Promac (polaprezinc) / Zeria Pharma - LARVOL DELTA

A randomized, open, two-cycle, cross-over single dose bioequivalence study of fasting/postprandial oral Jupric Zinc Granules in healthy subjects (ChiCTR) - P=N/A | N=48 | Completed | Sponsor: Henan Infectious Disease Hospital; Henan Infectious Disease Hospital

New trial • Gastroenterology • Gastrointestinal Disorder • Peptic Ulcer

Prophylactic metformin after antenatal corticosteroids (PROMAC): a double blind randomized controlled trial. (PubMed, BMC Pregnancy Childbirth) - "In euglycemic and diet controllable gestational diabetes mellitus women, antenatal corticosteroids cause sustained maternal hyperglycemia only on Day-1. The magnitude of Day-1 hyperglycemia is generally low. Prophylactic metformin does not reduce antenatal corticosteroids' hyperglycemic effect."

Clinical • Journal • Diabetes • Gestational Diabetes • Hypoglycemia • Metabolic Disorders

Efficacy of quadruple regimen with polaprezinc for gastric Helicobacter pylori infection eradication: protocol for a single-centre, single-blind, non-inferiority, randomised clinical trial. (PubMed, BMJ Open) - "Treatment group: PQT (esomeprazole 20 mg, amoxicillin 1 g, clarithromycin 500 mg, polaprezinc 75 mg) two times per day; control group: bismuth-containing quadruple therapy (esomeprazole 20 mg, amoxicillin 1 g, clarithromycin 500 mg, bismuth potassium citrate 220 mg) two times per day. On completion, the results of the study will be published in the appropriate peer-reviewed journal. ChiCTR1900025800; preresults."

Clinical • Head-to-Head • Journal • Gastric Cancer • Gastroenterology • Gastrointestinal Cancer • Gastrointestinal Disorder • Infectious Disease • Oncology • Solid Tumor

Taste disorder's management: a systematic review. (PubMed, Clin Oral Investig) - "The systematic review provided evidence about the clinical efficacy of oral procedures, zinc supplementation, and palliative cares in dysgeusic patients. Further research is needed to find effective treatments with low adverse effects."

Journal • Review • Anesthesia • Palliative care

Impaired hematopoiesis due to copper deficiency in a hemodialysis patient supplemented with zinc (PubMed, Rinsho Ketsueki) - "This is a case of a 75-year-old man who was on maintenance hemodialysis for 10 years due to diabetic nephropathy and was prescribed polaprezinc due to a low serum zinc level (55 µg/dl) and dysgeusia...Treatment with cocoa, a compound generally known to be rich in copper, gradually improved the pancytopenia and dysplastic bone marrow histology. This case indicates that clinicians should consider the risk of zinc-induced copper deficiency and its complications when zinc supplementation is administered to patients with chronic kidney disease, particularly those undergoing hemodialysis."

Clinical • Journal • Chronic Kidney Disease • Diabetic Nephropathy • Hematological Disorders • Myelodysplastic Syndrome • Nephrology • Renal Disease

Oral management with polaprezinc solution reduces adverse events in haematopoietic stem cell transplantation patients. (PubMed, Int J Oral Maxillofac Surg) - "Within the limitations of the study design, it may be concluded that oral management with PPAA reduces adverse events in HSCT. Oral management with concomitant use of PPAA decreased oral adverse events and reduced the systemic complication of GVHD."

Adverse events • Clinical • Journal • Graft versus Host Disease • Hematological Disorders • Hematological Malignancies • Immunology • Infectious Disease • Mucositis • Neutropenia • Oncology • Pain • Septic Shock • Stomatitis • Transplantation

Polaprezinc (Zinc-L-Carnosine Complex) as an Add-on Therapy for Binge Eating Disorder and Bulimia Nervosa, and the Possible Involvement of Zinc Deficiency in These Conditions: A Pilot Study. (PubMed, J Clin Psychopharmacol) - "These findings offer preliminary evidence for the effectiveness of polaprezinc in treating BED and BN and suggest the involvement of zinc deficiency in these conditions."

Clinical • Journal • Binge Eating Disorder • Bulimia • CNS Disorders • Peptic Ulcer

Sodium New Houttuyfonate Inhibits Candida albicans Biofilm Formation by Inhibiting the Ras1-cAMP-Efg1 Pathway Revealed by RNA-seq. (PubMed, Front Microbiol) - "We also found that SNH can effectively inhibit the biofilm formation of clinical C. albicans strains (Z103, Z3044, Z1402, and Z1407) and SNH in combination with fluconazole, berberine chloride, caspofungin and itraconazole antifungal agents can synergistically inhibit the biofilm formation of C. albicans...Furthermore, using Galleria mellonella as an in vivo model we found that SNH can effectively treat C. albicans infection in vivo. Our presented results suggest that SNH exhibits potential antibiofilm effects related to inhibiting the Ras1-cAMP-Efg1 pathway in the biofilm formation of C. albicans."

