drospirenone/ethinyl estradiol / Generic mfg. - LARVOL DELTA

Drug exposure before and during pregnancy and thromboembolic events: a disproportionality analysis from the FAERS database. (PubMed, Int J Surg) - "Drawing on the FAERS database, we have provided a list of drugs with risk signals for PTEs in this exploratory study. Our findings highlight the importance of considering both before and during-pregnancy drug exposures when assessing thromboembolism risk. More well-designed studies are warranted for drugs whose association with PTEs is not fully understood."

Journal • Cardiovascular

Cyproterone acetate for hirsutism. (PubMed, Cochrane Database Syst Rev) - "There were some differences in clinical outcome between CPA and spironolactone, CPA and flutamide, and CPA and finasteride. There were no clinical differences between CPA and the other medical therapies, possibly because of small study size, lack of standardised assessment and objective determinants of improvement in many studies. There are insufficient data presented to compare the adverse effects of all the treatment options. Larger, carefully designed studies are needed to compare efficacy and safety profiles between the therapeutic options available."

Clinical • Journal • Review • Gynecology

Hair cortisol/cortisone in combined oral contraceptive users: An exploratory analysis. (PubMed, Contraception) - "COC use was not associated with higher hair glucocorticoids, though hair treatments may influence detection."

Journal

Effects of drospirenone and ethinylestradiol tablets (II) combined with metformin on the composition of gut microbiota in polycystic ovary syndrome with insulin resistance. (PubMed, Front Endocrinol (Lausanne)) - "2. Drospirenone and ethinylestradiol tablets (II) combined with metformin tablets can change the gut microbiota relative abundance of patients with PCOS-IR, which may be related to the improvement of host lipid and glucose metabolism."

Journal • Polycystic Ovary Syndrome

Comparative Effectiveness of COCPs Versus Levonorgestrel and Other Therapies in Female Acne: A Systematic Review and Meta-Analysis (EADV 2025) - "Materials & A systematic search was performed to identify randomized controlled trials (randomized controlled trials) comparing combined oral contraceptives (e.g., ethinyl estradiol with drospirenone, norgestimate, desogestrel, or chlormadinone acetate) against levonorgestrel-only pills, topical agents, or combination therapies for the treatment of acne. Combined oral contraceptives are effective and safe options for the treatment of acne in women, with enhanced benefits observed when used in conjunction with other treatment modalities. Despite high heterogeneity in reported outcomes and treatment protocols, the evidence supports the use of combined oral contraceptives, particularly formulations containing ethinyl estradiol with drospirenone or ethinyl estradiol with norgestimate. Future clinical trials should aim for standardized reporting of acne severity and direct head-to-head comparisons between contraceptive formulations to better inform optimal treatment..."

HEOR • Retrospective data • Review • Acne Vulgaris • Seborrheic Dermatitis

A Drug-Drug Interaction Study Between HS-10374 Tablets and Drospirenone and Ethinyl Estradiol Tablets(Yasmin®) (clinicaltrials.gov) - P1 | N=18 | Completed | Sponsor: Hansoh BioMedical R&D Company

New P1 trial • Dermatology • Immunology • Psoriasis

Uterine arteries embolization for cesarean scar pregnancy with uterine arteriovenous fistula. (PubMed, SAGE Open Med Case Rep) - "After the operation, leprorelin 3.75 mg was given by intramuscular injection three times, followed by oral contraceptive drospirenone ethinylestradiol tablets, one tablet a day, to prevent recurrence of uterine arteriovenous fistula...Uterine arteriovenous fistula should be considered in the clinical treatment of patients with abnormal vaginal bleeding who cannot be diagnosed clearly. Uterine arteriography is the definitive method, and after interventional treatment, drugs can be used to prevent recurrence and close follow-up."

Journal • Cardiovascular • Hematological Disorders • Postpartum Hemorrhage

Effects of estetrol/drospirenone versus ethinyl estradiol/drospirenone on glucose tolerance in women with polycystic ovary syndrome: A randomised controlled trial. (PubMed, Diabetes Obes Metab) - "E4/DRSP was not inferior to EE/DRSP in its effects on glucose tolerance, insulin levels and HOMA-IR, supporting its use as a potential oral contraceptive option in women with PCOS."

Journal • Polycystic Ovary Syndrome

Oral contraceptives containing ethinyl estradiol and drospirenone increase hydroxylation and methylation of endogenous estrogen but not genotoxic estrogen DNA-adduct formation. (PubMed, Sci Rep) - "Our data suggests that the use of EE/DRSP increases the flux of endogenous hormones into the hormone biotransformation pathway, resulting in increased conversion of estrogens (especially E1) into conjugated, catechol, and methylated estrogens but that the latter is limited by methyl-group donor availability. Interestingly, the increased oxidation of estrogens in COC users does not result in increased DNA-adduct formation."

Journal • Breast Cancer • Oncology • Solid Tumor • COMT

Two Cases of Reduced Mother's Milk Production During Use of Combined Oral Contraceptives. (PubMed, J Hum Lact) - "These cases follow two experiences of low milk production after initiation of combined oral contraceptives. In these cases, there was a resolution of infant weight gain with discontinuation of the medication."

