Mohrus patch (ketoprofen) / Hisamitsu - LARVOL DELTA

Transdermal Ketoprofen Versus Fentanyl Patches for Pain Management Post-cesarean Section: A Comparative, Randomized, Double-Blind Study. (PubMed, Cureus) - "Both the ketoprofen patch (30 mg) and the fentanyl patch (25 mcg) provided comparable analgesia for the first 12 hours. However, at 16 and 20 hours, the ketoprofen patch was more effective than the fentanyl patch in providing analgesia. More patients in the fentanyl group were drowsy after 16 hours, though normal sleep patterns may have contributed to this observation."

Clinical • Journal • Anesthesia • Pain

Comparison of the Efficacy of Transdermal Buprenorphine Versus Ketoprofen Patches for Post-operative Analgesia in Total Knee Arthroplasty: A Randomised Controlled Trial. (PubMed, Cureus) - "Conclusion In conclusion, BTP patches demonstrated enhanced efficacy in managing post-operative pain compared to KTP, without exacerbating side effects in the early stages following total knee arthroplasty. BTP can be definitively considered as an adjuvant in post-operative total knee arthroplasty analgesia."

Journal • Musculoskeletal Diseases • Orthopedics • Pain

Design and evaluation of a drug-in-adhesive patch for the transdermal delivery of ketoprofen. (PubMed, Drug Deliv Transl Res) - "The purpose of this study was to design a drug-in-adhesive (DIA) patch for transdermal delivery of ketoprofen, using hot-melt pressure-sensitive adhesive as the matrix of the patch. Pharmacokinetic and the tissue distribution study showed no matter in plasma, muscle or skin, the drug concentration of self-made ketoprofen patch was equivalent to that of commercial patch. These data indicated that the self-made patch provided a new reference for the development of ketoprofen dosage forms and promising alternative strategy for analgesic treatment."

Journal • Pain

Comparative evaluation of efficacy of diclofenac and ketoprofen administered using transdermal drug delivery route in management of post endodontic pain: A randomized controlled clinical trial. (PubMed, J Conserv Dent Endod) - "Oral diclofenac for Group I and transdermal diclofenac patch for Group II and transdermal ketoprofen patch for Group III were administered as postendodontic analgesics. Six out of ten patients who had received diclofenac tablets complained of gastric discomfort. Both transdermal ketoprofen and diclofenac patches were effective than oral diclofenac tablet and can be used as an alternative and effective analgesic for postendodontic pain management, especially in patients with gastric discomfort."

Clinical • Journal • Dental Disorders • Pain

Contact allergy to oxidised geraniol may be over-represented in individuals with photocontact allergy to ketoprofen. (PubMed, Contact Dermatitis) - "Contact allergy to ox. geraniol, geranial and citral is common in routinely tested dermatitis patients. There is an overrepresentation of simultaneous contact allergy to ox. geraniol, ox. limonene and ox. linalool in patients with photocontact allergy to ketoprofen."

Journal • Allergy • Contact Dermatitis • Dermatitis • Dermatology • Immunology

Comparative Evaluation of Efficacy of Ketoprofen and Diclofenac Transdermal Patches with Oral Diclofenac Tablet on Postoperative Endodontic Pain- A Randomized Clinical Trial. (PubMed, Patient Prefer Adherence) - "Groups A and B received transdermal patches with Ketoprofen and diclofenac sodium, respectively, applied to the right forearm for 24 hours, with an additional patch on the left forearm for the next day. Group C received four diclofenac sodium oral tablets, twice daily for two days...Notably, the Ketoprofen patch group exhibited superior performance compared to the diclofenac transdermal patch and oral diclofenac tablet groups at 48 hours, with statistical significance (p=0.047). The present evidence substantiates the efficacy of transdermal patches containing diclofenac and ketoprofen in managing postoperative pain arising from symptomatic irreversible pulpitis in single-rooted teeth. By avoiding the use of oral NSAIDs, these patches provide effective pain relief while minimizing the risk of adverse effects, presenting a favorable option for patients."

Clinical • Journal • Dental Disorders • Musculoskeletal Diseases • Orthopedics • Pain

Analgesic Efficacy of Ketoprofen Transdermal Patch versus Ibuprofen Oral Tablet on Postendodontic Pain in Patients with Irreversible Pulpitis: A Randomized Clinical Trial. (PubMed, Pain Res Manag) - "Both KTP and ibuprofen effectively decreased postendodontic pain. Considering the comparable pattern of pain reduction, KTP can be used as an alternative to ibuprofen tablets for effective pain control after endodontic treatment of mandibular first and second molars with irreversible pulpitis."

Clinical • Journal • Dental Disorders • Pain

Efficacy of Transdermal Ketoprofen Patch in Comparison to Transdermal Diclofenac Patch in Postoperative Analgesia for Orthodontic Extractions: A Randomized Split-Mouth Study. (PubMed, Cureus) - "Conclusion Ketoprofen and diclofenac transdermal patches provide similar analgesia post orthodontic extraction. The patients required rescue analgesics only during the initial hours of the postoperative follow-up period."