Journal

Polaprezinc for prevention of oral mucositis in patients receiving chemotherapy followed by hematopoietic stem cell transplantation: a multi-institutional randomized controlled trial. (PubMed, Int J Cancer) - "There were no significant differences in the incidence rates of other adverse events or the rate of engraftment (95.6% vs 97.2%, P = 0.693) between the two groups. These findings suggest that PZ lozenge is effective for prophylaxis against Grade ≥ 2 oral mucositis associated with chemotherapy in patients undergoing HSCT without any influence on the HSCT outcome."

Clinical • Journal • Mucositis • Oncology • Stomatitis • Transplantation

Zinc deficits, mucositis, and mucosal macrophage perturbation: is there a relationship? (PubMed, Curr Opin Clin Nutr Metab Care) - "Zinc deficits, dietary or induced by cancer, are common in patients with cancer. Febrile mucositis may better describe the condition linking mucositis with febrile neutropenia. Febrile mucositis disrupts treatment and may be life-threatening. A paradigm shift is needed for a more comprehensive understanding of febrile mucositis. Zinc effects on the thymic immunological network and T lymphocytes during chemoradiotherapy regimens also warrant further investigation."

Journal • Hematological Disorders • Mucositis • Neutropenia • Oncology • Otorhinolaryngology • Pediatrics • Stomatitis • Transplantation

Taste and smell disturbances in cancer patients: a scoping review of available treatments. (PubMed, Support Care Cancer) - "This scoping review identifies the current state of knowledge regarding chemosensory alterations within supportive cancer care. Despite not reaching firm conclusions, this article offers therapeutic venues to further explore in larger and more methodologically sound studies."

Clinical • Journal • Review • Dental Disorders • Oncology • Palliative care • Xerostomia

Pre-dialysis serum creatinine as an independent predictor of responsiveness to zinc supplementation among patients on hemodialysis. (PubMed, Clin Exp Nephrol) - "Pre-dialysis SCre level was independently associated with responsiveness to zinc supplementation after three months in patients on MHD."

Clinical • Journal

Protective effect of polaprezinc on cadmium-induced injury of lung epithelium. (PubMed, Metallomics) - "These results indicate that polaprezinc can suppress cadmium-induced lung epithelial cell death and oxidative stress by inducing metallothioneins. We therefore suggest that polaprezinc may have therapeutic effects against respiratory diseases, such as chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis."

Journal • Chronic Obstructive Pulmonary Disease • Fibrosis • Idiopathic Pulmonary Fibrosis • Immunology • Respiratory Diseases

Comparison of the Efficacy of Polaprezinc Plus Proton Pump Inhibitor and Rebamipide Plus Proton Pump Inhibitor Treatments for Endoscopic Submucosal Dissection-induced Ulcers. (PubMed, J Clin Gastroenterol) - "The polaprezinc plus PPI treatment showed noninferiority to rebamipide plus PPI treatment in the ulcer healing rate at 4 weeks after ESD."

Clinical • Journal • Gastric Cancer • Gastrointestinal Cancer • Oncology • Solid Tumor

Efficacy and Safety of Polaprezinc (Zinc Compound) on Zinc Deficiency: A Systematic Review and Dose-Response Meta-Analysis of Randomized Clinical Trials Using Individual Patient Data. (PubMed, Nutrients) - "All doses of polaprezinc were tolerable, but a dose-response relationship with adverse events (AEs) was observed in gastrointestinal disorders. The dose of 300 mg may be useful among patients with baseline serum zinc concentration of less than 70 µg/dL, and 150 mg for 70 µg/dL or more."

Journal • Retrospective data • Review • Gastroenterology • Gastrointestinal Disorder

Prediction of antiviral drugs against African swine fever viruses based on protein-protein interaction analysis. (PubMed, PeerJ) - "Several drugs with either broad-spectrum effect or high specificity on ASFV-interacting swine proteins were identified, such as Polaprezinc and Geldanamycin. Structural modeling and molecular dynamics simulation showed that Geldanamycin could bind with swine HSP90AB1 stably. This work could not only deepen our understanding towards the ASFV-swine interactions, but also help for the development of effective antiviral drugs against the ASFVs."