Journal

A Case of the Irregularly Bordered Thyroid nodule (ENDO 2025) - "She had no signs of thyroid dysfunction and was taking fluticasone, cetirizine, and drospirenone/ethinyl estradiol. This case highlights the challenges of managing thyroid nodules with indeterminate cytology and intermediate-risk molecular findings. Despite the benign final diagnosis, the decision to proceed with surgery was influenced by concerning ultrasound features and the molecular profile. With the increasing number of FNA biopsies performed, this case raises the question of whether a more conservative approach with serial imaging could have been an alternative."

Clinical • Allergic Rhinitis • Endocrine Disorders • Immunology • Oncology • Otorhinolaryngology • Polycystic Ovary Syndrome • NRAS

Isotretinoin-Induced Hypertriglyceridemia: A Silent Trigger for Acute Pancreatitis in a Young Patient" (ENDO 2025) - "Her only medications were drospirenone-ethinyl estradiol and isotretinoin (40 mg twice daily), which she had been using for 8 months...Isotretinoin was discontinued; she was discharged with fenofibrate... Isotretinoin-induced hypertriglyceridemia leading to acute pancreatitis, though rare, should be considered when a patient on isotretinoin presents with symptoms of pancreatitis. Clinicians should be proactive in educating patients on the signs of pancreatitis and consider lipid screening, especially for those with risk factors for hypertriglyceridemia."

Clinical • Acne Vulgaris • Cardiovascular • Dermatology • Dyslipidemia • Gastroenterology • Hypertriglyceridemia • Pain • Pancreatitis

Hormonal contraceptive use and anaemia: a nation-wide pharmacoepidemiological study from Northern Europe. (PubMed, Eur J Epidemiol) - "Individual product effects ranged from 0·77 [0·66-0·90] for drospirenone and ethinylestradiol to 0·40 [0·32-0·48] for desogestrel-only. Benefits of HC use extend to anaemia protection on population level. Anaemia protection should be included in guidelines on HC to support clinical decision making."

Journal • Anemia • Genetic Disorders • Hematological Disorders • Long-acting Reversible Contraceptives • Obesity • Oncology • Women's Health

Use of systemic hormonal contraception and risk of depression: a registry-based study from Finland. (PubMed, Eur J Epidemiol) - "Use of HC in the six preceding months, specifically that of combined hormonal contraceptives (containing gestodene and ethinylestradiol, drospirenone and ethinylestradiol, and nomegestrol and estradiol), was significantly associated with a lower risk of depression compared to non-use when controlling for marital status, socioeconomic status, education, recent delivery, recent psychiatric hospitalization, chronic diseases, use of psychiatric medications (excluding antidepressants) and former use of HC (odds ratio: 0.90, 95% confidence interval = 0.85-0.95; 0.86, 95% confidence interval = 0.81-0.91, respectively). Current use of progestogen-only preparations (norethisterone, levonorgestrel, desogestrel) was not associated with depression. This pattern was evident in all age groups, including adolescent girls. HC use appeared not associated with an increased risk of depression in fertile-aged women and across all age groups, including adolescent girls."

Journal • CNS Disorders • Depression • Mood Disorders • Psychiatry

Sustained Metabolic Improvements with Low-Dose Metformin Combined with Oral Contraceptives in Female Adolescents with PCOS: A Single-Center Retrospective Cohort Study. (PubMed, Adv Ther) - "Our study highlights the effectiveness of low-dose metformin therapy in improving insulin resistance and metabolic parameters among adolescent patients with PCOS. Sustained benefits were observed even after treatment cessation. These findings underscore the potential for early intervention with metformin during adolescence to confer long-lasting advantages in managing metabolic abnormalities associated with PCOS."

Journal • Retrospective data • Polycystic Ovary Syndrome

Efficacy of a four-drug combined regimen compared to uterine curettage in the treatment of incomplete medical abortion: a prospective observational study. (PubMed, J Health Popul Nutr) - "The combined regimen of four drugs boasts favorable efficacy for the treatment of incomplete MA, and is equally efficient as compared to uterine curettage."

Journal • Observational data

Decreased Incidence of ACL Injuries in Females by Selective Use of Hormonal Contraceptives (AAOS 2025) - "Among these groups, non-contraceptive users, hormonal systemic contraceptive (including pill, implant, injection, ring, and patch) users, OCP users (including formulations norethindrone (NE) only, drospirenone (DS) + ethinyl estradiol (EE), (NE + EE), norgestimate (NG + EE)), and levonorgestrel (a progestin found in intra-uterine devices) users were included in the analysis. Hormonal contraceptive use may be associated with a lower incidence of ACL injuries compared to no contraceptive use in females. Hormonal contraceptive formulations, specifically progestin containing, may play a protective role against ACL injuries in females. Further research is warranted to explore confounding variables that impact the association between hormonal contraceptive use and ACL injury."