Journal • Allergy • Anesthesia • Gastrointestinal Disorder • Pain

Pre-emptive Analgesic Efficacy of Single-Dose Transdermal Ketoprofen and Diclofenac Patches in Post-operative Pain Management Following Open Treatment of Mandibular Fractures: A Randomized Controlled Study. (PubMed, Cureus) - "The ketoprofen transdermal patch was found to be superior in comparison to the diclofenac patch in terms of providing optimal post-operative analgesia with a reduced requirement for post-operative rescue analgesics and minimal adverse events."

Journal • Musculoskeletal Diseases • Orthopedics • Pain

Angioedema of the Eyelids Induced by a Ketoprofen Adhesive Patch. (PubMed, Intern Med) - No abstract available

Journal • Cardiovascular

Acute generalized exanthematous pustulosis due to a transdermal ketoprofen patch. (PubMed, Contact Dermatitis) - No abstract available

Journal • Immunology

In-sewer stability of selected analgesics and their metabolites. (PubMed, Water Res) - "Ketoprofen, lidocaine, tapentadol, meperidine, hydromorphone were transformed to 0-20% whereas diclofenac, desmetramadol, ibuprofen carboxylic acid, valdecoxib, parecoxib, etoricoxib, indomethacin, naltrexone, piroxicam were transformed up to 20-50% in 12 h in rising main reactor (RMR). Sulindac, celecoxib, naloxone, oxymorphone and hydrocodone were transformed more than 50% in 12 h and considered as unstable biomarkers in RMR. This study provides the information for a better understanding of the in-sewer loss of the analgesics before using them in WBE biomarkers for estimating drug loads at the population level."

Journal • Pain

Efficacy of Transdermal Diclofenac Patch and Ketoprofen Patch as Postoperative Analgesia after Extraction of First Premolars Bilaterally in Both Arches for Orthodontic Purpose: A Comparative Study. (PubMed, J Pharm Bioallied Sci) - "Both diclofenac and ketoprofen transdermal patches are helpful in relieving pain after orthodontic extraction. Patients with diclofenac patch required more additional analgesia within 24 h compared to that with ketoprofen patch. None of the drugs showed any significant adverse effects and were well tolerated by the patients."

Clinical • Journal • Anesthesia • Pain

Effects of topically applied diclofenac and ketoprofen on prostaglandin E2 and Stat3 sera levels and body temperature in two different acute inflammation models in rats. (PubMed, Saudi J Biol Sci) - "Diclofenac or ketoprofen patches were applied in two different doses, i.e. equivalent to human therapeutic dose, and three times higher dose...Elevated Stat3 values post ketoprofen application in yeast model of induced inflammation were detected. Further investigation of cytokine microenvironment as well as the mechanisms of ketoprofen influence on inflammation are needed."

Journal • Preclinical • Immunology • Inflammation • STAT3

Generic selection criteria for safety and patient benefit [X]: Water-vapor permeability and peel force properties of brand-name and generic ketoprofen tapes. (PubMed, Drug Discov Ther) - "Furthermore, when the peel forces at 25°C and 40°C were compared, Mohrus and Toko showed significantly higher values at 40°C compared to 25°C. This study showed that there are many generic drugs with formulation characteristics different from those of brand-name drugs, and that there is a large difference among the products in terms of adhesion and detachment."

Clinical • Journal • Pain

Antinociception and less gastric injury with the dexketoprofen-tapentadol combination in mice. (PubMed, Fundam Clin Pharmacol) - "Interestingly, the 1:1 and 1:3 ratios of the drugs combination produced minor gastric injury in comparison with the 3:1 proportion of dexketoprofen, and tapentadol. Our data suggest that all proportions of the dexketoprofen-tapentadol combination produced a synergistic interaction in the acetic acid-induced visceral pain model in mice with a low incidence of gastric injury."

Journal • Pain

Thoughts on the interpretation of positive photopatch test reactions. (PubMed, Eur J Dermatol) - "The present interpretation of positive photopatch test reactions is unreliable and therefore insufficient regarding appropriate advice for patients."

Journal • Allergy • Dermatitis • Dermatology • Immunology

Comparison Between Efficacy of Transdermal Ketoprofen and Diclofenac Patch in Patients Undergoing Therapeutic Extraction-A Randomized Prospective Split Mouth Study. (PubMed, J Oral Maxillofac Surg) - "Both the ketoprofen and diclofenac transdermal patches were effective in achieving postoperative analgesia in patients after therapeutic extraction, with ketoprofen superior to diclofenac as a transdermal medicament."

Clinical • Journal • Anesthesia • Pain

Prediction of sustained fetal toxicity induced by ketoprofen based on PK/PD analysis using human placental perfusion and rat toxicity data. (PubMed, Br J Clin Pharmacol) - "The present approach successfully described the sustained fetal toxicity after discontinuing the transdermal administration of ketoprofen."

Journal • Preclinical • Biosimilar

Transdermal Ketoprofen Patch in Comparison to Eutectic Mixture of Local Anesthetic Cream and Subcutaneous Lidocaine to Control Pain Due to Venous Cannulation. (PubMed, Anesth Essays Res) - "Signs of inflammation at the site of cannulation (blanching, erythema, and induration) were very evident in Group I (EMLA) which showed significant difference than in other two groups. EMLA cream, ketoprofen patch, and lidocaine injection have equal ability to alleviate pain due to cannulation when applied before the procedure, but ketoprofen patch is more superior as it had less local inflammatory effect in comparison to EMLA cream and without double puncture as with lidocaine injection."

Journal