oxytocin / Generic mfg. - LARVOL DELTA

Generate and Test the Reliability of a PD Model of OXT on Pupillary Hippus as a Measure of CNS Activity (clinicaltrials.gov) - P2 | N=4 | Terminated | Sponsor: Wake Forest University Health Sciences | The study was maintained active in anticipation of returning to the protocol. Due to funding and current NIH grant work this study could not be completed.

Enrollment change • Trial completion date • Trial primary completion date • Trial termination • Immunology • Osteoarthritis • Pain • Rheumatology

BLOOM: Different Medications to Induce Labor (clinicaltrials.gov) - P3 | N=303 | Completed | Sponsor: Icahn School of Medicine at Mount Sinai | Recruiting ➔ Completed

Trial completion

The Stimulation To Induce Mothers Study (clinicaltrials.gov) - P4 | N=933 | Active, not recruiting | Sponsor: Yale University | Recruiting ➔ Active, not recruiting

Enrollment closed • Pain

Intravenous Oxytocin for Post Operative Pain After Minimally Invasive Hysterectomy (clinicaltrials.gov) - P2 | N=152 | Recruiting | Sponsor: Brigham and Women's Hospital | Trial completion date: Dec 2026 ➔ Jun 2028 | Trial primary completion date: Jul 2026 ➔ Dec 2027

Trial completion date • Trial primary completion date • Gynecology • Pain

Gene-environment interaction between perinatal oxytocin exposure and Pten mutation shapes epigenetic reprogramming of oxytocin signaling and behavior in mice. (PubMed, Neurobiol Dis) - "Synthetic oxytocin (Pitocin) is the most commonly used pharmacologic agent for induction and augmentation of labor...Our findings support a model in which genetic susceptibility shapes the epigenetic encoding of early-life hormonal signals, thereby recalibrating oxytocin system function and downstream behavioral outcomes. Together, these data highlight the context-dependent effects of perinatal oxytocin exposure and argue against uniformly beneficial or detrimental effects, emphasizing the importance of gene-environment interactions in neurodevelopmental trajectories."

Journal • Preclinical • Autism Spectrum Disorder • CNS Disorders • Developmental Disorders • Genetic Disorders • Mood Disorders • Psychiatry • PTEN

BLOOM: Different Medications to Induce Labor (clinicaltrials.gov) - P3 | N=281 | Recruiting | Sponsor: Icahn School of Medicine at Mount Sinai | Enrolling by invitation ➔ Recruiting

Enrollment status

Intranasal and Intravenous Oxytocin for Analgesia to Noxious Heat Pain (clinicaltrials.gov) - P2 | N=24 | Completed | Sponsor: Wake Forest University Health Sciences | Recruiting ➔ Completed

Trial completion • Pain

LIFT: Induction of Labor After Cesarean Using Foley Alone vs. Concurrent Foley and Oxytocin (clinicaltrials.gov) - P=N/A | N=100 | Active, not recruiting | Sponsor: University of Pennsylvania | Trial primary completion date: May 2027 ➔ Jul 2026 | Recruiting ➔ Active, not recruiting

Enrollment closed • Trial primary completion date

BLOOM: Different Medications to Induce Labor (clinicaltrials.gov) - P3 | N=266 | Enrolling by invitation | Sponsor: Icahn School of Medicine at Mount Sinai | Recruiting ➔ Enrolling by invitation

Enrollment status

Efficacy of Intravenous Oxytocin to Speed Recovery After THA (clinicaltrials.gov) - P2 | N=80 | Enrolling by invitation | Sponsor: Wake Forest University Health Sciences | Not yet recruiting ➔ Enrolling by invitation | Trial completion date: Jun 2027 ➔ Dec 2027 | Trial primary completion date: Jun 2027 ➔ Dec 2027

Enrollment open • Trial completion date • Trial primary completion date • Orthopedics

Prophylactic oxytocin infusion for reducing blood loss during elective caesarean delivery: A randomised controlled trial. (PubMed, Indian J Med Res) - "All received oxytocin 5IU bolus after head delivery, followed by infusion for four hours postpartum...Ease of foetal head delivery, need for additional uterotonics, and neonatal outcomes were comparable between the groups. Interpretation and conclusions The initiation of oxytocin at the skin incision may lead to significantly lower blood loss and a lower fall in haemoglobin level compared to its initiation after foetal head delivery among women undergoing elective pre-labour caesarean section at term."

Clinical • Journal • Hypotension • Postpartum Hemorrhage

CBCT-OT RCT: Examining Intranasal Oxytocin Augmentation of Brief Couples Therapy for Veterans With PTSD (clinicaltrials.gov) - P2 | N=240 | Recruiting | Sponsor: VA Office of Research and Development | Trial completion date: Apr 2028 ➔ Sep 2028 | Trial primary completion date: Apr 2028 ➔ Sep 2028

Trial completion date • Trial primary completion date • CNS Disorders • Mood Disorders • Post-traumatic Stress Disorder

Oral calcium carbonate as an adjunct to oxytocin infusion for labor induction: A randomized controlled pilot study on feasibility and acceptability. (PubMed, Am J Obstet Gynecol MFM) - "Random allocation to standard care oxytocin or calcium carbonate in combination with oxytocin for labor induction was feasible and acceptable to patients and clinicians."