Long-acting Reversible Contraceptives • Orthopedics

Acute pancreatitis caused by oral contraceptives. (PubMed, Intern Emerg Med) - "Numerous research findings indicate that acute pancreatitis triggered by hypertriglyceridemia (HTG-AP, hypertriglyceridemic acute pancreatitis) may lead to increased death rates compared to other acute pancreatitis causes hypertriglyceridemia, characterized by fasting serum triglycerides exceeding (150mg/dL; 1.7mmol/L), and severe hypertriglyceridemia, identified by levels above (885 mg/dL; > 10 mmol/L) [2]. This paper presents an uncommon instance of HTG-AP, triggered by polycystic ovary syndrome and treated with oral contraceptive Drospirenone and ethinylestradiol tablets, where serum triglyceride levels reached an unprecedented 9906.37 mg/dL."

Journal • Dyslipidemia • Gastroenterology • Hepatology • Hypertriglyceridemia • Inflammation • Pancreatitis • Polycystic Ovary Syndrome • Severe Hypertriglyceridemia

Use of Hormonal Contraceptives is Associated with Decreased Incidence of ACL Injuries Requiring Reconstruction in Females. (PubMed, Arthroscopy) - "Systemic hormonal contraceptive use is associated with a lower incidence of ACL injury requiring ACL reconstruction compared to no contraceptive use in females ages 15 to 35, with a stronger association with progestin-only OCPs. Females ages 15 to 19 showed no difference in the association with ACL injury incidence between OCP use and no contraceptive use."

Journal • Orthopedics

Increased ferritin with contraceptives containing ethinyl estradiol drospirenone in polycystic ovary syndrome: a paradox of iron storage and iron deficiency. (PubMed, Endocrine) - "The study revealed a paradoxical increase in ferritin levels with EE/DRSP treatment, highlighting the complex role of ferritin as a metabolic marker in PCOS patients, particularly in relation to obesity, which is typically associated with low-grade chronic inflammation."

Journal • Retrospective data • Genetic Disorders • Hematological Disorders • Inflammation • Obesity • Polycystic Ovary Syndrome • CRP

Animal models of hormonal contraceptives: Understanding drug-specific and user-specific variables. (PubMed, J Neuroendocrinol) - "This review underscores the value of animal models in advancing our understanding of the broader neurobiological and behavioral impacts of HCs in humans. These studies are crucial for developing personalized medicine approaches and optimizing contraceptive regimens to mitigate risks."

Journal • Preclinical • Review

DRUG-INDUCED SECONDARY HYPERTENSION: A CASE OF ORAL CONTRACEPTIVE-INDUCED HYPERTENSION IN A YOUNG FEMALE (ISN-WCN 2025) - "The patient was taking ethinyl estradiol/drospirenone 3-0.03 mg, one tablet orally daily, as an oral contraceptive...Discontinuation of the offending agent is crucial in managing such cases. This case underscores the need for careful evaluation of medication history in young patients presenting with hypertension, particularly when other secondary causes are ruled out."

Clinical • Cardiovascular • Endocrine Disorders • Hypertension • Obesity • Pain • Pediatrics • Rheumatology

An Application Study of Digital Therapeutics Based on Lifestyle Interventions in Overweight and Obese Patients with Polycystic Ovary Syndrome (ChiCTR) - P=N/A | N=34 | Completed | Sponsor: Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine; Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Me

New trial • Obesity • Polycystic Ovary Syndrome

Comparison of Combined Oral Contraceptives and a Transdermal Estrogen Patch With Oral Progesterone: Treatment of Abnormal Uterine Bleeding in Adolescents. (PubMed, Cureus) - "Methods Thirty patients who were treated with either 30 μg ethinyl estradiol/3 mg drospirenone combined oral contraceptive (group A) or 1.95 mg 17β-estradiol transdermal patch and 5 mg oral medroxyprogesterone acetate combined treatment (group B) for six months in the pediatric endocrinology department between years 2017 and 2019 were enrolled in our study retrospectively, and a questionnaire was performed on them to assess their treatment satisfaction. Menstrual irregularity stopped after two months of treatment in both groups, but one (6.6%) and three (20.0%) patients reported that AUB repeated within three months of treatment cessation in group A and group B, respectively. Conclusion Immaturity of the hypothalamo-pituitary-ovarian axis in adolescence can present with a wide range of symptoms and proves challenging to choose the proper treatment regimen."

Journal • Endocrine Disorders • Pain • Pediatrics • Women's Health

Impact of Estetrol Combined with Drospirenone on Blood Coagulation and Fibrinolysis in Patients with Endometriosis: A Multicenter, Randomized, Open-Label, Active-Controlled, Parallel-Group Study. (PubMed, Clin Appl Thromb Hemost) - "Eventually, the fibrinolysis cascade was triggered to compensate for disturbed coagulation, and D-dimer levels were 4.7-fold higher in the EE/DRSP group than in the E4/DRSP group. This study demonstrated that the effect of E4/DRSP on the blood coagulation and fibrinolysis cascades was significantly less than that of EE/DRSP in participants with endometriosis, a disease of women of advanced and reproductive age (jRCT2080225090, https://jrct.niph.go.jp/en-latest-detail/jRCT2080225090)."

Clinical • Journal • Cardiovascular • Endometriosis • Gynecology • Venous Thromboembolism • Women's Health • PROS1