote their PD-L1 expression."

IO biomarker • Journal • Preclinical • Acute Lung Injury • Acute Respiratory Distress Syndrome • Immune Modulation • Immunology • Inflammation • Pneumonia • Pulmonary Disease • Respiratory Diseases • IFNG • IL10 • IL1B • IL2 • PD-1 • PD-L1 • TNFA

Human umbilical cord mesenchymal stem cells ameliorate acute liver failure by inhibiting apoptosis, inflammation and pyroptosis. (PubMed, Ann Transl Med) - "Furthermore, the UC-MSCs-CM reduced the levels of inflammatory cytokines and the activation of NLRP3 inflammasome in Raw264.7. Our results demonstrated that UC-MSCs exerted therapeutic effects on ALF by inhibiting apoptosis, inflammation, and pyroptosis."

Journal • Hepatology • Immune Modulation • Immunology • Inflammation • Liver Failure • BCL2L1 • CASP3 • CCL2 • IL1B • IL6 • NLRP3 • TNFA

Clinical Research of UC-MSCs in the Treatment of Diabetic Nephropathy (clinicaltrials.gov) - P=N/A; N=38; Recruiting; Sponsor: Renmin Hospital of Wuhan University

Clinical • New trial • Diabetic Nephropathy • Nephrology • Renal Disease

Therapy for Pneumonia Patients iInfected by 2019 Novel Coronavirus (clinicaltrials.gov) - P=N/A; N=0; Withdrawn; Sponsor: Puren Hospital Affiliated to Wuhan University of Science and Technology; Recruiting ➔ Withdrawn

Clinical • Trial withdrawal