Journal • Obstetrics

Comparing the Dose-response Profiles of Uterotonics After Initial Carbetocin Administration - an Ex-vivo Study in Desensitized Human Myometrium (clinicaltrials.gov) - P=N/A | N=32 | Recruiting | Sponsor: Samuel Lunenfeld Research Institute, Mount Sinai Hospital | Trial completion date: Dec 2025 ➔ Dec 2026 | Trial primary completion date: Dec 2025 ➔ Dec 2026

Trial completion date • Trial primary completion date • Hematological Disorders • Postpartum Hemorrhage

Oxytocin Maintenance Infusion in Labouring Women Undergoing Cesarean Delivery: an Up-down Sequential Allocation Study (clinicaltrials.gov) - P=N/A | N=40 | Recruiting | Sponsor: Samuel Lunenfeld Research Institute, Mount Sinai Hospital | Trial completion date: Dec 2025 ➔ Dec 2026 | Trial primary completion date: Dec 2025 ➔ Dec 2026

Trial completion date • Trial primary completion date • Hematological Disorders • Postpartum Hemorrhage

Effect of Ephedrine, Phenylepinephrine, and Norepinephrine on Myometrial Contractility in Pregnant People With Type II and Gestational Diabetes During Cesarean Section: An In-vitro Study (clinicaltrials.gov) - P=N/A | N=96 | Recruiting | Sponsor: Samuel Lunenfeld Research Institute, Mount Sinai Hospital | Suspended ➔ Recruiting | Trial completion date: Dec 2025 ➔ Dec 2026 | Trial primary completion date: Dec 2025 ➔ Dec 2026

Enrollment open • Trial completion date • Trial primary completion date • Diabetes • Gestational Diabetes • Hematological Disorders • Metabolic Disorders • Postpartum Hemorrhage

A Swift Solution: Early Removal of the JADA Device in the Management of Postpartum Hemorrhage. (PubMed, Cureus) - "Despite administration of Pitocin and tranexamic acid, the patient continued to have brisk vaginal bleeding after placental delivery. Overall, the JADA device offers a safe, effective, and versatile tool for PPH management. This case contributes to the growing evidence supporting its role in individualized care and underscores the need for further studies exploring early removal protocols."

Journal • Anesthesia • Gynecology • Hematological Disorders • Obstetrics • Postpartum Hemorrhage

Failure of Sequential JADA® Devices in Major Postpartum Hemorrhage Requiring Emergent Supracervical Hysterectomy: A Case Report. (PubMed, Cureus) - "Her bleeding was attributed to uterine atony and persisted despite the administration of multiple uterotonic agents, including Pitocin, methylergonovine, Hemabate, rectal misoprostol, and tranexamic acid. This case demonstrates sequential JADA® device failure in the setting of major PPH and emphasizes the need for clinicians to promptly recognize insufficient response, understand the limitations of uterine vacuum systems, and be prepared to escalate to surgical management when bleeding persists. As the JADA® device becomes further integrated into PPH algorithms, documenting real-world experiences with device failure is essential for refining clinical expectations, improving patient care, and reducing mortality."

Journal • Gynecology • Hematological Disorders • Obstetrics • Postpartum Hemorrhage

Comparative Efficacy of Carbetocin and Oxytocin in Parturients at Risk of Atonic Postpartum Hemorrhage Undergoing Elective Cesarean Delivery (clinicaltrials.gov) - P=N/A | N=160 | Recruiting | Sponsor: Samuel Lunenfeld Research Institute, Mount Sinai Hospital | Trial completion date: Dec 2025 ➔ Dec 2026 | Trial primary completion date: Dec 2025 ➔ Dec 2026

Trial completion date • Trial primary completion date • Hematological Disorders • Postpartum Hemorrhage

Efficacy of Intravenous Oxytocin to Speed Recovery After THA (clinicaltrials.gov) - P2 | N=80 | Not yet recruiting | Sponsor: Wake Forest University Health Sciences

New P2 trial • Orthopedics

Revisiting Risk: Uterine Rupture in a Low-Risk Gravida Without Prior Surgery. (PubMed, Cureus) - "Spontaneous rupture can occur in unscarred, low-risk uteri. Vigilant fetal monitoring and clinical awareness during labor induction and augmentation are essential for timely diagnosis and intervention."

Journal • Obstetrics

Cooling the Uterus in C-section After Dysfunctional Labor (clinicaltrials.gov) - P=N/A | N=8 | Terminated | Sponsor: Baylor Research Institute | N=100 ➔ 8 | Unknown status ➔ Terminated; Difficulty in acquiring patients in a reasonable amount of time.

Enrollment change • Trial termination • Gynecology

Time of Day of Induction Impacts the Total Duration of Labor. (PubMed, Am J Obstet Gynecol MFM) - "The time of day of initiation of labor induction influenced IOL duration, with the shortest duration when induced during early morning hours. No increase in adverse maternal and fetal outcomes was identified when controlling for time-of-day of labor induction. The optimal time-of-day to induce labor is influenced by BMI and parity and should be considered when performing this common obstetric intervention."

Journal • Genetic Disorders • Obesity • Obstetrics

Low-Dose Versus High-Dose Oxytocin Dosing for Induction and Augmentation of Labor (clinicaltrials.gov) - P4 | N=170 | Completed | Sponsor: The University of Texas Medical Branch, Galveston | Active, not recruiting ➔ Completed | Trial completion date: Apr 2026 ➔ Jun 2025

Trial completion • Trial completion date

Management of immediate and delayed postpartum hemorrhage with cesarean delivery. (PubMed, Am J Obstet Gynecol) - "Similarly, arterial embolization requires time and is feasible only for hemodynamically stable patients with slow persistent bleeding. We propose management algorithms for 2 types of postpartum hemorrhage associated with cesarean delivery: perioperative immediate hemorrhage and postoperative delayed hemorrhage."

Journal • Review • Anesthesia • Gynecology • Hematological Disorders • Long-acting Reversible Contraceptives • Obstetrics • Postpartum Hemorrhage