Journal

A Review of Zinc-L-Carnosine and Its Positive Effects on Oral Mucositis, Taste Disorders, and Gastrointestinal Disorders. (PubMed, Nutrients) - "Zinc-L-carnosine (ZnC), also called polaprezinc known as PepZin GI™, is a chelated compound that contains L-carnosine and zinc...Evidence supports the safety and efficacy of ZnC for the maintenance, prevention, and treatment of the mucosal lining and other epithelial tissues. The research supports its use for gastric ulcers (approved in Japan) and conditions of the upper GI and suggests other applications, particularly for oral mucositis."

Journal • Review

Risk of post-stroke pneumonia with proton pump inhibitors, H2 receptor antagonists and mucoprotective agents: A retrospective nationwide cohort study. (PubMed, PLoS One) - "Use of proton pump inhibitors, H2 receptor antagonists, and mucoprotective agents (rebamipide, teprenone, irsogladine, ecabet, polaprezinc, sofalcone, sucralfate, and misoprostol) after stroke were determined based on the prescription records, which were treated as time-dependent variables. In conclusion, the treatment with proton pump inhibitors and H2 receptor antagonists was associated with increased risk for pneumonia in stroke patients. Clinicians should use caution in prescribing the acid-suppressive medications for the stroke patients at great risk for pneumonia."

Journal • Retrospective data

Intrarectally administered polaprezinc attenuates the development of dextran sodium sulfate-induced ulcerative colitis in mice. (PubMed, Exp Ther Med) - "Histopathology indicated that the mice of the DSS model group had irregular colonic villi, a large number of inflammatory cells and mucosal damage, whereas mice of the group treated with PZ had small intestinal villus morphology and their villi showed signs of recovery from the damage of UC. The results of the present study indicated that PZ significantly alleviates DSS-induced UC in mice, relieves diarrhea, and inhibits the phosphorylation of inflammatory factors and the inflammatory AKT signaling pathway."

Journal • Preclinical

Comparison of zinc acetate hydrate and polaprezinc for zinc deficiency in patients on maintenance hemodialysis: A single-center, open-label, prospective randomized study. (PubMed, Ther Apher Dial) - "ZAH was superior to PPZ in increasing serum zinc levels. Clinicians should note the stronger decline in serum copper levels when using ZAH for MHD patients."

Clinical • Journal

Analysis of free and metabolized microcystins in samples following a bird mortality event. (PubMed, Harmful Algae) - "Free [D-Leu]MC-LR was quantitated in tissues at 25-67 ng g (LC-MS). The levels of microcystin varied based on analytical method used, highlighting the need to develop a comprehensive analysis strategy to elucidate the etiology of bird mortality events when microcystin-producing HABs are present."

Journal

From benzene to naphthalene: direct measurement of reactions and intermediates of phenyl radicals and acetylene. (PubMed, Phys Chem Chem Phys) - "An additional C8H7 isomer, bicyclo[4.2.0]octa-1,3,5-trien-7-yl, not considered by Mebel et al.'s calculations, contributes significantly to the signal at m/z 103 due to its stable energy and low reactivity...At 50 Torr, the branching was measured to be 2.8% at 600 K and 6.2% at 700 K. Adduct stabilization is favored at higher pressure and lower temperature, which hinders the formation of the H-loss product. The pressure-dependent model predicted the observed branching ratios within the experimental uncertainty, indicating that the rate parameters reported here can be used in combustion mechanisms to provide insights into phenyl HACA reactions and PAH formation."

Journal

The Effect of Proton Pump Inhibitor and Polaprezinc Combination Therapy for Healing of Endoscopic Submucosal Dissection-induced Ulcer (clinicaltrials.gov) - P=N/A; N=153; Completed; Sponsor: Yonsei University; Recruiting ➔ Completed

Combination therapy • Trial completion

Protective effect of polaprezinc on acute gastric mucosal injury in rats. (PubMed, Zhong Nan Da Xue Xue Bao Yi Xue Ban) - " Polaprezinc reduced gastric mucosa injury in the polaprezinc group compared to the model group. Compared with the blank group, the levels of PGE2 and EGF in blood serum were significantly decreased in the model group and the polaprezinc group (P0.05). Polaprezinc can provide effective protection for acute mucosal injury and the underlying mechanism is not directly related to PGE2 and EGF."

Journal • Preclinical

Beneficial effect of polaprezinc on cardiac function post-myocardial infarction: A prospective and randomized clinical trial. (PubMed, Medicine (Baltimore)) - "The results of the present study suggest that polaprezinc has an anti-inflammatory effect and improves cardiac function after AMI."

Biomarker • Clinical • Journal